1990 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein

Peters, S. T., Fahrenkopf, A., Choquette, J. M., Vermilyea, S. C., Lee, M. K. & Vossel, K., Jun 19 2020, In : Frontiers in Neurology. 11, 563.

Research output: Contribution to journalArticle

Open Access

α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

Karim, M. R., Liao, E. E., Kim, J., Meints, J., Martinez, H. M., Pletnikova, O., Troncoso, J. C. & Lee, M. K., Apr 16 2020, In : Molecular Neurodegeneration. 15, 1, 27.

Research output: Contribution to journalArticle

Open Access
2019
Open Access
2 Scopus citations

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy

Singh, B., Covelo, A., Martell-Martínez, H., Nanclares, C., Sherman, M. A., Okematti, E., Meints, J., Teravskis, P. J., Gallardo, C., Savonenko, A. V., Benneyworth, M. A., Lesne, S. E., Liao, D., Araque, A. & Lee, M. K., Oct 1 2019, In : Acta Neuropathologica. 138, 4, p. 551-574 24 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

UNC-45A is a novel microtubule-associated protein and regulator of paclitaxel sensitivity in ovarian cancer cells

Mooneyham, A., Iizuka, Y., Yang, Q., Coombes, C., McClellan, M., Shridhar, V., Emmings, E., Shetty, M., Chen, L., Ai, T., Meints, J., Lee, M. K., Gardner, M. K. & Bazzaro, M., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 370-383 14 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

A53t mutant alpha-synuclein induces tau-dependent postsynaptic impairment independently of neurodegenerative changes

Teravskis, P. J., Covelo, A., Miller, E. C., Singh, B., Martell-Martínez, H. A., Benneyworth, M. A., Gallardo, C., Oxnard, B. R., Araque, A., Lee, M. K. & Liao, D., Nov 7 2018, In : Journal of Neuroscience. 38, 45, p. 9754-9767 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons

Khan, S. S., LaCroix, M., Boyle, G., Sherman, M. A., Brown, J. L., Amar, F., Aldaco, J., Lee, M. K., Bloom, G. S. & Lesné, S. E., Oct 1 2018, In : Acta Neuropathologica. 136, 4, p. 589-605 17 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

Colla, E., Panattoni, G., Ricci, A., Rizzi, C., Rota, L., Carucci, N., Valvano, V., Gobbo, F., Capsoni, S., Lee, M. K. & Cattaneo, A., Mar 2018, In : Neurobiology of Disease. 111, p. 36-47 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

Ordonez, D. G., Lee, M. K. & Feany, M. B., Jan 3 2018, In : Neuron. 97, 1, p. 108-124.e6

Research output: Contribution to journalArticle

Open Access
48 Scopus citations
2017

Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification

Jung, B. C., Lim, Y. J., Bae, E. J., Lee, J. S., Choi, M. S., Lee, M. K., Lee, H. J., Kim, Y. S. & Lee, S. J., Apr 7 2017, In : Experimental and Molecular Medicine. 49, 4, e314.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Conditional deletion of Prnp rescues behavioral and synaptic deficits after disease onset in transgenic Alzheimer’s disease

Salazar, S. V., Gallardo, C., Kaufman, A. C., Herber, C. S., Haas, L. T., Robinson, S., Manson, J. C., Lee, M. K. & Strittmatter, S. M., Sep 20 2017, In : Journal of Neuroscience. 37, 38, p. 9207-9221 15 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Larson, M. E., Greimel, S. J., Amar, F., LaCroix, M., Boyle, G., Sherman, M. A., Schley, H., Miel, C., Schneider, J. A., Kayed, R., Benfenati, F., Lee, M. K., Bennett, D. A. & Lesné, S. E., Jun 6 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 23, p. E4648-E4657

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

UNC-45A is required for neurite extension via controlling NMII activation

Iizuka, Y., Mooneyham, A., Sieben, A., Chen, K., Maile, M., Hellweg, R., Schütz, F., Teckle, K., Starr, T., Thayanithy, V., Vogel, R. I., Lou, E., Lee, M. K. & Bazzaro, M., May 15 2017, In : Molecular biology of the cell. 28, 10, p. 1337-1346 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2015

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

Zhao, L., Hadziahmetovic, M., Wang, C., Xu, X., Song, Y., Jinnah, H. A., Wodzinska, J., Iacovelli, J., Wolkow, N., Krajacic, P., Weissberger, A. C., Connelly, J., Spino, M., Lee, M. K., Connor, J., Giasson, B., Leah Harris, Z. & Dunaief, J. L., Dec 1 2015, In : Journal of Neurochemistry. 135, 5, p. 958-974 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Method for measuring the activity of deubiquitinating enzymes in cell lines and tissue samples

Griffin, P., Sexton, A., Macneill, L., Iizuka, Y., Lee, M. K. & Bazzaro, M., May 10 2015, In : Journal of Visualized Experiments. 2015, 99, e52784.

Research output: Contribution to journalArticle

UNC-45A is a nonmuscle myosin IIA chaperone required for NK cell cytotoxicity via control of lytic granule secretion

Iizuka, Y., Cichocki, F. M., Sieben, A., Sforza, F., Karim, R., Coughlin, K., Vogel, R. I., Gavioli, R., Mc Cullar, V. J., Lenvik, T. R., Lee, M. K., Miller, J. S. & Bazzaro, M., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4760-4770 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein Responses

Coughlin, K., Anchoori, R., Iizuka, Y., Meints, J., MacNeill, L., Vogel, R. I., Orlowski, R. Z., Lee, M. K., Roden, R. B. S. & Bazzaro, M., Jun 15 2014, In : Clinical Cancer Research. 20, 12, p. 3174-3186 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2013

Neuropsychiatric symptoms in Alzheimer's disease: Past progress and anticipation of the future

Geda, Y. E., Schneider, L. S., Gitlin, L. N., Miller, D. S., Smith, G. S., Bell, J., Evans, J., Lee, M., Porsteinsson, A., Lanctôt, K. L., Rosenberg, P. B., Sultzer, D. L., Francis, P. T., Brodaty, H., Padala, P. P., Onyike, C. U., Ortiz, L. A., Ancoli-Israel, S., Bliwise, D. L., Martin, J. L. & 11 others, Vitiello, M. V., Yaffe, K., Zee, P. C., Herrmann, N., Sweet, R. A., Ballard, C., Khin, N. A., Alfaro, C., Murray, P. S., Schultz, S. & Lyketsos, C. G., Sep 2013, In : Alzheimer's and Dementia. 9, 5, p. 602-608 7 p.

Research output: Contribution to journalArticle

166 Scopus citations
2012

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo

Colla, E., Jensen, P. H., Pletnikova, O., Troncoso, J. C., Glabe, C. & Lee, M. K., Mar 7 2012, In : Journal of Neuroscience. 32, 10, p. 3301-3305 5 p.

Research output: Contribution to journalArticle

177 Scopus citations

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

Colla, E., Coune, P., Liu, Y., Pletnikova, O., Troncoso, J. C., Iwatsubo, T., Schneider, B. L. & Lee, M. K., Mar 7 2012, In : Journal of Neuroscience. 32, 10, p. 3306-3320 15 p.

Research output: Contribution to journalArticle

202 Scopus citations
9 Scopus citations

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2

Daher, J. P. L., Pletnikova, O., Biskup, S., Musso, A., Gellhaar, S., Galter, D., Troncoso, J. C., Lee, M. K., Dawson, T. M., Dawson, V. L. & Moore, D. J., Jun 2012, In : Human molecular genetics. 21, 11, p. 2420-2431 12 p., dds057.

Research output: Contribution to journalArticle

56 Scopus citations
2011

Dopaminergic Neuronal loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Ramonet, D., Daher, J. P. L., Lin, B. M., Stafa, K., Kim, J., Banerjee, R., Westerlund, M., Pletnikova, O., Glauser, L., Yang, L., Liu, Y., Swing, D. A., Beal, M. F., Troncoso, J. C., McCaffery, J. M., Jenkins, N. A., Copeland, N. G., Galter, D., Thomas, B., Lee, M. K. & 3 others, Dawson, T. M., Dawson, V. L. & Moore, D. J., 2011, In : PloS one. 6, 4, e18568.

Research output: Contribution to journalArticle

249 Scopus citations

Passive (Amyloid-β Immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice

Liu, Y., Lee, M. K., James, M. M., Price, D. L., Borchelt, D. R., Troncoso, J. C. & Oh, E. S., 2011, In : Journal of Alzheimer's Disease. 23, 2, p. 271-279 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

Thomas, B., Mandir, A. S., West, N., Liu, Y., Andrabi, S. A., Stirling, W., Dawson, V. L., Dawson, T. M. & Lee, M. K., 2011, In : PloS one. 6, 1, e16706.

Research output: Contribution to journalArticle

40 Scopus citations
2010

Alzheimer Disease: Protein Misfolding, Model Systems, and Experimental Therapeutics

Price, D. L., Savonenko, A. V., Li, T., Lee, M. K. & Wong, P. C., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 231-258 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

Nemani, V. M., Lu, W., Berge, V., Nakamura, K., Onoa, B., Lee, M. K., Chaudhry, F. A., Nicoll, R. A. & Edwards, R. H., Jan 14 2010, In : Neuron. 65, 1, p. 66-79 14 p.

Research output: Contribution to journalArticle

604 Scopus citations

Structural correlates of antibodies associated with acute reversal of amyloid β-related behavioral deficits in a mouse model of Alzheimer disease

Basi, G. S., Feinberg, H., Oshidari, F., Anderson, J., Barbour, R., Baker, J., Comery, T. A., Diep, L., Gill, D., Johnson-Wood, K., Goel, A., Grantcharova, K., Lee, M., Li, J., Partridge, A., Griswold-Prenner, I., Piot, N., Walker, D., Widom, A., Pangalos, M. N. & 4 others, Seubert, P., Jacobsen, J. S., Schenk, D. & Weis, W. I., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3417-3427 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Synphilin-1 attenuates neuronal degeneration in the A53T α-synuclein transgenic mouse model

Smith, W. W., Liu, Z., Liang, Y., Masuda, N., Swing, D. A., Jenkins, N. A., Copeland, N. G., Troncoso, J. C., Pletnikov, M., Dawson, T. M., Martin, L. J., Moran, T. H., Lee, M. K., Borchelt, D. R. & Ross, C. A., Feb 25 2010, In : Human molecular genetics. 19, 11, p. 2087-2098 12 p., ddq086.

Research output: Contribution to journalArticle

49 Scopus citations
2009

Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

Yang, Q., She, H., Gearing, M., Colla, E., Lee, M., Shacka, J. J. & Mao, Z., Jan 2 2009, In : Science. 323, 5910, p. 124-127 4 p.

Research output: Contribution to journalArticle

227 Scopus citations
2008

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

Liu, Y., Yoo, M. J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E. & Lee, M. K., Dec 17 2008, In : Journal of Neuroscience. 28, 51, p. 13805-13814 10 p.

Research output: Contribution to journalArticle

133 Scopus citations

Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases

Wang, J., Martin, E., Gonzales, V., Borchelt, D. R. & Lee, M. K., Apr 2008, In : Neurobiology of Aging. 29, 4, p. 586-597 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Identification of γ-secretase inhibitor potency determinants on presenilin

Zhao, B., Yu, M., Neitzel, M., Marugg, J., Jagodzinski, J., Lee, M., Hu, K., Schenk, D., Yednock, T. & Basi, G., Feb 1 2008, In : Journal of Biological Chemistry. 283, 5, p. 2927-2938 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., Ho, M. W. L., Troncoso, J., Gygi, S. P., Lee, M. K., Dawson, V. L., Dawson, T. M. & Lim, K. L., Feb 1 2008, In : Human molecular genetics. 17, 3, p. 431-439 9 p.

Research output: Contribution to journalArticle

264 Scopus citations

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

Bazzaro, M., Lin, Z., Santillan, A., Lee, M. K., Wang, M. C., Chan, K. C., Bristow, R. E., Mazitschek, R., Bradner, J. & Roden, R. B. S., Nov 15 2008, In : Clinical Cancer Research. 14, 22, p. 7340-7347 8 p.

Research output: Contribution to journalArticle

91 Scopus citations
2007

Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility

Bazzaro, M., Santillan, A., Lin, Z., Tang, T., Lee, M. K., Bristow, R. E., Shih, I. M. & Roden, R. B. S., Nov 2007, In : American Journal of Pathology. 171, 5, p. 1640-1649 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP transgenic mice

McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., Liu, W., Motter, R. & Sinha, S., Sep 7 2007, In : Journal of Biological Chemistry. 282, 36, p. 26326-26334 9 p.

Research output: Contribution to journalArticle

228 Scopus citations

Transgenic models of α-synucleinopathy

Lee, M. K., Jan 1 2007, Parkinson's Disease: Genetics and Pathogenesis. CRC Press, p. 251-268 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Wild-type and mutant α-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD

Miller, R. M., Kiser, G. L., Kaysser-Kranich, T., Casaceli, C., Colla, E., Lee, M. K., Palaniappan, C. & Federoff, H. J., Mar 1 2007, In : Experimental Neurology. 204, 1, p. 421-432 12 p.

Research output: Contribution to journalArticle

33 Scopus citations
2006

Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid

Riekse, R. G., Li, G., Petrie, E. C., Leverenz, J. B., Vavrek, D., Vuletic, S., Albers, J. J., Montine, T. J., Lee, V. M. Y., Lee, M., Seubert, P., Galasko, D., Schellenberg, G. D., Hazzard, W. R. & Peskind, E. R., Jan 1 2006, In : Journal of Alzheimer's Disease. 10, 4, p. 399-406 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of α-synucleinopathy

Von Coelln, R., Thomas, B., Andrabi, S. A., Kah, L. L., Savitt, J. M., Saffary, R., Stirling, W., Bruno, K., Hess, E. J., Lee, M. K., Dawson, V. L. & Dawson, T. M., Apr 5 2006, In : Journal of Neuroscience. 26, 14, p. 3685-3696 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human α-synuclein in mice

Unger, E. L., Eve, D. J., Perez, X. A., Reichenbach, D. K., Xu, Y., Lee, M. K. & Andrews, A. M., Feb 1 2006, In : Neurobiology of Disease. 21, 2, p. 431-443 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death

Martin, L. J., Pan, Y., Price, A. C., Sterling, W., Copeland, N. G., Jenkins, N. A., Price, D. L. & Lee, M. K., Jan 4 2006, In : Journal of Neuroscience. 26, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

457 Scopus citations

Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic lewy body disease

Anderson, J. P., Walker, D. E., Goldstein, J. M., De Laat, R., Banducci, K., Caccavello, R. J., Barbour, R., Huang, J., Kling, K., Lee, M., Diep, L., Keim, P. S., Shen, X., Chataway, T., Schlossmacher, M. G., Seubert, P., Schenk, D., Sinha, S., Gai, W. P. & Chilcote, T. J., Oct 6 2006, In : Journal of Biological Chemistry. 281, 40, p. 29739-29752 14 p.

Research output: Contribution to journalArticle

665 Scopus citations

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Bazzaro, M., Lee, M. K., Zoso, A., Stirling, W. L. H., Santillan, A., Shih, I. M. & Roden, R. B. S., Apr 1 2006, In : Cancer Research. 66, 7, p. 3754-3763 10 p.

Research output: Contribution to journalArticle

101 Scopus citations
2005

Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

Li, W., West, N., Colla, E., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jäkälä, P., Hartmann, T., Price, D. L. & Lee, M. K., Feb 8 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 6, p. 2162-2167 6 p.

Research output: Contribution to journalArticle

301 Scopus citations
21 Scopus citations

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

Moore, D. J., Zhang, L., Troncoso, J., Lee, M. K., Hattori, N., Mizuno, Y., Dawson, T. M. & Dawson, V. L., Jan 1 2005, In : Human molecular genetics. 14, 1, p. 71-84 14 p.

Research output: Contribution to journalArticle

199 Scopus citations

Aβ42 immunization in Alzheimer's disease generates Aβ N-terminal antibodies

Lee, M., Bard, F., Johnson-Wood, K., Lee, C., Hu, K., Griffith, S. G., Black, R. S., Schenk, D. & Seubert, P., Sep 1 2005, In : Annals of Neurology. 58, 3, p. 430-435 6 p.

Research output: Contribution to journalArticle

109 Scopus citations

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

Pletnikova, O., West, N., Lee, M. K., Rudow, G. L., Skolasky, R. L., Dawson, T. M., Marsh, L. & Troncoso, J. C., Aug 1 2005, In : Neurobiology of Aging. 26, 8, p. 1183-1192 10 p.

Research output: Contribution to journalArticle

160 Scopus citations