20022024
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Research Output 2002 2019

2019
2 Citations (Scopus)

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 1 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

Receptor Protein-Tyrosine Kinases
Mutagenesis
Carcinogenesis
Liver
Genes
2018
2 Citations (Scopus)

Cancer stem cell phenotypes in ER+ breast cancer models are promoted by PELP1/AIB1 complexes

Truong, T. H., Hu, H., Temiz, N. A., Hagen, K. M., Girard, B. J., Brady, N. J., Schwertfeger, K., Lange, C. A. & Ostrander, J. H., Apr 1 2018, In : Molecular Cancer Research. 16, 4, p. 707-719 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Breast Neoplasms
Phenotype
human PELP1 protein
Neoplasms
14 Citations (Scopus)
Gene Expression Profiling
Osteosarcoma
Survival
Multigene Family
Neoplasms
Tyrphostins
Insulin Receptor
Insulin-Like Growth Factor I
Insulin
Breast Neoplasms
2017
1 Citation (Scopus)

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Open Access
ras Genes
Oncogenes
Acute Myeloid Leukemia
Leukemia
Recurrence
8 Citations (Scopus)

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Beauty
Insertional Mutagenesis
Hepatocellular Carcinoma
Liver
Neoplasms
2016
11 Citations (Scopus)

Mutation processes in 293-based clones overexpressing the DNA cytosine deaminase APOBEC3B

Akre, M. K., Starrett, G. J., Quist, J. S., Temiz, N. A., Carpenter, M. A., Tutt, A. N. J., Grigoriadis, A. & Harris, R. S., May 1 2016, In : PloS one. 11, 5, e0155391.

Research output: Contribution to journalArticle

cytosine deaminase
Cytosine Deaminase
Mutagenesis
Clone Cells
Cells
17 Citations (Scopus)

MYC and PVT1 synergize to regulate RSPO1 levels in breast cancer

Sarver, A. L., Murray, C. D., Temiz, N. A., Tseng, Y. Y. & Bagchi, A., Apr 2 2016, In : Cell Cycle. 15, 7, p. 881-885 5 p.

Research output: Contribution to journalArticle

Plasmacytoma
Breast Neoplasms
Neoplasms
Oncogenes
Breast
15 Citations (Scopus)

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 1 2016, In : Genome Research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Beauty
Ligation
RNA
Polymerase Chain Reaction
45 Citations (Scopus)

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

Law, E. K., Sieuwerts, A. M., Lapara, K., Leonard, B., Starrett, G. J., Molan, A. M., Temiz, N. A., Vogel, R. I., Meijer-Van Gelder, M. E., Sweep, F. C. G. J., Span, P. N., Foekens, J. A., Martens, J. W. M., Yee, D. & Harris, R. S., Oct 2016, In : Science Advances. 2, 10, e1601737.

Research output: Contribution to journalArticle

Cytosine Deaminase
Apolipoproteins B
Tamoxifen
Breast Neoplasms
Peptides
60 Citations (Scopus)

The DNA cytosine deaminase APOBEC3H haplotype i likely contributes to breast and lung cancer mutagenesis

Starrett, G. J., Luengas, E. M., McCann, J. L., Ebrahimi, D., Temiz, N. A., Love, R. P., Feng, Y., Adolph, M. B., Chelico, L., Law, E. K., Carpenter, M. A. & Harris, R. S., Sep 21 2016, In : Nature communications. 7, 12918.

Research output: Contribution to journalArticle

Cytosine Deaminase
mutagenesis
Mutagenesis
mutations
breast
2015
105 Citations (Scopus)

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

Moriarity, B. S., Otto, G. M., Rahrmann, E. P., Rathe, S. K., Wolf, N. K., Weg, M. T., Manlove, L. A., Larue, R. S., Temiz, N. A., Molyneux, S. D., Choi, K., Holly, K. J., Sarver, A. L., Scott, M. C., Forster, C. L., Modiano, J. F., Khanna, C., Hewitt, S. M., Khokha, R., Yang, Y. & 3 others, Gorlick, R., Dyer, M. A. & Largaespada, D. A., May 27 2015, In : Nature Genetics. 47, 6, p. 615-624 10 p.

Research output: Contribution to journalArticle

Beauty
Osteosarcoma
Neoplasm Metastasis
Genes
Oncogenes

Erratum to: The somatic autosomal mutation matrix in cancer genomes[Human Genetics, (2015), DOI 10.1007/s00439-015-1566-1]

Temiz, N. A., Donohue, D. E., Bacolla, A., Vasquez, K. M., Cooper, D. N., Mudunuri, U., Ivanic, J., Cer, R. Z., Yi, M., Stephens, R. M., Collins, J. R. & Luke, B. T., Aug 23 2015, In : Human Genetics. 134, 8, p. 865-867 3 p.

Research output: Contribution to journalComment/debate

10 Citations (Scopus)

The somatic autosomal mutation matrix in cancer genomes

Temiz, N. A., Donohue, D. E., Bacolla, A., Vasquez, K. M., Cooper, D. N., Mudunuri, U., Ivanic, J., Cer, R. Z., Yi, M., Stephens, R. M., Collins, J. R. & Luke, B. T., Aug 23 2015, In : Human Genetics. 134, 8, p. 851-864 14 p.

Research output: Contribution to journalArticle

Genome
Mutation
Neoplasms
DNA Damage
Nucleotides
2014
82 Citations (Scopus)

Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B

Vieira, V. C., Leonard, B., White, E. A., Starrett, G. J., Temiz, N. A., Lorenz, L. D., Lee, D., Soares, M. A., Lambert, P. F., Howley, P. M. & Harris, R. S., Dec 23 2014, In : mBio. 5, 6, e02234-14.

Research output: Contribution to journalArticle

Antiviral Agents
Up-Regulation
DNA
Neoplasms
Head and Neck Neoplasms
2013
399 Citations (Scopus)

APOBEC3B is an enzymatic source of mutation in breast cancer

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., Mcdougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Feb 21 2013, In : Nature. 494, 7437, p. 366-370 5 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Mutation
Cytosine Deaminase
Genome
Cell Line
90 Citations (Scopus)

APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma

Leonard, B., Hart, S. N., Burns, M. B., Carpenter, M. A., Temiz, N. A., Rathore, A., Vogel, R. I., Nikas, J. B., Law, E. K., Brown, W. L., Li, Y., Zhang, Y., Maurer, M. J., Oberg, A. L., Cunningham, J. M., Shridhar, V., Bell, D. A., April, C., Bentley, D., Bibikova, M. & 14 others, Cheetham, R. K., Fan, J. B., Grocock, R., Humphray, S., Kingsbury, Z., Peden, J., Chien, J., Swisher, E. M., Hartmann, L. C., Kalli, K. R., Goode, E. L., Sicotte, H., Kaufmann, S. H. & Harris, R. S., Dec 15 2013, In : Cancer Research. 73, 24, p. 7222-7231 10 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Up-Regulation
Carcinoma
Mutation
Cytosine Deaminase

Erratum: APOBEC3B is an enzymatic source of mutation in breast cancer (Nature (2013) 494 (366-370) DOI: 10.1038/nature11881)

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., McDougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Nov 7 2013, In : Nature. 502, 7472, 1 p.

Research output: Contribution to journalComment/debate

348 Citations (Scopus)

Evidence for APOBEC3B mutagenesis in multiple human cancers

Burns, M. B., Temiz, N. A. & Harris, R., Sep 1 2013, In : Nature Genetics. 45, 9, p. 977-983 7 p.

Research output: Contribution to journalArticle

Mutagenesis
Mutation
Neoplasms
Cytidine Deaminase
Exome
18 Citations (Scopus)

Guanine Holes Are Prominent Targets for Mutation in Cancer and Inherited Disease

Bacolla, A., Temiz, N. A., Yi, M., Ivanic, J., Cer, R. Z., Donohue, D. E., Ball, E. V., Mudunuri, U. S., Wang, G., Jain, A., Volfovsky, N., Luke, B. T., Stephens, R. M., Cooper, D. N., Collins, J. R. & Vasquez, K. M., Sep 1 2013, In : PLoS genetics. 9, 9, e1003816.

Research output: Contribution to journalArticle

guanine
Guanine
mutation
cancer
Mutation
48 Citations (Scopus)

Non-B DB v2.0: A database of predicted non-B DNA-forming motifs and its associated tools

Cer, R. Z., Donohue, D. E., Mudunuri, U. S., Temiz, N. A., Loss, M. A., Starner, N. J., Halusa, G. N., Volfovsky, N., Yi, M., Luke, B. T., Bacolla, A., Collins, J. R. & Stephens, R. M., Jan 1 2013, In : Nucleic acids research. 41, D1

Research output: Contribution to journalArticle

Platypus
Pongo
Z-Form DNA
G-Quadruplexes
Nucleotide Motifs
2012
15 Citations (Scopus)

Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool)

Cer, R. Z., Bruce, K. H., Donohue, D. E., Temiz, N. A., Mudunuri, U. S., Yi, M., Volfovsky, N., Bacolla, A., Luke, B. T., Collins, J. R. & Stephens, R. M., Apr 1 2012, In : Current Protocols in Human Genetics. SUPPL.73, 18.7.

Research output: Contribution to journalArticle

Nucleotide Motifs
Z-Form DNA
Cruciform DNA
G-Quadruplexes
Viverridae
34 Citations (Scopus)

The role of methylation in the intrinsic dynamics of B- and Z-DNA

Temiz, N. A., Donohue, D. E., Bacolla, A., Luke, B. T. & Collins, J. R., Apr 17 2012, In : PloS one. 7, 4, e35558.

Research output: Contribution to journalArticle

Z-DNA
Z-Form DNA
Methylation
methylation
B-DNA
2010
7 Citations (Scopus)

Electrostatic hot spot on DNA-binding domains mediates phosphate desolvation and the pre-organization of specificity determinant side chains

Temiz, A. N., Benos, P. V. & Camacho, C. J., Jan 4 2010, In : Nucleic acids research. 38, 7, p. 2134-2144 11 p., gkp1132.

Research output: Contribution to journalArticle

Static Electricity
Phosphates
DNA
Hydrogen
Transcription Factors
4 Citations (Scopus)

Novel modulation factor quantifies the role of water molecules in protein interactions

Bueno, M., Temiz, N. A. & Camacho, C. J., Nov 15 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 15, p. 3226-3234 9 p.

Research output: Contribution to journalArticle

Modulation
Molecules
Water
Proteins
Hydrogen
8 Citations (Scopus)

Optimization of minimum set of protein-DNA interactions: a quasi exact solution with minimum over-fitting.

Temiz, N. A., Trapp, A., Prokopyev, O. A. & Camacho, C. J., Feb 1 2010, In : Bioinformatics (Oxford, England). 26, 3, p. 319-325 7 p.

Research output: Contribution to journalArticle

Overfitting
DNA
Exact Solution
Integer programming
Proteins
2009
16 Citations (Scopus)
Fingers
Water
DNA
Proteins
Molecular Dynamics Simulation
2004
125 Citations (Scopus)

Conformational changes in HIV-1 reverse transcriptase induced by nonnucleoside reverse transcriptase inhibitor binding

Sluis-Cremer, N., Temiz, N. A. & Bahar, I., Oct 1 2004, In : Current HIV research. 2, 4, p. 323-332 10 p.

Research output: Contribution to journalReview article

Reverse Transcriptase Inhibitors
RNA-Directed DNA Polymerase
Reverse Transcription
HIV-1
Enzymes
81 Citations (Scopus)

Escherichia coli adenylate kinase dynamics: Comparison of elastic network model modes with mode-coupling 15N-NMR relaxation data

Temiz, N. A., Meirovitch, E. & Bahar, I., Nov 15 2004, In : Proteins: Structure, Function and Genetics. 57, 3, p. 468-480 13 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Escherichia coli
Nuclear magnetic resonance
Adenosine Diphosphate
Enzymes
2002
75 Citations (Scopus)

Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase

Temiz, N. A. & Bahar, I., Oct 1 2002, In : Proteins: Structure, Function and Genetics. 49, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

RNA-Directed DNA Polymerase
Ribonuclease H
efavirenz
Thumb
Hinges