20022025

Research output per year

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Research Output

2019

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner

Conboy, C. B., Vélez-Reyes, G. L., Tschida, B. R., Hu, H., Kaufmann, G., Koes, N., Keller, B., Alsinet, C., Cornellà, H., Pinyol, R., Abrahante, J. E., Temiz, N. A., Linden, M. A., Amin, K., Kuka, T. P., Keng, V. W., Llovet, J. M., Starr, T. K. & Largaespada, D. A., Nov 2019, In : Hepatology communications. 3, 11, p. 1496-1509 14 p.

Research output: Contribution to journalArticle

Open Access
2018

Cancer stem cell phenotypes in ER+ breast cancer models are promoted by PELP1/AIB1 complexes

Truong, T. H., Hu, H., Temiz, N. A., Hagen, K. M., Girard, B. J., Brady, N. J., Schwertfeger, K. L., Lange, C. A. & Ostrander, J. H., Apr 1 2018, In : Molecular Cancer Research. 16, 4, p. 707-719 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
21 Scopus citations
2017

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016

Mutation processes in 293-based clones overexpressing the DNA cytosine deaminase APOBEC3B

Akre, M. K., Starrett, G. J., Quist, J. S., Temiz, N. A., Carpenter, M. A., Tutt, A. N. J., Grigoriadis, A. & Harris, R. S., May 1 2016, In : PloS one. 11, 5, e0155391.

Research output: Contribution to journalArticle

14 Scopus citations

MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer

Sarver, A. L., Murray, C. D., Temiz, N. A., Tseng, Y. Y. & Bagchi, A., Apr 2 2016, In : Cell Cycle. 15, 7, p. 881-885 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 2016, In : Genome research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Law, E. K., Sieuwerts, A. M., Lapara, K., Leonard, B., Starrett, G. J., Molan, A. M., Temiz, N. A., Vogel, R. I., Meijer-Van Gelder, M. E., Sweep, F. C. G. J., Span, P. N., Foekens, J. A., Martens, J. W. M., Yee, D. & Harris, R. S., Oct 2016, In : Science Advances. 2, 10, e1601737.

Research output: Contribution to journalArticle

52 Scopus citations

The DNA cytosine deaminase APOBEC3H haplotype i likely contributes to breast and lung cancer mutagenesis

Starrett, G. J., Luengas, E. M., McCann, J. L., Ebrahimi, D., Temiz, N. A., Love, R. P., Feng, Y., Adolph, M. B., Chelico, L., Law, E. K., Carpenter, M. A. & Harris, R. S., Sep 21 2016, In : Nature communications. 7, 12918.

Research output: Contribution to journalArticle

67 Scopus citations
2015

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 others, Gorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

113 Scopus citations

Erratum to: The somatic autosomal mutation matrix in cancer genomes[Human Genetics, (2015), DOI 10.1007/s00439-015-1566-1]

Temiz, N. A., Donohue, D. E., Bacolla, A., Vasquez, K. M., Cooper, D. N., Mudunuri, U., Ivanic, J., Cer, R. Z., Yi, M., Stephens, R. M., Collins, J. R. & Luke, B. T., Aug 23 2015, In : Human Genetics. 134, 8, p. 865-867 3 p.

Research output: Contribution to journalComment/debate

The somatic autosomal mutation matrix in cancer genomes

Temiz, N. A., Donohue, D. E., Bacolla, A., Vasquez, K. M., Cooper, D. N., Mudunuri, U., Ivanic, J., Cer, R. Z., Yi, M., Stephens, R. M., Collins, J. R. & Luke, B. T., Aug 23 2015, In : Human Genetics. 134, 8, p. 851-864 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B

Vieira, V. C., Leonard, B., White, E. A., Starrett, G. J., Temiz, N. A., Lorenz, L. D., Lee, D., Soares, M. A., Lambert, P. F., Howley, P. M. & Harris, R. S., Dec 23 2014, In : mBio. 5, 6, e02234-14.

Research output: Contribution to journalArticle

89 Scopus citations
2013

APOBEC3B is an enzymatic source of mutation in breast cancer

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., Mcdougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Feb 21 2013, In : Nature. 494, 7437, p. 366-370 5 p.

Research output: Contribution to journalArticle

418 Scopus citations

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma

Leonard, B., Hart, S. N., Burns, M. B., Carpenter, M. A., Temiz, N. A., Rathore, A., Vogel, R. I., Nikas, J. B., Law, E. K., Brown, W. L., Li, Y., Zhang, Y., Maurer, M. J., Oberg, A. L., Cunningham, J. M., Shridhar, V., Bell, D. A., April, C., Bentley, D., Bibikova, M. & 14 others, Cheetham, R. K., Fan, J. B., Grocock, R., Humphray, S., Kingsbury, Z., Peden, J., Chien, J., Swisher, E. M., Hartmann, L. C., Kalli, K. R., Goode, E. L., Sicotte, H., Kaufmann, S. H. & Harris, R. S., Dec 15 2013, In : Cancer Research. 73, 24, p. 7222-7231 10 p.

Research output: Contribution to journalArticle

93 Scopus citations

Erratum: APOBEC3B is an enzymatic source of mutation in breast cancer (Nature (2013) 494 (366-370) DOI: 10.1038/nature11881)

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., McDougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Nov 7 2013, In : Nature. 502, 7472, 1 p.

Research output: Contribution to journalComment/debate

Evidence for APOBEC3B mutagenesis in multiple human cancers

Burns, M. B., Temiz, N. A. & Harris, R. S., Sep 1 2013, In : Nature Genetics. 45, 9, p. 977-983 7 p.

Research output: Contribution to journalArticle

361 Scopus citations

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

Bacolla, A., Temiz, N. A., Yi, M., Ivanic, J., Cer, R. Z., Donohue, D. E., Ball, E. V., Mudunuri, U. S., Wang, G., Jain, A., Volfovsky, N., Luke, B. T., Stephens, R. M., Cooper, D. N., Collins, J. R. & Vasquez, K. M., Sep 1 2013, In : PLoS genetics. 9, 9, e1003816.

Research output: Contribution to journalArticle

18 Scopus citations

Non-B DB v2.0: A database of predicted non-B DNA-forming motifs and its associated tools

Cer, R. Z., Donohue, D. E., Mudunuri, U. S., Temiz, N. A., Loss, M. A., Starner, N. J., Halusa, G. N., Volfovsky, N., Yi, M., Luke, B. T., Bacolla, A., Collins, J. R. & Stephens, R. M., Jan 1 2013, In : Nucleic acids research. 41, D1, p. D94-D100

Research output: Contribution to journalArticle

51 Scopus citations
2012

Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool)

Cer, R. Z., Bruce, K. H., Donohue, D. E., Temiz, N. A., Mudunuri, U. S., Yi, M., Volfovsky, N., Bacolla, A., Luke, B. T., Collins, J. R. & Stephens, R. M., Apr 1 2012, In : Current Protocols in Human Genetics. SUPPL.73, 18.7.

Research output: Contribution to journalArticle

16 Scopus citations

The role of methylation in the intrinsic dynamics of B- and Z-DNA

Temiz, N. A., Donohue, D. E., Bacolla, A., Luke, B. T. & Collins, J. R., Apr 17 2012, In : PloS one. 7, 4, e35558.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Electrostatic hot spot on DNA-binding domains mediates phosphate desolvation and the pre-organization of specificity determinant side chains

Temiz, A. N., Benos, P. V. & Camacho, C. J., Jan 4 2010, In : Nucleic acids research. 38, 7, p. 2134-2144 11 p., gkp1132.

Research output: Contribution to journalArticle

7 Scopus citations

Novel modulation factor quantifies the role of water molecules in protein interactions

Bueno, M., Temiz, N. A. & Camacho, C. J., Nov 15 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 15, p. 3226-3234 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Optimization of minimum set of protein-DNA interactions: a quasi exact solution with minimum over-fitting.

Temiz, N. A., Trapp, A., Prokopyev, O. A. & Camacho, C. J., Feb 1 2010, In : Bioinformatics (Oxford, England). 26, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

9 Scopus citations
2009
16 Scopus citations
2004

Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding

Sluis-Cremer, N., Temiz, N. A. & Bahar, I., Oct 1 2004, In : Current HIV research. 2, 4, p. 323-332 10 p.

Research output: Contribution to journalReview article

130 Scopus citations

Escherichia coli adenylate kinase dynamics: Comparison of elastic network model modes with mode-coupling 15N-NMR relaxation data

Temiz, N. A., Meirovitch, E. & Bahar, I., Nov 15 2004, In : Proteins: Structure, Function and Genetics. 57, 3, p. 468-480 13 p.

Research output: Contribution to journalArticle

81 Scopus citations
2002

Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase

Temiz, N. A. & Bahar, I., Oct 1 2002, In : Proteins: Structure, Function and Genetics. 49, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

76 Scopus citations