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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Allosteric mechanisms driving paradoxical activation of RAF kinases
Levinson, N. M. (PI), Freedman, T. (CoI) & Sheedlo, M. J. (CoI)
NATIONAL INSTITUTES OF HEALTH (NIH)
7/1/24 → 6/30/25
Project: Research project
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Targeting N-Myc with Selective Aurora Kinase A Degraders for Neuroblastoma Therapy
Harki, D. A. (PI), Harris, R. (CoI) & Levinson, N. M. (CoI)
7/15/21 → 7/14/25
Project: Research project
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Targeting allosteric scaffolding functions of Aurora kinase A in cancer
Levinson, N. M. (PI), Drake, J. M. (CoI) & Muretta, J. M. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
4/1/21 → 3/31/26
Project: Research project
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A transformative drug discovery platform for allosteric kinase inhibitors
Levinson, N. M. (PI) & Muretta, J. M. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
3/1/21 → 2/28/26
Project: Research project
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Time-resolved FRET-based allostery sensors for any protein kinase drug target
Levinson, N. M. (PI), Drake, J. M. (CoI), Georg, G. (CoI) & Thomas, D. D. (CoI)
NIH NATIONAL CANCER INSTITUTE (NCI)
3/1/20 → 2/29/24
Project: Research project
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Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors
Rasmussen, D. M., Semonis, M. M., Greene, J. T., Muretta, J. M., Thompson, A. R., Toledo Ramos, S., Thomas, D. D., Pomerantz, W. C. K., Freedman, T. S. & Levinson, N. M., May 14 2024, In: eLife. 13, 13:RP95481.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the conformational landscapes of protein kinases: perspectives from FRET and DEER
Baker, Z. D., Rasmussen, D. M. & Levinson, N. M., Jun 2024, In: Biochemical Society transactions. 52, 3, p. 1071-1083 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Faber, E. B., Sun, L., Tang, J., Roberts, E., Ganeshkumar, S., Wang, N., Rasmussen, D., Majumdar, A., Hirsch, L. E., John, K., Yang, A., Khalid, H., Hawkinson, J. E., Levinson, N. M., Chennathukuzhi, V., Harki, D. A., Schönbrunn, E. & Georg, G. I., Dec 2023, In: Nature communications. 14, 1, 3213.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice
Faber, E. B., Wang, N., John, K., Sun, L., Wong, H. L., Burban, D., Francis, R., Tian, D., Hong, K. H., Yang, A., Wang, L., Elsaid, M., Khalid, H., Levinson, N. M., Schönbrunn, E., Hawkinson, J. E. & Georg, G. I., Feb 9 2023, In: Journal of medicinal chemistry. 66, 3, p. 1928-1940 13 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
Majumdar, A., Burban, D. J., Muretta, J. M., Thompson, A. R., Engel, T. A., Rasmussen, D. M., Subrahmanian, M. V., Veglia, G., Thomas, D. D. & Levinson, N. M., Apr 2021, In: Nature Chemical Biology. 17, 4, p. 456-464 9 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations