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Research Output 1989 2019

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2019

Gemcitabine and metabolite pharmacokinetics in advanced NSCLC patients after bronchial artery infusion and intravenous infusion

Alharbi, A. F., Kratzke, R. A., D’Cunha, J., Maddaus, M. A., Sanghavi, K. & Kirstein, M. N., Feb 5 2019, In : Cancer chemotherapy and pharmacology. 83, 2, p. 387-391 5 p.

Research output: Contribution to journalArticle

gemcitabine
Bronchial Arteries
Pharmacokinetics
Metabolites
Intravenous Infusions
2018
3 Citations (Scopus)

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

Isakson, S. H., Rizzardi, A. E., Coutts, A. W., Carlson, D. F., Kirstein, M. N., Fisher, J., Vitte, J., Williams, K. B., Pluhar, L., Dahiya, S., Widemann, B. C., Dombi, E., Rizvi, T., Ratner, N., Messiaen, L., Stemmer-Rachamimov, A. O., Fahrenkrug, S. C., Gutmann, D. H., Giovannini, M., Moertel, C. L. & 2 others, Largaespada, D. A. & Watson, A. L., Dec 1 2018, In : Communications Biology. 1, 1, 158.

Research output: Contribution to journalArticle

Open Access
Miniature Swine
Neurofibromatosis 1
mitogen-activated protein kinase
Neurofibromin 1
genetic disorders
2016
7 Citations (Scopus)

Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning

Sanghavi, K. J., Wiseman, A., Kirstein, M. N., Cao, Q., Brundage, R., Jensen, K., Rogosheske, J., Kurtzweil, A., Long-Boyle, J., Wagner, J. E., Warlick, E. D., Brunstein, C. G., Weisdorf, D. J. & Jacobson, P. A., Sep 1 2016, In : Translational Research. 175, p. 103-115.e4

Research output: Contribution to journalArticle

Transplants
Hematopoietic Stem Cells
Stem cells
Mortality
Cell Transplantation
2 Citations (Scopus)
Brain Natriuretic Peptide
Doxorubicin
Breast Neoplasms
Troponin
Enalapril
15 Citations (Scopus)

Randomized, blinded trial of vitamin D 3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Shapiro, A. C., Adlis, S. A., Robien, K., Kirstein, M. N., Liang, S., Richter, S. A. & Lerner, R. E., Feb 1 2016, In : Breast Cancer Research and Treatment. 155, 3, p. 501-512 12 p.

Research output: Contribution to journalArticle

letrozole
Aromatase Inhibitors
Cholecalciferol
Pharmacokinetics
Hormones
2014
12 Citations (Scopus)

SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours

Khatri, A., Williams, B. W., Fisher, J., Brundage, R., Gurvich, V. J., Lis, L. G., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A., Lamba, J. K. & Kirstein, M. N., Jan 21 2014, In : British Journal of Cancer. 110, 2, p. 304-312 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacokinetics
Genotype
Neoplasms
Cytidine Deaminase
2012
9 Citations (Scopus)

Cytotoxic purine nucleoside analogues bind to A 1, A 2A, and A 3 adenosine receptors

Jensen, K., Johnson, LA. A., Jacobson, P. A., Kachler, S., Kirstein, M. N., Lamba, J. & Klotz, K. N., May 1 2012, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 385, 5, p. 519-525 7 p.

Research output: Contribution to journalArticle

Adenosine A2A Receptors
Purine Nucleosides
Cladribine
Purinergic P1 Receptors
Adenosine
20 Citations (Scopus)

Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors

Mitra, A. K., Kirstein, M. N., Khatri, A., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A. & Lamba, J. K., Jul 1 2012, In : Pharmacogenomics. 13, 9, p. 1009-1021 13 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacogenetics
Pharmacokinetics
Single Nucleotide Polymorphism
Neoplasms
8 Citations (Scopus)

Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine

Khatri, A., Brundage, R., Hull, J. M., Williams, B. W., Yee, D. & Kirstein, M. N., Mar 1 2012, In : AAPS Journal. 14, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

gemcitabine
Somatomedins
Cell Line
Bayes Theorem
Receptor Protein-Tyrosine Kinases
2011
3 Citations (Scopus)

Combinatorial Pharmacologic Effects of Gemcitabine and its Metabolite dFdU

Benyumov, A., Gurvich, V. J., Lis, L. G., Williams, B. W. & Kirstein, M. N., Mar 7 2011, In : ChemMedChem. 6, 3, p. 457-464 8 p.

Research output: Contribution to journalArticle

gemcitabine
Metabolites
Zebrafish
Tumor Cell Line
Drug Interactions
10 Citations (Scopus)

Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid

Khatri, A., Gaber, M. W., Brundage, R., Naimark, M. D., Hanna, S. K., Stewart, C. F. & Kirstein, M. N., Sep 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 3, p. 721-731 11 p.

Research output: Contribution to journalArticle

irinotecan
Cerebrospinal fluid
Radiation Effects
Cerebrospinal Fluid
Rats
5 Citations (Scopus)

Phase 1 trial of gemcitabine with bortezomib in elderly patients with advanced solid tumors

Bommakanti, S. V., Dudek, A. Z., Khatri, A., Kirstein, M. N. & Gada, P. D., Dec 1 2011, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 34, 6, p. 597-602 6 p.

Research output: Contribution to journalArticle

gemcitabine
Neoplasms
Thrombocytopenia
Bortezomib
Antimetabolites
22 Citations (Scopus)

Severe electrolyte disturbances after hyperthermic intraperitoneal chemotherapy: Oxaliplatin versus mitomycin C

Rueth, N. M., Murray, S. E., Huddleston, S. J., Abbott, A. M., Greeno, E. W., Kirstein, M. N. & Tuttle, T. M., Jan 1 2011, In : Annals of Surgical Oncology. 18, 1, p. 174-180 7 p.

Research output: Contribution to journalArticle

oxaliplatin
Mitomycin
Electrolytes
Drug Therapy
Hyponatremia
2010
35 Citations (Scopus)

Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines

Zwolak, P., Manivel, J. C., Jasinski, P., Kirstein, M. N., Dudek, A. Z., Fisher, J. & Cheng, E. Y., Jan 1 2010, In : Journal of Bone and Joint Surgery - Series A. 92, 1, p. 162-168 7 p.

Research output: Contribution to journalArticle

zoledronic acid
Giant Cell Tumors
Bone Cements
Multiple Myeloma
Renal Cell Carcinoma

Enhanced sensitivity method for measuring gemcitabine in human plasma

Khatri, A., Fisher, J. & Kirstein, M. N., Nov 1 2010, In : Chromatographia. 72, 9-10, p. 1005-1008 4 p.

Research output: Contribution to journalArticle

gemcitabine
Plasma (human)
Solid Phase Extraction
Assays
Cell Division
2009
3 Citations (Scopus)

Cap-dependent translation blockade and fixed dose-rate gemcitabine: Interaction in an in vitro bioreactor system

Williams, B. W., Chang, J. J., Chi, R. M., Marker, P. H., Frethem, C. D., Le, C. T., Kratzke, R. A. & Kirstein, M. N., Oct 18 2009, In : Cancer Letters. 284, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

gemcitabine
Bioreactors
Cell Survival
Electron Scanning Microscopy
Carrier Proteins
2008
5 Citations (Scopus)

Exposure-response relationships for oxaliplatin-treated colon cancer cells

Kirstein, M. N., Root, S. A., Moore, M. M., Wieman, K. M., Williams, B. W., Jacobson, P. A., Marker, P. H. & Tuttle, T. M., Jan 1 2008, In : Anti-Cancer Drugs. 19, 1, p. 37-44 8 p.

Research output: Contribution to journalArticle

oxaliplatin
Colonic Neoplasms
Inhibitory Concentration 50
Hot Temperature
Therapeutics
12 Citations (Scopus)

Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system

Kirstein, M. N., Brundage, R., Moore, M. M., Williams, B. W., Hillman, L. A., Dagit, J. W., Fisher, J. E., Marker, P. H., Kratzke, R. A. & Yee, D., Feb 1 2008, In : Cancer chemotherapy and pharmacology. 61, 2, p. 291-299 9 p.

Research output: Contribution to journalArticle

gemcitabine
Pharmacodynamics
Bioreactors
Cytotoxicity
Cell culture
2007
5 Citations (Scopus)

Short versus continuous gemcitabine treatment of non-small cell lung cancer in an in vitro cell culture bioreactor system

Kirstein, M. N., Wieman, K. M., Williams, B. W., Fisher, J. E., Marker, P. H., Le, C. T., Yee, D. & Kratzke, R. A., Nov 1 2007, In : Lung Cancer. 58, 2, p. 196-204 9 p.

Research output: Contribution to journalArticle

gemcitabine
Bioreactors
Non-Small Cell Lung Carcinoma
Cell Culture Techniques
In Situ Nick-End Labeling
2006
12 Citations (Scopus)
gemcitabine
Bioreactors
Cell Culture Techniques
Pharmaceutical Preparations
S Phase
45 Citations (Scopus)
gemcitabine
Tissue culture
Culture Media
Plasmas
Liquids
2005
2 Citations (Scopus)

A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with carboplatin and etoposide in extensive stage small cell lung cancer

Gillenwater, H. H., McCune, J. S., Lindley, C., Faucette, S., Shord, S., Donahue, A., Socinski, M. A., Stewart, C. F., Zamboni, W. C., Kirstein, M. N. & Moore, D., Oct 25 2005, In : Cancer Investigation. 23, 6, p. 511-519 9 p.

Research output: Contribution to journalArticle

Topotecan
Carboplatin
Small Cell Lung Carcinoma
Etoposide
Area Under Curve
8 Citations (Scopus)

Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC

Kirstein, M. N., Panetta, J. C., Gajjar, A., Nair, G., Iacono, L. C., Freeman, B. B. & Stewart, C. F., May 1 2005, In : Cancer chemotherapy and pharmacology. 55, 5, p. 433-438 6 p.

Research output: Contribution to journalArticle

5-(3-methyl-1-triazeno)imidazole-4-carboxamide
temozolomide
Pharmacokinetics
Metabolites
Sampling
2004
50 Citations (Scopus)

Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor

Stewart, C. F., Iacono, L. C., Chintagumpala, M., Kellie, S. J., Ashley, D., Zamboni, W. C., Kirstein, M. N., Fouladi, M., Seele, L. G., Wallace, D., Houghton, P. J. & Gajjar, A., Dec 1 2004, In : Journal of Clinical Oncology. 22, 16, p. 3357-3365 9 p.

Research output: Contribution to journalArticle

Topotecan
Primitive Neuroectodermal Tumors
Medulloblastoma
Area Under Curve
Pharmacokinetics
2003
30 Citations (Scopus)

A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas

Panetta, J. C., Kirstein, M. N., Gajjar, A. J., Nair, G., Fouladi, M. & Stewart, C. F., Jan 1 2003, In : Mathematical Biosciences. 186, 1, p. 29-41 13 p.

Research output: Contribution to journalArticle

temozolomide
Neutrophils
mechanistic models
Glioma
neutrophils
60 Citations (Scopus)

A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors

Santana, V. M., Zamboni, W. C., Kirstein, M. N., Tan, M., Liu, T., Gajjar, A., Houghton, P. J. & Stewart, C. F., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 633-640 8 p.

Research output: Contribution to journalArticle

Topotecan
Neoplasms
Area Under Curve
Pharmacokinetics
Febrile Neutropenia
26 Citations (Scopus)
Topotecan
Liquid chromatography
Lactones
Reverse-Phase Chromatography
Metabolites
42 Citations (Scopus)

Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors

Panetta, J. C., Kirstein, M. N., Gajjar, A., Nair, G., Fouladi, M., Heideman, R. L., Wilkinson, M. & Stewart, C. F., Dec 1 2003, In : Cancer chemotherapy and pharmacology. 52, 6, p. 435-441 7 p.

Research output: Contribution to journalArticle

temozolomide
5-(3-methyl-1-triazeno)imidazole-4-carboxamide
Central Nervous System Neoplasms
Pharmacokinetics
Neurology
2002
12 Citations (Scopus)
Amifostine
Assays
Liquids
WR 1065
Metabolites
33 Citations (Scopus)

Protracted intermittent schedule of topotecan in children with refractory acute leukemia: A Pediatric Oncology Group study

Furman, W. L., Stewart, C. F., Kirstein, M., Kepner, J. L., Bernstein, M. L., Kung, F., Vietti, T. J., Philip Steuber, C., Lee Becton, D., Baruchel, S. & Pratt, C., Mar 15 2002, In : Journal of Clinical Oncology. 20, 6, p. 1617-1624 8 p.

Research output: Contribution to journalArticle

Topotecan
Appointments and Schedules
Leukemia
Pediatrics
Maximum Tolerated Dose
2001
8 Citations (Scopus)

Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction

Herrington, J. D., Figueroa, J. A., Kirstein, M. N., Zamboni, W. C. & Stewart, C. F., Jan 1 2001, In : Cancer chemotherapy and pharmacology. 47, 1, p. 89-93 5 p.

Research output: Contribution to journalArticle

Topotecan
Renal Dialysis
Kidney
Lactones
Renal Insufficiency
33 Citations (Scopus)

Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts

Kirstein, M. N., Houghton, P. J., Cheshire, P. J., Richmond, L. B., Smith, A. K., Hanna, S. K. & Stewart, C. F., Mar 12 2001, In : Clinical Cancer Research. 7, 2, p. 358-366 9 p.

Research output: Contribution to journalArticle

9-aminocamptothecin
Heterografts
Neoplasms
Implosive Therapy
Topoisomerase I Inhibitors
2000
108 Citations (Scopus)

Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models

Houghton, P. J., Stewart, C. F., Cheshire, P. J., Richmond, L. B., Kirstein, M. N., Poquette, C. A., Tan, M., Friedman, H. S. & Brent, T. P., Nov 13 2000, In : Clinical Cancer Research. 6, 10, p. 4110-4118 9 p.

Research output: Contribution to journalArticle

irinotecan
temozolomide
DNA Mismatch Repair
Methyltransferases
Heterografts
89 Citations (Scopus)

Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models

Middlemas, D. S., Stewart, C. F., Kirstein, M. N., Poquette, C., Friedman, H. S., Houghton, P. J. & Brent, T. P., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 998-1007 10 p.

Research output: Contribution to journalArticle

temozolomide
Heterografts
Methyltransferases
Pediatrics
Neoplasms
1999
35 Citations (Scopus)

Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines

Zamboni, W. C., Houghton, P. J., Hulstein, J. L., Kirstein, M., Walsh, J., Cheshire, P. J., Hanna, S. K., Danks, M. K. & Stewart, C. F., Feb 17 1999, In : Cancer chemotherapy and pharmacology. 43, 4, p. 269-276 8 p.

Research output: Contribution to journalArticle

Topotecan
Extracellular Fluid
Neuroblastoma
Heterografts
Tumors
1997
362 Citations (Scopus)

ALK the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

Morris, S. W., Naeve, C., Mathew, P., James, P. L., Kirstein, M. N., Cui, X. & Witte, D. P., Jan 1 1997, In : Oncogene. 14, 18, p. 2175-2188 14 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 2
Sensory Receptor Cells
Protein-Tyrosine Kinases
Non-Hodgkin's Lymphoma
Leukocytes
1996
12 Citations (Scopus)

The genes encoding the Eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3

Cerretti, D. P., Lyman, S. D., Kozlosky, C. J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N. & Morris, S. W., Apr 15 1996, In : Genomics. 33, 2, p. 277-282 6 p.

Research output: Contribution to journalArticle

Ephrin-A4
Ephrin-A3
Ephrin-A1
Eph Family Receptors
Chromosomes, Human, Pair 3
253 Citations (Scopus)

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1

Yoneda-Kato, N., Look, A. T., Kirstein, M. N., Valentine, M. B., Raimondi, S. C., Cohen, K. J., Carroll, A. J. & Morris, S. W., Feb 14 1996, In : Oncogene. 12, 2, p. 265-275 11 p.

Research output: Contribution to journalArticle

Myeloid Leukemia
Gene Fusion
Myelodysplastic Syndromes
Acute Myeloid Leukemia
nucleophosmin
1995
95 Citations (Scopus)

Chromosomal assignment and genomic structure of Il15

Anderson, D. M., Johnson, L., Glaccum, M. B., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N., Morris, S. W., Grabstein, K. & Cosman, D., Jan 1 1995, In : Genomics. 25, 3, p. 701-706 6 p.

Research output: Contribution to journalArticle

Interleukin-15
Introns
Clone Cells
Genes
Chromosomes, Human, Pair 8
1994
1660 Citations (Scopus)

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K. G., Shapiro, D. N., Saltman, D. L. & Look, A. T., Mar 4 1994, In : Science. 263, 5151, p. 1281-1284 4 p.

Research output: Contribution to journalArticle

Nuclear Proteins
Non-Hodgkin's Lymphoma
Phosphotransferases
Genes
Chromosomes
1993
11 Citations (Scopus)

Reassignment of the Human ARH9 RAS-Related Gene to Chromosome 1p13-p21

Morris, S. W., Valentine, M. B., Kirstein, M. N. & Huebner, K., Jan 1 1993, In : Genomics. 15, 3, p. 677-679 3 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Hybrid Cells
Chromosomes, Human, Pair 1
Aplysia
1990
22 Citations (Scopus)

Limited Proteolysis as a Probe of the Conformation and Nucleic Acid Binding Regions of Nucleolin

Olson, M. O. J., Kirstein, M. N. & Wallace, M. O., Jun 19 1990, In : Biochemistry. 29, 24, p. 5682-5686 5 p.

Research output: Contribution to journalArticle

Poly G
Nucleic Acid Probes
Proteolysis
Nucleic Acid Conformation
Conformations
1989
29 Citations (Scopus)

Characterization of a 48‐kDa nucleic‐acid‐binding fragment of nucleolin

SAPP, M., RICHTER, A., WEISSHART, K., CAIZERGUES‐FERRER, M., AMALRIC, F., WALLACE, M. O., KIRSTEIN, M. N. & OLSON, M. O. J., Feb 1989, In : European Journal of Biochemistry. 179, 3, p. 541-548 8 p.

Research output: Contribution to journalArticle

Proteins
Nucleoproteins
Protein Sequence Analysis
Molecular mass
Hydrodynamics