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Research Output 1997 2019

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2019

BAY 94-9027 prophylaxis is efficacious and well tolerated for up to >5 years with extended dosing intervals: PROTECT VIII extension interim results

Lalezari, S., Reding, M. T., Pabinger, I., Holme, P. A., Negrier, C., Chalasani, P., Shin, H. J., Wang, M., Tseneklidou-Stoeter, D. & Maas Enriquez, M., Nov 1 2019, In : Haemophilia. 25, 6, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

Open Access
Factor VIII
Hemorrhage
Hemophilia A
Therapeutics
BAY 94-9027
von Willebrand Factor
B-Cell Chronic Lymphocytic Leukemia
Stem Cells
Transplants
Antibodies

Safety and efficacy of BAY 94-9027, an extended-half-life factor VIII, during surgery in patients with severe hemophilia A: Results of the PROTECT VIII clinical trial

Santagostino, E., Lalezari, S., Reding, M. T., Ducore, J., Ng, H. J., Poulsen, L. H., Michaels, L. A. & Linardi, C. C. G., Nov 2019, In : Thrombosis Research. 183, p. 13-19 7 p.

Research output: Contribution to journalArticle

Open Access
Factor VIII
Hemophilia A
Half-Life
Clinical Trials
Safety
2018
1 Citation (Scopus)

Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation

Hegerova, L., Bachan, A., Cao, Q., Vu, H. X., Rogosheske, J., Reding, M. T., Brunstein, C. G., Arora, M., Ustun, C., Vercellotti, G. M. & Bachanova, V., Dec 2018, In : Biology of Blood and Marrow Transplantation. 24, 12, p. e20-e25

Research output: Contribution to journalArticle

Stem Cell Transplantation
Lymphoma
Thrombosis
Catheters
Cell Transplantation
2017
21 Citations (Scopus)

Effect of late prophylaxis in hemophilia on joint status: a randomized trial

Manco-Johnson, M. J., Lundin, B., Funk, S., Peterfy, C., Raunig, D., Werk, M., Kempton, C. L., Reding, M. T., Goranov, S., Gercheva, L., Rusen, L., Uscatescu, V., Pierdominici, M., Engelen, S., Pocoski, J., Walker, D. & Hong, W., Nov 2017, In : Journal of Thrombosis and Haemostasis. 15, 11, p. 2115-2124 10 p.

Research output: Contribution to journalArticle

Hemophilia A
Joint Diseases
Joints
Hemorrhage
Least-Squares Analysis
9 Citations (Scopus)

Efficacy and safety of a VWF/FVIII concentrate (wilate®) in inherited von Willebrand disease patients undergoing surgical procedures

Srivastava, A., Serban, M., Werner, S., Schwartz, B. A., Kessler, C. M., Alkindi, S., Apte, S. J., Castaman, G., Gill, J. C., Hellmann, A., Kavakli, K., Kouides, P. A., Kuriakose, P., Lissitchkov, T., Ma, A., Mahlangu, J., Morfini, M., Neufeld, E. J., Peyvandi, F., Reding, M. & 8 others, Rodriguez, N. I., Ross, C., Rusen, L., Shapiro, A., Uscatescu, V., Windyga, J., Zulfikar, B. & the Wonders Study Investigators, Mar 1 2017, In : Haemophilia. 23, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

von Willebrand Diseases
Type 3 Von Willebrand's Disease
Safety
Hemorrhage
Clinical Trials Data Monitoring Committees
34 Citations (Scopus)

Safety and efficacy of BAY 94-9027, a prolonged-half-life factor VIII

Reding, M. T., Ng, H. J., Poulsen, L. H., Eyster, M. E., Pabinger, I., Shin, H. J., Walsch, R., Lederman, M., Wang, M., Hardtke, M. & Michaels, L. A., Mar 1 2017, In : Journal of Thrombosis and Haemostasis. 15, 3, p. 411-419 9 p.

Research output: Contribution to journalArticle

Factor VIII
Half-Life
Safety
Random Allocation
Hemorrhage
2015
31 Citations (Scopus)

Anti-Factor Xa and Activated Partial Thromboplastin Time Measurements for Heparin Monitoring in Mechanical Circulatory Support

Adatya, S. N., Uriel, N., Yarmohammadi, H., Holley, C. T., Feng, A., Roy, S. S., Reding, M. T., John, R., Eckman, P. M. & Zantek, N. D., Apr 1 2015, In : JACC: Heart Failure. 3, 4, p. 314-322 9 p.

Research output: Contribution to journalArticle

Factor Xa
Partial Thromboplastin Time
Heparin
Heart-Assist Devices
Hemolysis
27 Citations (Scopus)

Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: Risk factors, graft source and survival

Lunde, L. E., Dasaraju, S., Cao, Q., Cohn, C. S., Reding, M., Bejanyan, N., Trottier, B., Rogosheske, J., Brunstein, C., Warlick, E., Young, J. A. H., Weisdorf, D. J. & Ustun, C., Nov 1 2015, In : Bone marrow transplantation. 50, 11, p. 1432-1437 6 p.

Research output: Contribution to journalArticle

Cystitis
Cell Transplantation
Graft Survival
Fetal Blood
Transplants
2014

Improving the management of severe hemophilia

Reding, M. T., 2014, In : Journal of Managed Care Medicine. 17, 1, p. 47-51 5 p.

Research output: Contribution to journalArticle

Hemophilia A
Blood Coagulation Factors
6 Citations (Scopus)
Factor X
International Normalized Ratio
Prothrombin Time
Prothrombin
Warfarin
82 Citations (Scopus)

Phase I study of BAY 94-9027, a PEGylated B-domain-deleted recombinant factor VIII with an extended half-life, in subjects with hemophilia A

Coyle, T. E., Reding, M. T., Lin, J. C., Michaels, L. A., Shah, A. & Powell, J., Apr 2014, In : Journal of Thrombosis and Haemostasis. 12, 4, p. 488-496 9 p.

Research output: Contribution to journalArticle

Hemophilia A
Half-Life
Factor VIII
Pharmacokinetics
Ethylene Glycol
2013
7 Citations (Scopus)

Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors

Valentino, L. A., Allen, G., Gill, J. C., Hurlet, A., Konkle, B. A., Leissinger, C. A., Luchtman-Jones, L., Powell, J., Reding, M. & Stine, K., May 1 2013, In : Haemophilia. 19, 3, p. e151-e166

Research output: Contribution to journalArticle

Organizational Case Studies
Hemophilia A
Hemorrhage
Extremities
Guidelines
119 Citations (Scopus)

Randomized, controlled, parallel-group trial of routine prophylaxis vs. on-demand treatment with sucrose-formulated recombinant factor VIII in adults with severe hemophilia A (SPINART)

Manco-Johnson, M. J., Kempton, C. L., Reding, M. T., Lissitchkov, T., Goranov, S., Gercheva, L., Rusen, L., Ghinea, M., Uscatescu, V., Rescia, V. & Hong, W., Jun 1 2013, In : Journal of Thrombosis and Haemostasis. 11, 6, p. 1119-1127 9 p.

Research output: Contribution to journalArticle

Sucrose
Hemorrhage
Therapeutics
Controlled Clinical Trials
Statistical Models
2012
11 Citations (Scopus)
Partial Thromboplastin Time
Hemorrhage
Physicians
Emergency Medicine
Blood Cell Count
7 Citations (Scopus)

Patient- and caregiver-reported bleeding symptoms and reasons for starting and stopping treatment with recombinant factor VIIa: Analysis of the Dosing Observational Study in Haemophilia (DOSE)

Valentino, L. A., Walsh, C. E., Reding, M. T., Young, G. A., Levendoglu-Tugal, O. & Cooper, D. L., Jul 1 2012, In : Haemophilia. 18, 4, p. 554-560 7 p.

Research output: Contribution to journalArticle

Hemophilia A
Caregivers
Statistical Factor Analysis
Observational Studies
Hemorrhage
2009
21 Citations (Scopus)

Bleeding symptoms and laboratory correlation in patients with severe von Willebrand disease

Metjian, A. D., Wang, C., Sood, S. L., Cuker, A., Peterson, S. M., Soucie, J. M., Konkle, B. A., Boyd, M., Roy, G., Forman, E., Marandola, J., Homans, A. C., Granat, M., Lusher, J., Fleming, P., DiMichele, D., Goldberg, I., Saidi, P., Schwartz, R., Desposito, F. & 142 others, Joseph, D., Kouides, P. A., La Franco, J., Coyle, T., Dhar, N., Porter, J., Frank, M., Lipton, R., Bosch, M., Holmberg, R. P., Menza, L., Cohen, A., White, E., Guerrera, M., Guelcher, C., Kessler, C., Jacobs, H., Massey, G., Nolte, M., Werner, E., Stewart, K., Ragni, M., Jaworski, K., Rogers, J. S., Webber, S., Jubelirer, S., Arden, D., Casella, J., Underland, T., Panckeri, K., Palumbo, L., Sabio, H., Smith, A., Sharma, V., Ashby, P., Radulescu, V., Hanna, W., Zimmerman, C., Neff, A., Hudson, M. G., Reiss, U., Grant, R., Key, N., Nielsen, B., Dunn, A., Gutting, K., Watts, R., Noa, M. C., Abshire, T., Bryant, C., Ameri, A., Crenshaw, V., Kuriakose, P., Lambing, A., Heggie, G., Kovats-Bell, S., Inoue, S., Ruff, J. A., Mitchell, D., Sandon-Kleiboer, E., Kraut, E., Witkoff, L., Gruppo, R., Chambers, A., Kerlin, B., Lupia, C., French, J., Hibner, S., Shapiro, A., May, S., Alexander, S., Hopewell, S., Bockenstedt, P., Pipe, S., Mathis, D., Zakarija, A., Harris, S., Thompson, A., Allen, G. A., Brummel, A. T., Tarantino, M., Riedel, A., Reding, M., Curoe, S., Pruthi, R., Schmidt, K., Kralovetz, K., Charles, J., Diamond, C., Drozdowicz, P., Gill, J. C., Haar, J., Hoots, W. K., Gonzalez, V., Leissinger, C., Schmidt, C. V., Stine, K., Eckert, G., Sexauer, C., Kiplinger, F., Amerson, P., Johnson, E., Buchanan, G., Torres, R., DiPaola, J., Lammer, M., Wicklund, B., Nelson, D., Haire, W. D., Hanlon, E., Manco-Johnson, M., Geraghty, S., Yaish, H., Green, J., Young, G., McGinty, K., Herbst, K., Glass, C., Glader, B., Zoland, J. M., Medeiros, D., Omatsu, D. A., Ducore, J., Herr, M., Koerper, M., Karp, S., Lovejoy, A. E., Farrow, K., Ewing, N., Pullens, L., Meadows, L., Tackney, A., Mignacca, R., Patterson, F., Bernstein, J., Berkowitz, B., Thompson, A. R., Brower, C., Recht, M., Granger, K., Schulz, L. & Stewart, A., Jul 10 2009, In : Haemophilia. 15, 4, p. 918-925 8 p.

Research output: Contribution to journalArticle

von Willebrand Diseases
Hemorrhage
von Willebrand Factor
Joints
Type 3 Von Willebrand's Disease
72 Citations (Scopus)

Nanocapsule-delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice

Kren, B. T., Unger, G. M., Sjeklocha, L., Trossen, A. A., Korman, V., Diethelm-Okita, B. M., Reding, M. T. & Steer, C. J., Jul 1 2009, In : Journal of Clinical Investigation. 119, 7, p. 2086-2099 14 p.

Research output: Contribution to journalArticle

Nanocapsules
Beauty
Factor VIII
Hemophilia A
Endothelial Cells
2006
46 Citations (Scopus)

Immunological aspects of inhibitor development

Reding, M. T., Dec 1 2006, In : Haemophilia. 12, SUPPL. 6, p. 30-36 7 p.

Research output: Contribution to journalArticle

Factor VIII
Immune Tolerance
Hemophilia A
Blood Coagulation Factors
T-Lymphocyte Subsets
65 Citations (Scopus)

Inhibitor treatment in haemophilias A and B: Summary statement for the 2006 international consensus conference

Berntorp, E., Shapiro, A., Astermark, J., Blanchette, V. S., Collins, P. W., Dimichele, D., Escuriola, C., Hay, C. R. M., Hoots, W. K., Leissinger, C. A., Negrier, C., Oldenburg, J., Peerlinck, K., Reding, M. T. & Hart, C., Dec 1 2006, In : Haemophilia. 12, SUPPL. 6, p. 1-7 7 p.

Research output: Contribution to journalArticle

Immune Tolerance
International Cooperation
Joint Diseases
Hemophilia A
Therapeutics
2004
46 Citations (Scopus)

Epitope repertoire of human CD4+ T cells on the A3 domain of coagulation factor VIII

Reding, M. T., Okita, D. K., Diethelm-Okita, B. M., Anderson, T. A. & Conti-Fine, B. M., Aug 1 2004, In : Journal of Thrombosis and Haemostasis. 2, 8, p. 1385-1394 10 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Epitopes
T-Lymphocytes
Healthy Volunteers
21 Citations (Scopus)

Successful liver transplantation in a patient with severe haemophilia A and a high-titre factor VIII inhibitor

Ashrani, A. A., Reding, M. T., Shet, A., Osip, J., Humar, A., Lake, J. R. & Key, N. S., Nov 1 2004, In : Haemophilia. 10, 6, p. 735-737 3 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Liver Transplantation
Immune Tolerance
Hepatocellular Carcinoma
2003
80 Citations (Scopus)

Human CD4+ T-cell epitope repertoire on the C2 domain of coagulation factor VIII

Reding, M. T., Okita, D. K., Dlethelaa-Okita, B. M., Anderson, T. A. & Conti-Fine, B. M., Aug 1 2003, In : Journal of Thrombosis and Haemostasis. 1, 8, p. 1777-1784 8 p.

Research output: Contribution to journalArticle

T-Lymphocyte Epitopes
Factor VIII
Hemophilia A
Peptides
T-Lymphocytes
2002
90 Citations (Scopus)

Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients

Reding, M. T., Lei, S., Lei, H., Green, D., Gill, J. & Conti-Fine, B. M., Oct 1 2002, In : Thrombosis and Haemostasis. 88, 4, p. 568-575 8 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Immunoglobulin G
Th1 Cells
Antibodies
3 Citations (Scopus)

Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia

Ashrani, A. A., Reding, M. T., Greeno, E. W., Shet, A. & Key, N. S., Apr 9 2002, In : Haemophilia. 8, 1, p. 56-58 3 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Swine
Stroke
Middle Cerebral Artery Infarction
2001
16 Citations (Scopus)

CD4+ T cells specific for factor VIII as a target for specific suppression of inhibitor production

Reding, M. T., Wu, H., Krampf, M., Okita, D. K., Diethelm-Okita, B. M., Key, N. S. & Conti-Fine, B. M., May 7 2001, In : Advances in experimental medicine and biology. 489, p. 119-134 16 p.

Research output: Contribution to journalArticle

TCF Transcription Factors
T-cells
Factor VIII
Hemophilia A
Testing
67 Citations (Scopus)

Mechanism of the immune response to human factor VIII in murine hemophilia A

Wu, H., Reding, M. T., Qian, J., Okita, D. K., Parker, E., Lollar, P., Hoyer, L. W. & Conti-Fine, B. M., Jan 25 2001, In : Thrombosis and Haemostasis. 85, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

Hemophilia A
Th2 Cells
Th1 Cells
Immunoglobulin G
Factor VIII
2000
65 Citations (Scopus)

Sensitization of CD4+ T cells to coagulation factor VIII: Response in congenital and acquired hemophilia patients and in healthy subjects

Reding, M. T., Wu, H., Krampf, M., Okita, D. K., Diethelm-Okita, B. M., Christie, B. A., Key, N. S. & Conti-Fine, B. M., Jan 1 2000, In : Thrombosis and Haemostasis. 84, 4, p. 643-652 10 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Healthy Volunteers
T-Lymphocytes
Antibodies
1999
47 Citations (Scopus)

CD4+ T cell response to factor VIII in hemophilia A, acquired hemophilia, and healthy subjects

Reding, M. T., Wu, H., Krampf, M., Okita, D. K., Diethelm-Okita, B. M., Key, N. S. & Conti-Fine, B. M., Dec 8 1999, In : Thrombosis and Haemostasis. 82, 2, p. 509-515 7 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Healthy Volunteers
T-Lymphocytes
Epitopes
1998
26 Citations (Scopus)

Diagnosis and outcome of 100 consecutive patients with extreme granulocytic leukocytosis

Reding, M. T., Hibbs, J. R., Morrison, V. A., Swaim, W. R. & Filice, G. A., Jan 1 1998, In : American Journal of Medicine. 104, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

Leukocytosis
Infection
Leukocyte Count
Granulocytes
Fever
1997
6 Citations (Scopus)

Toxoplasma gondii: Metabolism of intracellular tachyzoites is affected by host cell ATP production

Sorensen, S. W., Billington, C. J., Norris, S. A., Briggs, J. E., Reding, M. T. & Filice, G. A., Jan 1997, In : Experimental Parasitology. 85, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle