Personal profile
Personal profile
Dr. Nichole (Nikki) Klatt is a Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research in the Department of Surgery, University of Minnesota Medical School. She is also an Affiliate Professor in the Department of Microbiology, Immunology, and Cancer Biology (MICaB), University of Minnesota Medical School. Prior to this she was an Associate Professor, Vice Chair of Research, and the Adrienne Arsht Endowed Chair in Pediatric Clinical Research in the Department of Pediatrics, Miller School of Medicine, and Sylvester Cancer Center of University of Miami from 2018-2020. Dr. Klatt was also an Associate Professor in the Department of Pharmaceutics at the University of Washington from 2012- 2018. Dr. Klatt received her PhD from Emory University in Immunology and Molecular Pathogenesis in 2009, and was also a visiting PhD candidate at the University of Pennsylvania from 2006-2008. Dr. Klatt performed her Postdoctoral research in the Laboratory of Molecular Microbiology at the National Institutes of Health from 2009-2012. The goal of Dr. Klatt’s research laboratory is to understand mechanisms of microbiome, mucosal dysfunction and drug metabolism to improve human health.
Research interests
More effective prevention and intervention strategies for human disease are crucial to improve human health. The Klatt lab focuses on mucosal immunology and the microbiome in human disease, including HIV, Covid-19, STIs, cancer, sepsis, etc. We perform highly translational basic and and clinical research to determine mechanism underlying disease and how to intervene and prevent disease. It is our mission to keep our research fluid and ever expanding, to always be contributing to the advancements in research.
Education/Academic qualification
PhD, Immunology & Molecular Pathogenesis, Emory University
Award Date: Dec 1 2008
PhD, Molecular & Cellular Biology, University of Pennsylvania
Award Date: Dec 1 2008
BS, Biology, Chemistry, University of Minnesota Duluth
Award Date: May 1 2004
External Positions
Affiliate Associate Professor, University of Miami
2020 → …
Affiliate Associate Professor, University of Washington
2018 → …
Research Interest Keywords
- Microbiome
- HIV
- infectious diseases
- Vaccine
- Bacterial vaginosis
- COVID-19
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 1 No Poverty
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 5 Gender Equality
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SDG 10 Reduced Inequalities
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SDG 13 Climate Action
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Collaborations and top research areas from the last five years
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HIV Reservoir Dynamics Associated with Metabolic Complications of HIV Infection
Crawford, P. (PI), Gale, M. (PI), Klatt, N. R. (PI), Schacker, T. W. (PI), Beilman, G. (CoI), Bolan, P. J. (CoI), Chipman, J. G. (CoI), Dengel, D. R. (CoI), Khoruts, A. (CoI), Puchalska, P. (CoI), Rhein, J. R. (CoI) & Seaquist, E. R. (CoI)
NIH NATL INST OF DIABETES/DIG/KIDNEY DIS
9/16/25 → 6/30/29
Project: Research project
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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Klatt, N. R. (PI)
FLORIDA INTERNATIONAL UNIVERSITY, NATIONAL INSTITUTES OF HEALTH (NIH)
9/1/23 → 8/31/26
Project: Research project
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Test and Verify ULTRAN Device to Provide a Measurable Therapeutic Benefit in Patients with Long COVID
Cui, E. (PI), Ikramuddin, F. S. (PI) & Klatt, N. R. (PI)
THE ULTRAN GROUP, INC., MEDICAL CBRN DEFENSE CONSORTIUM
7/1/23 → 4/30/25
Project: Research project
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Penile viral and bacterial microbiome, inflammation and HIV susceptibility
Klatt, N. R. (PI)
SEATTLE CHILDREN'S HOSPITAL, NATIONAL INSTITUTES OF HEALTH (NIH)
6/15/22 → 5/31/24
Project: Research project
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Reversing Immune Dysfunction for HIV-1 Eradication
Klatt, N. R. (PI) & Schifanella, L. (CoI)
SCRIPPS RESEARCH INSTITUTE DBA CALIBR, NIH NATIONAL INST OF ALLERGY & INFECT DI
5/1/22 → 4/30/23
Project: Research project
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Distinct gastrointestinal microbial signatures predict parasite levels in controlled Plasmodium infections in both rhesus macaques and humans
Gustin, A. T., Broedlow, C. A., Hager, K., Coronado, E., Wangari, S., Iwayama, N., Ahrens, C. Y., Garrison, W. D., Guerriero, K. A., De Paris, K., Londono-Renteria, B., Gale, M., Klatt, N. R., Kublin, J. G. & Manuzak, J. A., Dec 2026, In: Nature communications. 17, 1, 550.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Douching Is Associated with Dysregulated Rectal Mucosal Immunity in Sexual Minority Men
Broedlow, C. A., McGaugh, A., Glynn, T. R., Cherenack, E. M., Miller, C., Alcaide, M. L., Bauermeister, J. A., Grov, C., Parisi, R., Martinez, D., Carrico, A. W., Klatt, N. R. & Manuzak, J. A., Mar 15 2026, In: Journal of Infectious Diseases. 233, 3, p. e828-e838Research output: Contribution to journal › Article › peer-review
Open Access -
The vaginal microbiome of pregnant people living with HIV on antiretroviral therapy in the Democratic Republic of Congo: a pilot study and global meta-analysis
Ndlovu, K. S., Pavan, R. R., Corry, J., Gregory, A. C., Mahamed, S., Zotova, N., Tabala, M., Babakazo, P., Funderburg, N. T., Yotebieng, M., Klatt, N. R., Kwiek, J. J. & Sullivan, M. B., Feb 24 2026, In: mSphere. 11, 2, p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cannabis Use in HIV: Impact on Inflammation, Immunity and the Microbiome
Langat, R., Chakrawarti, A. & Klatt, N. R., Feb 2025, In: Current HIV/AIDS Reports. 22, 1, 19.Research output: Contribution to journal › Review article › peer-review
1 Link opens in a new tab Scopus citations -
Common cervicovaginal sequencing methods result in discordant molecular diagnoses of bacterial vaginosis and reveal strain level effects of Gardnerella vaginalis
Broedlow, C. A., Swanson, E., Cherenack, E. M., Basting, C., Nogueira, N. F., France, M., Yue, P., Chakrawarti, A., Salazar, A., Acosta, L., Raccamarich, P., Gale, M., Ravel, J., Fein, L. A., Holm, J., Alcaide, M. L. & Klatt, N. R., Jul 5 2025, In: npj Women's Health.Research output: Contribution to journal › Article › peer-review
Open Access