Mark N Kirstein &ndash; Research Output

2019

Gemcitabine and metabolite pharmacokinetics in advanced NSCLC patients after bronchial artery infusion and intravenous infusion

Alharbi, A. F., Kratzke, R. A., D’Cunha, J., Maddaus, M. A., Sanghavi, K. J. & Kirstein, M. N., Feb 5 2019, In : Cancer chemotherapy and pharmacology. 83, 2, p. 387-391 5 p.

Research output: Contribution to journal › Article

gemcitabine

Bronchial Arteries

Pharmacokinetics

Metabolites

Intravenous Infusions

2016

7 Citations (Scopus)

Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning

Sanghavi, K. J., Wiseman, A., Kirstein, M. N., Cao, Q., Brundage, R., Jensen, K., Rogosheske, J., Kurtzweil, A., Long-Boyle, J., Wagner, J. E., Warlick, E. D., Brunstein, C. G., Weisdorf, D. J. & Jacobson, P. A., Sep 1 2016, In : Translational Research. 175, p. 103-115.e4

Research output: Contribution to journal › Article

Transplants

Hematopoietic Stem Cells

Stem cells

Mortality

Cell Transplantation

2 Citations (Scopus)

Pharmacokinetic–pharmacodynamic modelling of acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer

Liang, S., Brundage, R., Jacobson, P. A., Blaes, A. H. & Kirstein, M. N., Jan 1 2016, In : British Journal of Clinical Pharmacology. p. 773-783 11 p.

Research output: Contribution to journal › Article

Brain Natriuretic Peptide

Doxorubicin

Breast Neoplasms

Troponin

Enalapril

15 Citations (Scopus)

Randomized, blinded trial of vitamin D ₃ for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)

Shapiro, A. C., Adlis, S. A., Robien, K., Kirstein, M. N., Liang, S., Richter, S. A. & Lerner, R. E., Feb 1 2016, In : Breast Cancer Research and Treatment. 155, 3, p. 501-512 12 p.

Research output: Contribution to journal › Article

letrozole

Aromatase Inhibitors

Cholecalciferol

Pharmacokinetics

Hormones

2014

12 Citations (Scopus)

SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours

Khatri, A., Williams, B. W., Fisher, J., Brundage, R., Gurvich, V. J., Lis, L. G., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A., Lamba, J. K. & Kirstein, M. N., Jan 21 2014, In : British Journal of Cancer. 110, 2, p. 304-312 9 p.

Research output: Contribution to journal › Article

gemcitabine

Pharmacokinetics

Genotype

Neoplasms

Cytidine Deaminase

2013

Lung cancer

Kirstein, M. N., Kratzke, R. A. & Dudek, A. Z., Jul 8 2013, Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drugs. Wolters Kluwer Health Adis (ESP), p. 2210-2222 13 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Lung Neoplasms

2012

9 Citations (Scopus)

Cytotoxic purine nucleoside analogues bind to A 1, A 2A, and A 3 adenosine receptors

Jensen, K., Johnson, LA. A., Jacobson, P. A., Kachler, S., Kirstein, M. N., Lamba, J. & Klotz, K. N., May 1 2012, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 385, 5, p. 519-525 7 p.

Research output: Contribution to journal › Article

Adenosine A2A Receptors

Purine Nucleosides

Cladribine

Purinergic P1 Receptors

Adenosine

19 Citations (Scopus)

Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors

Mitra, A. K., Kirstein, M. N., Khatri, A., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A. & Lamba, J. K., Jul 1 2012, In : Pharmacogenomics. 13, 9, p. 1009-1021 13 p.

Research output: Contribution to journal › Article

gemcitabine

Pharmacogenetics

Pharmacokinetics

Single Nucleotide Polymorphism

Neoplasms

8 Citations (Scopus)

Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine

Khatri, A., Brundage, R., Hull, J. M., Williams, B. W., Yee, D. & Kirstein, M. N., Mar 1 2012, In : AAPS Journal. 14, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article

gemcitabine

Somatomedins

Cell Line

Bayes Theorem

Receptor Protein-Tyrosine Kinases

2011

3 Citations (Scopus)

Combinatorial Pharmacologic Effects of Gemcitabine and its Metabolite dFdU

Benyumov, A., Gurvich, V. J., Lis, L. G., Williams, B. W. & Kirstein, M. N., Mar 7 2011, In : ChemMedChem. 6, 3, p. 457-464 8 p.

Research output: Contribution to journal › Article

gemcitabine

Metabolites

Zebrafish

Tumor Cell Line

Drug Interactions

10 Citations (Scopus)

Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid

Khatri, A., Gaber, M. W., Brundage, R., Naimark, M. D., Hanna, S. K., Stewart, C. F. & Kirstein, M. N., Sep 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 3, p. 721-731 11 p.

Research output: Contribution to journal › Article

irinotecan

Cerebrospinal fluid

Radiation Effects

Cerebrospinal Fluid

Rats

5 Citations (Scopus)

Phase 1 trial of gemcitabine with bortezomib in elderly patients with advanced solid tumors

Bommakanti, S. V., Dudek, A. Z., Khatri, A., Kirstein, M. N. & Gada, P. D., Dec 1 2011, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 34, 6, p. 597-602 6 p.

Research output: Contribution to journal › Article

gemcitabine

Neoplasms

Thrombocytopenia

Bortezomib

Antimetabolites

21 Citations (Scopus)

Severe electrolyte disturbances after hyperthermic intraperitoneal chemotherapy: Oxaliplatin versus mitomycin C

Rueth, N. M., Murray, S. E., Huddleston, S. J., Abbott, A. M., Greeno, E. W., Kirstein, M. N. & Tuttle, T. M., Jan 1 2011, In : Annals of Surgical Oncology. 18, 1, p. 174-180 7 p.

Research output: Contribution to journal › Article

oxaliplatin

Mitomycin

Electrolytes

Drug Therapy

Hyponatremia

2010

35 Citations (Scopus)

Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines

Zwolak, P., Manivel, J. C., Jasinski, P., Kirstein, M. N., Dudek, A. Z., Fisher, J. & Cheng, E. Y., Jan 1 2010, In : Journal of Bone and Joint Surgery - Series A. 92, 1, p. 162-168 7 p.

Research output: Contribution to journal › Article

zoledronic acid

Giant Cell Tumors

Bone Cements

Multiple Myeloma

Renal Cell Carcinoma

Enhanced sensitivity method for measuring gemcitabine in human plasma

Khatri, A., Fisher, J. E. & Kirstein, M. N., Nov 1 2010, In : Chromatographia. 72, 9-10, p. 1005-1008 4 p.

Research output: Contribution to journal › Article

gemcitabine

Plasma (human)

Solid Phase Extraction

Assays

Cell Division

2009

3 Citations (Scopus)

Cap-dependent translation blockade and fixed dose-rate gemcitabine: Interaction in an in vitro bioreactor system

Williams, B. W., Chang, J. J., Chi, R. M., Marker, P. H., Frethem, C. D., Le, C. T., Kratzke, R. A. & Kirstein, M. N., Oct 18 2009, In : Cancer Letters. 284, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article

gemcitabine

Bioreactors

Cell Survival

Electron Scanning Microscopy

Carrier Proteins

2008

5 Citations (Scopus)

Exposure-response relationships for oxaliplatin-treated colon cancer cells

Kirstein, M. N., Root, S. A., Moore, M. M., Wieman, K. M., Williams, B. W., Jacobson, P. A., Marker, P. H. & Tuttle, T. M., Jan 1 2008, In : Anti-Cancer Drugs. 19, 1, p. 37-44 8 p.

Research output: Contribution to journal › Article

oxaliplatin

Colonic Neoplasms

Inhibitory Concentration 50

Hot Temperature

Therapeutics

12 Citations (Scopus)

Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system

Kirstein, M. N., Brundage, R., Moore, M. M., Williams, B. W., Hillman, L. A., Dagit, J. W., Fisher, J. E., Marker, P. H., Kratzke, R. A. & Yee, D., Feb 1 2008, In : Cancer chemotherapy and pharmacology. 61, 2, p. 291-299 9 p.

Research output: Contribution to journal › Article

gemcitabine

Pharmacodynamics

Bioreactors

Cytotoxicity

Cell culture

2007

5 Citations (Scopus)

Short versus continuous gemcitabine treatment of non-small cell lung cancer in an in vitro cell culture bioreactor system

Kirstein, M. N., Wieman, K. M., Williams, B. W., Fisher, J. E., Marker, P. H., Le, C. T., Yee, D. & Kratzke, R. A., Nov 1 2007, In : Lung Cancer. 58, 2, p. 196-204 9 p.

Research output: Contribution to journal › Article

gemcitabine

Bioreactors

Non-Small Cell Lung Carcinoma

Cell Culture Techniques

In Situ Nick-End Labeling

2006

12 Citations (Scopus)

Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens

Kirstein, M. N., Brundage, R., Elmquist, W. F., Remmel, R. P., Marker, P. H., Guire, D. E. & Yee, D., Apr 1 2006, In : Breast Cancer Research and Treatment. 96, 3, p. 217-225 9 p.

Research output: Contribution to journal › Article

gemcitabine

Bioreactors

Cell Culture Techniques

Pharmaceutical Preparations

S Phase

43 Citations (Scopus)

High-performance liquid chromatographic method for the determination of gemcitabine and 2′,2′-difluorodeoxyuridine in plasma and tissue culture media

Kirstein, M. N., Hassan, I., Guire, D. E., Weller, D. R., Dagit, J. W., Fisher, J. E. & Remmel, R. P., May 1 2006, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 835, 1-2, p. 136-142 7 p.

Research output: Contribution to journal › Article

gemcitabine

Tissue culture

Culture Media

Plasmas

Liquids

5 Citations (Scopus)

Review of selected patents for cancer therapy targeting tumor angiogenesis

Kirstein, M. N., Moore, M. M. & Dudek, A. Z., Dec 1 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 2, p. 153-161 9 p.

Research output: Contribution to journal › Review article

Patents

Neoplasms

Therapeutics

Biological Phenomena

Angiogenesis Inhibitors

2005

2 Citations (Scopus)

A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with carboplatin and etoposide in extensive stage small cell lung cancer

Gillenwater, H. H., McCune, J. S., Lindley, C., Faucette, S., Shord, S., Donahue, A., Socinski, M. A., Stewart, C. F., Zamboni, W. C., Kirstein, M. N. & Moore, D., Oct 25 2005, In : Cancer Investigation. 23, 6, p. 511-519 9 p.

Research output: Contribution to journal › Article

Topotecan

Carboplatin

Small Cell Lung Carcinoma

Etoposide

Area Under Curve

8 Citations (Scopus)

Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC

Kirstein, M. N., Panetta, J. C., Gajjar, A., Nair, G., Iacono, L. C., Freeman, B. B. & Stewart, C. F., May 1 2005, In : Cancer Chemotherapy and Pharmacology. 55, 5, p. 433-438 6 p.

Research output: Contribution to journal › Article

5-(3-methyl-1-triazeno)imidazole-4-carboxamide

temozolomide

Pharmacokinetics

Metabolites

Sampling

2004

50 Citations (Scopus)

Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor

Stewart, C. F., Iacono, L. C., Chintagumpala, M., Kellie, S. J., Ashley, D., Zamboni, W. C., Kirstein, M. N., Fouladi, M., Seele, L. G., Wallace, D., Houghton, P. J. & Gajjar, A., Dec 1 2004, In : Journal of Clinical Oncology. 22, 16, p. 3357-3365 9 p.

Research output: Contribution to journal › Article

Topotecan

Primitive Neuroectodermal Tumors

Medulloblastoma

Area Under Curve

Pharmacokinetics

2003

28 Citations (Scopus)

A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas

Panetta, J. C., Kirstein, M. N., Gajjar, A. J., Nair, G., Fouladi, M. & Stewart, C. F., Jan 1 2003, In : Mathematical Biosciences. 186, 1, p. 29-41 13 p.

Research output: Contribution to journal › Article

temozolomide

Neutrophils

mechanistic models

Glioma

neutrophils

60 Citations (Scopus)

A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors

Santana, V. M., Zamboni, W. C., Kirstein, M. N., Tan, M., Liu, T., Gajjar, A., Houghton, P. J. & Stewart, C. F., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 633-640 8 p.

Research output: Contribution to journal › Article

Topotecan

Neoplasms

Area Under Curve

Pharmacokinetics

Febrile Neutropenia

26 Citations (Scopus)

Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection

Bai, F., Kirstein, M. N., Hanna, S. K., Iacono, L. C., Johnston, B. & Stewart, C. F., Feb 5 2003, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 784, 2, p. 225-232 8 p.

Research output: Contribution to journal › Article

Topotecan

Liquid chromatography

Lactones

Reverse-Phase Chromatography

Metabolites

41 Citations (Scopus)

Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors

Panetta, J. C., Kirstein, M. N., Gajjar, A., Nair, G., Fouladi, M., Heideman, R. L., Wilkinson, M. & Stewart, C. F., Dec 1 2003, In : Cancer chemotherapy and pharmacology. 52, 6, p. 435-441 7 p.

Research output: Contribution to journal › Article

temozolomide

5-(3-methyl-1-triazeno)imidazole-4-carboxamide

Central Nervous System Neoplasms

Pharmacokinetics

Neurology

2002

12 Citations (Scopus)

New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065

Bai, F., Kirstein, M. N., Hanna, S. K. & Stewart, C. F., Jun 5 2002, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 772, 2, p. 257-265 9 p.

Research output: Contribution to journal › Article

Amifostine

Assays

Liquids

WR 1065

Metabolites

33 Citations (Scopus)

Protracted intermittent schedule of topotecan in children with refractory acute leukemia: A Pediatric Oncology Group study

Furman, W. L., Stewart, C. F., Kirstein, M., Kepner, J. L., Bernstein, M. L., Kung, F., Vietti, T. J., Philip Steuber, C., Lee Becton, D., Baruchel, S. & Pratt, C., Mar 15 2002, In : Journal of Clinical Oncology. 20, 6, p. 1617-1624 8 p.

Research output: Contribution to journal › Article

Topotecan

Appointments and Schedules

Leukemia

Pediatrics

Maximum Tolerated Dose

6 Citations (Scopus)

Topoisomerase I interactive agents.

Kirstein, M. N., Turner, P. K. & Stewart, C. F., Jan 1 2002, In : Cancer chemotherapy and biological response modifiers. 20, p. 99-123 25 p.

Research output: Contribution to journal › Review article

Type I DNA Topoisomerase

irinotecan

Appointments and Schedules

Clinical Trials

Topotecan

2001

8 Citations (Scopus)

Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction

Herrington, J. D., Figueroa, J. A., Kirstein, M. N., Zamboni, W. C. & Stewart, C. F., Jan 1 2001, In : Cancer chemotherapy and pharmacology. 47, 1, p. 89-93 5 p.

Research output: Contribution to journal › Article

Topotecan

Renal Dialysis

Kidney

Lactones

Renal Insufficiency

33 Citations (Scopus)

Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts

Kirstein, M. N., Houghton, P. J., Cheshire, P. J., Richmond, L. B., Smith, A. K., Hanna, S. K. & Stewart, C. F., Mar 12 2001, In : Clinical Cancer Research. 7, 2, p. 358-366 9 p.

Research output: Contribution to journal › Article

9-aminocamptothecin

Heterografts

Neoplasms

Implosive Therapy

Topoisomerase I Inhibitors

2000

105 Citations (Scopus)

Antitumor activity of temozolomide combined with irinotecan is partly independent of O⁶-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models

Houghton, P. J., Stewart, C. F., Cheshire, P. J., Richmond, L. B., Kirstein, M. N., Poquette, C. A., Tan, M., Friedman, H. S. & Brent, T. P., Nov 13 2000, In : Clinical Cancer Research. 6, 10, p. 4110-4118 9 p.

Research output: Contribution to journal › Article

irinotecan

temozolomide

DNA Mismatch Repair

Methyltransferases

Heterografts

87 Citations (Scopus)

Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models

Middlemas, D. S., Stewart, C. F., Kirstein, M. N., Poquette, C., Friedman, H. S., Houghton, P. J. & Brent, T. P., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 998-1007 10 p.

Research output: Contribution to journal › Article

temozolomide

Heterografts

Methyltransferases

Pediatrics

Neoplasms

1999

35 Citations (Scopus)

Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines

Zamboni, W. C., Houghton, P. J., Hulstein, J. L., Kirstein, M., Walsh, J., Cheshire, P. J., Hanna, S. K., Danks, M. K. & Stewart, C. F., Feb 17 1999, In : Cancer chemotherapy and pharmacology. 43, 4, p. 269-276 8 p.

Research output: Contribution to journal › Article

Topotecan

Extracellular Fluid

Neuroblastoma

Heterografts

Tumors

1997

355 Citations (Scopus)

ALK the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

Morris, S. W., Naeve, C., Mathew, P., James, P. L., Kirstein, M. N., Cui, X. & Witte, D. P., Jan 1 1997, In : Oncogene. 14, 18, p. 2175-2188 14 p.

Research output: Contribution to journal › Article

Chromosomes, Human, Pair 2

Sensory Receptor Cells

Protein-Tyrosine Kinases

Non-Hodgkin's Lymphoma

Leukocytes

1996

12 Citations (Scopus)

The genes encoding the Eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3

Cerretti, D. P., Lyman, S. D., Kozlosky, C. J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N. & Morris, S. W., Apr 15 1996, In : Genomics. 33, 2, p. 277-282 6 p.

Research output: Contribution to journal › Article

Ephrin-A4

Ephrin-A3

Ephrin-A1

Eph Family Receptors

Chromosomes, Human, Pair 3

252 Citations (Scopus)

The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1

Yoneda-Kato, N., Look, A. T., Kirstein, M. N., Valentine, M. B., Raimondi, S. C., Cohen, K. J., Carroll, A. J. & Morris, S. W., Feb 14 1996, In : Oncogene. 12, 2, p. 265-275 11 p.

Research output: Contribution to journal › Article

Myeloid Leukemia

Gene Fusion

Myelodysplastic Syndromes

Acute Myeloid Leukemia

nucleophosmin

1995

95 Citations (Scopus)

Chromosomal assignment and genomic structure of Il15

Anderson, D. M., Johnson, L., Glaccum, M. B., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N., Morris, S. W., Grabstein, K. & Cosman, D., Jan 1 1995, In : Genomics. 25, 3, p. 701-706 6 p.

Research output: Contribution to journal › Article

Interleukin-15

Introns

Clone Cells

Genes

Chromosomes, Human, Pair 8

141 Citations (Scopus)

Sequence correction [8]

Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K., Shapiro, D. N., Look, A. T. & Saltman, D. L., Jan 1 1995, In : Science. 267, 5196, p. 316-317 2 p.

Research output: Contribution to journal › Letter

Molecular Sequence Data

Cultured Tumor Cells

Genetic Translocation

Phosphoproteins

Nuclear Proteins

1994

1633 Citations (Scopus)

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K. G., Shapiro, D. N., Saltman, D. L. & Look, A. T., Mar 4 1994, In : Science. 263, 5151, p. 1281-1284 4 p.

Research output: Contribution to journal › Article

Nuclear Proteins

Non-Hodgkin's Lymphoma

Phosphotransferases

Genes

Chromosomes

1993

9 Citations (Scopus)

Reassignment of the Human ARH9 RAS-Related Gene to Chromosome 1p13-p21

Morris, S. W., Valentine, M. B., Kirstein, M. N. & Huebner, K., Jan 1 1993, In : Genomics. 15, 3, p. 677-679 3 p.

Research output: Contribution to journal › Article

Chromosomes

Genes

Hybrid Cells

Chromosomes, Human, Pair 1

Aplysia

1990

22 Citations (Scopus)

Limited Proteolysis as a Probe of the Conformation and Nucleic Acid Binding Regions of Nucleolin

Olson, M. O. J., Kirstein, M. N. & Wallace, M. O., Jun 19 1990, In : Biochemistry. 29, 24, p. 5682-5686 5 p.

Research output: Contribution to journal › Article

Poly G

Nucleic Acid Probes

Proteolysis

Nucleic Acid Conformation

Conformations

1989

29 Citations (Scopus)

Characterization of a 48‐kDa nucleic‐acid‐binding fragment of nucleolin

SAPP, M., RICHTER, A., WEISSHART, K., CAIZERGUES‐FERRER, M., AMALRIC, F., WALLACE, M. O., KIRSTEIN, M. N. & OLSON, M. O. J., Jan 1 1989, In : European Journal of Biochemistry. 179, 3, p. 541-548 8 p.

Research output: Contribution to journal › Article

Proteins

Nucleoproteins

Protein Sequence Analysis

Molecular mass

Hydrodynamics