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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Allosteric mechanisms driving paradoxical activation of RAF kinases
Levinson, N. M. (PI), Freedman, T. (CoI) & Sheedlo, M. J. (CoI)
NATIONAL INSTITUTES OF HEALTH (NIH)
7/1/24 → 6/30/25
Project: Research project
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Defining the mechanism of protein translocation using a bacterial exotoxin as a model system
Sheedlo, M. J. (PI)
NIH Nat'l Inst of Allergy & Infect Dis
9/1/21 → 12/31/23
Project: Research project
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Cryo-EM Analysis of the Clostridioides difficile Transferase Reveals Intoxication Intermediates
Mullard, R. M., Grant, E. & Sheedlo, M. J., Jul 22 2023, In: Microscopy and Microanalysis. 29, 1, p. 922 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular architecture of bacterial type IV secretion systems
Sheedlo, M. J., Ohi, M. D., Lacy, D. B. & Cover, T. L., Aug 2022, In: PLoS pathogens. 18, 8, e1010720.Research output: Contribution to journal › Review article › peer-review
Open Access31 Scopus citations -
Cryo-em reveals new species-specific proteins and symmetry elements in the legionella pneumophila dot/icm t4ss
Sheedlo, M. J., Durie, C. L., Chung, J. M., Chang, L., Roberts, J., Swanson, M., Lacy, D. B. & Ohi, M. D., Sep 2021, In: eLife. 10, e70427.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Insights into Ubiquitin Product Release in Hydrolysis Catalyzed by the Bacterial Deubiquitinase SdeA
Sheedlo, M. J., Kenny, S., Podkorytov, I. S., Brown, K., Ma, J., Iyer, S., Hewitt, C. S., Arbough, T., Mikhailovskii, O., Flaherty, D. P., Wilson, M. A., Skrynnikov, N. R. & Das, C., Mar 2 2021, In: Biochemistry. 60, 8, p. 584-596 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease
Mileto, S. J., Jardé, T., Childress, K. O., Jensen, J. L., Rogers, A. P., Kerr, G., Hutton, M. L., Sheedlo, M. J., Bloch, S. C., Shupe, J. A., Horvay, K., Flores, T., Engel, R., Wilkins, S., McMurrick, P. J., Lacy, D. B., Abud, H. E. & Lyras, D., Apr 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 8064-8073 10 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations