1989 …2020

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1989

Cloning and expression of the cDNA for the murine interferon γ receptor

Gray, P. W., Leong, S., Fennie, E. H., Farrar, M. A., Pingel, J. T., Fernandez-Luna, J. & Schreiber, R. D., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 21, p. 8497-8501 5 p.

Research output: Contribution to journalArticle

77 Scopus citations

Evidence for heterogeneity of the DPA and DPB alleles derived from a DRw11,DQw7,DPw4 cell line

Woulfe, S. L., Rice, K., Didier, D. K., Harris, M. R., Schiffenbauer, J., Klearman, M., Farrar, M. A. & Schwartz, B. D., Sep 1989, In : Human Immunology. 26, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
1991

Identification of two regions within the cytoplasmic domain of the human interferon-γ receptor required for function*

Farrar, M. A., Fernandez-Luna, J. & Schreiber, R. D., Jan 1 1991, In : Journal of Biological Chemistry. 266, 29, p. 19626-19635 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
1992

Identification of a functionally important sequence in the C terminus of the interferon-γ receptor

Farrar, M. A., Campbell, J. D. & Schreiber, R. D., Jan 1 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 24, p. 11706-11710 5 p.

Research output: Contribution to journalArticle

87 Scopus citations

The structure and function of interferon-γ receptors

Schreiber, R. D., Farrar, M. A., Hershey, G. K. & Fernandez-Luna, J., Apr 1992, In : International Journal of Immunopharmacology. 14, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

12 Scopus citations
1993

Inhibition of cellular responsiveness to interferon-γ (IFNγ) induced by overexpression of inactive forms of the IFNγ receptor

Dighe, A. S., Farrar, M. A. & Schreiber, R. D., Jan 1 1993, In : Journal of Biological Chemistry. 268, 14, p. 10645-10653 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

The biology and biochemistry of interferon-gamma and its receptor

Schreiber, R. D. & Farrar, M. A., Aug 1 1993, In : Gastroenterologia Japonica. 28, 4 Supplement, p. 88-94 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
1994

Ligand-induced IFN(γ) receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)

Greenlund, A. C., Farrar, M. A., Viviano, B. L. & Schreiber, R. D., Jan 1 1994, In : EMBO Journal. 13, 7, p. 1591-1600 10 p.

Research output: Contribution to journalArticle

358 Scopus citations
1996

Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization

Farrar, M. A., Alberola-Ila, J. & Perlmutter, R. M., Sep 25 1996, In : Nature. 383, 6596, p. 178-181 4 p.

Research output: Contribution to journalArticle

248 Scopus citations
1997

Control of B cell development by Ras-mediated activation of Raf

Iritani, B. M., Forbush, K. A., Farrar, M. A. & Perlmutter, R. M., Dec 1 1997, In : EMBO Journal. 16, 23, p. 7019-7031 13 p.

Research output: Contribution to journalArticle

126 Scopus citations
1998

Regulation of L-selectin-mediated rolling through receptor dimerization

Li, X., Steeber, D. A., Tang, M. L. K., Farrar, M. A., Perlmutter, R. M. & Tedder, T. F., Oct 5 1998, In : Journal of Experimental Medicine. 188, 7, p. 1385-1390 6 p.

Research output: Contribution to journalArticle

56 Scopus citations
2000

Coumermycin-induced dimerization of GyrB-containing fusion proteins

Farrar, M. A., Olson, S. H. & Perlmutter, R. M., Jan 1 2000, In : Methods in enzymology. 327, p. 421-429 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Membrane localization of Raf assists engagement of downstream effectors

Farrar, M. A., Tian, J. & Perlmutter, R. M., Oct 6 2000, In : Journal of Biological Chemistry. 275, 40, p. 31318-31324 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2003

Distinct Effects of STAT5 Activation on CD4+ and CD8 + T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells

Burchill, M. A., Goetz, C. A., Prlic, M., O'Neil, J. J., Harmon, I. R., Bensinger, S. J., Turka, L. A., Brennan, P., Jameson, S. C. & Farrar, M. A., Dec 1 2003, In : Journal of Immunology. 171, 11, p. 5853-5864 12 p.

Research output: Contribution to journalArticle

158 Scopus citations

In vivo survival and homeostatic proliferation of natural killer cells

Prlic, M., Blazar, B. R., Farrar, M. A. & Jameson, S. C., Apr 21 2003, In : Journal of Experimental Medicine. 197, 8, p. 967-976 10 p.

Research output: Contribution to journalArticle

179 Scopus citations

Membrane Localization, Oligomerization, and Phosphorylation Are Required for Optimal Raf Activation

Goetz, C. A., O'Neil, J. J. & Farrar, M. A., Dec 19 2003, In : Journal of Biological Chemistry. 278, 51, p. 51184-51189 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

Distinct IL-2 Receptor Signaling Pattern in CD4+CD25 + Regulatory T Cells

Bensinger, S. J., Walsh, P. T., Zhang, J., Carroll, M., Parsons, R., Rathmell, J. C., Thompson, C. B., Burchill, M. A., Farrar, M. A. & Turka, L. A., May 1 2004, In : Journal of Immunology. 172, 9, p. 5287-5296 10 p.

Research output: Contribution to journalArticle

207 Scopus citations

STAT5 Activation Underlies IL7 Receptor-Dependent B Cell Development

Goetz, C. A., Harmon, I. R., O'Neil, J. J., Burchill, M. A. & Farrar, M. A., Apr 15 2004, In : Journal of Immunology. 172, 8, p. 4770-4778 9 p.

Research output: Contribution to journalArticle

108 Scopus citations
2005

Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment

Goetz, C. A., Harmon, I. R., O'Neil, J. J., Burchill, M. A., Johanns, T. M. & Farrar, M. A., Jun 15 2005, In : Journal of Immunology. 174, 12, p. 7753-7763 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2006

Attenuation of IL-7 receptor signaling is not required for allelic exclusion

Will, W. M., Aaker, J. D., Burchill, M. A., Harmon, I. R., O'Neil, J. J., Goetz, C. A., Hippen, K. L. & Farrar, M. A., Mar 15 2006, In : Journal of Immunology. 176, 6, p. 3350-3355 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis

Taylor, D. K., Walsh, P. T., LaRosa, D. F., Zhang, J., Burchill, M. A., Farrar, M. A. & Turka, L. A., Aug 15 2006, In : Journal of Immunology. 177, 4, p. 2216-2223 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2007

IL-2 receptor β-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells

Burchill, M. A., Yang, J., Vogtenhuber, C., Blazar, B. R. & Farrar, M. A., Jan 1 2007, In : Journal of Immunology. 178, 1, p. 280-290 11 p.

Research output: Contribution to journalArticle

Open Access
515 Scopus citations

IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs

Seki, Y. I., Yang, J., Okamoto, M., Tanaka, S., Goitsuka, R., Farrar, M. A. & Kubo, M., Jan 1 2007, In : Journal of Immunology. 178, 1, p. 262-270 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008

B cell receptor basal signaling regulates antigen-induced ig light chain rearrangements

Schram, B. R., Tze, L. E., Ramsey, L. B., Liu, J., Najera, L., Vegoe, A. L., Hardy, R. R., Hippen, K. L., Farrar, M. A. & Behrens, T. W., Apr 1 2008, In : Journal of Immunology. 180, 7, p. 4728-4741 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

Vang, K. B., Yang, J., Mahmud, S. A., Burchill, M. A., Vegoe, A. L. & Farrar, M. A., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3285-3290 6 p.

Research output: Contribution to journalArticle

161 Scopus citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

Burchill, M. A., Yang, J., Vang, K. B., Moon, J. J., Chu, H. H., Lio, C. W. J., Vegoe, A. L., Hsieh, C. S., Jenkins, M. K. & Farrar, M. A., Jan 18 2008, In : Immunity. 28, 1, p. 112-121 10 p.

Research output: Contribution to journalArticle

265 Scopus citations

Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection

Welner, R. S., Pelayo, R., Nagai, Y., Garrett, K. P., Wuest, T. R., Carr, D. J., Borghesi, L. A., Farrar, M. A. & Kincade, P. W., Nov 1 2008, In : Blood. 112, 9, p. 3753-3761 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

Regulation of lymphocyte development by cell-type-specific interpretation of notch signals

Nie, L., Perry, S. S., Zhao, Y., Huang, J., Kincade, P. W., Farrar, M. A. & Sun, X. H., Mar 1 2008, In : Molecular and cellular biology. 28, 6, p. 2078-2090 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

BLNK suppresses pre B-cell leukemogenesis through inhibition of JAK3

Nakayama, J., Yamamoto, M., Hayashi, K., Satoh, H., Bundo, K., Kubo, M., Goitsuka, R., Farrar, M. A. & Kitamura, D., Feb 12 2009, In : Blood. 113, 7, p. 1483-1492 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

CARMA1 controls an early checkpoint in the thymic development of foxP3 + regulatory T cells

Molinero, L. L., Yang, J., Gajewski, T., Abraham, C., Farrar, M. A. & Alegre, M. L., Jun 1 2009, In : Journal of Immunology. 182, 11, p. 6736-6743 8 p.

Research output: Contribution to journalArticle

77 Scopus citations

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Hewitt, S. L., Yin, B., Ji, Y., Chaumeil, J., Marszalek, K., Tenthorey, J., Salvagiotto, G., Steinel, N., Ramsey, L. B., Ghysdael, J., Farrar, M. A., Sleckman, B. P., Schatz, D. G., Busslinger, M., Bassing, C. H. & Skok, J. A., May 18 2009, In : Nature immunology. 10, 6, p. 655-664 10 p.

Research output: Contribution to journalArticle

109 Scopus citations
2010

A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness

Li, N. X., Goetz, C. A., Katerndahl, C. D. S., Sakaguchi, N. & Farrar, M. A., Feb 15 2010, In : Journal of Immunology. 184, 4, p. 1728-1736 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Constitutively active Stat5b in CD4+ T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

Vogtenhuber, C., Bucher, C., Highfill, S. L., Koch, L. K., Goren, E., Panoskaltsis-Mortari, A., Taylor, P. A., Farrar, M. A. & Blazar, B. R., Jul 22 2010, In : Blood. 116, 3, p. 466-474 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development

Vang, K. B., Yang, J., Pagán, A. J., Li, L. X., Wang, J., Green, J. M., Beg, A. A. & Farrar, M. A., Apr 15 2010, In : Journal of Immunology. 184, 8, p. 4074-4077 4 p.

Research output: Contribution to journalArticle

76 Scopus citations

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells

Liang, X., Moseman, E. A., Farrar, M. A., Bachanova, V., Weisdorf, D. J., Blazar, B. R. & Chen, W., Jun 17 2010, In : Blood. 115, 24, p. 5041-5052 12 p.

Research output: Contribution to journalArticle

77 Scopus citations
2011

Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acutelymphoblastic leukemia

Heltemes-Harris, L. M., Willette, M. J. L., Ramsey, L. B., Qiu, Y. H., Neeley, E. S., Zhang, N., Thomas, D. A., Koeuth, T., Baechler, E. C., Kornblau, S. M. & Farrar, M. A., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, p. 1135-1149 15 p.

Research output: Contribution to journalArticle

82 Scopus citations

Enhancement of T-cell-mediated antitumor response: Angiostatic adjuvant to immunotherapy against cancer

Dings, R. P. M., Vang, K. B., Castermans, K., Popescu, F. E., Zhang, Y., Oude Egbrink, M. G. A., Mescher, M. F., Farrar, M. A., Griffioen, A. W. & Mayo, K. H., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3134-3145 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Foxp3 + regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens

Rowe, J. H., Ertelt, J. M., Aguilera, M. N., Farrar, M. A. & Way, S. S., Jul 21 2011, In : Cell Host and Microbe. 10, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

97 Scopus citations

The role of STAT5 in the development, function, and transformation of B and T lymphocytes

Heltemes-Harris, L. M., Willette, M. J. L., Vang, K. B. & Farrar, M. A., Jan 2011, In : Annals of the New York Academy of Sciences. 1217, 1, p. 18-31 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways

Ramsey, L. B., Vegoe, A. L., Miller, A. T., Cooke, M. P. & Farrar, M. A., Mar 30 2011, In : Immunology Letters. 135, 1-2, p. 74-77 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

A developmentally controlled competitive STAT5-PU.1 DNA binding mechanism regulates activity of the Ig κE3′enhancer

Hodawadekar, S., Park, K., Farrar, M. A. & Atchison, M. L., Mar 1 2012, In : Journal of Immunology. 188, 5, p. 2276-2284 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo

Zou, T., Satake, A., Corbo-Rodgers, E., Schmidt, A. M., Farrar, M. A., Maltzman, J. S. & Kambayashi, T., Jul 1 2012, In : Journal of Immunology. 189, 1, p. 28-32 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle

Johnson, K., Chaumeil, J., Micsinai, M., Wang, J. M. H., Ramsey, L. B., Baracho, G. V., Rickert, R. C., Strino, F., Kluger, Y., Farrar, M. A. & Skok, J. A., Jun 15 2012, In : Journal of Immunology. 188, 12, p. 6084-6092 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

Mahmud, S. A., Manlove, L. S., Schmitz, H. M., Xing, Y., Wang, Y., Owen, D. L., Schenkel, J. M., Boomer, J. S., Green, J. M., Yagita, H., Chi, H., Hogquist, K. A. & Farrar, M. A., May 2014, In : Nature immunology. 15, 5, p. 473-481 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

Liu, G. J., Cimmino, L., Jude, J. G., Hu, Y., Witkowski, M. T., McKenzie, M. D., Kartal-Kaess, M., Best, S. A., Tuohey, L., Liao, Y., Shi, W., Mullighan, C. G., Farrar, M. A., Nutt, S. L., Smyth, G. K., Zuber, J. & Dickins, R. A., Jun 15 2014, In : Genes and Development. 28, 12, p. 1337-1350 14 p.

Research output: Contribution to journalArticle

44 Scopus citations
2015

Adaptive immunity to leukemia is inhibited by cross-reactive induced regulatory T cells

Manlove, L. S., Berquam-Vrieze, K. E., Pauken, K. E., Williams, R. T., Jenkins, M. K. & Farrar, M. A., Oct 15 2015, In : Journal of Immunology. 195, 8, p. 4028-4037 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

Hepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., Eberl, G., Baldassano, R. N., Laufer, T. M., Elson, C. O. & Sonnenberg, G. F., May 29 2015, In : Science. 348, 6238, p. 1031-1035 5 p.

Research output: Contribution to journalArticle

202 Scopus citations

Interleukin-7 is required for CD4+ T cell activation and autoimmune neuroinflammation

Lawson, B. R., Gonzalez-Quintial, R., Eleftheriadis, T., Farrar, M. A., Miller, S. D., Sauer, K., McGavern, D. B., Kono, D. H., Baccala, R. & Theofilopoulos, A. N., Dec 1 2015, In : Clinical Immunology. 161, 2, p. 260-269 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Heterologous vaccination and checkpoint blockade synergize to induce antileukemia immunity

Manlove, L. S., Schenkel, J. M., Manlove, K. R., Pauken, K. E., Williams, R. T., Vezys, V. & Farrar, M. A., Jun 1 2016, In : Journal of Immunology. 196, 11, p. 4793-4804 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Heltemes-Harris, L. M., Larson, J. D., Starr, T. K., Hubbard, G. K., Sarver, A. L., Largaespada, D. A. & Farrar, M. A., Jun 30 2016, In : Oncogene. 35, 26, p. 3454-3464 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations