1983 …2022
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1983 2019

Filter
Article
2018
5 Citations (Scopus)

A-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

Diaz-Rodriguez, V., Hsu, E. T., Ganusova, E., Werst, E. R., Becker, J. M., Hrycyna, C. A. & Distefano, M. D., Feb 21 2018, In : Bioconjugate Chemistry. 29, 2, p. 316-323 8 p.

Research output: Contribution to journalArticle

Alkynes
Azides
Terpenes
Bioactivity
Proteins
9 Citations (Scopus)

Efficient farnesylation of an extended C-terminal C(x) 3 X sequence motif expands the scope of the prenylated proteome

Blanden, M. J., Suazo, K. F., Hildebrandt, E. R., Hardgrove, D. S., Patel, M., Saunders, W. P., Distefano, M. D., Schmidt, W. K. & Hougland, J. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 8, p. 2770-2785 16 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Proteome
Cysteine
Proteins
1 Citation (Scopus)

Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues

Suazo, K. F., Hurben, A. K., Liu, K., Xu, F., Thao, P., Sudheer, C., Li, L. & Distefano, M. D., Sep 1 2018, In : Current protocols in chemical biology. 10, 3, p. e46

Research output: Contribution to journalArticle

Alkynes
Terpenes
Proteins
Protein Prenylation
Prenylation
9 Citations (Scopus)

Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels

Fisher, S. A., Tam, R. Y., Fokina, A., Mahmoodi, M. M., Distefano, M. D. & Shoichet, M. S., Sep 1 2018, In : Biomaterials. 178, p. 751-766 16 p.

Research output: Contribution to journalArticle

Hydrogels
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Cells
Breast Neoplasms
1 Citation (Scopus)

Site-specific cross-linking of proteins to DNA: Via a new bioorthogonal approach employing oxime ligation

Pujari, S., Zhang, Y., Ji, S., Distefano, M. D. & Tretyakova, N. Y., Jan 1 2018, In : Chemical Communications. 54, 49, p. 6296-6299 4 p.

Research output: Contribution to journalArticle

Oximes
DNA
Proteins
DNA Adducts
Aldehydes
2017
2 Citations (Scopus)

Polymeric Medical Sutures: An Exploration of Polymers and Green Chemistry

Knutson, C. M., Schneiderman, D. K., Yu, M., Javner, C. H., Distefano, M. D. & Wissinger, J. E., Nov 14 2017, In : Journal of Chemical Education. 94, 11, p. 1761-1765 5 p.

Research output: Contribution to journalArticle

Polymers
chemistry
experiment
Students
student
2016
7 Citations (Scopus)

6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning

Mahmoodi, M. M., Fisher, S. A., Tam, R. Y., Goff, P. C., Anderson, R. B., Wissinger, J. E., Blank, D. A., Shoichet, M. S. & Distefano, M. D., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 35, p. 8289-8300 12 p.

Research output: Contribution to journalArticle

Photons
Sulfhydryl Compounds
thiols
peptides
photons
13 Citations (Scopus)

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

Mohammed, I., Hampton, S. E., Ashall, L., Hildebrandt, E. R., Kutlik, R. A., Manandhar, S. P., Floyd, B. J., Smith, H. E., Dozier, J. K., Distefano, M. D., Schmidt, W. K. & Dore, T. M., Jan 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 2, p. 160-178 19 p.

Research output: Contribution to journalArticle

Oxyquinoline
Peptide Hydrolases
Cells
Membranes
Enzymes
8 Citations (Scopus)

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

Jennings, B. C., Danowitz, A. M., Wang, Y. C., Gibbs, R. A., Distefano, M. D. & Fierke, C. A., Feb 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 4, p. 1333-1336 4 p.

Research output: Contribution to journalArticle

Prenylation
Alkynes
Substrate Specificity
Reaction rates
Drug therapy
13 Citations (Scopus)

Bypass of DNA-protein cross-links conjugated to the 7-deazaguanine position of DNA by translesion synthesis polymerases

Wickramaratne, S., Ji, S., Mukherjee, S., Su, Y., Pence, M. G., Lior-Hoffmann, L., Fu, I., Broyde, S., Guengerich, F. P., Distefano, M., Schãrer, O. D., Sham, Y. Y. & Tretyakova, N., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23589-23603 15 p.

Research output: Contribution to journalArticle

DNA
Proteins
Peptides
Guanine
7-deazaguanine
16 Citations (Scopus)

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue

Suazo, K. F. G., Schaber, C., Palsuledesai, C. C., Odom John, A. R. & Distefano, M. D., Dec 7 2016, In : Scientific reports. 6, 38615.

Research output: Contribution to journalArticle

Alkynes
Terpenes
Plasmodium falciparum
Proteomics
Malaria
15 Citations (Scopus)

Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

Palsuledesai, C. C., Ochocki, J. D., Kuhns, M. M., Wang, Y. C., Warmka, J. K., Chernick, D. S., Wattenberg, E. V., Li, L., Arriaga, E. & Distefano, M. D., Oct 21 2016, In : ACS Chemical Biology. 11, 10, p. 2820-2828 9 p.

Research output: Contribution to journalArticle

Protein Prenylation
Alkynes
Terpenes
Labeling
Imaging techniques
13 Citations (Scopus)

Nitrodibenzofuran: A One-and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides

Mahmoodi, M. M., Abate-Pella, D., Pundsack, T. J., Palsuledesai, C. C., Goff, P. C., Blank, D. A. & Distefano, M. D., May 11 2016, In : Journal of the American Chemical Society. 138, 18, p. 5848-5859 12 p.

Research output: Contribution to journalArticle

Photons
Sulfhydryl Compounds
Peptides
Cysteine
Light
2015
4 Citations (Scopus)

Application of meta- and para-phenylenediamine as enhanced oxime ligation catalysts for protein labeling, PEGylation, immobilization, and release

Mahmoodi, M. M., Rashidian, M., Zhang, Y. & Distefano, M. D., Jan 1 2015, In : Current Protocols in Protein Science. 2015, p. 15.4.1-15.4.28

Research output: Contribution to journalArticle

Oximes
Aldehydes
Immobilization
Labeling
Ligation
14 Citations (Scopus)

Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine

Wickramaratne, S. S., Boldry, E. J., Buehler, C., Wang, Y. C., Distefano, M. D. & Tretyakova, N. Y., Sep 9 2015, In : Journal of Biological Chemistry. 290, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

Thymidine
Peptides
DNA
Reactive Oxygen Species
Proteins
6 Citations (Scopus)

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases

Zhang, Y., Blanden, M. J., Chava, S., Gangopadhyay, S. A., Rashidian, M., Hougland, J. L. & Distefano, M. D., Dec 16 2015, In : Bioconjugate Chemistry. 26, 12, p. 2542-2553 12 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Labeling
Proteins
Terpenes
Rats
10 Citations (Scopus)
Pheromones
Yeast
Esters
Peptides
Cysteine
13 Citations (Scopus)

The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse

Laudenbach, M., Baruffaldi, F., Vervacke, J. S., Distefano, M. D., Titcombe, P. J., Mueller, D. L., Tubo, N. J., Griffith, T. S. & Pravetoni, M., Jun 15 2015, In : Journal of Immunology. 194, 12, p. 5926-5936 11 p.

Research output: Contribution to journalArticle

B-Lymphocyte Subsets
Haptens
Oxycodone
Opioid Analgesics
Prescriptions
2014
17 Citations (Scopus)
Farnesyltranstransferase
Electrophoresis, Gel, Two-Dimensional
Post Translational Protein Processing
Proteins
Alkynes
9 Citations (Scopus)

Diazirine-containing photoactivatable isoprenoid: Synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase

Vervacke, J. S., Funk, A. L., Wang, Y. C., Strom, M., Hrycyna, C. A. & Distefano, M. D., Mar 7 2014, In : Journal of Organic Chemistry. 79, 5, p. 1971-1978 8 p.

Research output: Contribution to journalArticle

Diazomethane
Terpenes
Benzophenones
Peptides
Labeling
18 Citations (Scopus)

Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats

Pravetoni, M., Vervacke, J. S., Distefano, M. D., Tucker, A. M., Laudenbach, M. & Pentel, P. R., May 5 2014, In : PloS one. 9, 5, e96547.

Research output: Contribution to journalArticle

Oxycodone
Conjugate Vaccines
toxoids
tetanus
adjuvants
16 Citations (Scopus)

Engineering protein farnesyltransferase for enzymatic protein labeling applications

Dozier, J. K., Khatwani, S. L., Wollack, J. W., Wang, Y. C., Schmidt-Dannert, C. & Distefano, M. D., Jul 16 2014, In : Bioconjugate Chemistry. 25, 7, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Alanine
Mutation
Mutagenesis

Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis

Ochocki, J. D., Igbavboa, U., Wood, W. G., Arriaga, E. A., Wattenberg, E. V. & Distefano, M. D., Jan 1 2014, In : Methods in Molecular Biology. 1088, p. 213-223 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prenylation
Peptides
Dimethylallyltranstransferase
ras Proteins
15 Citations (Scopus)

Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues

Wang, Y. C., Dozier, J. K., Beese, L. S. & Distefano, M. D., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

Peptide Library
Diphosphates
Terpenes
Substrate Specificity
Libraries
14 Citations (Scopus)

Site-specific labeling of proteins and peptides with trans-cyclooctene containing handles capable of tetrazine ligation

Wollack, J. W., Monson, B. J., Dozier, J. K., Dalluge, J. J., Poss, K., Hilderbrand, S. A. & Distefano, M. D., Jan 1 2014, In : Chemical Biology and Drug Design. 84, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

Labeling
Ligation
Copper
Peptides
Substrates
25 Citations (Scopus)

Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication

Yeo, J. E., Wickramaratne, S. S., Khatwani, S., Wang, Y. C., Vervacke, J., Distefano, M. D. & Tretyakova, N. Y., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

DNA Replication
DNA
Proteins
Peptides
Alkynes
19 Citations (Scopus)

The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif

Schuld, N. J., Vervacke, J. S., Lorimer, E. L., Simon, N. C., Hauser, A. D., Barbieri, J. T., Distefano, M. D. & Williams, C. L., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6862-6876 15 p.

Research output: Contribution to journalArticle

Prenylation
Monomeric GTP-Binding Proteins
GTP Phosphohydrolases
Amino Acids
Proteins
2013
78 Citations (Scopus)

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Hydrazones
Oximes
Ligation
Aniline
Catalysts
87 Citations (Scopus)

Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 t cells

Wang, H., Henry, O., Distefano, M. D., Wang, Y. C., Raikkonen, J., Monkkonen, J., Tanaka, Y. & Morita, C. T., Aug 1 2013, In : Journal of Immunology. 191, 3, p. 1029-1042 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Diphosphates
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Jurkat Cells
Papio
7 Citations (Scopus)
hydrazine
Oximes
Complex Mixtures
Immobilization
Ligation
24 Citations (Scopus)

Chemoselective immobilization of proteins by microcontact printing and bio-orthogonal click reactions

Tolstyka, Z. P., Richardson, W., Bat, E., Stevens, C. J., Parra, D. P., Dozier, J. K., Distefano, M. D., Dunn, B. & Maynard, H. D., Dec 1 2013, In : ChemBioChem. 14, 18, p. 2464-2471 8 p.

Research output: Contribution to journalArticle

Printing
Immobilization
Azides
Gold
Alkynes
6 Citations (Scopus)
Terpenes
Benzophenones
Molecules
Azides
Sesquiterpenes
25 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
2012
7 Citations (Scopus)

An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases

Dozier, J. K. & Distefano, M. D., Feb 1 2012, In : Analytical Biochemistry. 421, 1, p. 158-163 6 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Assays
Fluorescence
Enzymes
Prenylation
57 Citations (Scopus)

Chemoenzymatic reversible immobilization and labeling of proteins without prior purification

Rashidian, M., Song, J. M., Pricer, R. E. & Distefano, M. D., May 23 2012, In : Journal of the American Chemical Society. 134, 20, p. 8455-8467 13 p.

Research output: Contribution to journalArticle

Immobilization
Labeling
Purification
Proteins
Aldehydes
23 Citations (Scopus)

Covalent protein-oligonucleotide conjugates by copper-free click reaction

Khatwani, S. L., Kang, J. S., Mullen, D. G., Hast, M. A., Beese, L. S., Distefano, M. D. & Taton, T. A., Jul 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 14, p. 4532-4539 8 p.

Research output: Contribution to journalArticle

Oligonucleotides
Copper
Azides
Oligodeoxyribonucleotides
Proteins
9 Citations (Scopus)

Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes

Hahne, K., Vervacke, J. S., Shrestha, L., Donelson, J. L., Gibbs, R. A., Distefano, M. D. & Hrycyna, C. A., Jun 22 2012, In : Biochemical and Biophysical Research Communications. 423, 1, p. 98-103 6 p.

Research output: Contribution to journalArticle

Mating Factor
Yeast
Yeasts
Protein Methyltransferases
Binding Sites
15 Citations (Scopus)

Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One- and Two-Photon Excitation

Abate-Pella, D., Zeliadt, N. A., Ochocki, J. D., Warmka, J. K., Dore, T. M., Blank, D. A., Wattenberg, E. V. & Distefano, M. D., May 7 2012, In : ChemBioChem. 13, 7, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Photochemistry
ras Proteins
Signal transduction
11 Citations (Scopus)

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Wang, Y. C. & Distefano, M. D., Aug 25 2012, In : Chemical Communications. 48, 66, p. 8228-8230 3 p.

Research output: Contribution to journalArticle

Peptide Library
Cellulose
Peptides
Proteins
Membranes
19 Citations (Scopus)

Synthesis of peptides containing C -terminal methyl esters using trityl side-chain anchoring: Application to the synthesis of a-factor and a-factor analogs

Diaz-Rodriguez, V., Mullen, D. G., Ganusova, E., Becker, J. M. & Distefano, M. D., Nov 16 2012, In : Organic Letters. 14, 22, p. 5648-5651 4 p.

Research output: Contribution to journalArticle

peptides
esters
Esters
cysteine
Mating Factor
2011
27 Citations (Scopus)

A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes

Gaffarogullari, E. C., Masterson, L. R., Metcalfe, E. E., Traaseth, N. J., Balatri, E., Musa, M. M., Mullen, D., Distefano, M. D. & Veglia, G., Aug 26 2011, In : Journal of Molecular Biology. 411, 4, p. 823-836 14 p.

Research output: Contribution to journalArticle

Phosphoserine
Cyclic AMP-Dependent Protein Kinases
Membranes
Lipid Bilayers
Enzymes
14 Citations (Scopus)

Evaluation of a cell penetrating prenylated peptide lacking an intrinsic fluorophore via in situ click reaction

Ochocki, J. D., Mullen, D. G., Wattenberg, E. V. & Distefano, M. D., Sep 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 17, p. 4998-5001 4 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Fluorophores
Peptides
Cell membranes
Protein Prenylation
11 Citations (Scopus)

Nuclear magnetic resonance-based quantification of organic diphosphates

Lenevich, S. & Distefano, M. D., Jan 15 2011, In : Analytical Biochemistry. 408, 2, p. 316-320 5 p.

Research output: Contribution to journalArticle

Capillary tubes
Diphosphates
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Diphosphonates
9 Citations (Scopus)

Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: Improved labeling and structural implications

Kyro, K., Manandhar, S. P., Mullen, D., Schmidt, W. K. & Distefano, M. D., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7559-7569 11 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Substrates
Enzymes
Catalytic Domain
13 Citations (Scopus)

Synthesis of a-factor peptide from Saccharomyces cerevisiae and photoactive analogues via Fmoc solid phase methodology

Mullen, D. G., Kyro, K., Hauser, M., Gustavsson, M., Veglia, G., Becker, J. M., Naider, F. & Distefano, M. D., Jan 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 1, p. 490-497 8 p.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
G-Protein-Coupled Receptors
Yeast
Saccharomyces cerevisiae
Yeasts
2010
7 Citations (Scopus)

Enlarging the scope of cell-penetrating prenylated peptides to include farnesylated 'CAAX' box sequences and diverse cell types

Ochocki, J. D., Igbavboa, U., Wood, W. G., Wattenberg, E. V. & Distefano, M. D., Jan 1 2010, In : Chemical Biology and Drug Design. 76, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Prenylation
Protein Prenylation
Peptides
Proteins
49 Citations (Scopus)

Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation

DeGraw, A. J., Palsuledesai, C., Ochocki, J. D., Dozier, J. K., Lenevich, S., Rashidian, M. & Distefano, M. D., Dec 1 2010, In : Chemical Biology and Drug Design. 76, 6, p. 460-471 12 p.

Research output: Contribution to journalArticle

Protein Prenylation
Alkynes
Terpenes
Proteins
Dimethylallyltranstransferase
11 Citations (Scopus)

Investigation of the sequence and length dependence for cell-penetrating prenylated peptides

Wollack, J. W., Zeliadt, N. A., Ochocki, J. D., Mullen, D. G., Barany, G., Wattenberg, E. V. & Distefano, M. D., Jan 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 1, p. 161-163 3 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Peptides
Molecules
Amino Acids
10 Citations (Scopus)

On-resin conversion of Cys(Acm)-containing peptides to their corresponding Cys(Scm) congeners

Mullen, D. G., Weigel, B., Barany, G. & Distefano, M. D., May 1 2010, In : Journal of Peptide Science. 16, 5, p. 219-222 4 p.

Research output: Contribution to journalArticle

Resins
Peptides
Cysteine
Amino Acids
Solid-Phase Synthesis Techniques
7 Citations (Scopus)

Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate

Kyro, K., Manandhar, S. P., Mullen, D., Schmidt, W. K. & Distefano, M. D., Aug 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 15, p. 5675-5684 10 p.

Research output: Contribution to journalArticle

Labeling
Photolysis
Peptides
Membrane Proteins
Substrates