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Research Output 1990 2019

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Article
2019

Distinct dual antiviral mechanism that enhances hepatitis B virus mutagenesis and reduces viral DNA synthesis

McDaniel, Y. Z., Patterson, S. & Mansky, L. M., Oct 1 2019, In : Antiviral Research. 170, 104540.

Research output: Contribution to journalArticle

Viral DNA
Hepatitis B virus
Mutagenesis
Antiviral Agents
Mutagens
2018

Critical role of the human T-Cell leukemia virus type 1 capsid N-Terminal domain for gag-gag interactions and virus particle assembly

Martin, J. L., Mendonça, L. M., Marusinec, R., Zuczek, J., Angert, I., Blower, R. J., Mueller, J., Perill, J. R., Zhang, W. & Mansky, L. M., Jul 1 2018, In : Journal of virology. 92, 14, e00333-18.

Research output: Contribution to journalArticle

Deltaretrovirus
Virus Assembly
capsid
Capsid
virion
Open Access
Deltaretrovirus
Virus Assembly
HIV-1
Virion
Cell Membrane
1 Citation (Scopus)

Human T-cell leukemia virus type 1 Gag domains have distinct RNA-binding specificities with implications for RNA packaging and dimerization

Wu, W., Hatterschide, J., Syu, Y. C., Cantara, W. A., Blower, R. J., Hanson, H. M., Mansky, L. M. & Musier-Forsyth, K., Jan 1 2018, In : Journal of Biological Chemistry. 293, 42, p. 16261-16276 16 p.

Research output: Contribution to journalArticle

Open Access
Deltaretrovirus
T-cells
Dimerization
Product Packaging
Viruses
1 Citation (Scopus)
Dideoxynucleosides
HIV-1
Mutation
Viruses
Pharmaceutical Preparations
2017
3 Citations (Scopus)

Disparate contributions of human retrovirus capsid subdomains to Gag-Gag oligomerization, virus morphology, and particle biogenesis

Martin, J. L., Mendonca, L., Angert, I., Mueller, J., Zhang, W. & Mansky, L. M., Jul 1 2017, In : Journal of Virology. 91, 14, e00298-17.

Research output: Contribution to journalArticle

Retroviridae
Deltaretrovirus
capsid
Capsid
Virion
1 Citation (Scopus)

Perturbation of human T-cell leukemia virus type 1 particle morphology by differential gag co-packaging

Maldonado, J. O., Angert, I., Cao, S., Berk, S., Zhang, W., Mueller, J. D. & Mansky, L. M., Jul 19 2017, In : Viruses. 9, 7, 191.

Research output: Contribution to journalArticle

Deltaretrovirus
Product Packaging
Virion
Antigens
Fluorescence
3 Citations (Scopus)

Polymorphic nature of human T-cell leukemia virus type 1 particle cores as revealed through characterization of a chronically infected cell line

Meissner, M. E., Mendonca, L., Zhang, W. & Mansky, L. M., Aug 1 2017, In : Journal of virology. 91, 16, e00369-17.

Research output: Contribution to journalArticle

Deltaretrovirus
Virion
cell lines
Cell Line
virion
2 Citations (Scopus)

Single-Strand Consensus Sequencing Reveals that HIV Type but not Subtype Significantly Impacts Viral Mutation Frequencies and Spectra

Rawson, J. M. O., Gohl, D. M., Landman, S. R., Roth, M. E., Meissner, M. E., Peterson, T. S., Hodges, J. S., Beckman, K. B. & Mansky, L. M., Jul 21 2017, In : Journal of Molecular Biology. 429, 15, p. 2290-2307 18 p.

Research output: Contribution to journalArticle

Mutation Rate
HIV
HIV-2
HIV-1
Mutagenesis
2016
2 Citations (Scopus)

5-Azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2'-deoxycytidine

Rawson, J. M. O., Daly, M. B., Xie, J., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. & Mansky, L. M., Apr 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2318-2325 8 p.

Research output: Contribution to journalArticle

decitabine
Azacitidine
Mutagenesis
HIV-1
Reverse Transcription
6 Citations (Scopus)

Distinct morphology of human T-cell leukemia virus type 1-like particles

Maldonado, J. O., Cao, S., Zhang, W. & Mansky, L. M., May 11 2016, In : Viruses. 8, 5, 132.

Research output: Contribution to journalArticle

Deltaretrovirus
Virion
Retroviridae
Membranes
Railroads
9 Citations (Scopus)

Distinct particle morphologies revealed through comparative parallel analyses of retrovirus-like particles

Martin, J. L., Cao, S., Maldonado, J. O., Zhang, W. & Mansky, L. M., Jan 1 2016, In : Journal of Virology. 90, 18, p. 8074-8084 11 p.

Research output: Contribution to journalArticle

Epsilonretrovirus
Retroviridae
gag Gene Products
Transmission Electron Microscopy
Deltaretrovirus
2 Citations (Scopus)

Dual anti-HIV mechanism of clofarabine

Daly, M. B., Roth, M. E., Bonnac, L., Maldonado, J. O., Xie, J., Clouser, C. L., Patterson, S. E., Kim, B. & Mansky, L. M., Mar 24 2016, In : Retrovirology. 13, 1, 20.

Research output: Contribution to journalArticle

HIV-1
HIV
Macrophages
Viral DNA
T-Lymphocytes
2 Citations (Scopus)

Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase

Rawson, J. M. O., Roth, M. E., Xie, J., Daly, M. B., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. & Mansky, L. M., Jun 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2410-2422 13 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Azacitidine
HIV-1
Ribonucleosides
Mutagenesis
2015
11 Citations (Scopus)

Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography

Cao, S., Maldonado, J. O., Grigsby, I. F., Mansky, L. M. & Zhang, W., Jan 1 2015, In : Journal of virology. 89, 4, p. 2430-2435 6 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Electron Microscope Tomography
tomography
Virion
Capsid
13 Citations (Scopus)

HIV-1 and HIV-2 exhibit similar mutation frequencies and spectra in the absence of G-to-A hypermutation

Rawson, J. M. O., Landman, S. R., Reilly, C. S. & Mansky, L. M., Jul 10 2015, In : Retrovirology. 12, 1, 60.

Research output: Contribution to journalArticle

HIV-2
Mutation Rate
HIV-1
Mutation
RNA-Directed DNA Polymerase
8 Citations (Scopus)

Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis

Rawson, J. M. O., Landman, S. R., Reilly, C. S., Bonnac, L., Patterson, S. & Mansky, L. M., Nov 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6834-6843 10 p.

Research output: Contribution to journalArticle

decitabine
Mutagenesis
HIV-1
Mutation Rate
Guanine
2014
12 Citations (Scopus)

Anti-HIV-1 activity of trim 37

Tabah, A. A., Tardif, K. & Mansky, L. M., Jan 1 2014, In : Journal of General Virology. 95, PART 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

HIV-1
Viral DNA
Virus Replication
Antiviral Agents
Human Activities
9 Citations (Scopus)
decitabine
gemcitabine
Prodrugs
HIV-1
Permeability
10 Citations (Scopus)

Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1

Dapp, M. J., Bonnac, L., Patterson, S. & Mansky, L. M., Jan 1 2014, In : Journal of virology. 88, 1, p. 354-363 10 p.

Research output: Contribution to journalArticle

ribonucleosides
Ribonucleosides
Human immunodeficiency virus 1
reverse transcription
HIV-1
18 Citations (Scopus)

Interrelationship between cytoplasmic retroviral Gag concentration and Gag-membrane association

Fogarty, K. H., Berk, S., Grigsby, I. F., Chen, Y., Mansky, L. M. & Mueller, J., Apr 3 2014, In : Journal of Molecular Biology. 426, 7, p. 1611-1624 14 p.

Research output: Contribution to journalArticle

Deltaretrovirus
HIV-1
Cell Membrane
Human Immunodeficiency Virus gag Gene Products
Membranes
16 Citations (Scopus)

Novel inhibitors of human immunodeficiency virus type 2 infectivity

Beach, L. B., Rawson, J. M., Kim, B., Patterson, S. & Mansky, L. M., Dec 1 2014, In : Journal of General Virology. 95, p. 2778-2783 6 p.

Research output: Contribution to journalArticle

HIV-2
Azacitidine
gemcitabine
Mutagenesis
Pharmaceutical Preparations
16 Citations (Scopus)

Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: Implications for genomic RNA packaging

Sun, M., Grigsby, I. F., Gorelick, R. J., Mansky, L. M. & Musier-Forsyth, K., Jan 1 2014, In : Journal of virology. 88, 2, p. 1271-1280 10 p.

Research output: Contribution to journalArticle

Primate T-lymphotropic virus 2
Retroviridae
Human T-lymphotropic virus 2
nucleocapsid proteins
Nucleocapsid Proteins
2013
15 Citations (Scopus)

5,6-Dihydro-5-aza-2′-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

Rawson, J. M., Heineman, R. H., Beach, L. B., Martin, J. L., Schnettler, E. K., Dapp, M. J., Patterson, S. E. & Mansky, L. M., Nov 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 22, p. 7222-7228 7 p.

Research output: Contribution to journalArticle

Ribonucleotide Reductases
Viruses
HIV-1
Mutagens
gemcitabine
29 Citations (Scopus)

APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

Holtz, C. M., Sadler, H. A. & Mansky, L. M., Jul 1 2013, In : Nucleic acids research. 41, 12, p. 6139-6148 10 p.

Research output: Contribution to journalArticle

Deamination
Single-Stranded DNA
Cytosine
Cytosine Deaminase
Nucleotides
21 Citations (Scopus)

Interrelationship between HIV-1 fitness and mutation rate

Dapp, M. J., Heineman, R. H. & Mansky, L. M., Jan 9 2013, In : Journal of Molecular Biology. 425, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Mutation Rate
HIV-1
Viruses
Phenotype
Genetic Selection
20 Citations (Scopus)

Variation of HIV-1 mutation spectra among cell types

Holtz, C. M. & Mansky, L. M., May 1 2013, In : Journal of Virology. 87, 9, p. 5296-5299 4 p.

Research output: Contribution to journalArticle

Mutation Rate
Human immunodeficiency virus 1
HIV-1
mutation
Mutation
2012
13 Citations (Scopus)

Activity of a novel combined antiretroviral therapy of gemcitabine and decitabine in a mouse model for HIV-1

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., O'Sullivan, G., Patterson, S. & Mansky, L. M., Apr 1 2012, In : Antimicrobial Agents and Chemotherapy. 56, 4, p. 1942-1948 7 p.

Research output: Contribution to journalArticle

decitabine
gemcitabine
HIV-1
Murine Leukemia Viruses
Murine Acquired Immunodeficiency Syndrome
52 Citations (Scopus)

Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine

Clouser, C. L., Chauhan, J., Bess, M. A., Oploo, J. L. V., Zhou, D., Dimick-Gray, S., Mansky, L. M. & Patterson, S., Nov 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 21, p. 6642-6646 5 p.

Research output: Contribution to journalArticle

decitabine
HIV-1
Ribonucleotide Reductases
Derivatives
Nucleosides
12 Citations (Scopus)

Concomitant lethal mutagenesis of human immunodeficiency virus type 1

Dapp, M. J., Holtz, C. M. & Mansky, L. M., Jun 8 2012, In : Journal of Molecular Biology. 419, 3-4, p. 158-170 13 p.

Research output: Contribution to journalArticle

Mutagenesis
HIV-1
Azacitidine
Mutagens
Viral Structures
14 Citations (Scopus)

Discovery of drugs that possess activity against feline leukemia virus

Greggs, W. M., Clouser, C. L., Patterson, S. & Mansky, L. M., Apr 1 2012, In : Journal of General Virology. 93, 4, p. 900-905 6 p.

Research output: Contribution to journalArticle

Feline Leukemia Virus
Drug Discovery
HIV-1
Gammaretrovirus
Pharmaceutical Preparations
18 Citations (Scopus)

Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1

Guenzel, C. A., Hérate, C., Le Rouzic, E., Maidou-Peindara, P., Sadler, H. A., Rouyez, M. C., Mansky, L. M. & Benichou, S., Mar 1 2012, In : Journal of Virology. 86, 5, p. 2533-2544 12 p.

Research output: Contribution to journalArticle

Replication Protein A
Uracil-DNA Glycosidase
Human immunodeficiency virus 1
virion
Virion
2011
15 Citations (Scopus)

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., Chauhan, J., Vanhoutan, I. M., Patterson, S. & Mansky, L. M., Feb 1 2011, In : PLoS One. 6, 1, e15840.

Research output: Contribution to journalArticle

gemcitabine
ribonucleotide reductase
hydroxyurea
mice
toxicity
19 Citations (Scopus)

A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses

Wu, K., Chen, L., Peng, G., Zhou, W., Pennell, C. A., Mansky, L. M., Geraghty, R. J. & Li, F., Jun 1 2011, In : Journal of virology. 85, 11, p. 5331-5337 7 p.

Research output: Contribution to journalArticle

Virus Attachment
Coronavirus
Coronavirinae
peptidyl-dipeptidase A
SARS Virus
22 Citations (Scopus)

Characterization of cytoplasmic gag-gag interactions by dual-color z-scan fluorescence fluctuation spectroscopy

Fogarty, K. H., Chen, Y., Grigsby, I. F., MacDonald, P. J., Smith, E. M., Johnson, J. L., Rawson, J. M., Mansky, L. M. & Mueller, J., Mar 16 2011, In : Biophysical Journal. 100, 6, p. 1587-1595 9 p.

Research output: Contribution to journalArticle

Fluorescence Spectrometry
gag Gene Products
Human T-lymphotropic virus 1
Color
Artifacts
40 Citations (Scopus)

Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms

Ni, Z., Knorr, D. A., Clouser, C. L., Hexum, M. K., Southern, P., Mansky, L. M., Park, I. H. & Kaufman, D. S., Jan 1 2011, In : Journal of virology. 85, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
natural killer cells
Human immunodeficiency virus 1
Natural Killer Cells
stem cells
18 Citations (Scopus)

Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Dorr, C. R., Yemets, S. V., Kolomitsyna, O. N., Krasutsky, P. & Mansky, L. M., Jan 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 542-545 4 p.

Research output: Contribution to journalArticle

Triterpenes
Virus Replication
Viruses
HIV-1
Derivatives
2010
107 Citations (Scopus)

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

Sadler, H. A., Stenglein, M. D., Harris, R. & Mansky, L. M., Jul 1 2010, In : Journal of Virology. 84, 14, p. 7396-7404 9 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
mutagenesis
Mutagenesis
HIV-1
pathogenicity
24 Citations (Scopus)

Biophysical analysis of HTLV-1 particles reveals novel insights into particle morphology and Gag stochiometry

Grigsby, I. F., Zhang, W., Johnson, J. L., Fogarty, K. H., Chen, Y., Rawson, J. M., Crosby, A. J., Mueller, J. & Mansky, L. M., Sep 20 2010, In : Retrovirology. 7, 75.

Research output: Contribution to journalArticle

Human T-lymphotropic virus 1
Virion
Cryoelectron Microscopy
Fluorescence Spectrometry
Transmission Electron Microscopy
27 Citations (Scopus)

Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts

Grigsby, I. F., Pham, L., Gopalakrishnan, R., Mansky, L. M. & Mansky, K., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1324-1329 6 p.

Research output: Contribution to journalArticle

Tenofovir
Osteoclasts
Down-Regulation
Bone Density
Bone
56 Citations (Scopus)

Exploiting drug repositioning for discovery of a novel HIV combination therapy

Clouser, C. L., Patterson, S. & Mansky, L. M., Jan 1 2010, In : Journal of Virology. 84, 18, p. 9301-9309 9 p.

Research output: Contribution to journalArticle

Drug Repositioning
decitabine
Drug Discovery
HIV
Ribonucleotide Reductases
48 Citations (Scopus)

Tenofovir treatment of primary osteoblasts alters gene expression profiles: Implications for bone mineral density loss

Grigsby, I. F., Pham, L., Mansky, L. M., Gopalakrishnan, R., Carlson, A. E. & Mansky, K., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 48-53 6 p.

Research output: Contribution to journalArticle

Tenofovir
Osteoblasts
Transcriptome
Gene expression
Bone Density
429 Citations (Scopus)

Viral mutation rates

Sanjuán, R., Nebot, M. R., Chirico, N., Mansky, L. M. & Belshaw, R., Jan 1 2010, In : Journal of Virology. 84, 19, p. 9733-9748 16 p.

Research output: Contribution to journalArticle

Mutation Rate
mutation
DNA Viruses
Viruses
RNA Viruses
2009
65 Citations (Scopus)

5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1

Dapp, M. J., Clouser, C. L., Patterson, S. & Mansky, L. M., Nov 1 2009, In : Journal of Virology. 83, 22, p. 11950-11958 9 p.

Research output: Contribution to journalArticle

Azacitidine
Human immunodeficiency virus 1
reverse transcription
lethal genes
mutagenesis
37 Citations (Scopus)

Fluorescence fluctuation spectroscopy on viral-like particles reveals variable Gag stoichiometry

Chen, Y., Wu, B., Musier-Forsyth, K., Mansky, L. M. & Mueller, J., Jan 1 2009, In : Biophysical journal. 96, 5, p. 1961-1969 9 p.

Research output: Contribution to journalArticle

Fluorescence Spectrometry
Virion
HIV-1
COS Cells
Human Immunodeficiency Virus gag Gene Products
2008
9 Citations (Scopus)

Deciphering evolutionary mechanisms between mutualistic and pathogenic symbioses

Nishiguchi, M. K., Hirsch, A. M., Devinney, R., Vedantam, G., Riley, M. A. & Mansky, L. M., Jun 1 2008, In : Vie et Milieu. 58, 2, p. 87-106 20 p.

Research output: Contribution to journalArticle

symbiont
symbiosis
symbionts
pathogen
virulence
2007
213 Citations (Scopus)

Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

Mbisa, J. L., Barr, R., Thomas, J. A., Vandegraaff, N., Dorweiler, I. J., Svarovskaia, E. S., Brown, W. L., Mansky, L. M., Gorelick, R. J., Harris, R., Engelman, A. & Pathak, V. K., Jul 1 2007, In : Journal of virology. 81, 13, p. 7099-7110 12 p.

Research output: Contribution to journalArticle

transfer DNA
Viral DNA
Human immunodeficiency virus 1
HIV-1
Complementary DNA
2006
18 Citations (Scopus)

Role of the human T-cell leukemia virus type 1 PTAP motif in Gag targeting and particle release

Dorweiler, I. J., Ruone, S. J., Wang, H., Burry, R. W. & Mansky, L. M., Apr 1 2006, In : Journal of virology. 80, 7, p. 3634-3643 10 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Multivesicular Bodies
Virion
Virus Release
Clathrin
2005
5 Citations (Scopus)

Construction and characterization of deltaretrovirus indicator cell lines

Jewell, N. A. & Mansky, L. M., Jan 1 2005, In : Journal of Virological Methods. 123, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

Bovine Leukemia Virus
Deltaretrovirus
Human T-lymphotropic virus 2
Human T-lymphotropic virus 1
Terminal Repeat Sequences