1995 …2023

Research output per year

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Research Output

2020

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

Pampusch, M. S., Haran, K. P., Hart, G. T., Rakasz, E. G., Rendahl, A. K., Berger, E. A., Connick, E. & Skinner, P. J., Mar 13 2020, In : Molecular Therapy - Methods and Clinical Development. 16, p. 1-10 10 p.

Research output: Contribution to journalArticle

Open Access
2019

Detection of antigen-specific t cells using in situ mhc tetramer staining

Abdelaal, H. M., Cartwright, E. K. & Skinner, P. J., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5165.

Research output: Contribution to journalArticle

Open Access

Low levels of siv-specific CD8+ T cells in germinal centers characterizes acute SIV infection

Li, S., Folkvord, J. M., Kovacs, K. J., Wagstaff, R. K., Mwakalundwa, G., Rendahl, A. K., Rakasz, E. G., Connick, E. & Skinner, P. J., Mar 2019, In : PLoS pathogens. 15, 3, e1007311.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Detection of HIV-1-specific gastrointestinal tissue resident CD8 + T-cells in chronic infection

Kiniry, B. E., Li, S., Ganesh, A., Hunt, P. W., Somsouk, M., Skinner, P. J., Deeks, S. G. & Shacklett, B. L., May 1 2018, In : Mucosal Immunology. 11, 3, p. 909-920 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Simian immunodeficiency virus (SIV)-specific chimeric antigen receptor-T cells engineered to target B cell follicles and suppress SIV replication

Haran, K. P., Hajduczki, A., Pampusch, M. S., Mwakalundwa, G., Vargas-Inchaustegui, D. A., Rakasz, E. G., Connick, E., Berger, E. A. & Skinner, P. J., Mar 20 2018, In : Frontiers in immunology. 9, MAR, 492.

Research output: Contribution to journalArticle

17 Scopus citations

The B-cell follicle in HIV infection: Barrier to a cure

Bronnimann, M. P., Skinner, P. J. & Connick, E., Jan 25 2018, In : Frontiers in immunology. 9, JAN, 20.

Research output: Contribution to journalReview article

14 Scopus citations

The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles

Webb, G. M., Li, S., Mwakalundwa, G., Folkvord, J. M., Greene, J. M., Reed, J. S., Stanton, J. J., Legasse, A. W., Hobbs, T., Martin, L. D., Park, B. S., Whitney, J. B., Jeng, E. K., Wong, H. C., Nixon, D. F., Jones, R. B., Connick, E., Skinner, P. J. & Sacha, J. B., Jan 23 2018, In : Blood Advances. 2, 2, p. 76-84 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Virus and CTL dynamics in the extrafollicular and follicular tissue compartments in SIV-infected macaques

Wodarz, D., Skinner, P. J., Levy, D. N. & Connick, E., Oct 2018, In : PLoS computational biology. 14, 10, e1006461.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection

Mylvaganam, G. H., Rios, D., Abdelaal, H. M., Iyer, S., Tharp, G., Mavinger, M., Hicks, S., Chahroudi, A., Ahmed, R., Bosinger, S. E., Williams, I. R., Skinner, P. J., Velu, V. & Amara, R. R., Feb 21 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 1976-1981 6 p.

Research output: Contribution to journalArticle

49 Scopus citations
5 Scopus citations
2016

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Miles, B., Miller, S. M., Folkvord, J. M., Levy, D. N., Rakasz, E. G., Skinner, P. J. & Connick, E., Oct 2016, In : PLoS pathogens. 12, 10, e1005924.

Research output: Contribution to journalArticle

27 Scopus citations

Potential approaches for heterologous prion protein treatment of prion diseases

Seelig, D. M., Goodman, P. A. & Skinner, P. J., Jan 2 2016, In : Prion. 10, 1, p. 18-24 7 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Simian immunodeficiency virus-producing cells in follicles are partially suppressed by CD8+ cells in vivo

Li, S., Folkvord, J. M., Rakasz, E. G., Abdelaal, H. M., Wagstaff, R. K., Kovacs, K. J., Kim, H. O., Sawahata, R., MaWhinney, S., Masopust, D., Connick, E. & Skinner, P. J., Jan 1 2016, In : Journal of virology. 90, 24, p. 11168-11180 13 p.

Research output: Contribution to journalArticle

41 Scopus citations
2015

Comparison of Vibratome and Compresstome sectioning of fresh primate lymphoid and genital tissues for in situ MHC-tetramer and immunofluorescence staining

Abdelaal, H. M., Kim, H. O., Wagstaff, R., Sawahata, R., Southern, P. & Skinner, P. J., Jan 7 2015, In : Biological Procedures Online. 17, 1, 2.

Research output: Contribution to journalArticle

10 Scopus citations

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

Miles, B., Miller, S. M., Folkvord, J. M., Kimball, A., Chamanian, M., Meditz, A. L., Arends, T., McCarter, M. D., Levy, D. N., Rakasz, E. G., Skinner, P. J. & Connick, E., Oct 20 2015, In : Nature communications. 6, 8608.

Research output: Contribution to journalArticle

50 Scopus citations

In situ peptide-MHC-II tetramer staining of antigen-specific CD4+ T cells in tissues

Dileepan, T., Kim, H. O., Cleary, P. P. & Skinner, P. J., Jun 11 2015, In : PloS one. 10, 6, e0128862.

Research output: Contribution to journalArticle

3 Scopus citations

Treatment of prion disease with heterologous prion proteins

Skinner, P. J., Kim, H. O., Bryant, D., Kinzel, N. J., Reilly, C., Priola, S. A., Ward, A. E., Goodman, P. A., Olson, K. & Seelig, D. M., Jul 2 2015, In : PloS one. 10, 7, e0131993.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL

Connick, E., Folkvord, J. M., Lind, K. T., Rakasz, E. G., Miles, B., Wilson, N. A., Santiago, M. L., Schmitt, K., Stephens, E. B., Kim, H. O., Wagstaff, R., Li, S., Abdelaal, H. M., Kemp, N., Watkins, D. I., MaWhinney, S. & Skinner, P. J., Dec 1 2014, In : Journal of Immunology. 193, 11, p. 5613-5625 13 p.

Research output: Contribution to journalArticle

72 Scopus citations

Live simian immunodeficiency virus vaccine correlate of protection: Local antibody production and concentration on the path of virus entry

Li, Q., Zeng, M., Duan, L., Voss, J. E., Smith, A. J., Pambuccian, S., Shang, L., Wietgrefe, S., Southern, P. J., Reilly, C. S., Skinner, P. J., Zupancic, M. L., Carlis, J. V., Piatak, M., Waterman, D., Reeves, R. K., Masek-Hammerman, K., Derdeyn, C. A., Alpert, M. D., Evans, D. T. & 7 others, Kohler, H., Müller, S., Robinson, J., Lifson, J. D., Burton, D. R., Johnson, R. P. & Haase, A. T., Sep 15 2014, In : Journal of Immunology. 193, 6, p. 3113-3125 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2013

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

Sasikala-Appukuttan, A. K., Kim, H. O., Kinzel, N. J., Hong, J. J., Smith, A. J., Wagstaff, R., Reilly, C., Piatak, M., Lifson, J. D., Reeves, R. K., Johnson, R. P., Haase, A. T. & Skinner, P. J., Dec 9 2013, In : PloS one. 8, 12, e81623.

Research output: Contribution to journalArticle

18 Scopus citations
2011

GagCM9-specific CD8 + T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo

Vojnov, L., Martins, M. A., Almeida, J. R., Ende, Z., Rakasz, E. G., Reynolds, M. R., Leon, E. J., Weisgrau, K. L., Burwitz, B. J., Folkvord, J. M., de Santana, M. G. V., Neves, P. C. C., Connick, E., Skinner, P. J., Gostick, E., O'Connor, D. H., Wilson, N. A., Bonaldo, M. C., Galler, R., Price, D. A. & 2 others, Douek, D. C. & Watkins, D. I., Aug 26 2011, In : PloS one. 6, 8, e23515.

Research output: Contribution to journalArticle

9 Scopus citations

Selection and characterization of DNA aptamers against PrPSc

Wang, P., Hatcher, K. L., Bartz, J. C., Chen, S. G., Skinner, P., Richt, J., Liu, H. & Sreevatsan, S., Apr 1 2011, In : Experimental Biology and Medicine. 236, 4, p. 466-476 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2009
8 Scopus citations

Localized populations of CD8low/- MHC class I tetramer+ SIV-specific T cells in lymphoid follicles and genital epithelium

Hong, J. J., Reynolds, M. R., Mattila, T. L., Hage, A., Watkins, D. I., Miller, C. J. & Skinner, P. J., Jan 5 2009, In : PloS one. 4, 1, e4131.

Research output: Contribution to journalArticle

12 Scopus citations

Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection

Li, Q., Skinner, P. J., Ha, S. J., Duan, L., Mattila, T. L., Hage, A., White, C., Barber, D. L., O'Mara, L., Southern, P., Reilly, C. S., Carlis, J. V., Miller, C. J., Ahmed, R. & Haase, A. T., Mar 27 2009, In : Science. 323, 5922, p. 1726-1729 4 p.

Research output: Contribution to journalArticle

151 Scopus citations
2008

Allogeneic lymphocytes persist and traffic in feral MHC-matched Mauritian cynomolgus macaques

Greene, J. M., Burwitz, B. J., Blasky, A. J., Mattila, T. L., Hong, J. J., Rakasz, E. G., Wiseman, R. W., Hasenkrug, K. J., Skinner, P. J., O'Connor, S. L. & O'Connor, D. H., Jun 11 2008, In : PloS one. 3, 6, e2384.

Research output: Contribution to journalArticle

21 Scopus citations

Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms

Kim, H. O., Snyder, G. P., Blazey, T. M., Race, R. E., Chesebro, B. & Skinner, P. J., Dec 1 2008, In : Advances and Applications in Bioinformatics and Chemistry. 1, 1, p. 29-50 22 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protective attenuated lentivirus immunization induces SIV-specific T cells in the genital tract of rhesus monkeys

Genescà, M., Skinner, P. J., Bost, K. M., Lu, D., Wang, Y., Rourke, T. L., Haase, A. T., McChesney, M. B. & Miller, C. J., May 1 2008, In : Mucosal Immunology. 1, 3, p. 219-228 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

With minimal systemic T-cell expansion, CD8+ T cells mediate protection of rhesus macaques immunized with attenuated simian-human immunodeficiency virus SHIV89.6 from vaginal challenge with simian immunodeficiency virus

Genescà, M., Skinner, P. J., Hong, J. J., Li, J., Lu, D., McChesney, M. B. & Miller, C. J., Nov 1 2008, In : Journal of virology. 82, 22, p. 11181-11196 16 p.

Research output: Contribution to journalArticle

48 Scopus citations
2007

CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue

Connick, E., Mattila, T., Folkvord, J. M., Schlichtemeier, R., Meditz, A. L., Ray, M. G., McCarter, M. D., MaWhinney, S., Hage, A., White, C. & Skinner, P. J., Jun 1 2007, In : Journal of Immunology. 178, 11, p. 6975-6983 9 p.

Research output: Contribution to journalArticle

132 Scopus citations
2006

Gene expression alterations in brains of mice infected with three strains of scrapie

Skinner, P. J., Abbassi, H., Chesebro, B., Race, R. E., Reilly, C. S. & Haase, A. T., May 16 2006, In : BMC Genomics. 7, 114.

Research output: Contribution to journalArticle

78 Scopus citations
2005

CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: Too late and too little

Reynolds, M. R., Rakasz, E., Skinner, P. J., White, C., Abel, K., Ma, Z. M., Compton, L., Napoé, G., Wilson, N., Miller, C. J., Haase, A. & Watkins, D. I., Jul 1 2005, In : Journal of virology. 79, 14, p. 9228-9235 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

In situ MHC tetramer staining: In situ tetramers

Skinner, P. J., Dec 1 2005, Analyzing T Cell Responses: How to Analyze Cellular Immune Responses against Tumor Associated Antigens. Springer Netherlands, p. 219-225 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
2002

Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice

Skinner, P. J., Vierra-Green, C. A., Emamian, E., Zoghbi, H. Y. & Orr, H. T., Dec 1 2002, In : NeuroMolecular Medicine. 1, 1, p. 33-42 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Dominance of CD8 responses specific for epitopes bound by a single major histocompatibility complex class I molecule during the acute phase of viral infection

Mothé, B. R., Horton, H., Carter, D. K., Allen, T. M., Liebl, M. E., Skinner, P., Vogel, T. U., Fuenger, S., Vielhuber, K., Rehrauer, W., Wilson, N., Franchini, G., Altman, J. D., Haase, A., Picker, L. J., Allison, D. B. & Watkins, D. I., Jan 15 2002, In : Journal of virology. 76, 2, p. 875-884 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

In situ tetramer staining

Skinner, P. J. & Haase, A. T., Oct 1 2002, In : Journal of Immunological Methods. 268, 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

28 Scopus citations
2001

Altered trafficking of membrane proteins in Purkinje cells of SCA1 transgenic mice

Skinner, P. J., Vierra-Green, C. A., Clark, H. B., Zoghbi, H. Y. & Orr, H. T., Jan 1 2001, In : American Journal of Pathology. 159, 3, p. 905-913 9 p.

Research output: Contribution to journalArticle

79 Scopus citations
2000

Cutting edge: In situ tetramer staining of antigen-specific T cells in tissues

Skinner, P. J., Daniels, M. A., Schmidt, C. S., Jameson, S. C. & Haase, A. T., Jul 15 2000, In : Journal of Immunology. 165, 2, p. 613-617 5 p.

Research output: Contribution to journalArticle

115 Scopus citations

Identification of genes that modify ataxin-1-induced neurodegeneration

Fernandez-Funez, P., Nino-Rosales, M. L., De Gouyon, B., She, W. C., Luchak, J. M., Martinez, P., Turiegano, E., Benito, J., Capovilla, M., Skinner, P. J., McCall, A., Canal, I., Orr, H. T., Zoghbi, H. Y. & Botas, J., Nov 2 2000, In : Nature. 408, 6808, p. 101-106 6 p.

Research output: Contribution to journalArticle

505 Scopus citations
1999

Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7

Kaytor, M. D., Duvick, L. A., Skinner, P. J., Koob, M. D., Ranum, L. P. W. & Orr, H. T., Sep 17 1999, In : Human molecular genetics. 8, 9, p. 1657-1664 8 p.

Research output: Contribution to journalArticle

87 Scopus citations
1998

Ataxin-1 nuclear localization and aggregation: Role in polyglutarnine- induced disease in SCA1 transgenic mice

Klement, I. A., Skinner, P. J., Kaytor, M. D., Yi, H., Hersch, S. M., Clark, H. B., Zoghbi, H. Y. & Orr, H. T., Oct 2 1998, In : Cell. 95, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

837 Scopus citations

Ataxin-1 with an expanded glutamine tract induces disease via alterations in nuclear function

Orr, H., Skiement, I., Skinner, P., Davidson, J., Burright, E., Cumminigs, C., Koshy, B. & Zoghh, H., Dec 1 1998, In : FASEB Journal. 12, 8, p. A1322

Research output: Contribution to journalArticle

Erratum: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures (Nature (1997) 389 (971-974))

Skinner, P. J., Koshy, B. T., Cummings, C. J., Klement, I. A., Helin, K., Servadio, A., Zoghbi, H. Y. & Orr, H. T., Jan 15 1998, In : Nature. 391, 6664, 1 p.

Research output: Contribution to journalComment/debate

1997

Ataxin-1 with an expanded glutamine tract alters nuclear matrix- associated structures

Skinner, P. J., Koshy, B. T., Cummings, C. J., Klement, I. A., Helin, K., Servadio, A., Zoghbi, H. Y. & Orr, H. T., Nov 24 1997, In : Nature. 389, 6654, p. 971-974 4 p.

Research output: Contribution to journalArticle

474 Scopus citations

Preferential translation of reovirus mRNA by a σ3-dependent mechanism

Schmechel, S., Chute, M., Skinner, P., Anderson, R. & Schiff, L., May 26 1997, In : Virology. 232, 1, p. 62-73 12 p.

Research output: Contribution to journalArticle

50 Scopus citations
1996

Mutations in the zinc-binding motif of the reovirus capsid protein σ3 eliminate its ability to associate with capsid protein μ1

Shepard, D. A., Ehnstrom, J. G., Skinner, P. J. & Schiff, L. A., Feb 27 1996, In : Journal of Virology. 70, 3, p. 2065-2068 4 p.

Research output: Contribution to journalArticle

23 Scopus citations
1995

S elements: A family of Tc1-like transposons in the genome of Drosophila melanogaster

Merriman, P. J., Grimes, C. D., Ambroziak, J., Hackett, D. A., Skinner, P. & Simmons, M. J., Jan 1 1995, In : Genetics. 141, 4, p. 1425-1438 14 p.

Research output: Contribution to journalArticle

32 Scopus citations