Research output per year
Research output per year
Search results
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2022
Combining nilotinib and PD-L1 blockade reverses CD4+ T-cell dysfunction and prevents relapse in acute B-cell leukemia
Tracy, S. I., Venkatesh, H., Hekim, C., Heltemes-Harris, L. M., Knutson, T. P., Bachanova, V. & Farrar, M. A., Jul 28 2022, In: Blood. 140, 4, p. 335-348 14 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Nuclear corepressors NCOR1/NCOR2 regulate B cell development, maintain genomic integrity and prevent transformation
Lee, R. D., Knutson, T. P., Munro, S. A., Miller, J. T., Heltemes-Harris, L. M., Mullighan, C. G., Jepsen, K. & Farrar, M. A., Dec 2022, In: Nature immunology. 23, 12, p. 1763-1776 14 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2021
Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia
Heltemes-Harris, L. M., Hubbard, G. K., LaRue, R. S., Munro, S. A., Yang, R., Henzler, C. M., Starr, T. K., Sarver, A. L., Kornblau, S. M. & Farrar, M. A., Oct 28 2021, In: Oncogene. 40, 43, p. 6166-6179 14 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Single-cell analysis identifies dynamic gene expression networks that govern B cell development and transformation
Lee, R. D., Munro, S. A., Knutson, T. P., LaRue, R. S., Heltemes-Harris, L. M. & Farrar, M. A., Dec 2021, In: Nature communications. 12, 1, 6843.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
2019
B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage
Wong, J. B., Hewitt, S. L., Heltemes-Harris, L. M., Mandal, M., Johnson, K., Rajewsky, K., Koralov, S. B., Clark, M. R., Farrar, M. A. & Skok, J. A., Dec 1 2019, In: Nature communications. 10, 1, 4768.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma
Rahrmann, E. P., Wolf, N. K., Otto, G. M., Heltemes-Harris, L., Ramsey, L. B., Shu, J., LaRue, R. S., Linden, M. A., Rathe, S. K., Starr, T. K., Farrar, M. A., Moriarity, B. S. & Largaespada, D. A., Feb 2019, In: Molecular Cancer Research. 17, 2, p. 567-582 16 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2017
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival
Katerndahl, C. D. S., Heltemes-Harris, L. M., Willette, M. J. L., Henzler, C. M., Frietze, S., Yang, R., Schjerven, H., Silverstein, K. A. T., Ramsey, L. B., Hubbard, G., Wells, A. D., Kuiper, R. P., Scheijen, B., van Leeuwen, F. N., Müschen, M., Kornblau, S. M. & Farrar, M. A., May 18 2017, In: Nature immunology. 18, 6, p. 694-704 11 p.Research output: Contribution to journal › Article › peer-review
Open Access66 Scopus citations -
2016
Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia
Heltemes-Harris, L. M., Larson, J. D., Starr, T. K., Hubbard, G. K., Sarver, A. L., Largaespada, D. A. & Farrar, M. A., Jun 30 2016, In: Oncogene. 35, 26, p. 3454-3464 11 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2013
Cutting edge: IL-12 and Type I IFN differentially program cd8 t cells for programmed death 1 re-expression levels and tumor control
Gerner, M. Y., Heltemes-Harris, L. M., Fife, B. T. & Mescher, M. F., Aug 1 2013, In: Journal of Immunology. 191, 3, p. 1011-1015 5 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acutelymphoblastic leukemia
Heltemes-Harris, L. M., Willette, M. J. L., Ramsey, L. B., Qiu, Y. H., Neeley, E. S., Zhang, N., Thomas, D. A., Koeuth, T., Baechler, E. C., Kornblau, S. M. & Farrar, M. A., Jun 2011, In: Journal of Experimental Medicine. 208, 6, p. 1135-1149 15 p.Research output: Contribution to journal › Article › peer-review
133 Scopus citations -
The role of STAT5 in the development, function, and transformation of B and T lymphocytes
Heltemes-Harris, L. M., Willette, M. J. L., Vang, K. B. & Farrar, M. A., Jan 2011, In: Annals of the New York Academy of Sciences. 1217, 1, p. 18-31 14 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
2008
Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion
Heltemes-Harris, L. M., Gearhart, P. J., Ghosh, P. & Longo, D. L., Mar 2008, In: Molecular Immunology. 45, 6, p. 1799-1806 8 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
2005
An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion
Heltemes-Harris, L., Liu, X. & Manser, T., Nov 2005, In: International Immunology. 17, 11, p. 1447-1461 15 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2004
Progressive Surface B Cell Antigen Receptor Down-Regulation Accompanies Efficient Development of Antinuclear Antigen B Cells to Mature, Follicular Phenotype
Heltemes-Harris, L., Liu, X. & Manser, T., Jan 15 2004, In: Journal of Immunology. 172, 2, p. 823-833 11 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
2003
The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells
Heltemes, L. M., Hagan, C. R., Mitrofanova, E. E., Panchal, R. G., Guo, J. & Link, C. J., Jan 1 2003, In: Cancer gene therapy. 10, 1, p. 14-22 9 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
2002
Dominant, hierarchical induction of peripheral tolerance during foreign antigen-driven B cell development
Notidis, E., Heltemes, L. & Manser, T., Sep 1 2002, In: Immunity. 17, 3, p. 317-327 11 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Level of B cell antigen receptor surface expression influences both positive and negative selection of B cells during primary development
Heltemes, L. M. & Manser, T., Aug 1 2002, In: Journal of Immunology. 169, 3, p. 1283-1292 10 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2001
Predominance of a novel splenic B cell population in mice expressing a transgene that encodes multireactive antibodies: Support for additional heterogeneity of the B cell compartment
Tumas-Brundage, K. M., Notidis, E., Heltemes, L., Zhang, X., Wysocki, L. J. & Manser, T., 2001, In: International Immunology. 13, 4, p. 475-484 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
1999
Tissue expression patterns of chicken octamer-binding proteins
Heltemes, L. M., Tuggle, C. K. & Lamont, S. J., Apr 1999, In: Poultry science. 78, 4, p. 574-578 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
1997
Isolation and mapping, of two chicken POU family genes and the identification of a syntenic group with human and mouse
Heltemes, L. M., Tuggle, C. K. & Lamont, S. J., Oct 1997, In: Animal Genetics. 28, 5, p. 346-350 5 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Octamer function in the chicken lambda immunoglobulin light chain promoter
Heltemes, L. M., Tuggle, C. K. & Lamont, S. J., 1997, In: Immunogenetics. 47, 1, p. 73-76 4 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
TaqI polymorphism in Oct-1 in chickens
Heltemes, L. M., Tuggle, C. K. & Lamont, S. J., Feb 1997, In: Animal Genetics. 28, 1, p. 70 1 p.Research output: Contribution to journal › Article › peer-review