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Research Output

2011

A unified taxonomy for ciliary dyneins

Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 1 2011, In : Cytoskeleton. 68, 10, p. 555-565 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In : Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Building blocks of the nexin-dynein regulatory complex in chlamydomonas flagella

Lin, J., Tritschler, D., Song, K., Barber, C. F., Cobb, J. S., Porter, M. E. & Nicastro, D., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 29175-29191 17 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cryo-electron tomography reveals conserved features of doublet microtubules in flagella

Nicastro, D., Fu, X., Heuser, T., Tso, A., Porter, M. E. & Linck, R. W., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. E845-E853

Research output: Contribution to journalArticle

72 Scopus citations

Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 of Chlamydomonas flagella

Toba, S., Fox, L. A., Sakakibara, H., Porter, M. E., Oiwa, K. & Sale, W. S., Feb 1 2011, In : Molecular biology of the cell. 22, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Computer-assisted image analysis of human cilia and chlamydomonas flagella reveals both similarities and differences in axoneme structure

O'Toole, E. T., Giddings, T. H., Porter, M. E. & Ostrowski, L. E., Aug 1 2012, In : Cytoskeleton. 69, 8, p. 577-590 14 p.

Research output: Contribution to journalArticle

30 Scopus citations

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein

Heuser, T., Barber, C. F., Lin, J., Krell, J., Rebesco, M., Porter, M. E. & Nicastro, D., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. E2067-E2076

Research output: Contribution to journalArticle

56 Scopus citations

Flagellar motility and the dynein regulatory complex

Porter, M. E., Dec 1 2012, Dyneins. Elsevier Inc., p. 336-365 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2013

A differential cargo-loading model of ciliary length regulation by IFT

Wren, K. N., Craft, J. M., Tritschler, D., Schauer, A., Patel, D. K., Smith, E. F., Porter, M. E., Kner, P. & Lechtreck, K. F., Dec 16 2013, In : Current Biology. 23, 24, p. 2463-2471 9 p.

Research output: Contribution to journalArticle

84 Scopus citations

The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes

Bower, R., Tritschler, D., VanderWaal, K., Perrone, C. A., Mueller, J., Fox, L., Sale, W. S. & Porter, M. E., Apr 15 2013, In : Molecular biology of the cell. 24, 8, p. 1134-1152 19 p.

Research output: Contribution to journalArticle

58 Scopus citations

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

Wirschell, M., Olbrich, H., Werner, C., Tritschler, D., Bower, R., Sale, W. S., Loges, N. T., Pennekamp, P., Lindberg, S., Stenram, U., Carlén, B., Horak, E., Köhler, G., Nürnberg, P., Nürnberg, G., Porter, M. E. & Omran, H., Mar 1 2013, In : Nature Genetics. 45, 3, p. 262-268 7 p.

Research output: Contribution to journalArticle

110 Scopus citations

Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia

Austin-Tse, C., Halbritter, J., Zariwala, M. A., Gilberti, R. M., Gee, H. Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J. R., Patel-King, R. S., Tritschler, D., Bower, R., O'Toole, E., Porath, J. D., Hurd, T. W., Chaki, M., Diaz, K. A., Kohl, S., Lovric, S., Hwang, D. Y. & 23 others, Braun, D. A., Schueler, M., Airik, R., Otto, E. A., Leigh, M. W., Noone, P. G., Carson, J. L., Davis, S. D., Pittman, J. E., Ferkol, T. W., Atkinson, J. J., Olivier, K. N., Sagel, S. D., Dell, S. D., Rosenfeld, M., Milla, C. E., Loges, N. T., Omran, H., Porter, M. E., King, S. M., Knowles, M. R., Drummond, I. A. & Hildebrandt, F., Oct 3 2013, In : American Journal of Human Genetics. 93, 4, p. 672-686 15 p.

Research output: Contribution to journalArticle

91 Scopus citations
2014

The Chlamydomonas genome project: A decade on

Blaby, I. K., Blaby-Haas, C. E., Tourasse, N., Hom, E. F. Y., Lopez, D., Aksoy, M., Grossman, A., Umen, J., Dutcher, S., Porter, M., King, S., Witman, G. B., Stanke, M., Harris, E. H., Goodstein, D., Grimwood, J., Schmutz, J., Vallon, O., Merchant, S. S. & Prochnik, S., Oct 1 2014, In : Trends in Plant Science. 19, 10, p. 672-680 9 p.

Research output: Contribution to journalReview article

68 Scopus citations
2015

In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography

Song, K., Awata, J., Tritschler, D., Bower, R., Witman, G. B., Porter, M. E. & Nicastro, D., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5341-5353 13 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease

Lewis, W. R., Malarkey, E. B., Tritschler, D., Bower, R., Pasek, R. C., Porath, J. D., Birket, S. E., Saunier, S., Antignac, C., Knowles, M. R., Leigh, M. W., Zariwala, M. A., Challa, A. K., Kesterson, R. A., Rowe, S. M., Drummond, I. A., Parant, J. M., Hildebrandt, F., Porter, M. E., Yoder, B. K. & 1 others, Berbari, N. F., Jul 2016, In : PLoS genetics. 12, 7, e1006220.

Research output: Contribution to journalArticle

9 Scopus citations

The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

Alford, L. M., Stoddard, D., Li, J. H., Hunter, E. L., Tritschler, D., Bower, R., Nicastro, D., Porter, M. E. & Sale, W. S., Jun 1 2016, In : Cytoskeleton. 73, 7, p. 331-340 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

Reck, J., Schauer, A. M., Van Der Waal Mills, K., Bower, R., Tritschler, D., Perrone, C. A. & Porter, M. E., Aug 1 2016, In : Molecular biology of the cell. 27, 15, p. 2404-2422 19 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

Ciliary and flagellar motility and the nexin-dynein regulatory complex

Porter, M. E., Nov 22 2017, Dyneins: The Biology of Dynein Motors: Second Edition. Elsevier Inc., p. 299-335 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Ciliary motility: Regulation of axonemal dynein motors

Viswanadha, R., Sale, W. S. & Porter, M. E., Jan 1 2017, In : Cold Spring Harbor Perspectives in Biology. 9, 8, a018325.

Research output: Contribution to journalArticle

24 Scopus citations

Dynamics of the IFT machinery at the ciliary tip

Chien, A., Shih, S. M., Bower, R., Tritschler, D., Porter, M. E. & Yildiz, A., Sep 20 2017, In : eLife. 6, e28606.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations
2019

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

Lin, J., Le, T. V., Augspurger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E. T., VanderWaal Mills, K., Dymek, E., Smith, E., Nicastro, D. & Porter, M. E., Oct 1 2019, In : Molecular biology of the cell. 30, 21, p. 2659-2680 22 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility

Dymek, E. E., Lin, J., Fu, G., Porter, M. E., Nicastro, D. & Smith, E. F., Jul 15 2019, In : Molecular biology of the cell. 30, 15, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

Gui, L., Song, K., Tritschler, D., Bower, R., Yan, S., Dai, A., Augspurger, K., Sakizadeh, J., Grzemska, M., Ni, T., Porter, M. E. & Nicastro, D., Nov 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 46, p. 23152-23162 11 p.

Research output: Contribution to journalArticle

Open Access