20062020
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Research Output 2006 2020

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2020

Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

Shah, U. A., Shah, N., Qiao, B., Acuna-Villaorduna, A., Pradhan, K., Adrianzen Herrera, D., Sica, R. A., Shastri, A., Mantzaris, I., Derman, O., Kornblum, N., Braunschweig, I., Ye, B. H., Verma, A. & Janakiram, M., Feb 1 2020, In : Cancer. 126, 3, p. 567-574 8 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
Epidemiology
Incidence
Registries
SEER Program
Lymphoma, Large B-Cell, Diffuse
Cell Transplantation
Survival
Confidence Intervals
Recurrence
2019

B7x - From bench to bedside

Kaur, G. & Janakiram, M., Sep 1 2019, In : ESMO Open. 4, 5, e000554.

Research output: Contribution to journalArticle

Open Access
Tumor Escape
Autoimmunity
Prostatic Neoplasms
Neoplasms
Proteins
1 Citation (Scopus)

Barriers to Allogeneic Hematopoietic Stem Cell Transplantation for Human T Cell Lymphotropic Virus 1–Associated Adult T Cell Lymphoma–Leukemia in the United States: Experience from a Large Cohort in a Major Tertiary Center

Adrianzen Herrera, D., Kornblum, N., Acuna-Villaorduna, A., Sica, R. A., Shah, U., Butler, M., Vishnuvardhan, N., Shah, N., Bachier-Rodriguez, L., Derman, O., Shastri, A., Mantzaris, I., Verma, A. K., Braunschweig, I. & Janakiram, M., Jun 2019, In : Biology of Blood and Marrow Transplantation. 25, 6, p. e199-e203

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells
Viruses
T-Lymphocytes
Tissue Donors
46 Citations (Scopus)

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

ECHELON-2 Study Group, Jan 19 2019, In : The Lancet. 393, 10168, p. 229-240 12 p.

Research output: Contribution to journalArticle

Open Access
Peripheral T-Cell Lymphoma
Drug Therapy
Vincristine
Prednisone
Doxorubicin
1 Citation (Scopus)

Characteristics and outcomes of progressive multifocal leukoencephalopathy in hematologic malignancies and stem cell transplant–a case series

Adrianzen Herrera, D., Ayyappan, S., Jasra, S., Kornblum, N., Derman, O., Shastri, A., Mantzaris, I., Verma, A., Braunschweig, I. & Janakiram, M., Jan 28 2019, In : Leukemia and Lymphoma. 60, 2, p. 395-401 7 p.

Research output: Contribution to journalArticle

Progressive Multifocal Leukoencephalopathy
Hematologic Neoplasms
Stem Cells
Monoclonal Antibodies
Immunomodulation

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Acuna-Villaorduna, A., Gonzalez-Lugo, J., Ye, B. H., Adrianzen Herrera, D. A., Sica, R. A., Shah, U., Shah, N., Kornblum, N., Braunschweig, I., Derman, O., Mantzaris, I., Shastri, A., Wang, Y., Verma, A., Zalta, B. & Janakiram, M., Nov 10 2019, In : Leukemia and Lymphoma. 60, 13, p. 3272-3276 5 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Tomography
Lung
Thorax

HIV portends a poor prognosis in myelodysplastic syndromes

Kaner, J. D., Thibaud, S., Jasra, S., Wang, Y., Janakiram, M., Sharma, A., Sridharan, A., Elias, H., Polineni, R., Assal, A., Weiss, L., Braunschweig, I., Steidl, U., Pradhan, K., Shastri, A., Chaitowitz, M., Zingman, B., Will, B., Mantzaris, I. & Verma, A., Dec 6 2019, In : Leukemia and Lymphoma. 60, 14, p. 3529-3535 7 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
HIV
Data Mining
Survival
Hematopoiesis
23 Citations (Scopus)

Oral ixazomib maintenance following autologous stem cell transplantation (TOURMALINE-MM3): a double-blind, randomised, placebo-controlled phase 3 trial

TOURMALINE-MM3 study group, Jan 19 2019, In : The Lancet. 393, 10168, p. 253-264 12 p.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Placebos
Maintenance
Multiple Myeloma
Disease-Free Survival

Outcomes of Autologous Hematopoietic Cell Transplantation Compared With Chemotherapy Consolidation Alone for Non–High-Risk Acute Myeloid Leukemia in First Complete Remission in a Minority-Rich Inner-City Cohort With Limited Access to Allografts

Adrianzen Herrera, D., Kornblum, N., Derman, O., Bachier-Rodriguez, L., Sica, R. A., Shastri, A., Janakiram, M., Verma, A., Braunschweig, I. & Mantzaris, I., Aug 2019, In : Clinical Lymphoma, Myeloma and Leukemia. 19, 8, p. 516-521 6 p.

Research output: Contribution to journalArticle

Consolidation Chemotherapy
Cell Transplantation
Acute Myeloid Leukemia
Allografts
Drug Therapy
1 Citation (Scopus)

PAK kinase inhibition has therapeutic activity in novel preclinical models of adult T-Cell leukemia/lymphoma

Chung, E. Y., Mai, Y., Shah, U. A., Wei, Y., Ishida, E., Kataoka, K., Ren, X., Pradhan, K., Bartholdy, B., Wei, X., Zou, Y., Zhang, J., Ogawa, S., Steidl, U., Zang, X., Verma, A., Janakiram, M. & Ye, B. H., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

p21-Activated Kinases
Adult T Cell Leukemia Lymphoma
Therapeutics
Cell Survival
Protein Isoforms
14 Citations (Scopus)
Multiple Myeloma
Dexamethasone
lenalidomide
Bortezomib
pomalidomide
2 Citations (Scopus)

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
T-cells
Tumors
Neoplasms
Hematologic Neoplasms
2018
5 Citations (Scopus)

An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer

McLemore, L. E., Janakiram, M., Albanese, J., Shapiro, N., Lo, Y., Zang, X. & Fineberg, S., Oct 1 2018, In : Applied Immunohistochemistry and Molecular Morphology. 26, 9, p. 611-619 9 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Residual Neoplasm
Breast Neoplasms
Drug Therapy
Biopsy
4 Citations (Scopus)

Diagnostic challenges of adult T-cell leukemia/lymphoma in North America–a clinical, histological, and immunophenotypic correlation with a workflow proposal

Licata, M. J., Janakiram, M., Tan, S., Fang, Y., Shah, U. A., Verma, A. K. & Wang, Y., May 4 2018, In : Leukemia and Lymphoma. 59, 5, p. 1188-1194 7 p.

Research output: Contribution to journalArticle

Adult T Cell Leukemia Lymphoma
Workflow
Human T-lymphotropic virus 1
T-Lymphocytes
Hepatomegaly
14 Citations (Scopus)

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Shah, U. A., Chung, E. Y., Giricz, O., Pradhan, K., Kataoka, K., Gordon-Mitchel, S., Bhagat, T. D., Mai, Y., Wei, Y., Ishida, E., Choudhary, G. S., Joseph, A., Rice, R., Gitego, N., Parrish, C., Bartenstein, M., Goel, S., Mantzaris, I., Shastri, A., Derman, O. & 13 others, Binder, A., Gritsman, K., Kornblum, N., Braunschweig, I., Bhagat, C., Hall, J., Graber, A., Ratner, L., Wang, Y., Ogawa, S., Verma, A., Ye, B. H. & Janakiram, M., Oct 4 2018, In : Blood. 132, 14, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

Open Access
Adult T Cell Leukemia Lymphoma
T-cells
Epigenomics
decitabine
Mutation Rate
8 Citations (Scopus)

Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1–negative human lung cancers

Cheng, H., Borczuk, A., Janakiram, M., Ren, X., Lin, J., Assal, A., Halmos, B., Perez-Soler, R. & Zang, X., Apr 15 2018, In : Clinical Cancer Research. 24, 8, p. 1954-1964 11 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Neoplasms
Carcinoma
T-Lymphocytes
Immunotherapy
2017
22 Citations (Scopus)

HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status

Cheng, H., Janakiram, M., Borczuk, A., Lin, J., Qiu, W., Liu, H., Chinai, J. M., Halmos, B., Perez-Soler, R. & Zang, X., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle

Open Access
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Immunotherapy
Tumor-Infiltrating Lymphocytes
Neoplasms
1 Citation (Scopus)

Hispanic ethnicity is associated with younger age at presentation but worse survival in acute myeloid leukemia

Darbinyan, K., Shastri, A., Budhathoki, A., Helbig, D., Snyder, R., Pradhan, K., Saleh-Esa, J., Kornblum, N. S., Binder, A. F., Goel, S., Janakiram, M., Derman, O., Gritsman, K., Steidl, U., Braunschweig, I., Verma, A. & Mantzaris, I., Nov 14 2017, In : Blood Advances. 1, 24, p. 2120-2123 4 p.

Research output: Contribution to journalArticle

Open Access
Hispanic Americans
Acute Myeloid Leukemia
Mutation
3 Citations (Scopus)

Sites of extranodal involvement are prognostic in patients with stage 1 follicular lymphoma

Shastri, A., Janakiram, M., Mantzaris, I., Yu, Y., Londono, J. S., Verma, A. K. & Barta, S. K., Jan 1 2017, In : Oncotarget. 8, 45, p. 78410-78418 9 p.

Research output: Contribution to journalArticle

Open Access
Follicular Lymphoma
Survival
Confidence Intervals
Integumentary System
Musculoskeletal System
4 Citations (Scopus)

Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G-CSF in multiple myeloma: A pilot study

Shastri, A., Budhathoki, A., Barta, S. K., Kornblum, N., Derman, O., Battini, R., Raghupathy, R., Verma, A. K., Frenette, P. S., Braunschweig, I. & Janakiram, M., Oct 2017, In : American Journal of Hematology. 92, 10, p. 1047-1051 5 p.

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cell Mobilization
Desipramine
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Multiple Myeloma
2016
13 Citations (Scopus)

Adult T-Cell leukemia/lymphoma in the Caribbean cohort is a distinct clinical entity with dismal response to conventional chemotherapy

Zell, M., Assal, A., Derman, O., Kornblum, N., Battini, R., Wang, Y., Narasimhulu, D. M., Mantzaris, I., Shastri, A., Verma, A., Ye, H., Braunschweig, I. & Janakiram, M., Aug 1 2016, In : Oncotarget. 7, 32, p. 51981-51990 10 p.

Research output: Contribution to journalArticle

Open Access
Adult T Cell Leukemia Lymphoma
Drug Therapy
Survival
Homologous Transplantation
Cytogenetics
1 Citation (Scopus)

Analysis of overall survival in a large multiethnic cohort reveals absolute neutrophil count of 1,100 as a novel prognostic cutoffin African Americans

Mantzaris, I., Yu, Y., Msaouel, P., Lam, A. P., Janakiram, M., Friedman, E. W., Steidl, U. & Verma, A. K., Jan 1 2016, In : Oncotarget. 7, 42, p. 67948-67955 8 p.

Research output: Contribution to journalArticle

Open Access
Survival Analysis
African Americans
Neutrophils
Neutropenia
Hispanic Americans
2015
42 Citations (Scopus)

Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein

Janakiram, M., Chinai, J. M., Fineberg, S., Fiser, A., Montagna, C., Medavarapu, R., Castano, E., Jeon, H., Ohaegbulam, K. C., Zhao, R., Zhao, A., Almo, S. C., Sparano, J. A. & Zang, X., May 15 2015, In : Clinical Cancer Research. 21, 10, p. 2359-2366 8 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Proteins
Breast Neoplasms
Triple Negative Breast Neoplasms
T-Lymphocytes
19 Citations (Scopus)

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Janakiram, M., Chinai, J. M., Zhao, A., Sparano, J. A. & Zang, X., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
Therapeutics
Neoplasms
Immunoglobulin Domains
2014
35 Citations (Scopus)

Structure and cancer immunotherapy of the B7 family member B7x

Jeon, H., Vigdorovich, V., Garrett-Thomson, S. C., Janakiram, M., Ramagopal, U. A., Abadi, Y. M., Lee, J. S., Scandiuzzi, L., Ohaegbulam, K. C., Chinai, J. M., Zhao, R., Yao, Y., Mao, Y., Sparano, J. A., Almo, S. C. & Zang, X., Jan 1 2014, In : Cell reports. 9, 3, p. 1089-1098 10 p.

Research output: Contribution to journalArticle

Open Access
Immunotherapy
Tumors
Monoclonal Antibodies
Neoplasms
T-cells
2012
7 Citations (Scopus)

Emerging therapeutic targets in diffuse large B-cell lymphoma

Janakiram, M., Thirukonda, V. K., Sullivan, M. & Petrich, A. M., Mar 1 2012, In : Current treatment options in oncology. 13, 1, p. 82-101 20 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Therapeutics
Stem Cells
Clinical Trials
Transplants
2006

An unusual cause of paraplegia

Saravanan, V., Janakiram, M., Bankar, R. N., Kumar, S. & Nasar, A., Feb 2006, In : British Journal of Hospital Medicine. 67, 2, 1 p.

Research output: Contribution to journalArticle

Cardiovascular Syphilis
Aortic Rupture
Fatal Outcome
Aortic Aneurysm
Paraplegia