Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
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Discovery and characterization of biocatalysts and metabolites for ribosomally encoded alpha-N-methylated peptide natural products
Freeman, M. F. (PI)
NATIONAL INSTITUTES OF HEALTH (NIH)
5/6/25 → 4/30/30
Project: Research project
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Discovery and characterization of biocatalysts for ribosomally encoded alpha-N-methylated peptide natural products
Freeman, M. F. (PI)
NIH NIGMS NATL INST OF GENERAL
8/1/19 → 5/31/24
Project: Research project
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α-N-Methyltransferase regiospecificity is mediated by proximal, redundant enzyme–substrate interactions
Crone, K. K., Labonte, J. W., Elias, M. H. & Freeman, M. F., Feb 2025, In: Protein Science. 34, 2, e70021.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Discovery of Borosin Catalytic Strategies and Function through Bioinformatic Profiling
Lee, A. R., Carter, R. S., Imani, A. S., Dommaraju, S. R., Hudson, G. A., Mitchell, D. A. & Freeman, M. F., May 17 2024, In: ACS Chemical Biology. 19, 5, p. 1116-1124 9 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
RiPP enzyme heterocomplex structure-guided discovery of a bacterial borosin α-N-methylated peptide natural product
Crone, K. K., Jomori, T., Miller, F. S., Gralnick, J. A., Elias, M. H. & Freeman, M. F., Aug 21 2023, In: RSC Chemical Biology. 4, 10, p. 804-816 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Diverse Protein Architectures and α- N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters
Imani, A. S., Lee, A. R., Vishwanathan, N., De Waal, F. & Freeman, M. F., Apr 15 2022, In: ACS Chemical Biology. 17, 4, p. 908-917 10 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
TaxiBGC: a Taxonomy-Guided Approach for Profiling Experimentally Characterized Microbial Biosynthetic Gene Clusters and Secondary Metabolite Production Potential in Metagenomes
Gupta, V. K., Bakshi, U., Chang, D., Lee, A. R., Davis, J. M., Chandrasekaran, S., Jin, Y. S., Freeman, M. F. & Sung, J., Dec 2022, In: mSystems. 7, 6Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Scopus citations
Datasets
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Conformational rearrangements enable iterative backbone 𝑁-methylation in RiPP biosynthesis
Miller, F. S., Crone, K. K., Jensen, M. R., Shaw, S., Harcombe, W., Elias, M. H. & Freeman, M. F., Data Repository for the University of Minnesota, Jul 30 2021
DOI: 10.13020/y8ry-gm18, https://hdl.handle.net/11299/222603
Dataset