Projects per year
Personal profile
Personal profile
Dr. Nichole (Nikki) Klatt is a Professor and the Director of the Division of Surgical Outcomes and Precision Medicine Research in the Department of Surgery, University of Minnesota Medical School. She is also an Affiliate Professor in the Department of Microbiology, Immunology, and Cancer Biology (MICaB), University of Minnesota Medical School. Prior to this she was an Associate Professor, Vice Chair of Research, and the Adrienne Arsht Endowed Chair in Pediatric Clinical Research in the Department of Pediatrics, Miller School of Medicine, and Sylvester Cancer Center of University of Miami from 2018-2020. Dr. Klatt was also an Associate Professor in the Department of Pharmaceutics at the University of Washington from 2012- 2018. Dr. Klatt received her PhD from Emory University in Immunology and Molecular Pathogenesis in 2009, and was also a visiting PhD candidate at the University of Pennsylvania from 2006-2008. Dr. Klatt performed her Postdoctoral research in the Laboratory of Molecular Microbiology at the National Institutes of Health from 2009-2012. The goal of Dr. Klatt’s research laboratory is to understand mechanisms of microbiome, mucosal dysfunction and drug metabolism to improve human health.
Research interests
More effective prevention and intervention strategies for human disease are crucial to improve human health. The Klatt lab focuses on mucosal immunology and the microbiome in human disease, including HIV, Covid-19, STIs, cancer, sepsis, etc. We perform highly translational basic and and clinical research to determine mechanism underlying disease and how to intervene and prevent disease. It is our mission to keep our research fluid and ever expanding, to always be contributing to the advancements in research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Immunology & Molecular Pathogenesis, Emory University
Award Date: Dec 1 2008
PhD, Molecular & Cellular Biology, University of Pennsylvania
Award Date: Dec 1 2008
BS, Biology, Chemistry, University of Minnesota Duluth
Award Date: May 1 2004
External Positions
Affiliate Associate Professor, University of Miami
2020 → …
Affiliate Associate Professor, University of Washington
2018 → …
Research Interest Keywords
- Microbiome
- HIV
- infectious diseases
- Vaccine
- Bacterial vaginosis
- COVID-19
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Collaborations and top research areas from the last five years
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Mechanisms underlying recurrent bacterial vaginosis and HIV risk a multidisciplinary approach
Klatt, N. R. (PI) & Schifanella, L. (CoI)
UNIVERSITY OF MIAMI, NATIONAL INSTITUTES OF HEALTH (NIH)
5/1/20 → 7/31/25
Project: Research project
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Penile viral and bacterial microbiome, inflammation and HIV susceptibility
Klatt, N. R. (PI)
SEATTLE CHILDREN'S HOSPITAL, NATIONAL INSTITUTES OF HEALTH (NIH)
6/15/22 → 5/31/24
Project: Research project
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Reversing Immune Dysfunction for HIV-1 Eradication
Klatt, N. R. (PI) & Schifanella, L. (CoI)
SCRIPPS RESEARCH INSTITUTE DBA CALIBR, NIH Nat'l Inst of Allergy & Infect Dis
5/1/22 → 4/30/23
Project: Research project
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Treatment Research Investigating Depression Effects on Neuroimmune Targets (TRIDENT)
Klatt, N. R. (PI) & Schifanella, L. (CoI)
UNIVERSITY OF MIAMI, NATIONAL INSTITUTES OF HEALTH (NIH)
9/15/21 → 8/31/23
Project: Research project
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RID HIV: Reversing Immune Dysfunction for HIV Eradication
Klatt, N. R. (PI) & Schifanella, L. (CoI)
SANFORD-BURNHAM MEDICAL RESEARCH INST., NATIONAL INSTITUTES OF HEALTH (NIH)
8/16/21 → 10/31/21
Project: Research project
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Cannabis Use in HIV: Impact on Inflammation, Immunity and the Microbiome
Langat, R., Chakrawarti, A. & Klatt, N. R., Dec 2025, In: Current HIV/AIDS Reports. 22, 1, 19.Research output: Contribution to journal › Review article › peer-review
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Favorable Antiviral Effect of Metformin on SARS-CoV-2 Viral Load in a Randomized, Placebo-Controlled Clinical Trial of COVID-19
for the COVID-OUT Study Team, Aug 15 2024, In: Clinical Infectious Diseases. 79, 2, p. 354-363 10 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Gender Identity Stigma in Transgender Women Is Higher After Gender-Affirming Vaginoplasty
Fein, L. A., Barnett, R., Liu, T., Potter, J. N. E., Klatt, N. R., Alcaide, M. L. & Jones, D. L., Jun 17 2024, In: AIDS Research and Human Retroviruses. 40, 6, p. 376-383 8 p.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Microbiota, Gender-Affirming Hormone Therapy, and Inflammatory Biomarkers in Transgender Women with HIV: Potential Implications for Cardiovascular Disease
Glynn, T. R., Broedlow, C. A., Rodriguez, V., Nogueira, N. F., Londono, V., Brophy, T., Pallikkuth, S., Roach, M., Pahwa, S., Fein, L. A., Hurwitz, B. E., Jones, D., Alcaide, M. L., Klatt, N. & Martinez, C., 2024, (Accepted/In press) In: Transgender Health.Research output: Contribution to journal › Article › peer-review
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Natural killer like B cells are a distinct but infrequent innate immune cell subset modulated by SIV infection of rhesus macaques
Manickam, C., Upadhyay, A. A., Woolley, G., Kroll, K. W., Terry, K., Broedlow, C. A., Klatt, N. R., Bosinger, S. E. & Reeves, R. K., May 2024, In: PLoS pathogens. 20, 5, e1012223.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations