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2019

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

Lin, J., Le, T. V., Augspurger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E. T., VanderWaal Mills, K., Dymek, E., Smith, E., Nicastro, D. & Porter, M. E., Oct 1 2019, In : Molecular biology of the cell. 30, 21, p. 2659-2680 22 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility

Dymek, E. E., Lin, J., Fu, G., Porter, M. E., Nicastro, D. & Smith, E. F., Jul 15 2019, In : Molecular biology of the cell. 30, 15, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

Gui, L., Song, K., Tritschler, D., Bower, R., Yan, S., Dai, A., Augspurger, K., Sakizadeh, J., Grzemska, M., Ni, T., Porter, M. E. & Nicastro, D., Nov 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 46, p. 23152-23162 11 p.

Research output: Contribution to journalArticle

Open Access
2017

Ciliary motility: Regulation of axonemal dynein motors

Viswanadha, R., Sale, W. S. & Porter, M. E., Jan 1 2017, In : Cold Spring Harbor Perspectives in Biology. 9, 8, a018325.

Research output: Contribution to journalArticle

24 Scopus citations

Dynamics of the IFT machinery at the ciliary tip

Chien, A., Shih, S. M., Bower, R., Tritschler, D., Porter, M. E. & Yildiz, A., Sep 20 2017, In : eLife. 6, e28606.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
2016

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease

Lewis, W. R., Malarkey, E. B., Tritschler, D., Bower, R., Pasek, R. C., Porath, J. D., Birket, S. E., Saunier, S., Antignac, C., Knowles, M. R., Leigh, M. W., Zariwala, M. A., Challa, A. K., Kesterson, R. A., Rowe, S. M., Drummond, I. A., Parant, J. M., Hildebrandt, F., Porter, M. E., Yoder, B. K. & 1 others, Berbari, N. F., Jul 2016, In : PLoS genetics. 12, 7, e1006220.

Research output: Contribution to journalArticle

9 Scopus citations

The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

Alford, L. M., Stoddard, D., Li, J. H., Hunter, E. L., Tritschler, D., Bower, R., Nicastro, D., Porter, M. E. & Sale, W. S., Jun 1 2016, In : Cytoskeleton. 73, 7, p. 331-340 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

Reck, J., Schauer, A. M., Van Der Waal Mills, K., Bower, R., Tritschler, D., Perrone, C. A. & Porter, M. E., Aug 1 2016, In : Molecular biology of the cell. 27, 15, p. 2404-2422 19 p.

Research output: Contribution to journalArticle

18 Scopus citations
2015

In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography

Song, K., Awata, J., Tritschler, D., Bower, R., Witman, G. B., Porter, M. E. & Nicastro, D., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5341-5353 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2013

A differential cargo-loading model of ciliary length regulation by IFT

Wren, K. N., Craft, J. M., Tritschler, D., Schauer, A., Patel, D. K., Smith, E. F., Porter, M. E., Kner, P. & Lechtreck, K. F., Dec 16 2013, In : Current Biology. 23, 24, p. 2463-2471 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes

Bower, R., Tritschler, D., VanderWaal, K., Perrone, C. A., Mueller, J., Fox, L., Sale, W. S. & Porter, M. E., Apr 15 2013, In : Molecular biology of the cell. 24, 8, p. 1134-1152 19 p.

Research output: Contribution to journalArticle

58 Scopus citations

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

Wirschell, M., Olbrich, H., Werner, C., Tritschler, D., Bower, R., Sale, W. S., Loges, N. T., Pennekamp, P., Lindberg, S., Stenram, U., Carlén, B., Horak, E., Köhler, G., Nürnberg, P., Nürnberg, G., Porter, M. E. & Omran, H., Mar 1 2013, In : Nature Genetics. 45, 3, p. 262-268 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia

Austin-Tse, C., Halbritter, J., Zariwala, M. A., Gilberti, R. M., Gee, H. Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J. R., Patel-King, R. S., Tritschler, D., Bower, R., O'Toole, E., Porath, J. D., Hurd, T. W., Chaki, M., Diaz, K. A., Kohl, S., Lovric, S., Hwang, D. Y. & 23 others, Braun, D. A., Schueler, M., Airik, R., Otto, E. A., Leigh, M. W., Noone, P. G., Carson, J. L., Davis, S. D., Pittman, J. E., Ferkol, T. W., Atkinson, J. J., Olivier, K. N., Sagel, S. D., Dell, S. D., Rosenfeld, M., Milla, C. E., Loges, N. T., Omran, H., Porter, M. E., King, S. M., Knowles, M. R., Drummond, I. A. & Hildebrandt, F., Oct 3 2013, In : American Journal of Human Genetics. 93, 4, p. 672-686 15 p.

Research output: Contribution to journalArticle

91 Scopus citations
2012

Computer-assisted image analysis of human cilia and chlamydomonas flagella reveals both similarities and differences in axoneme structure

O'Toole, E. T., Giddings, T. H., Porter, M. E. & Ostrowski, L. E., Aug 1 2012, In : Cytoskeleton. 69, 8, p. 577-590 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein

Heuser, T., Barber, C. F., Lin, J., Krell, J., Rebesco, M., Porter, M. E. & Nicastro, D., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. E2067-E2076

Research output: Contribution to journalArticle

56 Scopus citations
2011

A unified taxonomy for ciliary dyneins

Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 1 2011, In : Cytoskeleton. 68, 10, p. 555-565 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In : Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Building blocks of the nexin-dynein regulatory complex in chlamydomonas flagella

Lin, J., Tritschler, D., Song, K., Barber, C. F., Cobb, J. S., Porter, M. E. & Nicastro, D., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 29175-29191 17 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cryo-electron tomography reveals conserved features of doublet microtubules in flagella

Nicastro, D., Fu, X., Heuser, T., Tso, A., Porter, M. E. & Linck, R. W., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. E845-E853

Research output: Contribution to journalArticle

72 Scopus citations

Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 of Chlamydomonas flagella

Toba, S., Fox, L. A., Sakakibara, H., Porter, M. E., Oiwa, K. & Sale, W. S., Feb 1 2011, In : Molecular biology of the cell. 22, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2009

A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii

Ikeda, K., Yamamoto, R., Wirschell, M., Yagi, T., Bower, R., Porter, M. E., Sale, W. S. & Kamiya, R., Aug 1 2009, In : Cell motility and the cytoskeleton. 66, 8, p. 448-456 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility

Bower, R., VanderWaal, K., O'Toole, E., Fox, L., Perrone, C., Mueller, J., Wirschell, M., Kamiya, R., Sale, W. S. & Porter, M. E., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3055-3063 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding

Wirschell, M., Yang, C., Yang, P., Fox, L., Yanagisawa, H. A., Kamiya, R., Witman, G. B., Porter, M. E. & Sale, W. S., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Recording and analyzing IFT in Chlamydomonas flagella.

Dentler, W., Vanderwaal, K. & Porter, M. E., 2009, In : Methods in cell biology. 93, p. 145-155 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella

Heuser, T., Raytchev, M., Krell, J., Porter, M. E. & Nicastro, D., Dec 14 2009, In : Journal of Cell Biology. 187, 6, p. 921-933 13 p.

Research output: Contribution to journalArticle

199 Scopus citations
2008

Structural investigations of human cilia from normal and primary ciliary dyskinesia patients

O'Toole, E. T., Porter, M. E. & Ostrowski, L. E., Aug 1 2008, In : Microscopy and Microanalysis. 14, SUPPL. 2, p. 1476-1477 2 p.

Research output: Contribution to journalArticle

2006

The molecular architecture of axonemes revealed by cryoelectron tomography

Nicastro, D., Schwartz, C., Pierson, J., Gaudette, R., Porter, M. E. & McIntosh, J. R., Aug 18 2006, In : Science. 313, 5789, p. 944-948 5 p.

Research output: Contribution to journalArticle

486 Scopus citations
2005

The FLA3 KAP subunit is required for localization of kinesin-2 to the site of flagellar assembly and processive anterograde intraflagellar transport

Mueller, J., Perrone, C. A., Bower, R., Cole, D. G. & Porter, M. E., Mar 1 2005, In : Molecular biology of the cell. 16, 3, p. 1341-1354 14 p.

Research output: Contribution to journalArticle

71 Scopus citations
2004

IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending

Hendrickson, T. W., Perrone, C. A., Griffin, P., Wuichet, K., Mueller, J., Yang, P., Porter, M. E. & Sale, W. S., Dec 1 2004, In : Molecular biology of the cell. 15, 12, p. 5431-5442 12 p.

Research output: Contribution to journalArticle

76 Scopus citations
2003

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in Chlamydomonas and mammalian cells

Perrone, C. A., Tritschler, D., Taulman, P., Bower, R., Yoder, B. K. & Porter, M. E., May 1 2003, In : Molecular biology of the cell. 14, 5, p. 2041-2056 16 p.

Research output: Contribution to journalArticle

98 Scopus citations

A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product

Rupp, G. & Porter, M. E., Jul 7 2003, In : Journal of Cell Biology. 162, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

85 Scopus citations
2001
60 Scopus citations
2000

Insights into the structural organization of the I1 inner arm dynein from a domain analysis of the 1β dynein heavy chain

Perrone, C. A., Myster, S. H., Bower, R., O'Toole, E. T. & Porter, M. E., Jul 2000, In : Molecular biology of the cell. 11, 7, p. 2297-2313 17 p.

Research output: Contribution to journalArticle

68 Scopus citations

The rib43a protein is associated with forming the specialized protofilament ribbons of flagellar microtubules in Chlamydomonas

Norrander, J. M., DeCathelineau, A. M., Brown, J. A., Porter, M. E. & Linck, R. W., Jan 2000, In : Molecular biology of the cell. 11, 1, p. 201-215 15 p.

Research output: Contribution to journalArticle

34 Scopus citations
1999

Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas

Porter, M. E., Bower, R., Knott, J. A., Byrd, P. & Dentler, W., Mar 1999, In : Molecular biology of the cell. 10, 3, p. 693-712 20 p.

Research output: Contribution to journalArticle

244 Scopus citations

Domains in the 1α dynein heavy chain required for inner arm assembly and flagellar motility in Chlamydomonas

Myster, S. H., Knott, J. A., Wysocki, K. M., O'Toole, E. & Porter, M. E., Aug 23 1999, In : Journal of Cell Biology. 146, 4, p. 801-818 18 p.

Research output: Contribution to journalArticle

52 Scopus citations
1998

The Chlamydomonas IDA7 locus encodes a 140-kDa dynein intermediate chain required to assemble the I1 inner arm complex

Perrone, C. A., Yang, P., O'Toole, E., Sale, W. S. & Porter, M. E., Dec 1998, In : Molecular biology of the cell. 9, 12, p. 3351-3365 15 p.

Research output: Contribution to journalArticle

76 Scopus citations
1997

The Chlamydomonas Dhc1 gene encodes a dynein heavy chain subunit required for assembly of the I1 inner arm complex

Myster, S. H., Knott, J. A., O'Toole, E. & Porter, M. E., Apr 1997, In : Molecular biology of the cell. 8, 4, p. 607-620 14 p.

Research output: Contribution to journalArticle

80 Scopus citations
1996

Axonemal dyneins: Assembly, organization, and regulation

Porter, M. E., Feb 1996, In : Current Opinion in Cell Biology. 8, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

The dynein gene family in Chlamydomonas reinhardtii

Porter, M. E., Knott, J. A., Myster, S. H. & Farlow, S. J., Oct 9 1996, In : Genetics. 144, 2, p. 569-585 17 p.

Research output: Contribution to journalArticle

68 Scopus citations

The sup-pf-2 mutations of Chlamydomonas alter the activity of the outer dynein arms by modification of the γ-dynein heavy chain

Rupp, G., O'Toole, E., Gardner, L. C., Mitchell, B. F. & Porter, M. E., Dec 1 1996, In : Journal of Cell Biology. 135, 6 II, p. 1853-1865 13 p.

Research output: Contribution to journalArticle

65 Scopus citations
1995

Computer-Assisted Analysis of Flagellar Structure

O'Toole, E., Mastronarde, D., McIntosh, J. R. & Porter, M. E., Jan 1 1995, In : Methods in cell biology. 47, C, p. 183-191 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
1994

A cytoplasmic dynein motor in Drosophila: Identification and localization during embryogenesis

Hays, T. S., Porter, M. E., McGrail, M., Grissom, P., Gosch, P., Fuller, M. T. & McIntosh, J. R., Jun 1 1994, In : Journal of cell science. 107, 6, p. 1557-1569 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Components of a 'dynein regulatory complex' are located at the junction between the radial spokes and the dynein arms in Chlamydomonas flagella

Gardner, L. C., O'Toole, E., Perrone, C. A., Giddings, T. & Porter, M. E., Dec 14 1994, In : Journal of Cell Biology. 127, 5, p. 1311-1325 15 p.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations

Mutations in the SUP-PF-1 locus of Chlamydomonas reinhardtii identify a regulatory domain in the β-dynein heavy chain

Porter, M. E., Knott, J. A., Gardner, L. C., Mitchell, D. R. & Dutcher, S. K., Sep 1994, In : Journal of Cell Biology. 126, 6, p. 1495-1507 13 p.

Research output: Contribution to journalArticle

87 Scopus citations
1992

Arrangement of inner dynein arms in wild-type and mutant flagella of Chlamydomonas

Mastronarde, D. N., O'Toole, E. T., McDonald, K. L., McIntosh, J. R. & Porter, M. E., Sep 1992, In : Journal of Cell Biology. 118, 5, p. 1145-1162 18 p.

Research output: Contribution to journalArticle

140 Scopus citations

Extragenic suppressors of paralyzed flagellar mutations in Chlamydomonas reinhardtii identify loci that alter the inner dynein arms

Porter, M. E., Power, J. & Dutcher, S. K., Sep 1992, In : Journal of Cell Biology. 118, 5, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

125 Scopus citations

Two distinct isoforms of sea urchin egg dynein

Grissom, P. M., Porter, M. E. & McIntosh, J. R., Jun 22 1992, In : Cell motility and the cytoskeleton. 21, 4, p. 281-292 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
1991

Reappraisal of the genetic map of Chlamydomonas reinhardtii

Dutcher, S. K., Power, J., Galloway, R. E. & Porter, M. E., Jan 1 1991, In : Journal of Heredity. 82, 4, p. 295-301 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
1990

Cytoplasmic dynein is localized to kinetochores during mitosis

Pfarr, C. M., Coue, M., Grissom, P. M., Hays, T. S., Porter, M. E. & McIntosh, J. R., Jan 1 1990, In : Nature. 345, 6272, p. 263-265 3 p.

Research output: Contribution to journalArticle

342 Scopus citations