Research Output per year
Research Output 1989 2019
Gemcitabine and metabolite pharmacokinetics in advanced NSCLC patients after bronchial artery infusion and intravenous infusion
Alharbi, A. F., Kratzke, R. A., D’Cunha, J., Maddaus, M. A., Sanghavi, K. & Kirstein, M. N., Feb 5 2019, In : Cancer chemotherapy and pharmacology. 83, 2, p. 387-391 5 p.Research output: Contribution to journal › Article
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
Isakson, S. H., Rizzardi, A. E., Coutts, A. W., Carlson, D. F., Kirstein, M. N., Fisher, J., Vitte, J., Williams, K. B., Pluhar, L., Dahiya, S., Widemann, B. C., Dombi, E., Rizvi, T., Ratner, N., Messiaen, L., Stemmer-Rachamimov, A. O., Fahrenkrug, S. C., Gutmann, D. H., Giovannini, M., Moertel, C. L. & 2 others, , Dec 1 2018, In : Communications Biology. 1, 1, 158.Research output: Contribution to journal › Article
Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning
Sanghavi, K. J., Wiseman, A., Kirstein, M. N., Cao, Q., Brundage, R., Jensen, K., Rogosheske, J., Kurtzweil, A., Long-Boyle, J., Wagner, J. E., Warlick, E. D., Brunstein, C. G., Weisdorf, D. J. & Jacobson, P. A., Sep 1 2016, In : Translational Research. 175, p. 103-115.e4Research output: Contribution to journal › Article
Pharmacokinetic–pharmacodynamic modelling of acute N-terminal pro B-type natriuretic peptide after doxorubicin infusion in breast cancer
Liang, S., Brundage, R., Jacobson, P. A., Blaes, A. H. & Kirstein, M. N., Jan 1 2016, In : British Journal of Clinical Pharmacology. p. 773-783 11 p.Research output: Contribution to journal › Article
Randomized, blinded trial of vitamin D 3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS)
Shapiro, A. C., Adlis, S. A., Robien, K., Kirstein, M. N., Liang, S., Richter, S. A. & Lerner, R. E., Feb 1 2016, In : Breast Cancer Research and Treatment. 155, 3, p. 501-512 12 p.Research output: Contribution to journal › Article
SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours
Khatri, A., Williams, B. W., Fisher, J., Brundage, R., Gurvich, V. J., Lis, L. G., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A., Lamba, J. K. & Kirstein, M. N., Jan 21 2014, In : British Journal of Cancer. 110, 2, p. 304-312 9 p.Research output: Contribution to journal › Article
Lung cancer
Kirstein, M. N., Kratzke, R. A. & Dudek, A. Z., Jul 8 2013, Koda-Kimble and Young's Applied Therapeutics: The Clinical Use of Drugs. Wolters Kluwer Health Adis (ESP), p. 2210-2222 13 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
Cytotoxic purine nucleoside analogues bind to A 1, A 2A, and A 3 adenosine receptors
Jensen, K., Johnson, LA. A., Jacobson, P. A., Kachler, S., Kirstein, M. N., Lamba, J. & Klotz, K. N., May 1 2012, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 385, 5, p. 519-525 7 p.Research output: Contribution to journal › Article
Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors
Mitra, A. K., Kirstein, M. N., Khatri, A., Skubitz, K. M., Dudek, A. Z., Greeno, E. W., Kratzke, R. A. & Lamba, J. K., Jul 1 2012, In : Pharmacogenomics. 13, 9, p. 1009-1021 13 p.Research output: Contribution to journal › Article
Pharmacodynamic modeling of sequence-dependent antitumor activity of insulin-like growth factor blockade and gemcitabine
Khatri, A., Brundage, R., Hull, J. M., Williams, B. W., Yee, D. & Kirstein, M. N., Mar 1 2012, In : AAPS Journal. 14, 1, p. 1-9 9 p.Research output: Contribution to journal › Article
Combinatorial Pharmacologic Effects of Gemcitabine and its Metabolite dFdU
Benyumov, A., Gurvich, V. J., Lis, L. G., Williams, B. W. & Kirstein, M. N., Mar 7 2011, In : ChemMedChem. 6, 3, p. 457-464 8 p.Research output: Contribution to journal › Article
Effect of radiation on the penetration of irinotecan in rat cerebrospinal fluid
Khatri, A., Gaber, M. W., Brundage, R., Naimark, M. D., Hanna, S. K., Stewart, C. F. & Kirstein, M. N., Sep 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 3, p. 721-731 11 p.Research output: Contribution to journal › Article
Phase 1 trial of gemcitabine with bortezomib in elderly patients with advanced solid tumors
Bommakanti, S. V., Dudek, A. Z., Khatri, A., Kirstein, M. N. & Gada, P. D., Dec 1 2011, In : American Journal of Clinical Oncology: Cancer Clinical Trials. 34, 6, p. 597-602 6 p.Research output: Contribution to journal › Article
Severe electrolyte disturbances after hyperthermic intraperitoneal chemotherapy: Oxaliplatin versus mitomycin C
Rueth, N. M., Murray, S. E., Huddleston, S. J., Abbott, A. M., Greeno, E. W., Kirstein, M. N. & Tuttle, T. M., Jan 1 2011, In : Annals of Surgical Oncology. 18, 1, p. 174-180 7 p.Research output: Contribution to journal › Article
Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines
Zwolak, P., Manivel, J. C., Jasinski, P., Kirstein, M. N., Dudek, A. Z., Fisher, J. & Cheng, E. Y., Jan 1 2010, In : Journal of Bone and Joint Surgery - Series A. 92, 1, p. 162-168 7 p.Research output: Contribution to journal › Article
Enhanced sensitivity method for measuring gemcitabine in human plasma
Khatri, A., Fisher, J. & Kirstein, M. N., Nov 1 2010, In : Chromatographia. 72, 9-10, p. 1005-1008 4 p.Research output: Contribution to journal › Article
Cap-dependent translation blockade and fixed dose-rate gemcitabine: Interaction in an in vitro bioreactor system
Williams, B. W., Chang, J. J., Chi, R. M., Marker, P. H., Frethem, C. D., Le, C. T., Kratzke, R. A. & Kirstein, M. N., Oct 18 2009, In : Cancer Letters. 284, 1, p. 37-46 10 p.Research output: Contribution to journal › Article
Exposure-response relationships for oxaliplatin-treated colon cancer cells
Kirstein, M. N., Root, S. A., Moore, M. M., Wieman, K. M., Williams, B. W., Jacobson, P. A., Marker, P. H. & Tuttle, T. M., Jan 1 2008, In : Anti-Cancer Drugs. 19, 1, p. 37-44 8 p.Research output: Contribution to journal › Article
Pharmacodynamic characterization of gemcitabine cytotoxicity in an in vitro cell culture bioreactor system
Kirstein, M. N., Brundage, R., Moore, M. M., Williams, B. W., Hillman, L. A., Dagit, J. W., Fisher, J. E., Marker, P. H., Kratzke, R. A. & Yee, D., Feb 1 2008, In : Cancer chemotherapy and pharmacology. 61, 2, p. 291-299 9 p.Research output: Contribution to journal › Article
Short versus continuous gemcitabine treatment of non-small cell lung cancer in an in vitro cell culture bioreactor system
Kirstein, M. N., Wieman, K. M., Williams, B. W., Fisher, J. E., Marker, P. H., Le, C. T., Yee, D. & Kratzke, R. A., Nov 1 2007, In : Lung Cancer. 58, 2, p. 196-204 9 p.Research output: Contribution to journal › Article
Characterization of an in vitro cell culture bioreactor system to evaluate anti-neoplastic drug regimens
Kirstein, M. N., Brundage, R. C., Elmquist, W. F., Remmel, R. P., Marker, P. H., Guire, D. E. & Yee, D., Apr 1 2006, In : Breast Cancer Research and Treatment. 96, 3, p. 217-225 9 p.Research output: Contribution to journal › Article
High-performance liquid chromatographic method for the determination of gemcitabine and 2′,2′-difluorodeoxyuridine in plasma and tissue culture media
Kirstein, M. N., Hassan, I., Guire, D. E., Weller, D. R., Dagit, J. W., Fisher, J. E. & Remmel, R. P., May 1 2006, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 835, 1-2, p. 136-142 7 p.Research output: Contribution to journal › Article
Review of selected patents for cancer therapy targeting tumor angiogenesis
Kirstein, M. N., Moore, M. M. & Dudek, A. Z., Dec 1 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 2, p. 153-161 9 p.Research output: Contribution to journal › Review article
A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with carboplatin and etoposide in extensive stage small cell lung cancer
Gillenwater, H. H., McCune, J. S., Lindley, C., Faucette, S., Shord, S., Donahue, A., Socinski, M. A., Stewart, C. F., Zamboni, W. C., Kirstein, M. N. & Moore, D., Oct 25 2005, In : Cancer Investigation. 23, 6, p. 511-519 9 p.Research output: Contribution to journal › Article
Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC
Kirstein, M. N., Panetta, J. C., Gajjar, A., Nair, G., Iacono, L. C., Freeman, B. B. & Stewart, C. F., May 1 2005, In : Cancer chemotherapy and pharmacology. 55, 5, p. 433-438 6 p.Research output: Contribution to journal › Article
Results of a phase II upfront window of pharmacokinetically guided topotecan in high-risk medulloblastoma and supratentorial primitive neuroectodermal tumor
Stewart, C. F., Iacono, L. C., Chintagumpala, M., Kellie, S. J., Ashley, D., Zamboni, W. C., Kirstein, M. N., Fouladi, M., Seele, L. G., Wallace, D., Houghton, P. J. & Gajjar, A., Dec 1 2004, In : Journal of Clinical Oncology. 22, 16, p. 3357-3365 9 p.Research output: Contribution to journal › Article
A mechanistic mathematical model of temozolomide myelosuppression in children with high-grade gliomas
Panetta, J. C., Kirstein, M. N., Gajjar, A. J., Nair, G., Fouladi, M. & Stewart, C. F., Jan 1 2003, In : Mathematical Biosciences. 186, 1, p. 29-41 13 p.Research output: Contribution to journal › Article
A pilot study of protracted topotecan dosing using a pharmacokinetically guided dosing approach in children with solid tumors
Santana, V. M., Zamboni, W. C., Kirstein, M. N., Tan, M., Liu, T., Gajjar, A., Houghton, P. J. & Stewart, C. F., Feb 1 2003, In : Clinical Cancer Research. 9, 2, p. 633-640 8 p.Research output: Contribution to journal › Article
Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection
Bai, F., Kirstein, M. N., Hanna, S. K., Iacono, L. C., Johnston, B. & Stewart, C. F., Feb 5 2003, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 784, 2, p. 225-232 8 p.Research output: Contribution to journal › Article
Molecular targets in the inhibition of angiogenesis
Dudek, A. Z., Pawlak, W. Z. & Kirstein Pharm, M. N., Aug 1 2003, In : Expert Opinion on Therapeutic Targets. 7, 4, p. 527-541 15 p.Research output: Contribution to journal › Review article
Population pharmacokinetics of temozolomide and metabolites in infants and children with primary central nervous system tumors
Panetta, J. C., Kirstein, M. N., Gajjar, A., Nair, G., Fouladi, M., Heideman, R. L., Wilkinson, M. & Stewart, C. F., Dec 1 2003, In : Cancer chemotherapy and pharmacology. 52, 6, p. 435-441 7 p.Research output: Contribution to journal › Article
New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065
Bai, F., Kirstein, M. N., Hanna, S. K. & Stewart, C. F., Jun 5 2002, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 772, 2, p. 257-265 9 p.Research output: Contribution to journal › Article
Protracted intermittent schedule of topotecan in children with refractory acute leukemia: A Pediatric Oncology Group study
Furman, W. L., Stewart, C. F., Kirstein, M., Kepner, J. L., Bernstein, M. L., Kung, F., Vietti, T. J., Philip Steuber, C., Lee Becton, D., Baruchel, S. & Pratt, C., Mar 15 2002, In : Journal of Clinical Oncology. 20, 6, p. 1617-1624 8 p.Research output: Contribution to journal › Article
Topoisomerase I interactive agents.
Kirstein, M. N., Turner, P. K. & Stewart, C. F., Jan 1 2002, In : Cancer chemotherapy and biological response modifiers. 20, p. 99-123 25 p.Research output: Contribution to journal › Review article
Effect of hemodialysis on topotecan disposition in a patient with severe renal dysfunction
Herrington, J. D., Figueroa, J. A., Kirstein, M. N., Zamboni, W. C. & Stewart, C. F., Jan 1 2001, In : Cancer chemotherapy and pharmacology. 47, 1, p. 89-93 5 p.Research output: Contribution to journal › Article
Relation between 9-aminocamptothecin systemic exposure and tumor response in human solid tumor xenografts
Kirstein, M. N., Houghton, P. J., Cheshire, P. J., Richmond, L. B., Smith, A. K., Hanna, S. K. & Stewart, C. F., Mar 12 2001, In : Clinical Cancer Research. 7, 2, p. 358-366 9 p.Research output: Contribution to journal › Article
Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models
Houghton, P. J., Stewart, C. F., Cheshire, P. J., Richmond, L. B., Kirstein, M. N., Poquette, C. A., Tan, M., Friedman, H. S. & Brent, T. P., Nov 13 2000, In : Clinical Cancer Research. 6, 10, p. 4110-4118 9 p.Research output: Contribution to journal › Article
Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models
Middlemas, D. S., Stewart, C. F., Kirstein, M. N., Poquette, C., Friedman, H. S., Houghton, P. J. & Brent, T. P., Mar 1 2000, In : Clinical Cancer Research. 6, 3, p. 998-1007 10 p.Research output: Contribution to journal › Article
Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines
Zamboni, W. C., Houghton, P. J., Hulstein, J. L., Kirstein, M., Walsh, J., Cheshire, P. J., Hanna, S. K., Danks, M. K. & Stewart, C. F., Feb 17 1999, In : Cancer chemotherapy and pharmacology. 43, 4, p. 269-276 8 p.Research output: Contribution to journal › Article
ALK the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Morris, S. W., Naeve, C., Mathew, P., James, P. L., Kirstein, M. N., Cui, X. & Witte, D. P., Jan 1 1997, In : Oncogene. 14, 18, p. 2175-2188 14 p.Research output: Contribution to journal › Article
The genes encoding the Eph-related receptor tyrosine kinase ligands LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4, Epl4) are clustered on human chromosome 1 and mouse chromosome 3
Cerretti, D. P., Lyman, S. D., Kozlosky, C. J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N. & Morris, S. W., Apr 15 1996, In : Genomics. 33, 2, p. 277-282 6 p.Research output: Contribution to journal › Article
The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
Yoneda-Kato, N., Look, A. T., Kirstein, M. N., Valentine, M. B., Raimondi, S. C., Cohen, K. J., Carroll, A. J. & Morris, S. W., Feb 14 1996, In : Oncogene. 12, 2, p. 265-275 11 p.Research output: Contribution to journal › Article
Chromosomal assignment and genomic structure of Il15
Anderson, D. M., Johnson, L., Glaccum, M. B., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Valentine, V., Kirstein, M. N., Shapiro, D. N., Morris, S. W., Grabstein, K. & Cosman, D., Jan 1 1995, In : Genomics. 25, 3, p. 701-706 6 p.Research output: Contribution to journal › Article
Sequence correction [8]
Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K., Shapiro, D. N., Look, A. T. & Saltman, D. L., Jan 1 1995, In : Science. 267, 5196, p. 316-317 2 p.Research output: Contribution to journal › Letter
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
Morris, S. W., Kirstein, M. N., Valentine, M. B., Dittmer, K. G., Shapiro, D. N., Saltman, D. L. & Look, A. T., Mar 4 1994, In : Science. 263, 5151, p. 1281-1284 4 p.Research output: Contribution to journal › Article
Reassignment of the Human ARH9 RAS-Related Gene to Chromosome 1p13-p21
Morris, S. W., Valentine, M. B., Kirstein, M. N. & Huebner, K., Jan 1 1993, In : Genomics. 15, 3, p. 677-679 3 p.Research output: Contribution to journal › Article
Limited Proteolysis as a Probe of the Conformation and Nucleic Acid Binding Regions of Nucleolin
Olson, M. O. J., Kirstein, M. N. & Wallace, M. O., Jun 19 1990, In : Biochemistry. 29, 24, p. 5682-5686 5 p.Research output: Contribution to journal › Article
Characterization of a 48‐kDa nucleic‐acid‐binding fragment of nucleolin
SAPP, M., RICHTER, A., WEISSHART, K., CAIZERGUES‐FERRER, M., AMALRIC, F., WALLACE, M. O., KIRSTEIN, M. N. & OLSON, M. O. J., Feb 1989, In : European Journal of Biochemistry. 179, 3, p. 541-548 8 p.Research output: Contribution to journal › Article