If you made any changes in Pure, your changes will be visible here soon.

Research Output 1983 2019

2019

A quantitative FRET assay for the upstream cleavage activity of the integral membrane proteases human ZMPSTE24 and yeast Ste24

Hsu, E. T., Vervacke, J. S., Distefano, M. D. & Hrycyna, C. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 279-293 15 p. (Methods in Molecular Biology; vol. 2009).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peptide Hydrolases
Yeasts
Membranes
Mating Factor
Enzymes

Cysteine-ethylation of tissue-extracted membrane proteins as a tool to detect conformational states by solid-state NMR spectroscopy

Weber, D. K., Bader, T., Larsen, E. K., Wang, S., Tata, G., Distefano, M. D. & Veglia, G., Jan 1 2019, Methods in Enzymology. Shukla, A. K. (ed.). Academic Press Inc., p. 281-304 24 p. (Methods in Enzymology; vol. 621).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nuclear magnetic resonance spectroscopy
Cysteine
Membrane Proteins
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance

Optimization of metabolic labeling with Alkyne-containing isoprenoid probes

Ahmadi, M., Suazo, K. F. & Distefano, M. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 35-43 9 p. (Methods in Molecular Biology; vol. 2009).

Research output: Chapter in Book/Report/Conference proceedingChapter

Alkynes
Terpenes
Protein Prenylation
Proteins
Monomeric GTP-Binding Proteins

Synthesis and NMR Characterization of the Prenylated Peptide, a-Factor

Bader, T. K., Rappe, T. M., Veglia, G. & Distefano, M. D., Jan 1 2019, Methods in Enzymology. Wand, A. J. (ed.). Academic Press Inc., p. 207-238 32 p. (Methods in Enzymology; vol. 614).

Research output: Chapter in Book/Report/Conference proceedingChapter

Prenylation
Nuclear magnetic resonance
Peptides
Mating Factor
Yeast
2018
4 Citations (Scopus)

A-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity

Diaz-Rodriguez, V., Hsu, E. T., Ganusova, E., Werst, E. R., Becker, J. M., Hrycyna, C. A. & Distefano, M. D., Feb 21 2018, In : Bioconjugate Chemistry. 29, 2, p. 316-323 8 p.

Research output: Contribution to journalArticle

Alkynes
Azides
Terpenes
Bioactivity
Proteins
7 Citations (Scopus)

Efficient farnesylation of an extended C-terminal C(x) 3 X sequence motif expands the scope of the prenylated proteome

Blanden, M. J., Suazo, K. F., Hildebrandt, E. R., Hardgrove, D. S., Patel, M., Saunders, W. P., Distefano, M. D., Schmidt, W. K. & Hougland, J. L., Jan 1 2018, In : Journal of Biological Chemistry. 293, 8, p. 2770-2785 16 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Prenylation
Proteome
Cysteine
Proteins
1 Citation (Scopus)

Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease

Jeong, A., Suazo, K. F., Wood, W. G., Distefano, M. D. & Li, L., May 4 2018, In : Critical Reviews in Biochemistry and Molecular Biology. 53, 3, p. 279-310 32 p.

Research output: Contribution to journalReview article

Protein Prenylation
Terpenes
Alzheimer Disease
Dimethylallyltranstransferase
Proteins
1 Citation (Scopus)

Metabolic Labeling of Prenylated Proteins Using Alkyne-Modified Isoprenoid Analogues

Suazo, K. F., Hurben, A. K., Liu, K., Xu, F., Thao, P., Sudheer, C., Li, L. & Distefano, M. D., Sep 1 2018, In : Current protocols in chemical biology. 10, 3, p. e46

Research output: Contribution to journalArticle

Alkynes
Terpenes
Proteins
Protein Prenylation
Prenylation
8 Citations (Scopus)

Photo-immobilized EGF chemical gradients differentially impact breast cancer cell invasion and drug response in defined 3D hydrogels

Fisher, S. A., Tam, R. Y., Fokina, A., Mahmoodi, M. M., Distefano, M. D. & Shoichet, M. S., Sep 1 2018, In : Biomaterials. 178, p. 751-766 16 p.

Research output: Contribution to journalArticle

Hydrogels
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Cells
Breast Neoplasms
7 Citations (Scopus)

Recent progress in enzymatic protein labelling techniques and their applications

Zhang, Y., Park, K. Y., Suazo, K. F. & Distefano, M. D., Dec 21 2018, In : Chemical Society Reviews. 47, 24, p. 9106-9136 31 p.

Research output: Contribution to journalReview article

Labeling
Proteins
Ligases
Polymers
Bearings (structural)
1 Citation (Scopus)

Site-specific cross-linking of proteins to DNA: Via a new bioorthogonal approach employing oxime ligation

Pujari, S., Zhang, Y., Ji, S., Distefano, M. D. & Tretyakova, N. Y., Jan 1 2018, In : Chemical Communications. 54, 49, p. 6296-6299 4 p.

Research output: Contribution to journalArticle

Oximes
DNA
Proteins
DNA Adducts
Aldehydes
2017
3 Citations (Scopus)

A-Factor: A chemical biology tool for the study of protein prenylation

Diaz-Rodriguez, V. & Distefano, M. D., Jan 1 2017, In : Current Topics in Peptide and Protein Research. 18, p. 133-151 19 p.

Research output: Contribution to journalReview article

Protein Prenylation
Mating Factor
Pheromones
Peptides
Proteins
1 Citation (Scopus)

Polymeric Medical Sutures: An Exploration of Polymers and Green Chemistry

Knutson, C. M., Schneiderman, D. K., Yu, M., Javner, C. H., Distefano, M. D. & Wissinger, J. E., Nov 14 2017, In : Journal of Chemical Education. 94, 11, p. 1761-1765 5 p.

Research output: Contribution to journalArticle

Polymers
chemistry
experiment
Students
student
2016
7 Citations (Scopus)

6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning

Mahmoodi, M. M., Fisher, S. A., Tam, R. Y., Goff, P. C., Anderson, R. B., Wissinger, J. E., Blank, D. A., Shoichet, M. S. & Distefano, M. D., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 35, p. 8289-8300 12 p.

Research output: Contribution to journalArticle

Photons
Sulfhydryl Compounds
thiols
peptides
photons
13 Citations (Scopus)

8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

Mohammed, I., Hampton, S. E., Ashall, L., Hildebrandt, E. R., Kutlik, R. A., Manandhar, S. P., Floyd, B. J., Smith, H. E., Dozier, J. K., Distefano, M. D., Schmidt, W. K. & Dore, T. M., Jan 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 2, p. 160-178 19 p.

Research output: Contribution to journalArticle

Oxyquinoline
Peptide Hydrolases
Cells
Membranes
Enzymes
8 Citations (Scopus)

Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase

Jennings, B. C., Danowitz, A. M., Wang, Y. C., Gibbs, R. A., Distefano, M. D. & Fierke, C. A., Feb 15 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 4, p. 1333-1336 4 p.

Research output: Contribution to journalArticle

Prenylation
Alkynes
Substrate Specificity
Reaction rates
Drug therapy
12 Citations (Scopus)

Bypass of DNA-protein cross-links conjugated to the 7-deazaguanine position of DNA by translesion synthesis polymerases

Wickramaratne, S., Ji, S., Mukherjee, S., Su, Y., Pence, M. G., Lior-Hoffmann, L., Fu, I., Broyde, S., Guengerich, F. P., Distefano, M., Schãrer, O. D., Sham, Y. Y. & Tretyakova, N., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23589-23603 15 p.

Research output: Contribution to journalArticle

DNA
Proteins
Peptides
Guanine
7-deazaguanine
14 Citations (Scopus)

Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue

Suazo, K. F., Schaber, C., Palsuledesai, C. C., Odom John, A. R. & Distefano, M. D., Dec 7 2016, In : Scientific reports. 6, 38615.

Research output: Contribution to journalArticle

Alkynes
Terpenes
Plasmodium falciparum
Proteomics
Malaria
14 Citations (Scopus)

Metabolic Labeling with an Alkyne-modified Isoprenoid Analog Facilitates Imaging and Quantification of the Prenylome in Cells

Palsuledesai, C. C., Ochocki, J. D., Kuhns, M. M., Wang, Y. C., Warmka, J. K., Chernick, D. S., Wattenberg, E. V., Li, L., Arriaga, E. & Distefano, M. D., Oct 21 2016, In : ACS Chemical Biology. 11, 10, p. 2820-2828 9 p.

Research output: Contribution to journalArticle

Protein Prenylation
Alkynes
Terpenes
Labeling
Imaging techniques
13 Citations (Scopus)

Nitrodibenzofuran: A One-and Two-Photon Sensitive Protecting Group That Is Superior to Brominated Hydroxycoumarin for Thiol Caging in Peptides

Mahmoodi, M. M., Abate-Pella, D., Pundsack, T. J., Palsuledesai, C. C., Goff, P. C., Blank, D. A. & Distefano, M. D., May 11 2016, In : Journal of the American Chemical Society. 138, 18, p. 5848-5859 12 p.

Research output: Contribution to journalArticle

Photons
Sulfhydryl Compounds
Peptides
Cysteine
Light
2 Citations (Scopus)

Synthetic isoprenoid analogues for the study of prenylated proteins: Fluorescent imaging and proteomic applications

Wang, Y. C. & Distefano, M. D., Feb 1 2016, In : Bioorganic Chemistry. 64, p. 59-65 7 p.

Research output: Contribution to journalReview article

Terpenes
Proteomics
Dimethylallyltranstransferase
Imaging techniques
Proteins
2015
4 Citations (Scopus)

Application of meta- and para-phenylenediamine as enhanced oxime ligation catalysts for protein labeling, PEGylation, immobilization, and release

Mahmoodi, M. M., Rashidian, M., Zhang, Y. & Distefano, M. D., Jan 1 2015, In : Current Protocols in Protein Science. 2015, p. 15.4.1-15.4.28

Research output: Contribution to journalArticle

Oximes
Aldehydes
Immobilization
Labeling
Ligation
13 Citations (Scopus)

Error-prone translesion synthesis past DNA-peptide cross-links conjugated to the major groove of DNA via C5 of thymidine

Wickramaratne, S. S., Boldry, E. J., Buehler, C., Wang, Y. C., Distefano, M. D. & Tretyakova, N. Y., Sep 9 2015, In : Journal of Biological Chemistry. 290, 2, p. 775-787 13 p.

Research output: Contribution to journalArticle

Thymidine
Peptides
DNA
Reactive Oxygen Species
Proteins
55 Citations (Scopus)

Protein prenylation: Enzymes, therapeutics, and biotechnology applications

Palsuledesai, C. C. & Distefano, M. D., Jan 16 2015, In : ACS Chemical Biology. 10, 1, p. 51-62 12 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Protein Prenylation
Biotechnology
Prenylation
ras Proteins
5 Citations (Scopus)

Simultaneous Site-Specific Dual Protein Labeling Using Protein Prenyltransferases

Zhang, Y., Blanden, M. J., Chava, S., Gangopadhyay, S. A., Rashidian, M., Hougland, J. L. & Distefano, M. D., Dec 16 2015, In : Bioconjugate Chemistry. 26, 12, p. 2542-2553 12 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Labeling
Proteins
Terpenes
Rats
71 Citations (Scopus)

Site-specific pegylation of therapeutic proteins

Dozier, J. K. & Distefano, M. D., Oct 1 2015, In : International journal of molecular sciences. 16, 10, p. 25831-25864 34 p.

Research output: Contribution to journalReview article

proteins
Proteins
Polyethylene glycols
glycols
polyethylenes
10 Citations (Scopus)
Pheromones
Yeast
Esters
Peptides
Cysteine
13 Citations (Scopus)

The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse

Laudenbach, M., Baruffaldi, F., Vervacke, J. S., Distefano, M. D., Titcombe, P. J., Mueller, D. L., Tubo, N. J., Griffith, T. S. & Pravetoni, M., Jun 15 2015, In : Journal of Immunology. 194, 12, p. 5926-5936 11 p.

Research output: Contribution to journalArticle

B-Lymphocyte Subsets
Haptens
Oxycodone
Opioid Analgesics
Prescriptions
2014
17 Citations (Scopus)

A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins

Palsuledesai, C. C., Ochocki, J. D., Markowski, T. W. & Distefano, M. D., Jan 1 2014, In : Molecular BioSystems. 10, 5, p. 1094-1103 10 p.

Research output: Contribution to journalArticle

Farnesyltranstransferase
Electrophoresis, Gel, Two-Dimensional
Post Translational Protein Processing
Proteins
Alkynes
9 Citations (Scopus)

Diazirine-containing photoactivatable isoprenoid: Synthesis and application in studies with isoprenylcysteine carboxyl methyltransferase

Vervacke, J. S., Funk, A. L., Wang, Y. C., Strom, M., Hrycyna, C. A. & Distefano, M. D., Mar 7 2014, In : Journal of Organic Chemistry. 79, 5, p. 1971-1978 8 p.

Research output: Contribution to journalArticle

Diazomethane
Terpenes
Benzophenones
Peptides
Labeling
18 Citations (Scopus)

Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats

Pravetoni, M., Vervacke, J. S., Distefano, M. D., Tucker, A. M., Laudenbach, M. & Pentel, P. R., May 5 2014, In : PloS one. 9, 5, e96547.

Research output: Contribution to journalArticle

Oxycodone
Conjugate Vaccines
toxoids
tetanus
adjuvants
15 Citations (Scopus)

Engineering protein farnesyltransferase for enzymatic protein labeling applications

Dozier, J. K., Khatwani, S. L., Wollack, J. W., Wang, Y. C., Schmidt-Dannert, C. & Distefano, M. D., Jul 16 2014, In : Bioconjugate Chemistry. 25, 7, p. 1203-1212 10 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Alanine
Mutation
Mutagenesis

Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis

Ochocki, J. D., Igbavboa, U., Wood, W. G., Arriaga, E. A., Wattenberg, E. V. & Distefano, M. D., Jan 1 2014, In : Methods in Molecular Biology. 1088, p. 213-223 11 p.

Research output: Contribution to journalArticle

Protein Prenylation
Prenylation
Peptides
Dimethylallyltranstransferase
ras Proteins
2 Citations (Scopus)

Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis

Ochocki, J. D., Igbavboa, U., Wood, W. G., Arriaga, E., Wattenberg, E. V. & Distefano, M. D., Jan 1 2014, Therapeutic Peptides: Methods and Protocols. Humana Press Inc., p. 213-223 11 p. (Methods in Molecular Biology; vol. 1088).

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein Prenylation
Prenylation
Peptides
Dimethylallyltranstransferase
ras Proteins
15 Citations (Scopus)

Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues

Wang, Y. C., Dozier, J. K., Beese, L. S. & Distefano, M. D., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1726-1735 10 p.

Research output: Contribution to journalArticle

Peptide Library
Diphosphates
Terpenes
Substrate Specificity
Libraries
14 Citations (Scopus)

Site-specific labeling of proteins and peptides with trans-cyclooctene containing handles capable of tetrazine ligation

Wollack, J. W., Monson, B. J., Dozier, J. K., Dalluge, J. J., Poss, K., Hilderbrand, S. A. & Distefano, M. D., Jan 1 2014, In : Chemical Biology and Drug Design. 84, 2, p. 140-147 8 p.

Research output: Contribution to journalArticle

Labeling
Ligation
Copper
Peptides
Substrates

Synthesis and screening of peptide libraries with free C-termini

Wang, Y. C. & Distefano, M. D., Jan 1 2014, In : Current Topics in Peptide and Protein Research. 15, p. 1-23 23 p.

Research output: Contribution to journalReview article

Peptide Library
Screening
Solid-Phase Synthesis Techniques
Bacteriophages
Libraries
23 Citations (Scopus)

Synthesis of site-specific DNA-protein conjugates and their effects on DNA replication

Yeo, J. E., Wickramaratne, S. S., Khatwani, S., Wang, Y. C., Vervacke, J., Distefano, M. D. & Tretyakova, N. Y., Aug 15 2014, In : ACS Chemical Biology. 9, 8, p. 1860-1868 9 p.

Research output: Contribution to journalArticle

DNA Replication
DNA
Proteins
Peptides
Alkynes
18 Citations (Scopus)

The chaperone protein smggds interacts with small gtpases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif

Schuld, N. J., Vervacke, J. S., Lorimer, E. L., Simon, N. C., Hauser, A. D., Barbieri, J. T., Distefano, M. D. & Williams, C. L., Mar 7 2014, In : Journal of Biological Chemistry. 289, 10, p. 6862-6876 15 p.

Research output: Contribution to journalArticle

Prenylation
Monomeric GTP-Binding Proteins
GTP Phosphohydrolases
Amino Acids
Proteins
2013
76 Citations (Scopus)

A highly efficient catalyst for oxime ligation and hydrazone-oxime exchange suitable for bioconjugation

Rashidian, M., Mahmoodi, M. M., Shah, R., Dozier, J. K., Wagner, C. R. & Distefano, M. D., Mar 20 2013, In : Bioconjugate Chemistry. 24, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

Hydrazones
Oximes
Ligation
Aniline
Catalysts
35 Citations (Scopus)

Bioanalysis of eukaryotic organelles

Satori, C. P., Henderson, M. M., Krautkramer, E. A., Kostal, V., Distefano, M. D. & Arriaga, E., Apr 10 2013, In : Chemical Reviews. 113, 4, p. 2733-2811 79 p.

Research output: Contribution to journalReview article

Tissue
Confocal microscopy
Pathogens
Fractionation
Aging of materials
85 Citations (Scopus)

Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 t cells

Wang, H., Henry, O., Distefano, M. D., Wang, Y. C., Raikkonen, J., Monkkonen, J., Tanaka, Y. & Morita, C. T., Aug 1 2013, In : Journal of Immunology. 191, 3, p. 1029-1042 14 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Diphosphates
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Jurkat Cells
Papio
6 Citations (Scopus)
hydrazine
Oximes
Complex Mixtures
Immobilization
Ligation
24 Citations (Scopus)

Chemoselective immobilization of proteins by microcontact printing and bio-orthogonal click reactions

Tolstyka, Z. P., Richardson, W., Bat, E., Stevens, C. J., Parra, D. P., Dozier, J. K., Distefano, M. D., Dunn, B. & Maynard, H. D., Dec 1 2013, In : ChemBioChem. 14, 18, p. 2464-2471 8 p.

Research output: Contribution to journalArticle

Printing
Immobilization
Azides
Gold
Alkynes
138 Citations (Scopus)

Enzymatic labeling of proteins: Techniques and approaches

Rashidian, M., Dozier, J. K. & Distefano, M. D., Aug 21 2013, In : Bioconjugate Chemistry. 24, 8, p. 1277-1294 18 p.

Research output: Contribution to journalReview article

Labeling
Proteins
Functional groups
Post Translational Protein Processing
Ligases
1 Citation (Scopus)

Erratum: Bioanalysis of eukaryotic organelles (Chemical Reviews (2013) 13: 4 (2733-2811) DOI: 10.1021/cr300354g)

Satori, C. P., Henderson, M. M., Krautkramer, E. A., Kostal, V., Distefano, M. D. & Arriaga, E., Jul 10 2013, In : Chemical Reviews. 113, 7, 1 p.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)
Terpenes
Benzophenones
Molecules
Azides
Sesquiterpenes
33 Citations (Scopus)

Prenyltransferase inhibitors: Treating human ailments from cancer to parasitic infections

Ochocki, J. D. & Distefano, M. D., Mar 1 2013, In : MedChemComm. 4, 3, p. 476-492 17 p.

Research output: Contribution to journalReview article

Dimethylallyltranstransferase
Parasitic Diseases
Protein Prenylation
Progeria
Hepatitis D
23 Citations (Scopus)

Simultaneous dual protein labeling using a triorthogonal reagent

Rashidian, M., Kumarapperuma, S. C., Gabrielse, K., Fegan, A., Wagner, C. R. & Distefano, M. D., Nov 6 2013, In : Journal of the American Chemical Society. 135, 44, p. 16388-16396 9 p.

Research output: Contribution to journalArticle

Labeling
Proteins
Tetrahydrofolate Dehydrogenase
Fluorophores
Polyethylene glycols
2012
7 Citations (Scopus)

An enzyme-coupled continuous fluorescence assay for farnesyl diphosphate synthases

Dozier, J. K. & Distefano, M. D., Feb 1 2012, In : Analytical Biochemistry. 421, 1, p. 158-163 6 p.

Research output: Contribution to journalArticle

Geranyltranstransferase
Assays
Fluorescence
Enzymes
Prenylation