Projects per year
Personal profile
Personal profile
Dr. Nichole (Nikki) Klatt is a Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research in the Department of Surgery, University of Minnesota Medical School. She is also an Affiliate Professor in the Department of Microbiology, Immunology, and Cancer Biology (MICaB), University of Minnesota Medical School. Prior to this she was an Associate Professor, Vice Chair of Research, and the Adrienne Arsht Endowed Chair in Pediatric Clinical Research in the Department of Pediatrics, Miller School of Medicine, and Sylvester Cancer Center of University of Miami from 2018-2020. Dr. Klatt was also an Associate Professor in the Department of Pharmaceutics at the University of Washington from 2012- 2018. Dr. Klatt received her PhD from Emory University in Immunology and Molecular Pathogenesis in 2009, and was also a visiting PhD candidate at the University of Pennsylvania from 2006-2008. Dr. Klatt performed her Postdoctoral research in the Laboratory of Molecular Microbiology at the National Institutes of Health from 2009-2012. The goal of Dr. Klatt’s research laboratory is to understand mechanisms of microbiome, mucosal dysfunction and drug metabolism to improve human health.
Research interests
More effective prevention and intervention strategies for human disease are crucial to improve human health. The Klatt lab focuses on mucosal immunology and the microbiome in human disease, including HIV, Covid-19, STIs, cancer, sepsis, etc. We perform highly translational basic and and clinical research to determine mechanism underlying disease and how to intervene and prevent disease. It is our mission to keep our research fluid and ever expanding, to always be contributing to the advancements in research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Immunology & Molecular Pathogenesis, Emory University
Award Date: Dec 1 2008
PhD, Molecular & Cellular Biology, University of Pennsylvania
Award Date: Dec 1 2008
BS, Biology, Chemistry, University of Minnesota Duluth
Award Date: May 1 2004
External Positions
Affiliate Associate Professor, University of Miami
2020 → …
Affiliate Associate Professor, University of Washington
2018 → …
Research Interest Keywords
- Microbiome
- HIV
- infectious diseases
- Vaccine
- Bacterial vaginosis
- COVID-19
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Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized control trial
Ikramuddin, S., Adeyi, O., Billington, C. J., Connett, J. E., Holker, E. G., Klatt, N. R. & Lake, J. R.
NIH Natl Inst of Diabetes/Dig/Kidney Dis
7/14/21 → 5/31/24
Project: Research project
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Microbial and innate immune mechanisms of oral inflammation during SIV infection
Beth Israel Deaconess Medical Center
6/1/20 → 5/31/21
Project: Research project
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Mechanisms of microbiome-driven antiretroviral biodegradation and effects on viral reservoir
Klatt, N. R. & Schifanella, L.
NIH Natl Inst of Diabetes/Dig/Kidney Dis
4/17/20 → 7/31/21
Project: Research project
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Effects of boosting mucosal by microbiota manipulation on B cell responses to HIV-1 vaccine
2/1/20 → 1/31/21
Project: Research project
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Accommodating multiple potential normalizations in microbiome associations studies
Song, H., Ling, W., Zhao, N., Plantinga, A. M., Broedlow, C. A., Klatt, N. R., Hensley-McBain, T. & Wu, M. C., Dec 2023, In: BMC bioinformatics. 24, 1, 22.Research output: Contribution to journal › Article › peer-review
Open Access -
Assessing Intravaginal Practices in HIV Prevention Research: Development and Validation of an Intravaginal Practices Questionnaire
Rodriguez, V. J., Salazar, A. S., Cherenack, E. M., Klatt, N. R., Jones, D. L. & Alcaide, M. L., Feb 2023, In: Archives of sexual behavior. 52, 2, p. 803-808 6 p.Research output: Contribution to journal › Article › peer-review
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Impact of SARS-CoV-2 vaccination and booster on COVID-19 symptom severity over time in the COVID-OUT trial
COVID-OUT study team, Feb 8 2023, In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 76, 3, p. e1-e9Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Mass spectrometry analysis of gut tissue in acute SIV-infection in rhesus macaques identifies early proteome alterations preceding the interferon inflammatory response
Berard, A. R., Hensley-McBain, T., Noël-Romas, L., Birse, K., Abou, M., Westmacott, G., McCorrister, S., Smedley, J., Klatt, N. R. & Burgener, A. D., Dec 2023, In: Scientific reports. 13, 1, 690.Research output: Contribution to journal › Article › peer-review
Open Access -
Upregulation of IFN-stimulated genes persists beyond the transitory broad immunologic changes of acute HIV-1 infection
for the Partners in Prevention HSV/HIV Transmission Study & the Partners PrEP Study Teams, Apr 21 2023, In: iScience. 26, 4, 106454.Research output: Contribution to journal › Article › peer-review
Open Access