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Research Output 1977 2019

Article
35 Citations (Scopus)

A cytoplasmic dynein motor in Drosophila: Identification and localization during embryogenesis

Hays, T. S., Porter, M. E., McGrail, M., Grissom, P., Gosch, P., Fuller, M. T. & McIntosh, J. R., Jun 1 1994, In : Journal of cell science. 107, 6, p. 1557-1569 13 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Microtubules
Drosophila
Embryonic Development
Dyneins
82 Citations (Scopus)

A differential cargo-loading model of ciliary length regulation by IFT

Wren, K. N., Craft, J. M., Tritschler, D., Schauer, A., Patel, D. K., Smith, E. F., Porter, M. E., Kner, P. & Lechtreck, K. F., Dec 16 2013, In : Current Biology. 23, 24, p. 2463-2471 9 p.

Research output: Contribution to journalArticle

Cilia
cilia
Cells
Proteins
Protein Precursors
116 Citations (Scopus)

Alpha-actinin localization in the cleavage furrow during cytokinesis

Fujiwara, K., Porter, M. E. & Pollard, T. D., Oct 1 1978, In : Journal of Cell Biology. 79, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

Actinin
Cytokinesis
Staining and Labeling
Coloring Agents
Ventricular Myosins
24 Citations (Scopus)

A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii

Ikeda, K., Yamamoto, R., Wirschell, M., Yagi, T., Bower, R., Porter, M. E., Sale, W. S. & Kamiya, R., Aug 1 2009, In : Cell motility and the cytoskeleton. 66, 8, p. 448-456 9 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Chlamydomonas reinhardtii
Dyneins
Axoneme
Proteins
98 Citations (Scopus)

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in Chlamydomonas and mammalian cells

Perrone, C. A., Tritschler, D., Taulman, P., Bower, R., Yoder, B. K. & Porter, M. E., May 1 2003, In : Molecular biology of the cell. 14, 5, p. 2041-2056 16 p.

Research output: Contribution to journalArticle

Axoneme
Chlamydomonas
Dyneins
Flagella
Cytoplasmic Dyneins
140 Citations (Scopus)

Arrangement of inner dynein arms in wild-type and mutant flagella of Chlamydomonas

Mastronarde, D. N., O'Toole, E. T., McDonald, K. L., McIntosh, J. R. & Porter, M. E., Sep 1992, In : Journal of Cell Biology. 118, 5, p. 1145-1162 18 p.

Research output: Contribution to journalArticle

Axoneme
Chlamydomonas
Dyneins
Flagella
Genetic Suppression
84 Citations (Scopus)

A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product

Rupp, G. & Porter, M. E., Jul 7 2003, In : Journal of Cell Biology. 162, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Growth
Genes
10 Citations (Scopus)

A synchronized multicellular movement initiated by light and mediated by microfilaments

Woollacott, R. M. & Porter, M. E., Nov 1977, In : Developmental Biology. 61, 1, p. 41-57 17 p.

Research output: Contribution to journalArticle

Actin Cytoskeleton
Spermatozoa
Light
Epithelium
Ciona intestinalis
47 Citations (Scopus)

A unified taxonomy for ciliary dyneins

Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 1 2011, In : Cytoskeleton. 68, 10, p. 555-565 11 p.

Research output: Contribution to journalArticle

Dyneins
Chlamydomonas
Flagella
Terminology
Alleles
103 Citations (Scopus)

Axonemal dyneins: Assembly, organization, and regulation

Porter, M. E., Feb 1996, In : Current Opinion in Cell Biology. 8, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Axonemal Dyneins
Dyneins
Microtubules
Sequence Analysis
Mutation
22 Citations (Scopus)

bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In : Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

Research output: Contribution to journalArticle

Dyneins
Phosphoproteins
Mutation
Alleles
Axoneme
53 Citations (Scopus)

Building blocks of the nexin-dynein regulatory complex in chlamydomonas flagella

Lin, J., Tritschler, D., Song, K., Barber, C. F., Cobb, J. S., Porter, M. E. & Nicastro, D., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 29175-29191 17 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Flagella
Phosphorylation
Protein Isoforms
56 Citations (Scopus)

Characterization of a second myosin from Acanthamoeba castellanii

Pollard, T. D., Stafford, W. F. & Porter, M. E., Jan 1 1978, In : Journal of Biological Chemistry. 253, 13, p. 4798-4808 11 p.

Research output: Contribution to journalArticle

Physical Chemistry
Acanthamoeba castellanii
Amoeba
Myosins
Adenosine Triphosphatases
81 Citations (Scopus)

Characterization of the ATP-sensitive binding of Tetrahymena 30 S dynein to bovine brain microtubules.

Porter, M. E. & Johnson, K. A., May 25 1983, In : Journal of Biological Chemistry. 258, 10, p. 6575-6581 7 p.

Research output: Contribution to journalArticle

Tetrahymena
Dyneins
Microtubules
Brain
Adenosine Triphosphate
84 Citations (Scopus)

Characterization of the microtubule movement produced by sea urchin egg kinesin.

Porter, M. E., Scholey, J. M., Stemple, D. L., Vigers, G. P., Vale, R. D., Sheetz, M. P. & McIntosh, J. R., Feb 25 1987, In : Journal of Biological Chemistry. 262, 6, p. 2794-2802 9 p.

Research output: Contribution to journalArticle

Kinesin
Sea Urchins
Microtubules
Ovum
Adenosine Triphosphate
23 Citations (Scopus)

Ciliary motility: Regulation of axonemal dynein motors

Viswanadha, R., Sale, W. S. & Porter, M. E., Jan 1 2017, In : Cold Spring Harbor Perspectives in Biology. 9, 8, a018325.

Research output: Contribution to journalArticle

Axonemal Dyneins
Dyneins
Calmodulin
Microtubules
Health
135 Citations (Scopus)

Components of a 'dynein regulatory complex' are located at the junction between the radial spokes and the dynein arms in Chlamydomonas flagella

Gardner, L. C., O'Toole, E., Perrone, C. A., Giddings, T. & Porter, M. E., Dec 14 1994, In : Journal of Cell Biology. 127, 5, p. 1311-1325 15 p.

Research output: Contribution to journalArticle

Open Access
Chlamydomonas
Dyneins
Flagella
Axoneme
Protein Isoforms
13 Citations (Scopus)

Computer-Assisted Analysis of Flagellar Structure

O'Toole, E., Mastronarde, D., McIntosh, J. R. & Porter, M. E., Jan 1 1995, In : Methods in cell biology. 47, C, p. 183-191 9 p.

Research output: Contribution to journalArticle

Dyneins
Axoneme
Microtubules
Sperm Tail
Chlamydomonas
30 Citations (Scopus)

Computer-assisted image analysis of human cilia and chlamydomonas flagella reveals both similarities and differences in axoneme structure

O'Toole, E. T., Giddings, T. H., Porter, M. E. & Ostrowski, L. E., Aug 1 2012, In : Cytoskeleton. 69, 8, p. 577-590 14 p.

Research output: Contribution to journalArticle

Axoneme
Chlamydomonas
Computer-Assisted Image Processing
Flagella
Cilia
71 Citations (Scopus)

Cryo-electron tomography reveals conserved features of doublet microtubules in flagella

Nicastro, D., Fu, X., Heuser, T., Tso, A., Porter, M. E. & Linck, R. W., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. E845-E853

Research output: Contribution to journalArticle

Electron Microscope Tomography
Flagella
Tubulin
Microtubules
Axoneme
55 Citations (Scopus)

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein

Heuser, T., Barber, C. F., Lin, J., Krell, J., Rebesco, M., Porter, M. E. & Nicastro, D., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. E2067-E2076

Research output: Contribution to journalArticle

Dyneins
Tomography
Axoneme
Chlamydomonas
Flagella
244 Citations (Scopus)

Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas

Porter, M. E., Bower, R., Knott, J. A., Byrd, P. & Dentler, W., Mar 1999, In : Molecular biology of the cell. 10, 3, p. 693-712 20 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Chlamydomonas
Dyneins
Axoneme
Tetrahymena
342 Citations (Scopus)

Cytoplasmic dynein is localized to kinetochores during mitosis

Pfarr, C. M., Coue, M., Grissom, P. M., Hays, T. S., Porter, M. E. & McIntosh, J. R., Jan 1 1990, In : Nature. 345, 6272, p. 263-265 3 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Kinetochores
Dyneins
Mitosis
Microtubules
24 Citations (Scopus)

Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 of Chlamydomonas flagella

Toba, S., Fox, L. A., Sakakibara, H., Porter, M. E., Oiwa, K. & Sale, W. S., Feb 1 2011, In : Molecular biology of the cell. 22, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Flagella
Microtubules
Axoneme
51 Citations (Scopus)

Domains in the 1α dynein heavy chain required for inner arm assembly and flagellar motility in Chlamydomonas

Myster, S. H., Knott, J. A., Wysocki, K. M., O'Toole, E. & Porter, M. E., Aug 23 1999, In : Journal of Cell Biology. 146, 4, p. 801-818 18 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Transgenes
Amino Acid Sequence
79 Citations (Scopus)

Drosophila kinesin: characterization of microtubule motility and ATPase.

Saxton, W. M., Porter, M. E., Cohn, S. A., Scholey, J. M., Raff, E. C. & McIntosh, J. R., Feb 1988, In : Proceedings of the National Academy of Sciences of the United States of America. 85, 4, p. 1109-1113 5 p.

Research output: Contribution to journalArticle

Kinesin
Microtubules
Drosophila
Adenosine Triphosphatases
Adenosine Triphosphate
27 Citations (Scopus)

Dynamics of the IFT machinery at the ciliary tip

Chien, A., Shih, S. M., Bower, R., Tritschler, D., Porter, M. E. & Yildiz, A., Sep 20 2017, In : eLife. 6, e28606.

Research output: Contribution to journalArticle

Open Access
Flagella
Machinery
Chlamydomonas
Dyneins
Basal Bodies
16 Citations (Scopus)

Dynein isoforms in sea urchin eggs.

Porter, M. E., Grissom, P. M., Scholey, J. M., Salmon, E. D. & McIntosh, J. R., May 15 1988, In : The Journal of biological chemistry. 263, 14, p. 6759-6771 13 p.

Research output: Contribution to journalArticle

Dyneins
Sea Urchins
Eggs
Protein Isoforms
Vanadates
123 Citations (Scopus)

Extragenic suppressors of paralyzed flagellar mutations in Chlamydomonas reinhardtii identify loci that alter the inner dynein arms

Porter, M. E., Power, J. & Dutcher, S. K., Sep 1992, In : Journal of Cell Biology. 118, 5, p. 1163-1176 14 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Dyneins
Genetic Suppression
Mutation
Axoneme
1 Citation (Scopus)

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

Lin, J., Le, T. V., Augspurger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E. T., VanderWaal Mills, K., Dymek, E., Smith, E., Nicastro, D. & Porter, M. E., Oct 1 2019, In : Molecular biology of the cell. 30, 21, p. 2659-2680 22 p.

Research output: Contribution to journalArticle

Open Access
Dyneins
Cilia
Electron Microscope Tomography
Insertional Mutagenesis
Protein Subunits
44 Citations (Scopus)

IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility

Bower, R., VanderWaal, K., O'Toole, E., Fox, L., Perrone, C., Mueller, J., Wirschell, M., Kamiya, R., Sale, W. S. & Porter, M. E., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3055-3063 9 p.

Research output: Contribution to journalArticle

Dyneins
Microtubules
Axoneme
Phosphoproteins
Electron Microscopy
76 Citations (Scopus)

IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending

Hendrickson, T. W., Perrone, C. A., Griffin, P., Wuichet, K., Mueller, J., Yang, P., Porter, M. E. & Sale, W. S., Dec 1 2004, In : Molecular biology of the cell. 15, 12, p. 5431-5442 12 p.

Research output: Contribution to journalArticle

Dyneins
Phosphorylation
Axoneme
Aptitude
Point Mutation
41 Citations (Scopus)

IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding

Wirschell, M., Yang, C., Yang, P., Fox, L., Yanagisawa, H. A., Kamiya, R., Witman, G. B., Porter, M. E. & Sale, W. S., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

Dyneins
Tubulin
Axoneme
Microtubules
Chlamydomonas
136 Citations (Scopus)

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans

Lye, R. J., Porter, M. E., Scholey, J. M. & McIntosh, J. R., Oct 23 1987, In : Cell. 51, 2, p. 309-318 10 p.

Research output: Contribution to journalArticle

Vanadates
Microtubules
Kinesin
Adenosine Triphosphate
Dyneins
183 Citations (Scopus)

Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle

Scholey, J. M., Porter, M. E., Grissom, P. M. & McIntosh, J. R., Dec 1 1985, In : Nature. 318, 6045, p. 483-486 4 p.

Research output: Contribution to journalArticle

Kinesin
Spindle Apparatus
Sea Urchins
Microtubules
Eggs
67 Citations (Scopus)

Insights into the structural organization of the I1 inner arm dynein from a domain analysis of the 1β dynein heavy chain

Perrone, C. A., Myster, S. H., Bower, R., O'Toole, E. T. & Porter, M. E., Jul 2000, In : Molecular Biology of the Cell. 11, 7, p. 2297-2313 17 p.

Research output: Contribution to journalArticle

Dyneins
Axoneme
Insertional Mutagenesis
Plasmids
Electrons
21 Citations (Scopus)

In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography

Song, K., Awata, J., Tritschler, D., Bower, R., Witman, G. B., Porter, M. E. & Nicastro, D., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5341-5353 13 p.

Research output: Contribution to journalArticle

Electron Microscope Tomography
Dyneins
Tomography
Flagella
Electrons
15 Citations (Scopus)

Mechanism of force production for microtubule-dependent movements

Johnson, K. A., Porter, M. E. & Shimizu, T., Jan 1 1984, In : Journal of Cell Biology. 99, 1 II, p. 132S-136S

Research output: Contribution to journalArticle

Chlamydomonas
Tetrahymena
Dyneins
Molecular Models
Myosins
9 Citations (Scopus)

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease

Lewis, W. R., Malarkey, E. B., Tritschler, D., Bower, R., Pasek, R. C., Porath, J. D., Birket, S. E., Saunier, S., Antignac, C., Knowles, M. R., Leigh, M. W., Zariwala, M. A., Challa, A. K., Kesterson, R. A., Rowe, S. M., Drummond, I. A., Parant, J. M., Hildebrandt, F., Porter, M. E., Yoder, B. K. & 1 others, Berbari, N. F., Jul 2016, In : PLoS genetics. 12, 7, e1006220.

Research output: Contribution to journalArticle

Cilia
cilia
human diseases
defect
phenotype
85 Citations (Scopus)

Mutations in the SUP-PF-1 locus of Chlamydomonas reinhardtii identify a regulatory domain in the β-dynein heavy chain

Porter, M. E., Knott, J. A., Gardner, L. C., Mitchell, D. R. & Dutcher, S. K., Sep 1994, In : Journal of Cell Biology. 126, 6, p. 1495-1507 13 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Dyneins
Mutation
Alleles
Polymerase Chain Reaction
15 Citations (Scopus)

Non-cooperative response of actin-cystein 373 in cooperatively behaving regulated actin filaments

Porter, M. & Weber, A., Sep 15 1979, In : FEBS Letters. 105, 2, p. 259-262 4 p.

Research output: Contribution to journalArticle

Naphthalenesulfonates
Iodoacetamide
Ethylmaleimide
Dithiothreitol
Fluorescence Spectrometry
3 Citations (Scopus)

PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility

Dymek, E. E., Lin, J., Fu, G., Porter, M. E., Nicastro, D. & Smith, E. F., Jul 15 2019, In : Molecular biology of the cell. 30, 15, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Open Access
Microtubules
Dyneins
Electron Microscope Tomography
Beak
Axoneme
16 Citations (Scopus)

Reappraisal of the genetic map of Chlamydomonas reinhardtii

Dutcher, S. K., Power, J., Galloway, R. E. & Porter, M. E., Jan 1 1991, In : Journal of Heredity. 82, 4, p. 295-301 7 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Genetic Linkage
10 Citations (Scopus)

Recording and analyzing IFT in Chlamydomonas flagella.

Dentler, W., Vanderwaal, K. & Porter, M. E., 2009, In : Methods in cell biology. 93, p. 145-155 11 p.

Research output: Contribution to journalArticle

Chlamydomonas
Flagella
Cilia
Cytoplasmic Dyneins
Interference Microscopy

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

Gui, L., Song, K., Tritschler, D., Bower, R., Yan, S., Dai, A., Augspurger, K., Sakizadeh, J., Grzemska, M., Ni, T., Porter, M. E. & Nicastro, D., Nov 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 46, p. 23152-23162 11 p.

Research output: Contribution to journalArticle

Open Access
Chlamydomonas
Dyneins
Flagella
Electron Microscope Tomography
Cilia

Structural investigations of human cilia from normal and primary ciliary dyskinesia patients

O'Toole, E. T., Porter, M. E. & Ostrowski, L. E., Aug 1 2008, In : Microscopy and Microanalysis. 14, SUPPL. 2, p. 1476-1477 2 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

The Chlamydomonas Dhc1 gene encodes a dynein heavy chain subunit required for assembly of the I1 inner arm complex

Myster, S. H., Knott, J. A., O'Toole, E. & Porter, M. E., Apr 1997, In : Molecular biology of the cell. 8, 4, p. 607-620 14 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Genes
Protein Isoforms
Axoneme
75 Citations (Scopus)

The Chlamydomonas IDA7 locus encodes a 140-kDa dynein intermediate chain required to assemble the I1 inner arm complex

Perrone, C. A., Yang, P., O'Toole, E., Sale, W. S. & Porter, M. E., Dec 1998, In : Molecular biology of the cell. 9, 12, p. 3351-3365 15 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Genes
Protein Isoforms
59 Citations (Scopus)
Chlamydomonas
Proline
Alanine
Dyneins
Peptides
68 Citations (Scopus)

The dynein gene family in Chlamydomonas reinhardtii

Porter, M. E., Knott, J. A., Myster, S. H. & Farlow, S. J., Oct 9 1996, In : Genetics. 144, 2, p. 569-585 17 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Dyneins
Genes
Chlamydomonas
Clone Cells