20042023
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Research Output 2004 2019

2019
1 Citation (Scopus)

A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis

Mukherjee, S., Sandri, B. J., Tank, D., McClellan, M., Harasymiw, L. A., Yang, Q., Parker, L. L. & Gardner, M. K., Apr 8 2019, In : Developmental Cell. 49, 1, p. 63-76.e10

Research output: Contribution to journalArticle

Metaphase
Chromosomes
Mitosis
Chromosome Segregation
Kinetochores

Centromere mechanical maturation during mammalian cell mitosis

Harasymiw, L. A., Tank, D., McClellan, M., Panigrahy, N. & Gardner, M. K., Dec 1 2019, In : Nature communications. 10, 1, 1761.

Research output: Contribution to journalArticle

Open Access
mitosis
Centromere
Chromosomes
Mitosis
Cells
2 Citations (Scopus)

UNC-45A is a novel microtubule-associated protein and regulator of paclitaxel sensitivity in ovarian cancer cells

Mooneyham, A., Iizuka, Y., Yang, Q., Coombes, C., McClellan, M., Shridhar, V., Emmings, E., Shetty, M., Chen, L., Ai, T., Meints, J., Lee, M. K., Gardner, M. K. & Bazzaro, M., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 370-383 14 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Paclitaxel
Ovarian Neoplasms
Spindle Apparatus
Microtubules
2017
1 Citation (Scopus)

Manipulation and quantification of microtubule lattice integrity

Reid, T. A., Coombes, C. E. & Gardner, M. K., Aug 15 2017, In : Biology Open. 6, 8, p. 1245-1256 12 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Microtubules
microtubules
Crystal defects
Fluorescence microscopy
2016
10 Citations (Scopus)

A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis

Edgerton, H., Johansson, M., Keifenheim, D. L., Mukherjee, S. R., Chacon, J. M., Bachant, J., Gardner, M. K. & Clarke, D. J., Jan 1 2016, In : Journal of Cell Biology. 213, 6, p. 651-664 14 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Centromere
Mitosis
Kinetochores
Aurora Kinase B

A novel role for SALL4 during scar-free wound healing in axolotl

Erickson, J. R., Gearhart, M. D., Honson, D. D., Reid, T. A., Gardner, M. K., Moriarity, B. S. & Echeverri, K., Dec 1 2016, In : Regenerative Medicine. 1, 1

Research output: Contribution to journalArticle

Open Access
Ambystoma mexicanum
Structural integrity
Transcription
Collagen
Wound Healing

Cell Biology: Microtubule Collisions to the Rescue

Gardner, M. K., Dec 19 2016, In : Current Biology. 26, 24, p. R1287-R1289

Research output: Contribution to journalShort survey

Cytology
Microtubules
cell biology
microtubules
Cell Biology
18 Citations (Scopus)

Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila

Mauvezin, C. C., Neisch, A. L., Ayala, C. I., Kim, J., Beltrame, A., Braden, C. R., Gardner, M. K., Hays, T. S. & Neufeld, T. P., Jan 1 2016, In : Journal of cell science. 129, 5, p. 971-982 12 p.

Research output: Contribution to journalArticle

Lysosomes
Drosophila
Kinesin
GTP Phosphohydrolases
Autophagy
9 Citations (Scopus)

Geometry and expression enhance enrichment of functional yeast-displayed ligands via cell panning

Stern, L. A., Schrack, I. A., Johnson, S. M., Deshpande, A., Bennett, N. R., Harasymiw, L. A., Gardner, M. K. & Hackel, B. J., Nov 1 2016, In : Biotechnology and Bioengineering. 113, 11, p. 2328-2341 14 p.

Research output: Contribution to journalArticle

Yeast
Yeasts
Ligands
Geometry
Display devices
8 Citations (Scopus)

Interactions between the Microtubule Binding Protein EB1 and F-Actin

Alberico, E. O., Zhu, Z. C., Wu, Y. F. O., Gardner, M. K., Kovar, D. R. & Goodson, H. V., Mar 27 2016, In : Journal of Molecular Biology. 428, 6, p. 1304-1314 11 p.

Research output: Contribution to journalArticle

Microtubule Proteins
Protein Binding
Actins
Carrier Proteins
Microtubules
21 Citations (Scopus)

Mechanism of microtubule lumen entry for the α-tubulin acetyltransferase enzyme αTAT1

Coombes, C. E., Yamamoto, A., McClellan, M., Reid, T. A., Plooster, M., Luxton, G. W. G., Alper, J., Howard, J. & Gardner, M. K., Nov 15 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 46, p. E7176-E7184

Research output: Contribution to journalArticle

Acetyltransferases
Tubulin
Microtubules
Acetylation
Enzymes
15 Citations (Scopus)

Suppression of microtubule assembly kinetics by the mitotic protein TPX2

Reid, T. A., Schuster, B. M., Mann, B. J., Balchand, S. K., Plooster, M., McClellan, M., Coombes, C. E., Wadsworth, P. & Gardner, M. K., Apr 1 2016, In : Journal of Cell Science. 129, 7, p. 1319-1328 10 p.

Research output: Contribution to journalArticle

Microtubules
Tubulin
Proteins
Spindle Apparatus
Microtubule-Associated Proteins
2014
52 Citations (Scopus)

Microtubule binding distinguishes dystrophin from utrophin

Belanto, J. J., Mader, T. L., Eckhoff, M. D., Strandjord, D. M., Banks, G. B., Gardner, M. K., Lowe, D. A. & Ervasti, J. M., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5723-5728 6 p.

Research output: Contribution to journalArticle

Utrophin
Dystrophin
Microtubules
Inbred mdx Mouse
Duchenne Muscular Dystrophy
30 Citations (Scopus)

Minus-end-directed kinesin-14 motors align antiparallel microtubules to control metaphase spindle length

Hepperla, A. J., Willey, P. T., Coombes, C. E., Schuster, B. M., Gerami-Nejad, M., McClellan, M., Mukherjee, S. R., Fox, J., Winey, M., Odde, D. J., O'Toole, E. & Gardner, M. K., Oct 13 2014, In : Developmental Cell. 31, 1, p. 61-72 12 p.

Research output: Contribution to journalArticle

Kinesin
Metaphase
Microtubules
Spindle Apparatus
Spindle Poles
21 Citations (Scopus)

Pericentromere tension is self-regulated by spindle structure in metaphase

Chacon, J. M., Mukherjee, S. R., Schuster, B. M., Clarke, D. J. & Gardner, M. K., Jan 1 2014, In : Journal of Cell Biology. 205, 3, p. 313-324 12 p.

Research output: Contribution to journalArticle

Metaphase
Spindle Apparatus
Chromosomes
Chromosome Structures
Chromosome Segregation
18 Citations (Scopus)

Quantitative analysis of microtubule self-assembly kinetics and tip structure

Prahl, L. S., Castle, B. T., Gardner, M. K. & Odde, D. J., Jan 1 2014, Reconstituting the Cytoskeleton. Academic Press Inc., p. 35-52 18 p. (Methods in Enzymology; vol. 540).

Research output: Chapter in Book/Report/Conference proceedingChapter

Microtubules
Self assembly
Polymers
Kinetics
Chemical analysis
1 Citation (Scopus)

Rapid microtubule self-assembly kinetics

Gardner, M. K., Charlebois, B. D., Jánosi, I. M., Howard, J., Hunt, A. J. & Odde, D. J., Sep 25 2014, In : Cell. 159, 1, 1 p.

Research output: Contribution to journalComment/debate

Self assembly
Kinetics
2013
5 Citations (Scopus)
Cisplatin
Chemotherapy
Chromosomes
Mitosis
Chromosome

CENP-E hangs on at dynamic microtubule ends

Gardner, M. K., Sep 1 2013, In : Nature Cell Biology. 15, 9, p. 1030-1032 3 p.

Research output: Contribution to journalReview article

Kinetochores
Microtubules
Kinesin
Mitosis
Chromosomes
53 Citations (Scopus)

Evolving tip structures can explain age-dependent microtubule catastrophe

Coombes, C. E., Yamamoto, A., Kenzie, M. R., Odde, D. J. & Gardner, M. K., Jul 22 2013, In : Current Biology. 23, 14, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

Tubulin
Microtubules
microtubules
Guanosine Triphosphate
tubulin
9 Citations (Scopus)

Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability

Choy, J. S., O'Toole, E., Schuster, B. M., Crisp, M. J., Karpova, T. S., McNally, J. G., Winey, M., Gardner, M. K. & Basrai, M. A., Sep 1 2013, In : Molecular Biology of the Cell. 24, 17, p. 2753-2763 11 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Chromosome Segregation
Anaphase
Gene Dosage
Genomic Instability
74 Citations (Scopus)

Microtubule catastrophe and rescue.

Gardner, M. K., Zanic, M. & Howard, J., Feb 2013, In : Current Opinion in Cell Biology. 25, 1, p. 14-22 9 p.

Research output: Contribution to journalArticle

Microtubules
Axoneme
Spindle Apparatus
Cell Shape
Cellular Structures
9 Citations (Scopus)

Monopolin recruits condensin to organize centromere DNA and repetitive DNA sequences

Burrack, L. S., Applen Clancey, S. E., Chacon, J. M., Gardner, M. K. & Berman, J., Sep 15 2013, In : Molecular Biology of the Cell. 24, 18, p. 2807-2819 13 p.

Research output: Contribution to journalArticle

Centromere
Nucleic Acid Repetitive Sequences
Kinetochores
Chromosome Segregation
DNA
2012
71 Citations (Scopus)

Dynein tethers and stabilizes dynamic microtubule plus ends

Hendricks, A. G., Lazarus, J. E., Perlson, E., Gardner, M. K., Odde, D. J., Goldman, Y. E. & Holzbaur, E. L. F., Apr 10 2012, In : Current Biology. 22, 7, p. 632-637 6 p.

Research output: Contribution to journalArticle

Dyneins
Microtubules
microtubules
Cytoplasmic Dyneins
Kinesin
14 Citations (Scopus)

Islands containing slowly hydrolyzable GTP analogs promote microtubule rescues

Tropini, C., Roth, E. A., Zanic, M., Gardner, M. K. & Howard, J., Jan 17 2012, In : PloS one. 7, 1, e30103.

Research output: Contribution to journalArticle

Guanosine Triphosphate
Islands
Microtubules
microtubules
Tubulin
2011
106 Citations (Scopus)

Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe

Gardner, M. K., Zanic, M., Gell, C., Bormuth, V. & Howard, J., Nov 23 2011, In : Cell. 147, 5, p. 1092-1103 12 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
Aging of materials
Random processes
Growth
60 Citations (Scopus)

Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation

Weaver, L. N., Ems-McClung, S. C., Stout, J. R., Leblanc, C., Shaw, S. L., Gardner, M. K. & Walczak, C. E., Sep 13 2011, In : Current Biology. 21, 17, p. 1500-1506 7 p.

Research output: Contribution to journalArticle

Microtubules
microtubules
binding sites
Kinesin
tail
30 Citations (Scopus)

Microtubule tip tracking and tip structures at the nanometer scale using digital fluorescence microscopy

Demchouk, A. O., Gardner, M. K. & Odde, D. J., Jun 1 2011, In : Cellular and Molecular Bioengineering. 4, 2, p. 192-204 13 p.

Research output: Contribution to journalArticle

Fluorescence Microscopy
Microtubules
Fluorescence microscopy
Tubulin
Dimers
113 Citations (Scopus)

Rapid microtubule self-assembly kinetics

Gardner, M. K., Charlebois, B. D., Jánosi, I. M., Howard, J., Hunt, A. J. & Odde, D. J., Aug 19 2011, In : Cell. 146, 4, p. 582-592 11 p.

Research output: Contribution to journalArticle

Microtubules
Self assembly
Kinetics
Fluorescence microscopy
Optical Tweezers
2010

Erratum: Model convolution: A computational approach to digital image interpretation (Cellular and Molecular Bioengineering (2010) 3:3 (331-332))

Gardner, M. K., Sprague, B. L., Pearson, C. G., Cosgrove, B. D., Bicek, A. D., Bloom, K., Salmon, E. D. & Odde, D. J., Sep 1 2010, In : Cellular and Molecular Bioengineering. 3, 3, p. 331-332 2 p.

Research output: Contribution to journalComment/debate

Bioengineering
Convolution
Digital Image
Model
Interpretation
18 Citations (Scopus)

Model convolution: A computational approach to digital image interpretation

Gardner, M. K., Sprague, B. L., Pearson, C. G., Cosgrove, B. D., Bicek, A. D., Bloom, K., Salmon, E. D. & Odde, D. J., Jun 1 2010, In : Cellular and Molecular Bioengineering. 3, 2, p. 163-170 8 p.

Research output: Contribution to journalReview article

Convolution
Digital Image
Fluorescence Microscopy
Noise
Deconvolution
6 Citations (Scopus)

Slk19p of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms

Havens, K. A., Gardner, M. K., Kamieniecki, R. J., Dresser, M. E. & Dawson, D. S., Dec 1 2010, In : Genetics. 186, 4, p. 1247-1260 14 p.

Research output: Contribution to journalArticle

Anaphase
Saccharomyces cerevisiae
Microtubules
Phenotype
Sequence Deletion
5 Citations (Scopus)

Stochastic simulation and graphic visualization of mitotic processes

Gardner, M. K. & Odde, D. J., Jun 1 2010, In : Methods. 51, 2, p. 251-256 6 p.

Research output: Contribution to journalArticle

Spindle Apparatus
Microtubules
Visualization
Stochastic models
Animation
2008
110 Citations (Scopus)

Chromosome Congression by Kinesin-5 Motor-Mediated Disassembly of Longer Kinetochore Microtubules

Gardner, M. K., Bouck, D. C., Paliulis, L. V., Meehl, J. B., O'Toole, E. T., Haase, J., Soubry, A., Joglekar, A. P., Winey, M., Salmon, E. D., Bloom, K. & Odde, D. J., Nov 28 2008, In : Cell. 135, 5, p. 894-906 13 p.

Research output: Contribution to journalArticle

Kinetochores
Kinesin
Chromosomes
Microtubules
Yeast
6 Citations (Scopus)

Dam1 complexes go it alone on disassembling microtubules

Gardner, M. K. & Odde, D. J., Aug 11 2008, In : Nature Cell Biology. 10, 4, p. 379-381 3 p.

Research output: Contribution to journalArticle

Microtubules
Hand Strength
Kinetochores
In Vitro Techniques
34 Citations (Scopus)

Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

Gardner, M. K., Odde, D. J. & Bloom, K., Jul 1 2008, In : Trends in Cell Biology. 18, 7, p. 307-310 4 p.

Research output: Contribution to journalShort survey

Kinesin
Chromosomes
Spindle Apparatus
Microtubules
Yeasts
49 Citations (Scopus)

Microtubule assembly dynamics: new insights at the nanoscale

Gardner, M. K., Hunt, A. J., Goodson, H. V. & Odde, D. J., Feb 1 2008, In : Current Opinion in Cell Biology. 20, 1, p. 64-70 7 p.

Research output: Contribution to journalReview article

Microtubules
Optical Tweezers
Molecular Models
Microtubule-Associated Proteins
Microscopy
53 Citations (Scopus)

The microtubule-based motor Kar3 and plus end-binding protein Bim1 provide structural support for the anaphase spindle

Gardner, M. K., Haase, J., Mythreye, K., Molk, J. N., Anderson, M., Joglekar, A. P., O'Toole, E. T., Winey, M., Salmon, E. D., Odde, D. J. & Bloom, K., Jan 14 2008, In : Journal of Cell Biology. 180, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Anaphase
Microtubules
Carrier Proteins
Kinetochores
Chromosomes
2007
18 Citations (Scopus)

Hypothesis testing via integrated computer modeling and digital fluorescence microscopy

Gardner, M. K., Odde, D. J. & Bloom, K., Feb 1 2007, In : Methods. 41, 2, p. 232-237 6 p.

Research output: Contribution to journalArticle

Fluorescence microscopy
Fluorescence Microscopy
Cell Biology
Yeasts
Fluorescence
124 Citations (Scopus)

Microtubule Assembly Dynamics at the Nanoscale

Schek, H. T., Gardner, M. K., Cheng, J., Odde, D. J. & Hunt, A. J., Sep 4 2007, In : Current Biology. 17, 17, p. 1445-1455 11 p.

Research output: Contribution to journalArticle

guanosine triphosphate
Microtubules
microtubules
Guanosine Triphosphate
shortenings
2006

Asymmetric Division: Motor Persistence Pays off

Gardner, M. K. & Odde, D. J., Dec 19 2006, In : Current Biology. 16, 24

Research output: Contribution to journalShort survey

Mitosis
mitosis
mitotic spindle apparatus
Spindle Apparatus
generators (equipment)
30 Citations (Scopus)

Measuring nanometer scale gradients in spindle microtubule dynamics using model convolution microscopy

Pearson, C. G., Gardner, M. K., Paliulis, L. V., Salmon, E. D., Odde, D. J. & Bloom, K., Sep 1 2006, In : Molecular Biology of the Cell. 17, 9, p. 4069-4079 11 p.

Research output: Contribution to journalArticle

Kinetochores
Tubulin
Microtubules
Microscopy
Yeasts
26 Citations (Scopus)

Modeling of chromosome motility during mitosis

Gardner, M. K. & Odde, D. J., Dec 1 2006, In : Current Opinion in Cell Biology. 18, 6, p. 639-647 9 p.

Research output: Contribution to journalReview article

Mitosis
Chromosomes
Kinetochores
Microtubules
Spindle Apparatus
66 Citations (Scopus)

Mps1 Phosphorylation of Dam1 Couples Kinetochores to Microtubule Plus Ends at Metaphase

Shimogawa, M. M., Graczyk, B., Gardner, M. K., Francis, S. E., White, E. A., Ess, M., Molk, J. N., Ruse, C., Niessen, S., Yates, J. R., Muller, E. G. D., Bloom, K., Odde, D. J. & Davis, T. N., Aug 8 2006, In : Current Biology. 16, 15, p. 1489-1501 13 p.

Research output: Contribution to journalArticle

Kinetochores
kinetochores
Phosphorylation
Metaphase
Chromosomes
2005
98 Citations (Scopus)

Tension-depenent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast

Gardner, M. K., Pearson, C. G., Sprague, B. L., Zarzar, T. R., Bloom, K., Salmon, E. D. & Odde, D. J., Aug 1 2005, In : Molecular Biology of the Cell. 16, 8, p. 3764-3775 12 p.

Research output: Contribution to journalArticle

Kinetochores
Metaphase
Microtubules
Yeasts
Fluorescence Recovery After Photobleaching
2004
6 Citations (Scopus)

Model-convolution approach to modeling fluorescent protein dynamics

Sprague, B. L., Gardner, M. K., Pearson, C. G., Maddox, P. S., Bloom, K., Salmon, E. D. & Odde, D. J., Dec 1 2004, In : Conference Record - Asilomar Conference on Signals, Systems and Computers. 2, p. 1821-1825 5 p.

Research output: Contribution to journalArticle

Convolution
Fluorophores
Proteins
Fluorescence microscopy
Optical transfer function
120 Citations (Scopus)

Stable kinetochore-microtubule attachment constrains centromere positioning in metaphase

Pearson, C. G., Yeh, E., Gardner, M. K., Odde, D. J., Salmon, E. D. & Bloom, K., Nov 9 2004, In : Current Biology. 14, 21, p. 1962-1967 6 p.

Research output: Contribution to journalArticle

Kinetochores
kinetochores
Centromere
centromeres
Metaphase