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Research Output 1997 2019

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2019

Circulating tumor biomarkers in meningiomas reveal a signature of equilibrium between tumor growth and immune modulation

Erkan, E. P., Ströbel, T., Dorfer, C., Sonntagbauer, M., Weinhäusel, A., Saydam, N. & Saydam, O., Sep 1 2019, In : Frontiers in Oncology. 9, SEP, 1031.

Research output: Contribution to journalArticle

Open Access
Meningioma
Tumor Biomarkers
Growth
Neoplasms
Blood Proteins

Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells

Harmati, M., Gyukity-Sebestyen, E., Dobra, G., Janovak, L., Dekany, I., Saydam, O., Hunyadi-Gulyas, E., Nagy, I., Farkas, A., Pankotai, T., Ujfaludi, Z., Horvath, P., Piccinini, F., Kovacs, M., Biro, T. & Buzas, K., Dec 1 2019, In : Scientific reports. 9, 1, 15329.

Research output: Contribution to journalArticle

Open Access
Melanoma
Cytostatic Agents
Mesenchymal Stromal Cells
Computer Simulation
Oxidative Stress
2017
5 Citations (Scopus)

Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma

Ströbel, T., Madlener, S., Tuna, S., Vose, S., Lagerweij, T., Wurdinger, T., Vierlinger, K., Wöhrer, A., Price, B. D., Demple, B., Saydam, O. & Saydam, N., Dec 1 2017, In : Scientific reports. 7, 1, 9674.

Research output: Contribution to journalArticle

Drug Tolerance
Glioblastoma
Recombinational DNA Repair
DNA Repair
temozolomide
6 Citations (Scopus)

Extracellular vesicle-mediated suicide mRNA/protein delivery inhibits glioblastoma tumor growth in vivo

Erkan, E. P., Senfter, D., Madlener, S., Jungwirth, G., Ströbel, T., Saydam, N. & Saydam, O., Jan 1 2017, In : Cancer gene therapy. 24, 1, p. 38-44 7 p.

Research output: Contribution to journalArticle

uracil phosphoribosyltransferase
Glioblastoma
Cytosine Deaminase
Suicide
Messenger RNA
3 Citations (Scopus)

Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications

Senfter, D., Erkan, E. P., Özer, E., Jungwirth, G., Madlener, S., Kool, M., Ströbel, T., Saydam, N. & Saydam, O., Dec 1 2017, In : Pediatric Blood and Cancer. 64, 12, e26670.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
Medulloblastoma
RNA Interference
Cell Proliferation
Cell Line
10 Citations (Scopus)

Stressors alter intercellular communication and exosome profile of nasopharyngeal carcinoma cells

Harmati, M., Tarnai, Z., Decsi, G., Kormondi, S., Szegletes, Z., Janovak, L., Dekany, I., Saydam, O., Gyukity-Sebestyen, E., Dobra, G., Nagy, I., Nagy, K. & Buzas, K., Apr 1 2017, In : Journal of Oral Pathology and Medicine. 46, 4, p. 259-266 8 p.

Research output: Contribution to journalArticle

Exosomes
Cytostatic Agents
MicroRNAs
Neoplasms
Head and Neck Neoplasms
2016
2 Citations (Scopus)

Extracellular vesicles as novel delivery tools for cancer treatment

Erkan, E. P. & Saydam, O., Jan 1 2016, In : Current Cancer Drug Targets. 16, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

Neoplasms
Cell Membrane
RNA
Lipids
Membranes
2014
21 Citations (Scopus)

Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo

Erkan, E. P., Ströbel, T., Lewandrowski, G., Tannous, B., Madlener, S., Czech, T., Saydam, N. & Saydam, O., Sep 1 2014, In : Oncogene. 33, 39, p. 4778-4785 8 p.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
Glioblastoma
Growth
Neoplasms
Maintenance
15 Citations (Scopus)

MiR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo

Senol, O., Schaaij-Visser, T. B. M., Erkan, E. P., Dorfer, C., Lewandrowski, G., Pham, T. V., Piersma, S. R., Peerdeman, S. M., Ströbel, T., Tannous, B., Saydam, N., Slavc, I., Knosp, E., Jimenez, C. R. & Saydam, O., May 26 2014, In : Oncogene. 34, 14, p. 1790-1798 9 p.

Research output: Contribution to journalArticle

Meningioma
Cell Movement
Growth
Neoplasms
Cell Migration Inhibition
2013
31 Citations (Scopus)

Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance

Madlener, S., Ströbel, T., Vose, S., Saydam, O., Price, B. D., Demple, B. & Saydam, N., Oct 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 44, p. 17844-17849 6 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Telomere
Maintenance
DNA Repair
Telomeric Repeat Binding Protein 2
136 Citations (Scopus)

Genetically engineered microvesicles carrying suicide mRNA/protein inhibit schwannoma tumor growth

Mizrak, A., Bolukbasi, M. F., Ozdener, G. B., Brenner, G. J., Madlener, S., Erkan, E. P., Ströbel, T., Breakefield, X. O. & Saydam, O., Jan 2013, In : Molecular Therapy. 21, 1, p. 101-108 8 p.

Research output: Contribution to journalArticle

Neurilemmoma
Suicide
uracil phosphoribosyltransferase
Messenger RNA
Growth
2012
2 Citations (Scopus)

Construction and packaging of herpes simplex virus/adeno-associated virus (HSV/AAV) hybrid amplicon vectors

Saydam, O., Glauser, D. L. & Fraefel, C., Mar 1 2012, In : Cold Spring Harbor Protocols. 7, 3, p. 352-356 5 p.

Research output: Contribution to journalArticle

Dependovirus
Product Packaging
Simplexvirus
Viruses
Transgenes
126 Citations (Scopus)

MiR-1289 and "zipcode"-like sequence enrich mRNAs in microvesicles

Bolukbasi, M. F., Mizrak, A., Ozdener, G. B., Madlener, S., Ströbel, T., Erkan, E. P., Fan, J. B., Breakefield, X. O. & Saydam, O., Jan 1 2012, In : Molecular Therapy - Nucleic Acids. 1, 2, p. e10 e10.

Research output: Contribution to journalArticle

Messenger RNA
3' Untranslated Regions
MicroRNAs
Glioblastoma
Binding Sites
2011
8 Citations (Scopus)

A novel imaging-compatible sciatic nerve schwannoma model

Saydam, O., Ozdener, G. B., Senol, O., Mizrak, A., Prabhakar, S., Stemmer-Rachamimov, A. O., Breakefield, X. O. & Brenner, G. J., Jan 30 2011, In : Journal of Neuroscience Methods. 195, 1, p. 75-77 3 p.

Research output: Contribution to journalArticle

Neurilemmoma
Sciatic Nerve
Neoplasms
Neurofibromatosis 2
Cranial Nerves
116 Citations (Scopus)

miRNA-7 attenuation in schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways

Saydam, O., Senol, O., Würdinger, T., Mizrak, A., Ozdener, G. B., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., Krichevsky, A. M., Saydam, N., Brenner, G. J. & Breakefield, X. O., Feb 1 2011, In : Cancer Research. 71, 3, p. 852-861 10 p.

Research output: Contribution to journalArticle

Neurilemmoma
MicroRNAs
p21-Activated Kinases
Growth
Phosphotransferases
17 Citations (Scopus)

miRNA signature of schwannomas: Possible role(s) of "tumor: Suppressor" miRNAs in benign tumors

Erkan, E. P., Breakefield, X. O. & Saydam, O., Jan 1 2011, In : Oncotarget. 2, 3, p. 265-270 6 p.

Research output: Contribution to journalArticle

Neurilemmoma
MicroRNAs
Neoplasms
Neurofibromatosis 2
Tumor Suppressor Proteins
2010
42 Citations (Scopus)

Comparative protein profiling reveals minichromosome maintenance (MCM) proteins as novel potential tumor markers for meningiomas

Saydam, O., Senol, O., Schaaij-Visser, T. B. M., Pham, T. V., Piersma, S. R., Stemmer-Rachamimov, A. O., Wurdinger, T., Peerdeman, S. M. & Jimenez, C. R., Jan 4 2010, In : Journal of Proteome Research. 9, 1, p. 485-494 10 p.

Research output: Contribution to journalArticle

Minichromosome Maintenance Proteins
Meningioma
Tumor Biomarkers
Proteins
Tumors
2009
179 Citations (Scopus)

Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/β-catenin signaling pathway

Saydam, O., Shen, Y., Würdinger, T., Senol, O., Boke, E., James, M. F., Tannous, B. A., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., Fraefel, C., Gusella, J. F., Krichevsky, A. M. & Breakefield, X. O., Nov 1 2009, In : Molecular and cellular biology. 29, 21, p. 5923-5940 18 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Meningioma
Cadherins
MicroRNAs
15 Citations (Scopus)

Mutant sodium channel for tumor therapy

Tannous, B. A., Christensen, A. P., Pike, L., Wurdinger, T., Perry, K. F., Saydam, O., Jacobs, A. H., García-Añoveros, J., Weissleder, R., Sena-Esteves, M., Corey, D. P. & Breakefield, X. O., Mar 4 2009, In : Molecular Therapy. 17, 5, p. 810-819 10 p.

Research output: Contribution to journalArticle

Sodium Channels
Neoplasms
Therapeutics
Doxycycline
Human Herpesvirus 4
2008
312 Citations (Scopus)

miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells

Würdinger, T., Tannous, B. A., Saydam, O., Skog, J., Grau, S., Soutschek, J., Weissleder, R., Breakefield, X. O. & Krichevsky, A. M., Nov 4 2008, In : Cancer Cell. 14, 5, p. 382-393 12 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Endothelial Cells
Intercellular Signaling Peptides and Proteins
Angiogenesis Inducing Agents
Brain
24 Citations (Scopus)

Targeted integration of functional human ATM cDNA into genome mediated by HSV/AAV hybrid amplicon vector

Cortés, M. L., Oehmig, A., Saydam, O., Sanford, J. D., Perry, K. F., Fraefel, C. & Breakefield, X. O., Jan 1 2008, In : Molecular Therapy. 16, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Dependovirus
Complementary DNA
Genome
Ionizing Radiation
2007
14 Citations (Scopus)

HSV-1 amplicon-mediated post-transcriptional inhibition of Rad51 sensitizes human glioma cells to ionizing radiation

Saydam, O., Saydam, N., Glauser, D. L., Pruschy, M., Dinh-Van, V., Hilbe, M., Jacobs, A. H., Ackermann, M. & Fraefel, C., Aug 1 2007, In : Gene therapy. 14, 15, p. 1143-1151 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Ionizing Radiation
Glioma
Radiation
Recombinational DNA Repair
17 Citations (Scopus)

Live covisualization of competing adeno-associated virus and herpes simplex virus type 1 DNA replication: Molecular mechanisms of interaction

Glauser, D. L., Strasser, R., Laimbacher, A. S., Saydam, O., Clément, N., Linden, R. M., Ackermann, M. & Fraefel, C., May 1 2007, In : Journal of virology. 81, 9, p. 4732-4743 12 p.

Research output: Contribution to journalArticle

Dependovirus
Human herpesvirus 1
Human Herpesvirus 1
DNA replication
DNA Replication
2006
4 Citations (Scopus)

Host cell targets of immediate-early protein BICP22 of bovine herpesvirus 1

Saydam, O., Steiner, F., Vogt, B. & Schwyzer, M., Mar 31 2006, In : Veterinary Microbiology. 113, 3-4 SPEC. ISS., p. 185-192 8 p.

Research output: Contribution to journalArticle

Bovine herpesvirus 1
Cyclic AMP Response Element-Binding Protein
Proteins
proteins
cells
2005
15 Citations (Scopus)

Four-dimensional visualization of the simultaneous activity of alternative adeno-associated virus replication origins

Glauser, D. L., Saydam, O., Balsiger, N. A., Heid, I., Linden, R. M., Ackermann, M. & Fraefel, C., Oct 1 2005, In : Journal of Virology. 79, 19, p. 12218-12230 13 p.

Research output: Contribution to journalArticle

Dependovirus
replication origin
Replication Origin
Virus Replication
virus replication
22 Citations (Scopus)

Gene transfer into hepatocytes mediated by herpes simplex virus-Epstein-Barr virus hybrid amplicons

Müller, L., Saydam, O., Saeki, Y., Heid, I. & Fraefel, C., Jan 1 2005, In : Journal of Virological Methods. 123, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Simplexvirus
Human Herpesvirus 4
Alkaline Phosphatase
Hepatocytes
58 Citations (Scopus)

Herpes simplex virus 1 amplicon vector-mediated siRNA targeting epidermal growth factor receptor inhibits growth of human glioma cells in vivo

Saydam, O., Glauser, D. L., Heid, I., Turkeri, G., Hilbe, M., Jacobs, A. H., Ackermann, M. & Fraefel, C., Nov 1 2005, In : Molecular Therapy. 12, 5, p. 803-812 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Epidermal Growth Factor Receptor
Glioma
Small Interfering RNA
Growth
2004
4 Citations (Scopus)

Transactivator Protein BICP0 of Bovine Herpesvirus 1 (BHV-1) Is Blocked by Prostaglandin D2 (PGD2), Which Points to a Mechanism for PGD2-Mediated Inhibition of BHV-1 Replication

Saydam, O., Abril, C., Vogt, B., Ackermann, M. & Schwyzer, M., Apr 1 2004, In : Journal of virology. 78, 8, p. 3805-3810 6 p.

Research output: Contribution to journalArticle

Bovine Herpesvirus 1
Prostaglandin D2
Trans-Activators
Bovine herpesvirus 1
prostaglandins
2002
3 Citations (Scopus)

Search for physical interaction between BICP0 of bovine herpesvirus-1 and p53 tumor suppressor protein

Saydam, O., Vogt, B., Ackermann, M. & Schwyzer, M., Apr 22 2002, In : Veterinary Microbiology. 86, 1-2, p. 95-102 8 p.

Research output: Contribution to journalArticle

Bovine Herpesvirus 1
Tumor Suppressor Protein p53
Bovine herpesvirus 1
Plasmids
two hybrid system techniques
1998
33 Citations (Scopus)

Cytoprotective effect of trimetazidine on 75 min warm renal ischemia-reperfusion injury in rats

Özden, A., Aybek, Z., Saydam, N., Çalli, N., Saydam, O., Düzcan, E. & Güner, G., Jul 1 1998, In : European Surgical Research. 30, 4, p. 227-234 8 p.

Research output: Contribution to journalArticle

Trimetazidine
Warm Ischemia
Reperfusion Injury
Kidney
Malondialdehyde

Ratlarda asetik asit ile olusturulan kolitte Nωnitro-L-arginin'in koruyucu etkisi

Translated title of the contribution: Protective effect of Nωnitro-L-arginine in the rat model of acetic acid induced colitisTetik, C., Bostanci, B., Ozden, A., Demirkan, N., Saydam, O. & Guner, G., Jan 1 1998, In : Turkish Journal of Surgery. 14, 3, p. 169-175 7 p.

Research output: Contribution to journalArticle

Colitis
Acetic Acid
Arginine
Malondialdehyde
Nitric Oxide
1 Citation (Scopus)

Structural changes in testicular tissue of experimentally varicocele induced rats

Koseoglu, M. H., Turan, T., Aybek, Z., Saydam, O., Demirkan, N. & Guner, G., Jan 1 1998, In : Biochemical Society transactions. 26, 4

Research output: Contribution to journalArticle

Rats
Animals
Collagen
Tissue
1997
91 Citations (Scopus)

Determination of glutathione, glutathione reductase, glutathione peroxidase and glutathione S-transferase levels in human lung cancer tissues

Saydam, N., Kirb, A., Demir, Ö., Hazan, E., Oto, Ö., Saydam, O. & Güner, G., Oct 28 1997, In : Cancer Letters. 119, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

Glutathione Reductase
Glutathione Peroxidase
Glutathione Transferase
Glutathione
Lung Neoplasms