Paolo Provenzano

19992021
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Research Output 1999 2019

2019
6 Citations (Scopus)

Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma

Elahi-Gedwillo, K. Y., Carlson, M., Zettervall, J. & Provenzano, P., Jan 15 2019, In : Cancer Research. 79, 2, p. 372-386 15 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Architectural Accessibility
Pharmaceutical Preparations
Therapeutics
Neoplasms

Non-invasive monitoring of stromal biophysics with targeted depletion of hyaluronan in pancreatic ductal adenocarcinoma

Maloney, E., Dufort, C. C., Provenzano, P., Farr, N., Carlson, M. A., Vohra, R., Park, J., Hingorani, S. R. & Lee, D., Jun 1 2019, In : Cancers. 11, 6, 772.

Research output: Contribution to journalArticle

Open Access
Biophysics
Hyaluronic Acid
Adenocarcinoma
Glycosaminoglycans
Collagen

The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance

Zhovmer, A. S., Tabdanov, E. D., Miao, H., Wen, H., Chen, J., Luo, X., Ma, X., Provenzano, P. & Adelstein, R. S., Jul 22 2019, In : Molecular biology of the cell. 30, 16, p. 1961-1973 13 p.

Research output: Contribution to journalArticle

Open Access
Actomyosin
Myosins
Microtubules
Cell Polarity
Aptitude
2018
3 Citations (Scopus)
cues
Fluidics
Cadherins
Cues
Adhesion

Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices

Ray, A., Morford, R. K. & Provenzano, P., Aug 1 2018, In : Current Protocols in Stem Cell Biology. 46, 1, e57.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Cell Movement
Collagen
Carcinoma
Extracellular Matrix
1 Citation (Scopus)

Dynamics of 3D carcinoma cell invasion into aligned collagen

Ray, A., Morford, R. K., Ghaderi, N., Odde, D. J. & Provenzano, P., Feb 1 2018, In : Integrative Biology (United Kingdom). 10, 2, p. 100-112 13 p.

Research output: Contribution to journalArticle

Collagen
Cells
Carcinoma
Tumors
Military electronic countermeasures

Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing

Tabdanov, E. D., Puram, V., Zhovmer, A. & Provenzano, P., Oct 9 2018, In : Cell Reports. 25, 2, p. 328-338.e6

Research output: Contribution to journalArticle

Actomyosin
Microtubules
Tumors
Cells
Stiffness
2 Citations (Scopus)

Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer

Shao, Q., Liu, F., Chung, C., Elahi-Gedwillo, K., Provenzano, P., Forsyth, B. & Bischof, J. C., Jan 1 2018, In : Annals of Biomedical Engineering. 46, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

Tumors
Cells
Glucose
Hot Temperature
Heterografts
2017
48 Citations (Scopus)

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

Ray, A., Lee, O., Win, Z., Edwards, R. M., Alford, P. W., Kim, D. H. & Provenzano, P., Apr 12 2017, In : Nature communications. 8, 14923.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Movement
adhesion
Adhesion
cells
25 Citations (Scopus)

Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices

Ray, A., Slama, Z. M., Morford, R. K., Madden, S. A. & Provenzano, P., Mar 14 2017, In : Biophysical journal. 112, 5, p. 1023-1036 14 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Collagen
Cell Movement
Breast Neoplasms
Cell Size
5 Citations (Scopus)

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

Carlson, M., Watson, A. L., Anderson, L., Largaespada, D. A. & Provenzano, P. P., Nov 1 2017, In : Journal of biomedical optics. 22, 11, 116010.

Research output: Contribution to journalArticle

Open Access
Chemotherapy
chemotherapy
Doxorubicin
Tumors
tumors

Tug of War at the Cell-Matrix Interface

Provenzano, P., May 9 2017, In : Biophysical journal. 112, 9, p. 1739-1741 3 p.

Research output: Contribution to journalShort survey

2016
14 Citations (Scopus)

Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites

Jung, J. P., Bache-Wiig, M. K., Provenzano, P. & Ogle, B. M., Jan 1 2016, In : BioResearch Open Access. 5, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Extracellular Matrix Proteins
Extracellular Matrix
Collagen Type I
30 Citations (Scopus)

Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

Dufort, C. C., DelGiorno, K. E., Carlson, M. A., Osgood, R. J., Zhao, C., Huang, Z., Thompson, C. B., Connor, R. J., Thanos, C. D., Scott Brockenbrough, J., Provenzano, P. P., Frost, G. I., Michael Shepard, H. & Hingorani, S. R., May 10 2016, In : Biophysical journal. 110, 9, p. 2106-2119 14 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Gels
Pressure
Hyaluronic Acid
Extracellular Fluid
15 Citations (Scopus)

Multiscale Cues Drive Collective Cell Migration

Nam, K. H., Kim, P., Wood, D. K., Kwon, S., Provenzano, P. & Kim, D. H., Jul 27 2016, In : Scientific reports. 6, 29749.

Research output: Contribution to journalArticle

Cell Movement
Cues
Biomimetics
Anisotropy
Contracts
2015

Synrtgistic effects of nanotopography and surface matrix patterning on contact guided migration of human breast cancer cells

Nam, K. H., Kim, P., Provenzano, P. P., Kwon, S. & Kim, D. H., Jan 1 2015, MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 221-223 3 p. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cells
Biomimetics
Surface treatment
Tumors
Adhesion
2014

Cell force-mediated collagen remodeling in cancer metastasis

Provenzano, P., Jan 1 2014, Cell and Matrix Mechanics. CRC Press, p. 329-350 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumors
Collagen
Neoplasm Metastasis
Neoplasms
Cellular Microenvironment
19 Citations (Scopus)

Response to Chauhan et al. Interstitial Pressure and Vascular Collapse in Pancreas Cancer-Fluids and Solids, Measurement and Meaning

DelGiorno, K., Carlson, M., Osgood, R., Provenzano, P. P., Brockenbough, J. S., Thompson, C., Shepard, H. M., Frost, G., Potter, J. & Hingorani, S., Jul 14 2014, In : Cancer Cell. 26, 1, p. 16-17 2 p.

Research output: Contribution to journalLetter

Antineoplastic Combined Chemotherapy Protocols
Pancreatic Ductal Carcinoma
Deoxycytidine
Hyaluronic Acid
Pancreatic Neoplasms
2013
124 Citations (Scopus)

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer

Provenzano, P. P. & Hingorani, S. R., Jan 15 2013, In : British Journal of Cancer. 108, 1, p. 1-8 8 p.

Research output: Contribution to journalReview article

Hyaluronic Acid
Pancreatic Neoplasms
Adenocarcinoma
Pressure
Complicity
2012
860 Citations (Scopus)

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D. & Hingorani, S. R., Mar 20 2012, In : Cancer Cell. 21, 3, p. 418-429 12 p.

Research output: Contribution to journalArticle

Architectural Accessibility
Hyaluronic Acid
Adenocarcinoma
Extracellular Fluid
gemcitabine
327 Citations (Scopus)

Matrix nanotopography as a regulator of cell function

Kim, D. H., Provenzano, P. P., Smith, C. L. & Levchenko, A., Apr 1 2012, In : Journal of Cell Biology. 197, 3, p. 351-360 10 p.

Research output: Contribution to journalReview article

Extracellular Matrix
Microtechnology
Physiological Phenomena
Nanotechnology
Behavior Control
2011
426 Citations (Scopus)

Aligned collagen is a prognostic signature for survival in human breast carcinoma

Conklin, M. W., Eickhoff, J. C., Riching, K. M., Pehlke, C. A., Eliceiri, K. W., Provenzano, P. P., Friedl, A. & Keely, P. J., Jan 1 2011, In : American Journal of Pathology. 178, 3, p. 1221-1232 12 p.

Research output: Contribution to journalArticle

Collagen
Breast Neoplasms
Survival
Neoplasms
Syndecan-1
226 Citations (Scopus)

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

Provenzano, P. P. & Keely, P. J., Apr 15 2011, In : Journal of Cell Science. 124, 8, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Focal Adhesions
Cytoskeleton
Cell Proliferation
Extracellular Matrix
2010
14 Citations (Scopus)

Engineering three-dimensional collagen matrices to provide contact guidance during 3D cell migration

Provenzano, P. P., Eliceiri, K. W., Inman, D. R. & Keely, P. J., Jun 28 2010, In : Current Protocols in Cell Biology. SUPPL. 47

Research output: Contribution to journalReview article

Cell Movement
Collagen
Cues
Neoplasms
2009
73 Citations (Scopus)

Fluorescence lifetime imaging of endogenous fluorophores in histopathology sections reveals differences between normal and tumor epithelium in carcinoma in situ of the breast

Conklin, M. W., Provenzano, P. P., Eliceiri, K. W., Sullivan, R. & Keely, P. J., Apr 1 2009, In : Cell Biochemistry and Biophysics. 53, 3, p. 145-157 13 p.

Research output: Contribution to journalArticle

Fluorophores
Optical Imaging
Tumors
Epithelium
Fluorescence
338 Citations (Scopus)

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

Provenzano, P. P., Inman, D. R., Eliceiri, K. W. & Keely, P. J., Dec 1 2009, In : Oncogene. 28, 49, p. 4326-4343 18 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Breast
Phosphotransferases
Collagen
Epithelial Cells
129 Citations (Scopus)

Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment

Provenzano, P. P., Eliceiri, K. W. & Keely, P. J., Apr 1 2009, In : Clinical and Experimental Metastasis. 26, 4, p. 357-370 14 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Optical Imaging
Microscopy
Neoplasm Metastasis
Neoplasms
9 Citations (Scopus)
Optical microscopy
Microscopy
Harmonic generation
Breast Neoplasms
Fluorescence Microscopy
9 Citations (Scopus)

Nonlinear optical microscopy and computational analysis of intrinsic signatures in breast cancer.

Rueden, C. T., Conklin, M. W., Provenzano, P. P., Keely, P. J. & Eliceiri, K. W., 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 4077-4080 4 p. 5334523

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optical microscopy
Microscopy
Harmonic generation
Breast Neoplasms
Fluorescence Microscopy
45 Citations (Scopus)

Shining new light on 3D cell motility and the metastatic process

Provenzano, P. P., Eliceiri, K. W. & Keely, P. J., Nov 1 2009, In : Trends in Cell Biology. 19, 11, p. 638-648 11 p.

Research output: Contribution to journalReview article

Cell Movement
Optical Imaging
Neoplasm Metastasis
Neoplasms
Cellular Microenvironment
48 Citations (Scopus)

The role of focal adhesion kinase in tumor initiation and progression

Provenzano, P. & Keely, P. J., Jan 1 2009, In : Cell Adhesion and Migration. 3, 4

Research output: Contribution to journalComment/debate

Focal Adhesion Protein-Tyrosine Kinases
Neoplasms
Neoplasm Metastasis
Carcinoma
rho GTP-Binding Proteins
2008
627 Citations (Scopus)

Collagen density promotes mammary tumor initiation and progression

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Knittel, J. G., Yan, L., Rueden, C. T., White, J. G. & Keely, P. J., Apr 23 2008, In : BMC Medicine. 6, 11.

Research output: Contribution to journalArticle

Collagen
Breast Neoplasms
Neoplasms
Breast
Neoplasm Metastasis
279 Citations (Scopus)

Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization

Provenzano, P., Inman, D. R., Eliceiri, K. W., Trier, S. M. & Keely, P. J., Dec 1 2008, In : Biophysical journal. 95, 11, p. 5374-5384 11 p.

Research output: Contribution to journalArticle

Cell Movement
Collagen
Extracellular Matrix
rho-Associated Kinases
Neoplasms
102 Citations (Scopus)

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E. & Keely, P. J., Jan 1 2008, In : American Journal of Pathology. 173, 5, p. 1551-1565 15 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Transgenic Mice
Breast
Breast Neoplasms
Neoplasm Metastasis
49 Citations (Scopus)

Nonlinear optical imaging and spectral-lifetime computational analysis of endogenous and exogenous fluorophores in breast cancer

Provenzano, P. P., Rueden, C. T., Trier, S. M., Yan, L., Ponik, S. M., Inman, D. R., Keely, P. J. & Eliceiri, K. W., Dec 1 2008, In : Journal of Biomedical Optics. 13, 3, 031220.

Research output: Contribution to journalArticle

Fluorophores
breast
cancer
adenines
Imaging techniques
45 Citations (Scopus)

Nonlinear optical imaging of cellular processes in breast cancer

Provenzano, P. P., Eliceiri, K. W., Yan, L., Ada-Nguema, A., Conklin, M. W., Inman, D. R. & Keely, P. J., Dec 1 2008, In : Microscopy and Microanalysis. 14, 6, p. 532-548 17 p.

Research output: Contribution to journalArticle

Harmonic generation
breast
harmonic generations
cancer
Fluorescence
2007
10 Citations (Scopus)

Adjuvant neuropeptides can improve neuropathic ligament healing in a rat model

Grorud, K. W., Jensen, K. T., Provenzano, P. P. & Vanderby, R., Jun 1 2007, In : Journal of Orthopaedic Research. 25, 6, p. 703-712 10 p.

Research output: Contribution to journalArticle

Neuropeptides
Ligaments
Connective Tissue
Collateral Ligaments
Neuropeptide Y
9 Citations (Scopus)

Investigating Integrin Regulation and Signaling Events in Three-Dimensional Systems

Keely, P. J., Conklin, M. W., Gehler, S., Ponik, S. M. & Provenzano, P. P., Dec 1 2007, Integrins. Cheresh, D. (ed.). p. 27-45 19 p. (Methods in Enzymology; vol. 426).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cytology
Molecular imaging
Molecular Imaging
Integrins
Extracellular Matrix
32 Citations (Scopus)

Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: Evaluation of loaded and unloaded ligaments

Provenzano, P. P., Alejandro-Osorio, A. L., Grorud, K. W., Martinez, D. A., Vailas, A. C., Grindeland, R. E. & Vanderby, R., Apr 19 2007, In : BMC Physiology. 7, 2.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Ligaments
Extracellular Matrix
Hindlimb
Growth Hormone
2006
212 Citations (Scopus)

Collagen fibril morphology and organization: Implications for force transmission in ligament and tendon

Provenzano, P. P. & Vanderby, R., Mar 1 2006, In : Matrix Biology. 25, 2, p. 71-84 14 p.

Research output: Contribution to journalArticle

Ligaments
Tendons
Collagen
Felidae
Proteoglycans
753 Citations (Scopus)

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Provenzano, P. P., Eliceiri, K. W., Campbell, J. M., Inman, D. R., White, J. G. & Keely, P. J., Dec 1 2006, In : BMC medicine. 4, 38.

Research output: Contribution to journalArticle

Collagen
Neoplasms
Breast Neoplasms
Breast
Human Mammary Glands
2005
43 Citations (Scopus)

Intrinsic fibroblast-mediated remodeling of damaged collagenous matrices in vivo

Provenzano, P. P., Alejandro-Osorio, A. L., Valhmu, W. B., Jensen, K. T. & Vanderby, R., Jan 1 2005, In : Matrix Biology. 23, 8, p. 543-555 13 p.

Research output: Contribution to journalArticle

Fibroblasts
Cicatrix
Collagen
Proteoglycans
Collagen Type I
2004
23 Citations (Scopus)

Blockade of the sympathetic nervous system degrades ligament in a rat MCL model

Dwyer, K. W., Provenzano, P. P., Muir, P., Valhmu, W. B. & Vanderby, R., Feb 1 2004, In : Journal of applied physiology. 96, 2, p. 711-718 8 p.

Research output: Contribution to journalArticle

Guanethidine
Collateral Ligaments
Sympathetic Nervous System
Ligaments
Matrix Metalloproteinase 13
69 Citations (Scopus)

Nonlinear viscoelasticity in rabbit medial collateral ligament

Hingorani, R. V., Provenzano, P. P., Lakes, R. S., Escarcega, A. & Vanderby, R., Feb 1 2004, In : Annals of Biomedical Engineering. 32, 2, p. 306-312 7 p.

Research output: Contribution to journalArticle

Ligaments
Viscoelasticity
Creep
Stress relaxation
Tissue
2003
25 Citations (Scopus)
Toes
Statistical Models
Connective Tissue
Tissue
Fibers
15 Citations (Scopus)

Collagen in connective tissue: From tendon to bone

Vanderby, R. & Provenzano, P. P., Oct 1 2003, In : Journal of Biomechanics. 36, 10, p. 1523-1527 5 p.

Research output: Contribution to journalEditorial

Tendons
Collagen
Connective Tissue
Bone
Tissue
40 Citations (Scopus)

Hindlimb unloading alters ligament healing

Provenzano, P. P., Martinez, D. A., Grindeland, R. E., Dwyer, K. W., Turner, J., Vailas, A. C. & Vanderby, R., Jan 1 2003, In : Journal of Applied Physiology. 94, 1, p. 314-324 11 p.

Research output: Contribution to journalArticle

Hindlimb Suspension
Ligaments
Connective Tissue
Thigh
Cicatrix
6 Citations (Scopus)

Required test duration for group comparisons in ligament viscoelasticity: A statistical approach

Manley, E., Provenzano, P. P., Heisey, D., Lakes, R. & Vanderby, R., Jun 20 2003, In : Biorheology. 40, 4, p. 441-450 10 p.

Research output: Contribution to journalArticle

Ligaments
32 Citations (Scopus)

Scanning electron microscopic characterization of healing and normal rat ligament microstructure under slack and loaded conditions

Hurschler, C., Provenzano, P. P. & Vanderby, R., Jan 1 2003, In : Connective Tissue Research. 44, 2, p. 59-68 10 p.

Research output: Contribution to journalArticle

Ligaments
Rats
Electrons
Scanning
Microstructure
2002
4 Citations (Scopus)

A boundary layer model for wall shear stress in arterial stenosis

Provenzano, P. P. & Rutland, C. J., Jan 1 2002, In : Biorheology. 39, 6, p. 743-754 12 p.

Research output: Contribution to journalArticle

Pathologic Constriction
Constriction
Blood Vessels
Thrombosis
Research Personnel