If you made any changes in Pure, your changes will be visible here soon.

Research Output 1999 2019

2019

A Cell-Based Method for Identification of Chemotherapy Resistance Cancer Genes

Hellweg, R., Mooneyham, A. & Bazzaro, M., Jan 1 2019, In : Methods in Molecular Biology. 1907, p. 83-90 8 p.

Research output: Contribution to journalArticle

Neoplasm Genes
Drug Therapy
RNA Sequence Analysis
Cell Line
Neoplasms

Targeting mitochondria for treatment of chemoresistant ovarian cancer

Emmings, E., Mullany, S. A., Chang, Z., Landen, C. N., Linder, S. & Bazzaro, M., Jan 1 2019, In : International journal of molecular sciences. 20, 1, 229.

Research output: Contribution to journalReview article

Mitochondria
mitochondria
Ovarian Neoplasms
Tumors
cancer
2 Citations (Scopus)

UNC-45A is a novel microtubule-associated protein and regulator of paclitaxel sensitivity in ovarian cancer cells

Mooneyham, A., Iizuka, Y., Yang, Q., Coombes, C., McClellan, M., Shridhar, V., Emmings, E., Shetty, M., Chen, L., Ai, T., Meints, J., Lee, M. K., Gardner, M. K. & Bazzaro, M., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 370-383 14 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Paclitaxel
Ovarian Neoplasms
Spindle Apparatus
Microtubules
2018

Cellular and molecular networking within the ecosystem of cancer cell communication via tunneling nanotubes

Lou, E., Zhai, E., Sarkari, A., Desir, S., Wong, P., Iizuka, Y., Yang, J., Subramanian, S., McCarthy, J., Bazzaro, M. & Steer, C. J., Oct 2 2018, In : Frontiers in Cell and Developmental Biology. 6, OCT, 95.

Research output: Contribution to journalArticle

Nanotubes
Cell Communication
Ecosystem
Neoplasms
Interdisciplinary Studies
1 Citation (Scopus)

RNA Sequencing of Carboplatin- and Paclitaxel-Resistant Endometrial Cancer Cells Reveals New Stratification Markers and Molecular Targets for Cancer Treatment

Hellweg, R., Mooneyham, A., Chang, Z., Shetty, M., Emmings, E., Iizuka, Y., Clark, C., Starr, T., Abrahante - Llorens, J. E., Schütz, F., Konecny, G., Argenta, P. A. & Bazzaro, M., Oct 1 2018, In : Hormones and Cancer. 9, 5, p. 326-337 12 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Carboplatin
Endometrial Neoplasms
Paclitaxel
Neoplasms
2017
14 Citations (Scopus)

Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

Winterhoff, B. J., Maile, M., Mitra, A. K., Sebe, A., Bazzaro, M., Geller, M. A., Abrahante - Llorens, J. E., Klein, M. E., Hellweg, R., Mullany, S. A., Beckman, K. B., Daniel, J. & Starr, T., Mar 1 2017, In : Gynecologic oncology. 144, 3, p. 598-606 9 p.

Research output: Contribution to journalArticle

Open Access
Stromal Cells
Ovarian Neoplasms
Epithelium
Neoplastic Stem Cells
Neoplasms
2 Citations (Scopus)

Targeting deubiquitinating enzymes and autophagy in cancer

Mooneyham, A. & Bazzaro, M., Jan 1 2017, In : Methods in Molecular Biology. 1513, p. 49-59 11 p.

Research output: Contribution to journalArticle

Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Neoplasms
Proteolysis
3 Citations (Scopus)

UNC-45A is required for neurite extension via controlling NMII activation

Iizuka, Y., Mooneyham, A., Sieben, A., Chen, K., Maile, M., Hellweg, R., Schütz, F., Teckle, K., Starr, T., Thayanithy, V., Vogel, R. I., Lou, E., Lee, M. K. & Bazzaro, M., May 15 2017, In : Molecular Biology of the Cell. 28, 10, p. 1337-1346 10 p.

Research output: Contribution to journalArticle

Open Access
Growth Cones
Neurites
Neurons
Multiprotein Complexes
Myosins
2016
13 Citations (Scopus)

USP14 is a predictor of recurrence in endometrial cancer and a molecular target for endometrial cancer treatment

Vogel, R. I., Pulver, T., Heilmann, W., Mooneyham, A., Mullany, S., Zhao, X., Shahi, M., Richter, J., Klein, M., Chen, L., Ding, R., Konecny, G., Kommoss, S., Winterhoff, B., Ghebre, R. & Bazzaro, M., May 24 2016, In : Oncotarget. 7, 21, p. 30962-30976 15 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Recurrence
Neoplasms
Apoptosis
Therapeutics
2015
3 Citations (Scopus)

Measurement of deubiquitinating enzyme activity via a suicidal HA-UB-VS probe

Rivard, C. & Bazzaro, M., Jan 1 2015, In : Methods in Molecular Biology. 1249, p. 193-200 8 p.

Research output: Contribution to journalArticle

Enzyme Assays
Uterine Cervical Neoplasms
Cell Line
Pharmaceutical Preparations
Neoplasms

Method for measuring the activity of deubiquitinating enzymes in cell lines and tissue samples

Griffin, P., Sexton, A., Macneill, L., Iizuka, Y., Lee, M. K. & Bazzaro, M., May 10 2015, In : Journal of Visualized Experiments. 2015, 99, e52784.

Research output: Contribution to journalArticle

Enzymes
Cells
Tissue
Cell Line
Ubiquitin
25 Citations (Scopus)

Simultaneous inhibition of deubiquitinating enzymes (DUBs) and autophagy synergistically kills breast cancer cells

Vogel, R. I., Coughlin, K., Scotti, A., Iizuka, Y., Anchoori, R., Roden, R. B. S., Marastoni, M. & Bazzaro, M., Jan 1 2015, In : Oncotarget. 6, 6, p. 4159-4170 12 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Autophagy
Breast Neoplasms
Tumor Biomarkers
Progesterone Receptors
8 Citations (Scopus)

UNC-45A is a nonmuscle myosin IIA chaperone required for NK cell cytotoxicity via control of lytic granule secretion

Iizuka, Y., Cichocki, F. M., Sieben, A., Sforza, F., Karim, R., Coughlin, K., Vogel, R. I., Gavioli, R., Mc Cullar, V. J., Lenvik, T. R., Lee, M. K., Miller, J. S. & Bazzaro, M., Nov 15 2015, In : Journal of Immunology. 195, 10, p. 4760-4770 11 p.

Research output: Contribution to journalArticle

Nonmuscle Myosin Type IIA
Natural Killer Cells
Wiskott-Aldrich Syndrome Protein
Immunological Synapses
Actin Depolymerizing Factors
2014

Measurement of deubiquitinating enzyme activity via a suicidal HA-Ub-VS probe

Rivard, C. & Bazzaro, M., Oct 27 2014, Cervical Cancer: Methods and Protocols. Springer New York, p. 193-200 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Enzyme Assays
Uterine Cervical Neoplasms
Cell Line
Pharmaceutical Preparations
Neoplasms
4 Citations (Scopus)

Method for obtaining primary ovarian cancer cells from solid specimens

Pribyl, L. J., Coughlin, K. A., Sueblinvong, T., Shields, K., Iizuka, Y., Downs, L. S., Ghebre, R. G. & Bazzaro, M., Feb 4 2014, In : Journal of Visualized Experiments. 84, e51581.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Cells
Cell Line
Surgery
Suspensions
26 Citations (Scopus)

Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein Responses

Coughlin, K., Anchoori, R., Iizuka, Y., Meints, J., MacNeill, L., Vogel, R. I., Orlowski, R. Z., Lee, M. K., Roden, R. B. S. & Bazzaro, M., Jun 15 2014, In : Clinical Cancer Research. 20, 12, p. 3174-3186 13 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Proteasome Endopeptidase Complex
Ovarian Neoplasms
Proteasome Inhibitors
Cell Line
2012
13 Citations (Scopus)

Establishment, Characterization and Downstream Application of Primary Ovarian Cancer Cells Derived from Solid Tumors

Sueblinvong, T., Ghebre, R. G., Iizuka, Y., Pambuccian, S. E., Vogel, R. I., Skubitz, A. P. & Bazzaro, M., Nov 30 2012, In : PLoS One. 7, 11, e50519.

Research output: Contribution to journalArticle

ovarian neoplasms
Ovarian Neoplasms
Tumors
Cells
neoplasms
2011
28 Citations (Scopus)

Stressing the ubiquitin-proteasome system without 20s proteolytic inhibition Selectively Kills cervical cancer cells

Anchoori, R. K., Khan, S. R., Sueblinvong, T., Felthauser, A., Iizuka, Y., Gavioli, R., Destro, F., Vogel, R. I., Peng, S., Roden, R. B. S. & Bazzaro, M., Sep 7 2011, In : PloS one. 6, 8, e23888.

Research output: Contribution to journalArticle

uterine cervical neoplasms
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
ubiquitin
Ubiquitin
50 Citations (Scopus)

α,β-unsaturated carbonyl system of chalcone-based derivatives is responsible for broad inhibition of proteasomal activity and preferential killing of human papilloma virus (HPV) positive cervical cancer cells

Bazzaro, M., Anchoori, R. K., Mudiam, M. K. R., Issaenko, O., Kumar, S., Karanam, B., Lin, Z., Vogel, R. I., Gavioli, R., Destro, F., Ferretti, V., Roden, R. B. S. & Khan, S. R., Jan 27 2011, In : Journal of Medicinal Chemistry. 54, 2, p. 449-456 8 p.

Research output: Contribution to journalArticle

Papillomaviridae
Chalcone
Proteasome Inhibitors
Uterine Cervical Neoplasms
Piperidones
2009
79 Citations (Scopus)

Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment

Lin, Z., Bazzaro, M., Wang, M. C., Chan, K. C., Peng, S. & Roden, R. B. S., Jan 15 2009, In : Clinical Cancer Research. 15, 2, p. 570-577 8 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Proteasome Endopeptidase Complex
Uterine Cervical Neoplasms
trichostatin A
Oncogene Proteins
2008
81 Citations (Scopus)

Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor

Bazzaro, M., Lin, Z., Santillan, A., Lee, M. K., Wang, M. C., Chan, K. C., Bristow, R. E., Mazitschek, R., Bradner, J. & Roden, R. B. S., Nov 15 2008, In : Clinical Cancer Research. 14, 22, p. 7340-7347 8 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Histone Deacetylases
Proteasome Endopeptidase Complex
Ubiquitin
Ovarian Neoplasms
2007
24 Citations (Scopus)

Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility

Bazzaro, M., Santillan, A., Lin, Z., Tang, T., Lee, M. K., Bristow, R. E., Shih, I. M. & Roden, R. B. S., Jan 1 2007, In : American Journal of Pathology. 171, 5, p. 1640-1649 10 p.

Research output: Contribution to journalArticle

Myosin Type II
Ovarian Neoplasms
Carcinoma
Cell Proliferation
Cystadenoma
2006
97 Citations (Scopus)

Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Bazzaro, M., Lee, M. K., Zoso, A., Stirling, W. L. H., Santillan, A., Shih, I. M. & Roden, R. B. S., Apr 1 2006, In : Cancer Research. 66, 7, p. 3754-3763 10 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Proteasome Endopeptidase Complex
Ubiquitin
Ovarian Neoplasms
Apoptosis
2003
4 Citations (Scopus)

Synthesis and activity of N-Benzyl pseudopeptides HIV protease inhibitors

Marastoni, M., Bazzaro, M., Bortolotti, F. & Tomatis, R., May 29 2003, In : Bioorganic and Medicinal Chemistry. 11, 11, p. 2477-2483 7 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Cell culture
Cell Culture Techniques
Pharmacokinetics
Enzymes
2002
5 Citations (Scopus)

Cytotoxic T lymphocyte epitope analogues containing cis- or trans-4-aminocyclohexanecarboxylic acid residues

Marastoni, M., Bazzaro, M., Micheletti, F., Gavioli, R. & Tomatis, R., Jul 23 2002, In : Bioorganic and Medicinal Chemistry. 10, 9, p. 3061-3066 6 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-Lymphocyte Epitopes
Cytotoxic T-Lymphocytes
Epitopes
Dipeptides
61 Citations (Scopus)

Effect of interferon-α therapy on epitope-specific cytotoxic T lymphocyte responses in hepatitis C virus-infected individuals

Vertuani, S., Bazzaro, M., Gualandi, G., Micheletti, F., Marastoni, M., Fortini, C., Canella, A., Marino, M., Tomatis, R., Traniello, S. & Gavioli, R., Feb 5 2002, In : European Journal of Immunology. 32, 1, p. 144-154 11 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Hepacivirus
Interferons
Epitopes
Antigens
43 Citations (Scopus)

Identification of cytotoxic T lymphocyte epitopes of human herpesvirus 8

Micheletti, F., Monini, P., Fortini, C., Rimessi, P., Bazzaro, M., Andreoni, M., Giuliani, M., Traniello, S., Ensoli, B. & Gavioli, R., Jul 20 2002, In : Immunology. 106, 3, p. 395-403 9 p.

Research output: Contribution to journalArticle

Human Herpesvirus 8
T-Lymphocyte Epitopes
Cytotoxic T-Lymphocytes
Epitopes
HLA Antigens
2001
16 Citations (Scopus)

HIV-1 protease inhibitors containing an N-Hydroxyamino acid core structure

Marastoni, M., Bazzaro, M., Salvadori, S., Bortolotti, F. & Tomatis, R., Apr 1 2001, In : Bioorganic and Medicinal Chemistry. 9, 4, p. 939-945 7 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Protease Inhibitors
Cell culture
Cell Culture Techniques
Viruses
8 Citations (Scopus)

Peptide analogues of a subdominant epitope expressed in EBV-associated tumors: Synthesis and immunological activity

Marastoni, M., Bazzaro, M., Micheletti, F., Gavioli, R. & Tomatis, R., Jul 5 2001, In : Journal of Medicinal Chemistry. 44, 14, p. 2370-2373 4 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Tumors
Epitopes
HLA-A2 Antigen
Peptides
2000
4 Citations (Scopus)

Design of dimeric peptides obtained from a subdominant Epstein-Barr virus LMP2-derived epitope

Marastoni, M., Bazzaro, M., Gavioli, R., Micheletti, F., Traniello, S. & Tomatis, R., Jan 1 2000, In : European Journal of Medicinal Chemistry. 35, 6, p. 593-598 6 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
T-cells
Cytotoxic T-Lymphocytes
Human Herpesvirus 4
Viruses
4 Citations (Scopus)

Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors

Marastoni, M., Bazzaro, M., Bortolotti, F. & Tomatis, R., Jul 11 2000, In : Arzneimittel-Forschung/Drug Research. 50, 6, p. 564-568 5 p.

Research output: Contribution to journalArticle

HIV Protease Inhibitors
Protease Inhibitors
Inhibitory Concentration 50
Peptide Hydrolases
HIV
1999
23 Citations (Scopus)

Selective amino acid substitutions of a subdominant Epstein-Barr virus LMP2-derived epitope increase HLA/peptide complex stability and immunogenicity: Implications for immunotherapy of Epstein-Barr virus-associated malignancies

Micheletti, F., Guerrini, R., Formentin, A., Canella, A., Marastoni, M., Bazzaro, M., Tomatis, R., Traniello, S. & Gavioli, R., Aug 20 1999, In : European Journal of Immunology. 29, 8, p. 2579-2589 11 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Amino Acid Substitution
Human Herpesvirus 4
Immunotherapy
Epitopes
6 Citations (Scopus)

Symmetry-based inhibitors of HIV-1 protease. Design, synthesis and preliminary structure-activity studies of acylated 2,3-diamino-1- hydroxypropanes and 2,4 diamino-1-hydroxybutanes

Marastoni, M., Bazzaro, M., Bortolotti, F., Salvadori, S. & Tomatis, R., Jan 1 1999, In : European Journal of Medicinal Chemistry. 34, 7-8, p. 651-657 7 p.

Research output: Contribution to journalArticle

Butanols
Cell culture
Inhibitory Concentration 50
Cell Culture Techniques
Peptidomimetics
15 Citations (Scopus)

The lifespan of major histocompatibility complex class I/peptide complexes determines the efficiency of cytotoxic T-lymphocyte responses

Micheletti, F., Bazzaro, M., Canella, A., Marastoni, M., Traniello, S. & Gavioli, R., Mar 17 1999, In : Immunology. 96, 3, p. 411-415 5 p.

Research output: Contribution to journalArticle

Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
HLA-A11 Antigen
Efficiency
Peptides