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Research Output 1995 2020

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Article
2020

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

Pampusch, M. S., Haran, K. P., Hart, G. T., Rakasz, E. G., Rendahl, A. K., Berger, E. A., Connick, E. & Skinner, P. J., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
Maintenance
T-Cell Antigen Receptor
Macaca mulatta
T-Lymphocytes
Population
2019

Detection of antigen-specific t cells using in situ mhc tetramer staining

Abdelaal, H. M., Cartwright, E. K. & Skinner, P. J., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5165.

Research output: Contribution to journalArticle

Open Access
T-cells
antigens
staining
Antigens
Tissue
2 Citations (Scopus)

Low levels of siv-specific CD8+ T cells in germinal centers characterizes acute SIV infection

Li, S., Folkvord, J. M., Kovacs, K. J., Wagstaff, R. K., Mwakalundwa, G., Rendahl, A. K., Rakasz, E. G., Connick, E. & Skinner, P. J., Mar 2019, In : PLoS pathogens. 15, 3, e1007311.

Research output: Contribution to journalArticle

Open Access
Germinal Center
T-Lymphocytes
Infection
CD8 Antigens
Perforin
2018
15 Citations (Scopus)

Detection of HIV-1-specific gastrointestinal tissue resident CD8 + T-cells in chronic infection

Kiniry, B. E., Li, S., Ganesh, A., Hunt, P. W., Somsouk, M., Skinner, P. J., Deeks, S. G. & Shacklett, B. L., May 1 2018, In : Mucosal Immunology. 11, 3, p. 909-920 12 p.

Research output: Contribution to journalArticle

HIV-1
T-Lymphocytes
Infection
Phenotype
Mucous Membrane
15 Citations (Scopus)

Simian immunodeficiency virus (SIV)-specific chimeric antigen receptor-T cells engineered to target B cell follicles and suppress SIV replication

Haran, K. P., Hajduczki, A., Pampusch, M. S., Mwakalundwa, G., Vargas-Inchaustegui, D. A., Rakasz, E. G., Connick, E., Berger, E. A. & Skinner, P. J., Mar 20 2018, In : Frontiers in immunology. 9, MAR, 492.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Replication
T-Cell Antigen Receptor
B-Lymphocytes
Antigen Receptors
21 Citations (Scopus)

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles

Webb, G. M., Li, S., Mwakalundwa, G., Folkvord, J. M., Greene, J. M., Reed, J. S., Stanton, J. J., Legasse, A. W., Hobbs, T., Martin, L. D., Park, B. S., Whitney, J. B., Jeng, E. K., Wong, H. C., Nixon, D. F., Jones, R. B., Connick, E., Skinner, P. J. & Sacha, J. B., Jan 23 2018, In : Blood Advances. 2, 2, p. 76-84 9 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
B-Lymphocytes
T-Lymphocytes
HIV
Macaca
2 Citations (Scopus)

Virus and CTL dynamics in the extrafollicular and follicular tissue compartments in SIV-infected macaques

Wodarz, D., Skinner, P. J., Levy, D. N. & Connick, E., Oct 2018, In : PLoS computational biology. 14, 10, e1006461.

Research output: Contribution to journalArticle

T Lymphocytes
cytotoxic T-lymphocytes
T-cells
Macaca
Cytotoxic T-Lymphocytes
2017
47 Citations (Scopus)

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection

Mylvaganam, G. H., Rios, D., Abdelaal, H. M., Iyer, S., Tharp, G., Mavinger, M., Hicks, S., Chahroudi, A., Ahmed, R., Bosinger, S. E., Williams, I. R., Skinner, P. J., Velu, V. & Amara, R. R., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 1976-1981 6 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Diseases
T-Lymphocytes
Helper-Inducer T-Lymphocytes
Germinal Center
5 Citations (Scopus)
CD8 Antigens
T-cells
Antigens
Tissue
Staining and Labeling
2016
27 Citations (Scopus)

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Miles, B., Miller, S. M., Folkvord, J. M., Levy, D. N., Rakasz, E. G., Skinner, P. J. & Connick, E., Oct 2016, In : PLoS pathogens. 12, 10, e1005924.

Research output: Contribution to journalArticle

Germinal Center
Regulatory T-Lymphocytes
HIV Infections
T-Lymphocytes
HIV
37 Citations (Scopus)

Simian immunodeficiency virus-producing cells in follicles are partially suppressed by CD8+ cells in vivo

Li, S., Folkvord, J. M., Rakasz, E. G., Abdelaal, H. M., Wagstaff, R. K., Kovacs, K. J., Kim, H. O., Sawahata, R., MaWhinney, S., Masopust, D., Connick, E. & Skinner, P. J., Jan 1 2016, In : Journal of virology. 90, 24, p. 11168-11180 13 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
T-lymphocytes
T-Lymphocytes
cells
2015
10 Citations (Scopus)

Comparison of Vibratome and Compresstome sectioning of fresh primate lymphoid and genital tissues for in situ MHC-tetramer and immunofluorescence staining

Abdelaal, H. M., Kim, H. O., Wagstaff, R., Sawahata, R., Southern, P. & Skinner, P. J., Jan 7 2015, In : Biological Procedures Online. 17, 1, 2.

Research output: Contribution to journalArticle

Lymphoid Tissue
Primates
Fluorescent Antibody Technique
Tissue
Staining and Labeling
50 Citations (Scopus)

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

Miles, B., Miller, S. M., Folkvord, J. M., Kimball, A., Chamanian, M., Meditz, A. L., Arends, T., McCarter, M. D., Levy, D. N., Rakasz, E. G., Skinner, P. J. & Connick, E., Oct 20 2015, In : Nature communications. 6, 8608.

Research output: Contribution to journalArticle

human immunodeficiency virus
T-cells
infectious diseases
Regulatory T-Lymphocytes
Helper-Inducer T-Lymphocytes
3 Citations (Scopus)

In situ peptide-MHC-II tetramer staining of antigen-specific CD4+ T cells in tissues

Dileepan, T., Kim, H. O., Cleary, P. P. & Skinner, P. J., Jun 11 2015, In : PloS one. 10, 6, e0128862.

Research output: Contribution to journalArticle

CD4 Antigens
T-cells
T-lymphocytes
peptides
Tissue
7 Citations (Scopus)

Treatment of prion disease with heterologous prion proteins

Skinner, P. J., Kim, H. O., Bryant, D., Kinzel, N. J., Reilly, C., Priola, S. A., Ward, A. E., Goodman, P. A., Olson, K. & Seelig, D. M., Jul 2 2015, In : PloS one. 10, 7, e0131993.

Research output: Contribution to journalArticle

Prion Diseases
prion diseases
Prions
prions
Cricetinae
2014
69 Citations (Scopus)

Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL

Connick, E., Folkvord, J. M., Lind, K. T., Rakasz, E. G., Miles, B., Wilson, N. A., Santiago, M. L., Schmitt, K., Stephens, E. B., Kim, H. O., Wagstaff, R., Li, S., Abdelaal, H. M., Kemp, N., Watkins, D. I., MaWhinney, S. & Skinner, P. J., Dec 1 2014, In : Journal of Immunology. 193, 11, p. 5613-5625 13 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Lymphoid Tissue
Virus Replication
Macaca mulatta
Simian Acquired Immunodeficiency Syndrome
46 Citations (Scopus)

Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry

Li, Q., Zeng, M., Duan, L., Voss, J. E., Smith, A. J., Pambuccian, S., Shang, L., Wietgrefe, S., Southern, P. J., Reilly, C. S., Skinner, P. J., Zupancic, M. L., Carlis, J. V., Piatak, M., Waterman, D., Reeves, R. K., Masek-Hammerman, K., Derdeyn, C. A., Alpert, M. D., Evans, D. T. & 7 others, Kohler, H., Müller, S., Robinson, J., Lifson, J. D., Burton, D. R., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3113-3125 13 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Virus Internalization
Antibody Formation
Vaccines
Epithelium
2013
18 Citations (Scopus)

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

Sasikala-Appukuttan, A. K., Kim, H. O., Kinzel, N. J., Hong, J. J., Smith, A. J., Wagstaff, R., Reilly, C., Piatak, M., Lifson, J. D., Reeves, R. K., Johnson, R. P., Haase, A. T. & Skinner, P. J., Dec 9 2013, In : PloS one. 8, 12, e81623.

Research output: Contribution to journalArticle

Immunization
SAIDS Vaccines
T-cells
live vaccines
HIV-1
2011
9 Citations (Scopus)

GagCM9-specific CD8 + T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo

Vojnov, L., Martins, M. A., Almeida, J. R., Ende, Z., Rakasz, E. G., Reynolds, M. R., Leon, E. J., Weisgrau, K. L., Burwitz, B. J., Folkvord, J. M., de Santana, M. G. V., Neves, P. C. C., Connick, E., Skinner, P. J., Gostick, E., O'Connor, D. H., Wilson, N. A., Bonaldo, M. C., Galler, R., Price, D. A. & 2 others, Douek, D. C. & Watkins, D. I., Aug 26 2011, In : PloS one. 6, 8, e23515.

Research output: Contribution to journalArticle

T-cells
T-lymphocytes
T-Lymphocytes
virus replication
Animals
12 Citations (Scopus)

Selection and characterization of DNA aptamers against PrPSc

Wang, P., Hatcher, K. L., Bartz, J. C., Chen, S. G., Skinner, P., Richt, J., Liu, H. & Sreevatsan, S., Apr 1 2011, In : Experimental Biology and Medicine. 236, 4, p. 466-476 11 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Prions
Protein Isoforms
Prion Diseases
Blood
2009
8 Citations (Scopus)
T-cells
Viruses
T-Lymphocytes
In Situ Hybridization
Infection
12 Citations (Scopus)

Localized populations of CD8low/- MHC class I tetramer+ SIV-specific T cells in lymphoid follicles and genital epithelium

Hong, J. J., Reynolds, M. R., Mattila, T. L., Hage, A., Watkins, D. I., Miller, C. J. & Skinner, P. J., Jan 5 2009, In : PloS one. 4, 1, e4131.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
T-cells
Viruses
genitalia
151 Citations (Scopus)

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection

Li, Q., Skinner, P. J., Ha, S. J., Duan, L., Mattila, T. L., Hage, A., White, C., Barber, D. L., O'Mara, L., Southern, P., Reilly, C. S., Carlis, J. V., Miller, C. J., Ahmed, R. & Haase, A. T., Mar 27 2009, In : Science. 323, 5922, p. 1726-1729 4 p.

Research output: Contribution to journalArticle

Virus Diseases
Infection Control
Antigens
Lymphocytic choriomeningitis virus
Simian Immunodeficiency Virus
2008
21 Citations (Scopus)

Allogeneic lymphocytes persist and traffic in feral MHC-matched Mauritian cynomolgus macaques

Greene, J. M., Burwitz, B. J., Blasky, A. J., Mattila, T. L., Hong, J. J., Rakasz, E. G., Wiseman, R. W., Hasenkrug, K. J., Skinner, P. J., O'Connor, S. L. & O'Connor, D. H., Jun 11 2008, In : PloS one. 3, 6, e2384.

Research output: Contribution to journalArticle

Lymphocytes
Macaca fascicularis
Macaca
traffic
Adoptive Transfer
17 Citations (Scopus)

Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms

Kim, H. O., Snyder, G. P., Blazey, T. M., Race, R. E., Chesebro, B. & Skinner, P. J., Dec 1 2008, In : Advances and Applications in Bioinformatics and Chemistry. 1, 1, p. 29-50 22 p.

Research output: Contribution to journalArticle

Prion Diseases
Prions
Gene expression
Brain
Spleen
40 Citations (Scopus)

Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys

Genescà, M., Skinner, P. J., Bost, K. M., Lu, D., Wang, Y., Rourke, T. L., Haase, A. T., McChesney, M. B. & Miller, C. J., May 1 2008, In : Mucosal Immunology. 1, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

Simian Immunodeficiency Virus
Lentivirus
Macaca mulatta
Immunization
T-Lymphocytes
48 Citations (Scopus)

With minimal systemic T-cell expansion, CD8+ T cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus

Genescà, M., Skinner, P. J., Hong, J. J., Li, J., Lu, D., McChesney, M. B. & Miller, C. J., Nov 1 2008, In : Journal of virology. 82, 22, p. 11181-11196 16 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Simian Immunodeficiency Virus
Cytoprotection
Human immunodeficiency virus
Macaca mulatta
2007
129 Citations (Scopus)

CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue

Connick, E., Mattila, T., Folkvord, J. M., Schlichtemeier, R., Meditz, A. L., Ray, M. G., McCarter, M. D., MaWhinney, S., Hage, A., White, C. & Skinner, P. J., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 6975-6983 9 p.

Research output: Contribution to journalArticle

Lymphoid Tissue
HIV-1
Lymph Nodes
RNA
Virus Replication
2006
77 Citations (Scopus)

Gene expression alterations in brains of mice infected with three strains of scrapie

Skinner, P. J., Abbassi, H., Chesebro, B., Race, R. E., Reilly, C. S. & Haase, A. T., May 16 2006, In : BMC Genomics. 7, 114.

Research output: Contribution to journalArticle

Scrapie
Prion Diseases
Gene Expression
Brain
Genes
2005
122 Citations (Scopus)

CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: Too late and too little

Reynolds, M. R., Rakasz, E., Skinner, P. J., White, C., Abel, K., Ma, Z. M., Compton, L., Napoé, G., Wilson, N., Miller, C. J., Haase, A. & Watkins, D. I., Jul 1 2005, In : Journal of virology. 79, 14, p. 9228-9235 8 p.

Research output: Contribution to journalArticle

Simian immunodeficiency virus
Immunodominant Epitopes
Simian Immunodeficiency Virus
T-lymphocytes
Lymphoid Tissue
4 Citations (Scopus)
Staining and Labeling
T-Lymphocytes
Antigens
Coloring Agents
Technology
2002
22 Citations (Scopus)

Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice

Skinner, P. J., Vierra-Green, C. A., Emamian, E., Zoghbi, H. Y. & Orr, H. T., Dec 1 2002, In : NeuroMolecular Medicine. 1, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Transgenic Mice
Disease Progression
Amino Acids
Proteins
113 Citations (Scopus)

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection

Mothé, B. R., Horton, H., Carter, D. K., Allen, T. M., Liebl, M. E., Skinner, P., Vogel, T. U., Fuenger, S., Vielhuber, K., Rehrauer, W., Wilson, N., Franchini, G., Altman, J. D., Haase, A., Picker, L. J., Allison, D. B. & Watkins, D. I., Jan 15 2002, In : Journal of virology. 76, 2, p. 875-884 10 p.

Research output: Contribution to journalArticle

Macaca
major histocompatibility complex
Cytotoxic T-Lymphocytes
Virus Diseases
Major Histocompatibility Complex
28 Citations (Scopus)

In situ tetramer staining

Skinner, P. J. & Haase, A. T., Oct 1 2002, In : Journal of Immunological Methods. 268, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Staining and Labeling
Research
2001
79 Citations (Scopus)

Altered trafficking of membrane proteins in Purkinje cells of SCA1 transgenic mice

Skinner, P. J., Vierra-Green, C. A., Clark, H. B., Zoghbi, H. Y. & Orr, H. T., Jan 1 2001, In : American Journal of Pathology. 159, 3, p. 905-913 9 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Purkinje Cells
Vacuoles
Transgenic Mice
Membrane Proteins
2000
115 Citations (Scopus)

Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues

Skinner, P. J., Daniels, M. A., Schmidt, C. S., Jameson, S. C. & Haase, A. T., Jul 15 2000, In : Journal of Immunology. 165, 2, p. 613-617 5 p.

Research output: Contribution to journalArticle

Staining and Labeling
T-Lymphocytes
Antigens
Adoptive Transfer
Transgenic Mice
502 Citations (Scopus)

Identification of genes that modify ataxin-1-induced neurodegeneration

Fernandez-Funez, P., Nino-Rosales, M. L., De Gouyon, B., She, W. C., Luchak, J. M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P. J., McCall, A., Canal, I., Orr, H. T., Zoghbi, H. Y. & Botas, J., Nov 2 2000, In : Nature. 408, 6808, p. 101-106 6 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Genes
Neurodegenerative Diseases
Proteins
Protein Folding
1999
86 Citations (Scopus)

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

Kaytor, M. D., Duvick, L. A., Skinner, P. J., Koob, M. D., Ranum, L. P. W. & Orr, H. T., Sep 17 1999, In : Human molecular genetics. 8, 9, p. 1657-1664 8 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Nuclear Matrix
Pyruvate Kinase
Muscle Proteins
COS Cells
1998
836 Citations (Scopus)

Ataxin-1 nuclear localization and aggregation: Role in polyglutarnine- induced disease in SCA1 transgenic mice

Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y. & Orr, H. T., Oct 2 1998, In : Cell. 95, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Transgenic Mice
Agglomeration
Purkinje Cells
Ataxia

Ataxin-1 with an expanded glutamine tract induces disease via alterations in nuclear function

Orr, H., Skiement, I., Skinner, P., Davidson, J., Burright, E., Cumminigs, C., Koshy, B. & Zoghh, H., Dec 1 1998, In : FASEB Journal. 12, 8, p. A1322

Research output: Contribution to journalArticle

Glutamine
glutamine
mice
mutants
Ataxia
1997
474 Citations (Scopus)

Ataxin-1 with an expanded glutamine tract alters nuclear matrix- associated structures

Skinner, P. J., Koshy, B. T., Cummings, C. J., Klement, I. A., Helin, K., Servadio, A., Zoghbi, H. Y. & Orr, H. T., Nov 24 1997, In : Nature. 389, 6654, p. 971-974 4 p.

Research output: Contribution to journalArticle

Nuclear Matrix
Glutamine
Purkinje Cells
Spinocerebellar Ataxias
COS Cells
50 Citations (Scopus)

Preferential translation of reovirus mRNA by a σ3-dependent mechanism

Schmechel, S., Chute, M., Skinner, P., Anderson, R. & Schiff, L., May 26 1997, In : Virology. 232, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
eIF-2 Kinase
Double-Stranded RNA
Capsid Proteins
Viral Proteins
1996
23 Citations (Scopus)

Mutations in the zinc-binding motif of the reovirus capsid protein σ3 eliminate its ability to associate with capsid protein μ1

Shepard, D. A., Ehnstrom, J. G., Skinner, P. J. & Schiff, L. A., Feb 27 1996, In : Journal of Virology. 70, 3, p. 2065-2068 4 p.

Research output: Contribution to journalArticle

Reoviridae
Double-Stranded RNA
double-stranded RNA
Capsid Proteins
coat proteins
1995
32 Citations (Scopus)

S elements: A family of Tc1-like transposons in the genome of Drosophila melanogaster

Merriman, P. J., Grimes, C. D., Ambroziak, J., Hackett, D. A., Skinner, P. & Simmons, M. J., Jan 1 1995, In : Genetics. 141, 4, p. 1425-1438 14 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Genome
Euchromatin
Peptides
DNA Transposable Elements