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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Collaborations and top research areas from the last five years
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Targeting N-Myc with Selective Aurora Kinase A Degraders for Neuroblastoma Therapy
Harki, D. A., Harris, R. & Levinson, N. M.
7/15/21 → 7/14/24
Project: Research project
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Targeting allosteric scaffolding functions of Aurora kinase A in cancer
Levinson, N. M., Drake, J. M. & Muretta, J. M.
NIH NATIONAL CANCER INSTITUTE (NCI)
4/1/21 → 3/31/26
Project: Research project
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A transformative drug discovery platform for allosteric kinase inhibitors
Levinson, N. M. & Muretta, J. M.
NIH NATIONAL CANCER INSTITUTE (NCI)
3/1/21 → 2/29/24
Project: Research project
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Time-resolved FRET-based allostery sensors for any protein kinase drug target
Levinson, N. M., Drake, J. M., Georg, G. & Thomas, D. D.
NIH NATIONAL CANCER INSTITUTE (NCI)
3/1/20 → 2/29/24
Project: Research project
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Decoding the dynamic mechanism of allosteric activation
NIH NIGMS NATL INST OF GENERAL
1/1/18 → 12/31/23
Project: Research project
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Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Faber, E. B., Sun, L., Tang, J., Roberts, E., Ganeshkumar, S., Wang, N., Rasmussen, D., Majumdar, A., Hirsch, L. E., John, K., Yang, A., Khalid, H., Hawkinson, J. E., Levinson, N. M., Chennathukuzhi, V., Harki, D. A., Schönbrunn, E. & Georg, G. I., Dec 2023, In: Nature communications. 14, 1, 3213.Research output: Contribution to journal › Article › peer-review
Open Access -
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice
Faber, E. B., Wang, N., John, K., Sun, L., Wong, H. L., Burban, D., Francis, R., Tian, D., Hong, K. H., Yang, A., Wang, L., Elsaid, M., Khalid, H., Levinson, N. M., Schönbrunn, E., Hawkinson, J. E. & Georg, G. I., Feb 9 2023, In: Journal of medicinal chemistry. 66, 3, p. 1928-1940 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors
Majumdar, A., Burban, D. J., Muretta, J. M., Thompson, A. R., Engel, T. A., Rasmussen, D. M., Subrahmanian, M. V., Veglia, G., Thomas, D. D. & Levinson, N. M., Apr 2021, In: Nature Chemical Biology. 17, 4, p. 456-464 9 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry
Tavernier, N., Thomas, Y., Vigneron, S., Maisonneuve, P., Orlicky, S., Mader, P., Regmi, S. G., Van Hove, L., Levinson, N. M., Gasmi-Seabrook, G., Joly, N., Poteau, M., Velez-Aguilera, G., Gavet, O., Castro, A., Dasso, M., Lorca, T., Sicheri, F. & Pintard, L., Dec 1 2021, In: Nature communications. 12, 1, 1899.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Cooperativity between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2
Faber, E. B., Tian, D., Burban, D., Levinson, N. M., Hawkinson, J. E. & Georg, G. I., Jul 17 2020, In: ACS Chemical Biology. 15, 7, p. 1759-1764 6 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations