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Research Output 1977 2019

2019
1 Citation (Scopus)

FAP57/WDR65 targets assembly of a subset of inner arm dyneins and connects to regulatory hubs in cilia

Lin, J., Le, T. V., Augspurger, K., Tritschler, D., Bower, R., Fu, G., Perrone, C., O'Toole, E. T., VanderWaal Mills, K., Dymek, E., Smith, E., Nicastro, D. & Porter, M. E., Oct 1 2019, In : Molecular biology of the cell. 30, 21, p. 2659-2680 22 p.

Research output: Contribution to journalArticle

Open Access
Dyneins
Cilia
Electron Microscope Tomography
Insertional Mutagenesis
Protein Subunits
3 Citations (Scopus)

PACRG and FAP20 form the inner junction of axonemal doublet microtubules and regulate ciliary motility

Dymek, E. E., Lin, J., Fu, G., Porter, M. E., Nicastro, D. & Smith, E. F., Jul 15 2019, In : Molecular biology of the cell. 30, 15, p. 1805-1816 12 p.

Research output: Contribution to journalArticle

Open Access
Microtubules
Dyneins
Electron Microscope Tomography
Beak
Axoneme

Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex

Gui, L., Song, K., Tritschler, D., Bower, R., Yan, S., Dai, A., Augspurger, K., Sakizadeh, J., Grzemska, M., Ni, T., Porter, M. E. & Nicastro, D., Nov 12 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 46, p. 23152-23162 11 p.

Research output: Contribution to journalArticle

Open Access
Chlamydomonas
Dyneins
Flagella
Electron Microscope Tomography
Cilia
2017
2 Citations (Scopus)

Ciliary and flagellar motility and the nexin-dynein regulatory complex

Porter, M. E., Nov 22 2017, Dyneins: The Biology of Dynein Motors: Second Edition. Elsevier Inc., p. 299-335 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dyneins
Axoneme
Microtubules
Electron Microscope Tomography
Genetic Suppression
20 Citations (Scopus)

Ciliary motility: Regulation of axonemal dynein motors

Viswanadha, R., Sale, W. S. & Porter, M. E., Jan 1 2017, In : Cold Spring Harbor Perspectives in Biology. 9, 8, a018325.

Research output: Contribution to journalArticle

Axonemal Dyneins
Dyneins
Calmodulin
Microtubules
Health
27 Citations (Scopus)

Dynamics of the IFT machinery at the ciliary tip

Chien, A., Shih, S. M., Bower, R., Tritschler, D., Porter, M. E. & Yildiz, A., Sep 20 2017, In : eLife. 6, e28606.

Research output: Contribution to journalArticle

Open Access
Flagella
Machinery
Chlamydomonas
Dyneins
Basal Bodies
2016
9 Citations (Scopus)

Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease

Lewis, W. R., Malarkey, E. B., Tritschler, D., Bower, R., Pasek, R. C., Porath, J. D., Birket, S. E., Saunier, S., Antignac, C., Knowles, M. R., Leigh, M. W., Zariwala, M. A., Challa, A. K., Kesterson, R. A., Rowe, S. M., Drummond, I. A., Parant, J. M., Hildebrandt, F., Porter, M. E., Yoder, B. K. & 1 others, Berbari, N. F., Jul 2016, In : PLoS genetics. 12, 7, e1006220.

Research output: Contribution to journalArticle

Cilia
cilia
human diseases
defect
phenotype
10 Citations (Scopus)

The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme

Alford, L. M., Stoddard, D., Li, J. H., Hunter, E. L., Tritschler, D., Bower, R., Nicastro, D., Porter, M. E. & Sale, W. S., Jun 1 2016, In : Cytoskeleton. 73, 7, p. 331-340 10 p.

Research output: Contribution to journalArticle

Axoneme
Adenosine Triphosphate
Tubulin
Microtubules
18 Citations (Scopus)

The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas

Reck, J., Schauer, A. M., Van Der Waal Mills, K., Bower, R., Tritschler, D., Perrone, C. A. & Porter, M. E., Aug 1 2016, In : Molecular biology of the cell. 27, 15, p. 2404-2422 19 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Flagella
Kinesin
Cilia
2015
20 Citations (Scopus)

In situ localization of N and C termini of subunits of the flagellar nexin-dynein regulatory complex (N-DRC) using SNAP tag and cryo-electron tomography

Song, K., Awata, J., Tritschler, D., Bower, R., Witman, G. B., Porter, M. E. & Nicastro, D., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5341-5353 13 p.

Research output: Contribution to journalArticle

Electron Microscope Tomography
Dyneins
Tomography
Flagella
Electrons
2014
66 Citations (Scopus)

The Chlamydomonas genome project: A decade on

Blaby, I. K., Blaby-Haas, C. E., Tourasse, N., Hom, E. F. Y., Lopez, D., Aksoy, M., Grossman, A., Umen, J., Dutcher, S., Porter, M., King, S., Witman, G. B., Stanke, M., Harris, E. H., Goodstein, D., Grimwood, J., Schmutz, J., Vallon, O., Merchant, S. S. & Prochnik, S., Oct 1 2014, In : Trends in Plant Science. 19, 10, p. 672-680 9 p.

Research output: Contribution to journalReview article

Chlamydomonas
genome
genomics
genes
genome assembly
2013
80 Citations (Scopus)

A differential cargo-loading model of ciliary length regulation by IFT

Wren, K. N., Craft, J. M., Tritschler, D., Schauer, A., Patel, D. K., Smith, E. F., Porter, M. E., Kner, P. & Lechtreck, K. F., Dec 16 2013, In : Current Biology. 23, 24, p. 2463-2471 9 p.

Research output: Contribution to journalArticle

Cilia
cilia
Cells
Proteins
Protein Precursors
55 Citations (Scopus)

The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes

Bower, R., Tritschler, D., VanderWaal, K., Perrone, C. A., Mueller, J., Fox, L., Sale, W. S. & Porter, M. E., Apr 15 2013, In : Molecular biology of the cell. 24, 8, p. 1134-1152 19 p.

Research output: Contribution to journalArticle

Axoneme
Dyneins
Microtubules
Adenosine Triphosphate
Calcium Signaling
107 Citations (Scopus)

The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans

Wirschell, M., Olbrich, H., Werner, C., Tritschler, D., Bower, R., Sale, W. S., Loges, N. T., Pennekamp, P., Lindberg, S., Stenram, U., Carlén, B., Horak, E., Köhler, G., Nürnberg, P., Nürnberg, G., Porter, M. E. & Omran, H., Mar 1 2013, In : Nature Genetics. 45, 3, p. 262-268 7 p.

Research output: Contribution to journalArticle

Dyneins
Cilia
Kartagener Syndrome
Mutation
Sperm Tail
87 Citations (Scopus)

Zebrafish ciliopathy screen plus human mutational analysis identifies C21orf59 and CCDC65 defects as causing primary ciliary dyskinesia

Austin-Tse, C., Halbritter, J., Zariwala, M. A., Gilberti, R. M., Gee, H. Y., Hellman, N., Pathak, N., Liu, Y., Panizzi, J. R., Patel-King, R. S., Tritschler, D., Bower, R., O'Toole, E., Porath, J. D., Hurd, T. W., Chaki, M., Diaz, K. A., Kohl, S., Lovric, S., Hwang, D. Y. & 23 others, Braun, D. A., Schueler, M., Airik, R., Otto, E. A., Leigh, M. W., Noone, P. G., Carson, J. L., Davis, S. D., Pittman, J. E., Ferkol, T. W., Atkinson, J. J., Olivier, K. N., Sagel, S. D., Dell, S. D., Rosenfeld, M., Milla, C. E., Loges, N. T., Omran, H., Porter, M. E., King, S. M., Knowles, M. R., Drummond, I. A. & Hildebrandt, F., Oct 3 2013, In : American Journal of Human Genetics. 93, 4, p. 672-686 15 p.

Research output: Contribution to journalArticle

Kartagener Syndrome
Cilia
Dyneins
Zebrafish
Chlamydomonas
2012
30 Citations (Scopus)

Computer-assisted image analysis of human cilia and chlamydomonas flagella reveals both similarities and differences in axoneme structure

O'Toole, E. T., Giddings, T. H., Porter, M. E. & Ostrowski, L. E., Aug 1 2012, In : Cytoskeleton. 69, 8, p. 577-590 14 p.

Research output: Contribution to journalArticle

Axoneme
Chlamydomonas
Computer-Assisted Image Processing
Flagella
Cilia
53 Citations (Scopus)

Cryoelectron tomography reveals doublet-specific structures and unique interactions in the I1 dynein

Heuser, T., Barber, C. F., Lin, J., Krell, J., Rebesco, M., Porter, M. E. & Nicastro, D., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. E2067-E2076

Research output: Contribution to journalArticle

Dyneins
Tomography
Axoneme
Chlamydomonas
Flagella
5 Citations (Scopus)

Flagellar motility and the dynein regulatory complex

Porter, M. E., Dec 1 2012, Dyneins. Elsevier Inc., p. 336-365 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dyneins
Microtubules
Genetic Suppression
Chlamydomonas
Flagella
2011
45 Citations (Scopus)

A unified taxonomy for ciliary dyneins

Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 1 2011, In : Cytoskeleton. 68, 10, p. 555-565 11 p.

Research output: Contribution to journalArticle

Dyneins
Chlamydomonas
Flagella
Terminology
Alleles
22 Citations (Scopus)

bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In : Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

Research output: Contribution to journalArticle

Dyneins
Phosphoproteins
Mutation
Alleles
Axoneme
52 Citations (Scopus)

Building blocks of the nexin-dynein regulatory complex in chlamydomonas flagella

Lin, J., Tritschler, D., Song, K., Barber, C. F., Cobb, J. S., Porter, M. E. & Nicastro, D., Aug 19 2011, In : Journal of Biological Chemistry. 286, 33, p. 29175-29191 17 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Flagella
Phosphorylation
Protein Isoforms
69 Citations (Scopus)

Cryo-electron tomography reveals conserved features of doublet microtubules in flagella

Nicastro, D., Fu, X., Heuser, T., Tso, A., Porter, M. E. & Linck, R. W., Oct 18 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. E845-E853

Research output: Contribution to journalArticle

Electron Microscope Tomography
Flagella
Tubulin
Microtubules
Axoneme
24 Citations (Scopus)

Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 of Chlamydomonas flagella

Toba, S., Fox, L. A., Sakakibara, H., Porter, M. E., Oiwa, K. & Sale, W. S., Feb 1 2011, In : Molecular biology of the cell. 22, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Flagella
Microtubules
Axoneme
2009
24 Citations (Scopus)

A novel ankyrin-repeat protein interacts with the regulatory proteins of inner arm dynein f (I1) of Chlamydomonas reinhardtii

Ikeda, K., Yamamoto, R., Wirschell, M., Yagi, T., Bower, R., Porter, M. E., Sale, W. S. & Kamiya, R., Aug 1 2009, In : Cell motility and the cytoskeleton. 66, 8, p. 448-456 9 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Chlamydomonas reinhardtii
Dyneins
Axoneme
Proteins
44 Citations (Scopus)

IC138 defines a subdomain at the base of the I1 dynein that regulates microtubule sliding and flagellar motility

Bower, R., VanderWaal, K., O'Toole, E., Fox, L., Perrone, C., Mueller, J., Wirschell, M., Kamiya, R., Sale, W. S. & Porter, M. E., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3055-3063 9 p.

Research output: Contribution to journalArticle

Dyneins
Microtubules
Axoneme
Phosphoproteins
Electron Microscopy
41 Citations (Scopus)

IC97 is a novel intermediate chain of I1 dynein that interacts with tubulin and regulates interdoublet sliding

Wirschell, M., Yang, C., Yang, P., Fox, L., Yanagisawa, H. A., Kamiya, R., Witman, G. B., Porter, M. E. & Sale, W. S., Jul 1 2009, In : Molecular biology of the cell. 20, 13, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

Dyneins
Tubulin
Axoneme
Microtubules
Chlamydomonas
10 Citations (Scopus)

Recording and analyzing IFT in Chlamydomonas flagella.

Dentler, W., Vanderwaal, K. & Porter, M. E., 2009, In : Methods in cell biology. 93, p. 145-155 11 p.

Research output: Contribution to journalArticle

Chlamydomonas
Flagella
Cilia
Cytoplasmic Dyneins
Interference Microscopy
193 Citations (Scopus)

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella

Heuser, T., Raytchev, M., Krell, J., Porter, M. E. & Nicastro, D., Dec 14 2009, In : Journal of Cell Biology. 187, 6, p. 921-933 13 p.

Research output: Contribution to journalArticle

Dyneins
Flagella
Cilia
Axoneme
Microtubules
12 Citations (Scopus)

The Regulation of Axonemal Bending

Wirschell, M., Nicastro, D., Porter, M. E. & Sale, W. S., Dec 1 2009, The Chlamydomonas Sourcebook 3-Vol set. Elsevier Inc., Vol. 3. p. 253-282 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dyneins
Chlamydomonas
microtubules
phosphotransferases (kinases)
proteins
2008

Structural investigations of human cilia from normal and primary ciliary dyskinesia patients

O'Toole, E. T., Porter, M. E. & Ostrowski, L. E., Aug 1 2008, In : Microscopy and Microanalysis. 14, SUPPL. 2, p. 1476-1477 2 p.

Research output: Contribution to journalArticle

2006
482 Citations (Scopus)

The molecular architecture of axonemes revealed by cryoelectron tomography

Nicastro, D., Schwartz, C., Pierson, J., Gaudette, R., Porter, M. E. & McIntosh, J. R., Aug 18 2006, In : Science. 313, 5789, p. 944-948 5 p.

Research output: Contribution to journalArticle

Axoneme
Dyneins
Microtubules
Tomography
Chlamydomonas
2005
138 Citations (Scopus)

Cytoplasmic dynein nomenclature

Kevin Pfister, K., Fisher, E. M. C., Gibbons, I. R., Hays, T. S., Holzbaur, E. L. F., Richard McIntosh, J., Porter, M. E., Schroer, T. A., Vaughan, K. T., Witman, G. B., King, S. M. & Vallee, R. B., Nov 7 2005, In : Journal of Cell Biology. 171, 3, p. 411-413 3 p.

Research output: Contribution to journalReview article

Cytoplasmic Dyneins
Terminology
Names
Genes
Protein Isoforms
70 Citations (Scopus)

The FLA3 KAP subunit is required for localization of kinesin-2 to the site of flagellar assembly and processive anterograde intraflagellar transport

Mueller, J., Perrone, C. A., Bower, R., Cole, D. G. & Porter, M. E., Mar 1 2005, In : Molecular biology of the cell. 16, 3, p. 1341-1354 14 p.

Research output: Contribution to journalArticle

Kinesin
Flagella
Basal Bodies
Chlamydomonas
Dacarbazine
2004
76 Citations (Scopus)

IC138 is a WD-repeat dynein intermediate chain required for light chain assembly and regulation of flagellar bending

Hendrickson, T. W., Perrone, C. A., Griffin, P., Wuichet, K., Mueller, J., Yang, P., Porter, M. E. & Sale, W. S., Dec 1 2004, In : Molecular biology of the cell. 15, 12, p. 5431-5442 12 p.

Research output: Contribution to journalArticle

Dyneins
Phosphorylation
Axoneme
Aptitude
Point Mutation
2003
98 Citations (Scopus)

A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in Chlamydomonas and mammalian cells

Perrone, C. A., Tritschler, D., Taulman, P., Bower, R., Yoder, B. K. & Porter, M. E., May 1 2003, In : Molecular biology of the cell. 14, 5, p. 2041-2056 16 p.

Research output: Contribution to journalArticle

Axoneme
Chlamydomonas
Dyneins
Flagella
Cytoplasmic Dyneins
84 Citations (Scopus)

A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product

Rupp, G. & Porter, M. E., Jul 7 2003, In : Journal of Cell Biology. 162, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Growth
Genes
2001
59 Citations (Scopus)
Chlamydomonas
Proline
Alanine
Dyneins
Peptides
2000
67 Citations (Scopus)

Insights into the structural organization of the I1 inner arm dynein from a domain analysis of the 1β dynein heavy chain

Perrone, C. A., Myster, S. H., Bower, R., O'Toole, E. T. & Porter, M. E., Jan 1 2000, In : Molecular Biology of the Cell. 11, 7, p. 2297-2313 17 p.

Research output: Contribution to journalArticle

Dyneins
Axoneme
Insertional Mutagenesis
Plasmids
Electrons
279 Citations (Scopus)

The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility

Porter, M. E. & Sale, W. S., Nov 27 2000, In : Journal of Cell Biology. 151, 5, p. F37-F42

Research output: Contribution to journalShort survey

Axoneme
Dyneins
Flagella
Locomotion
Phosphoric Monoester Hydrolases
34 Citations (Scopus)

The rib43a protein is associated with forming the specialized protofilament ribbons of flagellar microtubules in Chlamydomonas

Norrander, J. M., DeCathelineau, A. M., Brown, J. A., Porter, M. E. & Linck, R. W., Jan 2000, In : Molecular biology of the cell. 11, 1, p. 201-215 15 p.

Research output: Contribution to journalArticle

Chlamydomonas
Microtubules
Basal Bodies
Proteins
Flagella
1999
243 Citations (Scopus)

Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas

Porter, M. E., Bower, R., Knott, J. A., Byrd, P. & Dentler, W., Mar 1999, In : Molecular biology of the cell. 10, 3, p. 693-712 20 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Chlamydomonas
Dyneins
Axoneme
Tetrahymena
50 Citations (Scopus)

Domains in the 1α dynein heavy chain required for inner arm assembly and flagellar motility in Chlamydomonas

Myster, S. H., Knott, J. A., Wysocki, K. M., O'Toole, E. & Porter, M. E., Aug 23 1999, In : Journal of Cell Biology. 146, 4, p. 801-818 18 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Transgenes
Amino Acid Sequence
1998
75 Citations (Scopus)

The Chlamydomonas IDA7 locus encodes a 140-kDa dynein intermediate chain required to assemble the I1 inner arm complex

Perrone, C. A., Yang, P., O'Toole, E., Sale, W. S. & Porter, M. E., Dec 1998, In : Molecular biology of the cell. 9, 12, p. 3351-3365 15 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Axoneme
Genes
Protein Isoforms
1997
79 Citations (Scopus)

The Chlamydomonas Dhc1 gene encodes a dynein heavy chain subunit required for assembly of the I1 inner arm complex

Myster, S. H., Knott, J. A., O'Toole, E. & Porter, M. E., Apr 1997, In : Molecular biology of the cell. 8, 4, p. 607-620 14 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Genes
Protein Isoforms
Axoneme
1996
103 Citations (Scopus)

Axonemal dyneins: Assembly, organization, and regulation

Porter, M. E., Feb 1996, In : Current Opinion in Cell Biology. 8, 1, p. 10-17 8 p.

Research output: Contribution to journalArticle

Axonemal Dyneins
Dyneins
Microtubules
Sequence Analysis
Mutation
68 Citations (Scopus)

The dynein gene family in Chlamydomonas reinhardtii

Porter, M. E., Knott, J. A., Myster, S. H. & Farlow, S. J., Oct 9 1996, In : Genetics. 144, 2, p. 569-585 17 p.

Research output: Contribution to journalArticle

Chlamydomonas reinhardtii
Dyneins
Genes
Chlamydomonas
Clone Cells
63 Citations (Scopus)

The sup-pf-2 mutations of Chlamydomonas alter the activity of the outer dynein arms by modification of the γ-dynein heavy chain

Rupp, G., O'Toole, E., Gardner, L. C., Mitchell, B. F. & Porter, M. E., Dec 1 1996, In : Journal of Cell Biology. 135, 6 II, p. 1853-1865 13 p.

Research output: Contribution to journalArticle

Chlamydomonas
Dyneins
Mutation
Alleles
Genetic Complementation Test
1995
13 Citations (Scopus)

Computer-Assisted Analysis of Flagellar Structure

O'Toole, E., Mastronarde, D., McIntosh, J. R. & Porter, M. E., Jan 1 1995, In : Methods in cell biology. 47, C, p. 183-191 9 p.

Research output: Contribution to journalArticle

Dyneins
Axoneme
Microtubules
Sperm Tail
Chlamydomonas
1994
35 Citations (Scopus)

A cytoplasmic dynein motor in Drosophila: Identification and localization during embryogenesis

Hays, T. S., Porter, M. E., McGrail, M., Grissom, P., Gosch, P., Fuller, M. T. & McIntosh, J. R., Jun 1 1994, In : Journal of cell science. 107, 6, p. 1557-1569 13 p.

Research output: Contribution to journalArticle

Cytoplasmic Dyneins
Microtubules
Drosophila
Embryonic Development
Dyneins
135 Citations (Scopus)

Components of a 'dynein regulatory complex' are located at the junction between the radial spokes and the dynein arms in Chlamydomonas flagella

Gardner, L. C., O'Toole, E., Perrone, C. A., Giddings, T. & Porter, M. E., Dec 14 1994, In : Journal of Cell Biology. 127, 5, p. 1311-1325 15 p.

Research output: Contribution to journalArticle

Open Access
Chlamydomonas
Dyneins
Flagella
Axoneme
Protein Isoforms