1983 …2024
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Research Output 1983 2019

2012
7 Citations (Scopus)

An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases

Dozier, J. K. & Distefano, M. D., Feb 1 2012, In : Analytical Biochemistry. 421, 1, p. 158-163 6 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Assays
Fluorescence
Enzymes
Prenylation

Caging groups for cysteine: Synthesis and biological applications

Abate-Pella, D. & Distefano, M. D., Aug 1 2012, Cysteine: Biosynthesis, Chemical Structure and Toxicity. Nova Science Publishers, Inc., p. 155-171 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biological Phenomena
Functional groups
Cysteine
Light
Covalent bonds
57 Citations (Scopus)

Chemoenzymatic reversible immobilization and labeling of proteins without prior purification

Rashidian, M., Song, J. M., Pricer, R. E. & Distefano, M. D., May 23 2012, In : Journal of the American Chemical Society. 134, 20, p. 8455-8467 13 p.

Research output: Contribution to journalArticle

Immobilization
Labeling
Purification
Proteins
Aldehydes
23 Citations (Scopus)

Covalent protein-oligonucleotide conjugates by copper-free click reaction

Khatwani, S. L., Kang, J. S., Mullen, D. G., Hast, M. A., Beese, L. S., Distefano, M. D. & Taton, T. A., Jul 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 14, p. 4532-4539 8 p.

Research output: Contribution to journalArticle

Oligonucleotides
Copper
Azides
Oligodeoxyribonucleotides
Proteins
9 Citations (Scopus)

Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes

Hahne, K., Vervacke, J. S., Shrestha, L., Donelson, J. L., Gibbs, R. A., Distefano, M. D. & Hrycyna, C. A., Jun 22 2012, In : Biochemical and Biophysical Research Communications. 423, 1, p. 98-103 6 p.

Research output: Contribution to journalArticle

Mating Factor
Yeast
Yeasts
Protein Methyltransferases
Binding Sites
15 Citations (Scopus)

Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One- and Two-Photon Excitation

Abate-Pella, D., Zeliadt, N. A., Ochocki, J. D., Warmka, J. K., Dore, T. M., Blank, D. A., Wattenberg, E. V. & Distefano, M. D., May 7 2012, In : ChemBioChem. 13, 7, p. 1009-1016 8 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Photochemistry
ras Proteins
Signal transduction
11 Citations (Scopus)

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation

Wang, Y. C. & Distefano, M. D., Aug 25 2012, In : Chemical Communications. 48, 66, p. 8228-8230 3 p.

Research output: Contribution to journalArticle

Peptide Library
Cellulose
Peptides
Proteins
Membranes
19 Citations (Scopus)

Synthesis of peptides containing C -terminal methyl esters using trityl side-chain anchoring: Application to the synthesis of a-factor and a-factor analogs

Diaz-Rodriguez, V., Mullen, D. G., Ganusova, E., Becker, J. M. & Distefano, M. D., Nov 16 2012, In : Organic Letters. 14, 22, p. 5648-5651 4 p.

Research output: Contribution to journalArticle

peptides
esters
Esters
cysteine
Mating Factor
2011
27 Citations (Scopus)

A myristoyl/phosphoserine switch controls cAMP-dependent protein kinase association to membranes

Gaffarogullari, E. C., Masterson, L. R., Metcalfe, E. E., Traaseth, N. J., Balatri, E., Musa, M. M., Mullen, D., Distefano, M. D. & Veglia, G., Aug 26 2011, In : Journal of Molecular Biology. 411, 4, p. 823-836 14 p.

Research output: Contribution to journalArticle

Phosphoserine
Cyclic AMP-Dependent Protein Kinases
Membranes
Lipid Bilayers
Enzymes

Erratum: Synthesis of a-factor peptide from Saccharomyces cerevisiae and photoactive analogues via Fmoc solid phase methodology (Bioorganic and Medicinal Chemistry (2007)15 (931-938))

Mullen, D. G., Kyro, K., Hauser, M., Gustavsson, M., Veglia, G., Becker, J. M., Naider, F. & Distefano, M. D., May 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 9, 1 p.

Research output: Contribution to journalComment/debate

Pharmaceutical Chemistry
Saccharomyces cerevisiae
Peptides
14 Citations (Scopus)

Evaluation of a cell penetrating prenylated peptide lacking an intrinsic fluorophore via in situ click reaction

Ochocki, J. D., Mullen, D. G., Wattenberg, E. V. & Distefano, M. D., Sep 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 17, p. 4998-5001 4 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Fluorophores
Peptides
Cell membranes
Protein Prenylation
11 Citations (Scopus)

Nuclear magnetic resonance-based quantification of organic diphosphates

Lenevich, S. & Distefano, M. D., Jan 15 2011, In : Analytical Biochemistry. 408, 2, p. 316-320 5 p.

Research output: Contribution to journalArticle

Capillary tubes
Diphosphates
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Diphosphonates
9 Citations (Scopus)

Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: Improved labeling and structural implications

Kyro, K., Manandhar, S. P., Mullen, D., Schmidt, W. K. & Distefano, M. D., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7559-7569 11 p.

Research output: Contribution to journalArticle

Labeling
Peptides
Substrates
Enzymes
Catalytic Domain
13 Citations (Scopus)

Synthesis of a-factor peptide from Saccharomyces cerevisiae and photoactive analogues via Fmoc solid phase methodology

Mullen, D. G., Kyro, K., Hauser, M., Gustavsson, M., Veglia, G., Becker, J. M., Naider, F. & Distefano, M. D., Jan 1 2011, In : Bioorganic and Medicinal Chemistry. 19, 1, p. 490-497 8 p.

Research output: Contribution to journalArticle

Solid-Phase Synthesis Techniques
G-Protein-Coupled Receptors
Yeast
Saccharomyces cerevisiae
Yeasts
2010
7 Citations (Scopus)

Enlarging the scope of cell-penetrating prenylated peptides to include farnesylated 'CAAX' box sequences and diverse cell types

Ochocki, J. D., Igbavboa, U., Wood, W. G., Wattenberg, E. V. & Distefano, M. D., Jan 1 2010, In : Chemical Biology and Drug Design. 76, 2, p. 107-115 9 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Prenylation
Protein Prenylation
Peptides
Proteins
49 Citations (Scopus)

Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation

DeGraw, A. J., Palsuledesai, C., Ochocki, J. D., Dozier, J. K., Lenevich, S., Rashidian, M. & Distefano, M. D., Dec 1 2010, In : Chemical Biology and Drug Design. 76, 6, p. 460-471 12 p.

Research output: Contribution to journalArticle

Protein Prenylation
Alkynes
Terpenes
Proteins
Dimethylallyltranstransferase
11 Citations (Scopus)

Investigation of the sequence and length dependence for cell-penetrating prenylated peptides

Wollack, J. W., Zeliadt, N. A., Ochocki, J. D., Mullen, D. G., Barany, G., Wattenberg, E. V. & Distefano, M. D., Jan 1 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 1, p. 161-163 3 p.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides
Peptides
Molecules
Amino Acids
10 Citations (Scopus)

On-resin conversion of Cys(Acm)-containing peptides to their corresponding Cys(Scm) congeners

Mullen, D. G., Weigel, B., Barany, G. & Distefano, M. D., May 1 2010, In : Journal of Peptide Science. 16, 5, p. 219-222 4 p.

Research output: Contribution to journalArticle

Resins
Peptides
Cysteine
Amino Acids
Solid-Phase Synthesis Techniques
7 Citations (Scopus)

Photoaffinity labeling of Ras converting enzyme 1 (Rce1p) using a benzophenone-containing peptide substrate

Kyro, K., Manandhar, S. P., Mullen, D., Schmidt, W. K. & Distefano, M. D., Aug 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 15, p. 5675-5684 10 p.

Research output: Contribution to journalArticle

Labeling
Photolysis
Peptides
Membrane Proteins
Substrates
38 Citations (Scopus)

Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs

Degraw, A. J., Keiser, M. J., Ochocki, J. D., Shoichet, B. K. & Distefano, M. D., Mar 25 2010, In : Journal of Medicinal Chemistry. 53, 6, p. 2464-2471 8 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Pharmaceutical Preparations
Enzymes
Receptor Cross-Talk
Loratadine
27 Citations (Scopus)

Selective labeling of polypeptides using protein farnesyltransferase via rapid oxime ligation

Rashidian, M., Dozier, J. K., Lenevich, S. & Distefano, M. D., Dec 21 2010, In : Chemical Communications. 46, 47, p. 8998-9000 3 p.

Research output: Contribution to journalArticle

Oximes
Polypeptides
Labeling
Proteins
Peptides
42 Citations (Scopus)

Sesquiterpene synthases Cop4 and Cop6 from Coprinus cinereus: Catalytic promiscuity and cyclization of farnesyl pyrophosphate geometric isomers

Lopez-Gallego, F., Agger, S. A., Abate Pella, D., Distefano, M. D. & Schmidt-Dannert, C., May 17 2010, In : ChemBioChem. 11, 8, p. 1093-1106 14 p.

Research output: Contribution to journalArticle

Coprinus
Sesquiterpenes
Cyclization
Isomers
Enzymes
8 Citations (Scopus)

Synthesis, Properties, and applications of diazotrifluropropanoyl- containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability

Hovlid, M. L., Edelstein, R. L., Henry, O., Ochocki, J., Degraw, A., Lenevich, S., Talbot, T., Young, V. G., Hruza, A. W., Lopez-Gallego, F., Labello, N. P., Strickland, C. L., Schmidt-Dannert, C. & Distefano, M. D., Jan 1 2010, In : Chemical Biology and Drug Design. 75, 1, p. 51-67 17 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae Proteins
Amides
Transferases
Escherichia coli
Esters
2009
21 Citations (Scopus)

A minimalist substrate for enzymatic peptide and protein conjugation

Wollack, J. W., Silverman, J. M., Petzold, C. J., Mougous, J. D. & Distefano, M. D., Dec 1 2009, In : ChemBioChem. 10, 18, p. 2934-2943 10 p.

Research output: Contribution to journalArticle

Peptides
Alkynes
Substrates
Amino Acids
Solubility
11 Citations (Scopus)

A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes

Henry, O., Lopez-Gallego, F., Agger, S. A., Schmidt-Dannert, C., Sen, S., Shintani, D., Cornish, K. & Distefano, M. D., Jul 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 13, p. 4797-4805 9 p.

Research output: Contribution to journalArticle

Diphosphates
Labels
Isomers
Binding Sites
Saccharomyces cerevisiae Proteins
36 Citations (Scopus)

Multifunctional prenylated peptides for live cell analysis

Wollack, J. W., Zeliadt, N. A., Mullen, D. G., Amundson, G., Jasberg, S. G., Falkum, S., Wattenberg, E. V., Barany, G. & Distefano, M. D., Jun 3 2009, In : Journal of the American Chemical Society. 131, 21, p. 7293-7303 11 p.

Research output: Contribution to journalArticle

Peptides
Protein Prenylation
Proteins
Cells
Prenylation
46 Citations (Scopus)

Photoaffinity antigens for human γδ T cells

Sarikonda, G., Wang, H., Puan, K. J., Liu, X. H., Lee, H. K., Song, Y., Distefano, M. D., Oldfield, E., Prestwich, G. D. & Morita, C. T., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7738-7750 13 p.

Research output: Contribution to journalArticle

Diphosphates
Tumor Cell Line
T-Lymphocytes
Antigens
Terpenes
16 Citations (Scopus)

Purification of prenylated proteins by affinity chromatography on cyclodextrin-modified agarose

Chung, J. A., Wollack, J. W., Hovlid, M. L., Okesli, A., Chen, Y., Mueller, J., Distefano, M. D. & Taton, T. A., Mar 1 2009, In : Analytical Biochemistry. 386, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Affinity chromatography
Cyclodextrins
Affinity Chromatography
Sepharose
Purification
2008
18 Citations (Scopus)

Caged protein prenyltransferase substrates: Tools for understanding protein prenylation

DeGraw, A. J., Hast, M. A., Xu, J., Mullen, D., Beese, L. S., Barany, G. & Distefano, M. D., Sep 1 2008, In : Chemical Biology and Drug Design. 72, 3, p. 171-181 11 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Protein Prenylation
Photolysis
Substrates
Proteins
15 Citations (Scopus)

Initiation of rubber biosynthesis: In vitro comparisons of benzophenone-modified diphosphate analogues in three rubber-producing species

Xie, W., McMahan, C. M., DeGraw, A. J., Distefano, M. D., Cornish, K., Whalen, M. C. & Shintani, D. K., Oct 1 2008, In : Phytochemistry. 69, 14, p. 2539-2545 7 p.

Research output: Contribution to journalArticle

benzophenone
Diphosphates
Biosynthesis
Rubber
rubber

Photoaffinity antigens for human gammadelta T cells.

Sarikonda, G., Wang, H., Puan, K. J., Liu, X. H., Lee, H. K., Song, Y., Distefano, M. D., Oldfield, E., Prestwich, G. D. & Morita, C. T., Dec 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 11, p. 7738-7750 13 p.

Research output: Contribution to journalArticle

Diphosphates
Tumor Cell Line
T-Lymphocytes
Antigens
Terpenes
2007
31 Citations (Scopus)

A photoactive isoprenoid diphosphate analogue containing a stable phosphonate linkage: Synthesis and biochemical studies with prenyltransferases

DeGraw, A. J., Zhao, Z., Strickland, C. L., Taban, A. H., Hsieh, J., Jefferies, M., Xie, W., Shintani, D. K., McMahan, C. M., Cornish, K. & Distefano, M. D., Jun 22 2007, In : Journal of Organic Chemistry. 72, 13, p. 4587-4595 9 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Organophosphonates
Diphosphates
Terpenes
Biosynthesis
72 Citations (Scopus)

A universal method for the preparation of covalent protein-DNA conjugates for use in creating protein nanostructures

Duckworth, B. P., Chen, Y., Wollack, J. W., Sham, Y. Y., Mueller, J., Taton, T. A. & Distefano, M. D., Dec 10 2007, In : Angewandte Chemie - International Edition. 46, 46, p. 8819-8822 4 p.

Research output: Contribution to journalArticle

Nanostructures
DNA
Proteins
Alkynes
Azides
25 Citations (Scopus)

Evaluation of an alkyne-containing analogue of farnesyl diphosphate as a dual substrate for protein-prenyltransferases

Hosokawa, A., Wollack, J. W., Zhang, Z., Chen, L., Barany, G. & Distefano, M. D., Jun 1 2007, In : International Journal of Peptide Research and Therapeutics. 13, 1-2, p. 345-354 10 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Alkynes
Peptides
Proteins
Substrates
86 Citations (Scopus)

Selective labeling of proteins by using protein farnesyltransferase

Duckworth, B. P., Zhang, Z., Hosokawa, A. & Distefano, M. D., Jan 1 2007, In : ChemBioChem. 8, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

Labeling
Alkynes
Fluorophores
Proteins
Molecular modeling
16 Citations (Scopus)

Transition state analysis of model and enzymatic prenylation reactions

Lenevich, S., Xu, J., Hosokawa, A., Cramer, C. & Distefano, M. D., May 9 2007, In : Journal of the American Chemical Society. 129, 18, p. 5796-5797 2 p.

Research output: Contribution to journalArticle

Prenylation
Bond length
Isotopes
Enzymes
Kinetics
2006

Protein-based Artificial Enzymes

Duckworth, B. & Distefano, M. D., Mar 24 2006, Artificial Enzymes. John Wiley and Sons, p. 109-132 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Myoglobin
DNA-Binding Proteins
Catalysts
Enzymes
Proteins
108 Citations (Scopus)

Site-specific, covalent attachment of proteins to a solid surface

Duckworth, B. P., Xu, J., Taton, T. A., Guo, A. & Distefano, M. D., Jul 1 2006, In : Bioconjugate Chemistry. 17, 4, p. 967-974 8 p.

Research output: Contribution to journalArticle

Proteins
Azides
Bearings (structural)
Alkynes
Cycloaddition
18 Citations (Scopus)

Synthesis and reactivity of 6,7-dihydrogeranylazides: Reagents for primary azide incorporation into peptides and subsequent staudinger ligation

Xu, J., DeGraw, A. J., Duckworth, B. P., Lenevich, S., Tann, C. M., Jenson, E. C., Gruber, S. J., Barany, G. & Distefano, M. D., Aug 1 2006, In : Chemical Biology and Drug Design. 68, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Azides
Ligation
Peptides
Imidoesters
Diphosphates
2005
27 Citations (Scopus)
Azides
Diphosphates
Labeling
Peptides
Imidoesters
31 Citations (Scopus)

Evaluation of geranylazide and farnesylazide diphosphate for incorporation of prenylazides into a CAAX box-containing peptide using protein farnesyltransferase

Rose, M. W., Rose, N. D., Boggs, J., Lenevich, S., Xu, J., Barany, G. & Distefano, M. D., Jun 1 2005, In : Journal of Peptide Research. 65, 6, p. 529-537 9 p.

Research output: Contribution to journalArticle

Azides
Diphosphates
Imidoesters
Peptides
Social Responsibility
121 Citations (Scopus)

Growth cones turn and migrate up an immobilized gradient of the laminin IKVAV peptide

Adams, D. N., Kao, E. Y. C., Hypolite, C. L., Distefano, M. D., Hu, W. S. & Letourneau, P. C., Jan 1 2005, In : Journal of Neurobiology. 62, 1, p. 134-147 14 p.

Research output: Contribution to journalArticle

isoleucyl-lysyl-valyl-alanyl-valine
Growth Cones
Laminin
Peptides
Cues
2003
43 Citations (Scopus)

Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase

Turek-Etienne, T. C., Strickland, C. L. & Distefano, M. D., Apr 8 2003, In : Biochemistry. 42, 13, p. 3716-3724 9 p.

Research output: Contribution to journalArticle

Diphosphates
Terpenes
Transferases
Proteins
Protein Binding
19 Citations (Scopus)

Diazotrifluoropropionamido-containing prenylcysteines: Syntheses and applications for studying isoprenoid-protein interactions

Kale, T. A. & Distefano, M. D., Mar 6 2003, In : Organic Letters. 5, 5, p. 609-612 4 p.

Research output: Contribution to journalArticle

Terpenes
proteins
Photolysis
synthesis
photolysis
77 Citations (Scopus)

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)

Franklin, M. C., Kadkhodayan, S., Ackerly, H., Alexandru, D., Distefano, M. D., Elliott, L. O., Flygare, J. A., Mausisa, G., Okawa, D. C., Ong, D., Vucic, D., Deshayes, K. & Fairbrother, W. J., Jul 15 2003, In : Biochemistry. 42, 27, p. 8223-8231 9 p.

Research output: Contribution to journalArticle

Melanoma
Baculoviridae
Apoptosis
Peptides
X Chromosome
8 Citations (Scopus)

Synthesis of high specific activity 35S-labelled N-methanesulfonyl farnesylcysteine and a photoactive analog

Kale, T. A., Raab, C., Yu, N., Aquino, E., Dean, D. C. & Distefano, M. D., Jan 1 2003, In : Journal of Labelled Compounds and Radiopharmaceuticals. 46, 1, p. 29-54 26 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Dissociation Inhibitors
Photolysis
GTP-Binding Proteins
Cysteine
Esters
23 Citations (Scopus)

Use of synthetic isoprenoid analogues for understanding protein prenyltransferase mechanism and structure.

Kale, T. A., Hsieh, S. A. J., Rose, M. W. & Distefano, M. D., Jan 1 2003, In : Current Topics in Medicinal Chemistry. 3, 10, p. 1043-1074 32 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Terpenes
Protein Prenylation
Proteins
Prenylation
2002
7 Citations (Scopus)

Exploring routes to stabilize a cationic pyridoxamine in an artificial transaminase: Site-directed mutagenesis versus synthetic cofactors

Häring, D., Lees, M. R., Banaszak, L. J. & Distefano, M. D., Jul 1 2002, In : Protein Engineering. 15, 7, p. 603-610 8 p.

Research output: Contribution to journalArticle

Pyridoxamine
Fatty Acid-Binding Proteins
Mutagenesis
Site-Directed Mutagenesis
Transaminases
37 Citations (Scopus)

Quantifying β-sheet stability by phage display

Distefano, M. D., Zhong, A. & Cochran, A. G., Jan 1 2002, In : Journal of Molecular Biology. 322, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

Bacteriophages
Libraries
Protein Stability
Firearms
Alanine
2001
24 Citations (Scopus)

A photoactivatable prenylated cysteine designed to study isoprenoid recognition

Kale, T. A., Raab, C., Yu, N., Dean, D. C. & Distefano, M. D., Oct 14 2001, In : Journal of the American Chemical Society. 123, 19, p. 4373-4381 9 p.

Research output: Contribution to journalArticle

Terpenes
Cysteine
Guanine Nucleotide Dissociation Inhibitors
Proteins
Protein Prenylation