1990 …2020

Research output per year

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Article
2020

Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure

McDaniel, Y. Z., Wang, D., Love, R. P., Adolph, M. B., Mohammadzadeh, N., Chelico, L. & Mansky, L. M., Feb 20 2020, In : Nucleic acids research. 48, 3, p. 1353-1371 19 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sensitive Detection of Protein Binding to the Plasma Membrane with Dual-Color Z-Scan Fluorescence

Angert, I., Karuka, S. R., Hennen, J., Chen, Y., Albanesi, J. P., Mansky, L. M. & Mueller, J. D., Jan 21 2020, In : Biophysical journal. 118, 2, p. 281-293 13 p.

Research output: Contribution to journalArticle

2019
1 Scopus citations

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

Shepard, C., Xu, J., Holler, J., Kim, D. H., Mansky, L. M., Schinazi, R. F. & Kim, B., Oct 26 2019, In : Retrovirology. 16, 1, 29.

Research output: Contribution to journalArticle

Open Access
2018

Critical role of the human T-Cell leukemia virus type 1 capsid N-Terminal domain for gag-gag interactions and virus particle assembly

Martin, J. L., Mendonça, L. M., Marusinec, R., Zuczek, J., Angert, I., Blower, R. J., Mueller, J. D., Perill, J. R., Zhang, W. & Mansky, L. M., Jul 1 2018, In : Journal of virology. 92, 14, e00333-18.

Research output: Contribution to journalArticle

Open Access
Open Access
1 Scopus citations

Human T-cell leukemia virus type 1 Gag domains have distinct RNA-binding specificities with implications for RNA packaging and dimerization

Wu, W., Hatterschide, J., Syu, Y. C., Cantara, W. A., Blower, R. J., Hanson, H. M., Mansky, L. M. & Musier-Forsyth, K., Oct 19 2018, In : Journal of Biological Chemistry. 293, 42, p. 16261-16276 16 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
4 Scopus citations
2017

Disparate contributions of human retrovirus capsid subdomains to Gag-Gag oligomerization, virus morphology, and particle biogenesis

Martin, J. L., Mendonça, L. M., Angert, I., Mueller, J. D., Zhang, W. & Mansky, L. M., Jul 1 2017, In : Journal of virology. 91, 14, e00298-17.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Perturbation of human T-cell leukemia virus type 1 particle morphology by differential gag co-packaging

Maldonado, J. O., Angert, I., Cao, S., Berk, S., Zhang, W., Mueller, J. D. & Mansky, L. M., Jul 19 2017, In : Viruses. 9, 7, 191.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Polymorphic nature of human T-cell leukemia virus type 1 particle cores as revealed through characterization of a chronically infected cell line

Meissner, M. E., Mendonca, L., Zhang, W. & Mansky, L. M., Aug 1 2017, In : Journal of virology. 91, 16, e00369-17.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Single-Strand Consensus Sequencing Reveals that HIV Type but not Subtype Significantly Impacts Viral Mutation Frequencies and Spectra

Rawson, J. M. O., Gohl, D. M., Landman, S. R., Roth, M. E., Meissner, M. E., Peterson, T. S., Hodges, J. S., Beckman, K. B. & Mansky, L. M., Jul 21 2017, In : Journal of Molecular Biology. 429, 15, p. 2290-2307 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2016

5-Azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2'-deoxycytidine

Rawson, J. M. O., Daly, M. B., Xie, J., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. E. & Mansky, L. M., Apr 2016, In : Antimicrobial agents and chemotherapy. 60, 4, p. 2318-2325 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Distinct morphology of human T-cell leukemia virus type 1-like particles

Maldonado, J. O., Cao, S., Zhang, W. & Mansky, L. M., May 11 2016, In : Viruses. 8, 5, 132.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Distinct particle morphologies revealed through comparative parallel analyses of retrovirus-like particles

Martin, J. L., Cao, S., Maldonado, J. O., Zhang, W. & Mansky, L. M., Jan 1 2016, In : Journal of virology. 90, 18, p. 8074-8084 11 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Dual anti-HIV mechanism of clofarabine

Daly, M. B., Roth, M. E., Bonnac, L., Maldonado, J. O., Xie, J., Clouser, C. L., Patterson, S. E., Kim, B. & Mansky, L. M., Mar 24 2016, In : Retrovirology. 13, 1, 20.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase

Rawson, J. M. O., Roth, M. E., Xie, J., Daly, M. B., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. E. & Mansky, L. M., Jun 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2410-2422 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Analysis of human T-cell leukemia virus type 1 particles by using cryo-electron tomography

Cao, S., Maldonado, J. O., Grigsby, I. F., Mansky, L. M. & Zhang, W., 2015, In : Journal of virology. 89, 4, p. 2430-2435 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

HIV-1 and HIV-2 exhibit similar mutation frequencies and spectra in the absence of G-to-A hypermutation

Rawson, J. M. O., Landman, S. R., Reilly, C. S. & Mansky, L. M., Jul 10 2015, In : Retrovirology. 12, 1, 60.

Research output: Contribution to journalArticle

16 Scopus citations

Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis

Rawson, J. M. O., Landman, S. R., Reilly, C. S., Bonnac, L., Patterson, S. & Mansky, L. M., Nov 1 2015, In : Antimicrobial agents and chemotherapy. 59, 11, p. 6834-6843 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Anti-HIV-1 activity of trim 37

Tabah, A. A., Tardif, K. & Mansky, L. M., 2014, In : Journal of General Virology. 95, PART 4, p. 960-967 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
10 Scopus citations

Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1

Dapp, M. J., Bonnac, L., Patterson, S. E. & Mansky, L. M., Jan 1 2014, In : Journal of virology. 88, 1, p. 354-363 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Interrelationship between cytoplasmic retroviral Gag concentration and Gag-membrane association

Fogarty, K. H., Berk, S., Grigsby, I. F., Chen, Y., Mansky, L. M. & Mueller, J. D., Apr 3 2014, In : Journal of Molecular Biology. 426, 7, p. 1611-1624 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Novel inhibitors of human immunodeficiency virus type 2 infectivity

Beach, L. B., Rawson, J. M., Kim, B., Patterson, S. E. & Mansky, L. M., Dec 1 2014, In : Journal of General Virology. 95, p. 2778-2783 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Retrovirus-specific differences in matrix and nucleocapsid protein-nucleic acid interactions: Implications for genomic RNA packaging

Sun, M., Grigsby, I. F., Gorelick, R. J., Mansky, L. M. & Musier-Forsyth, K., Jan 1 2014, In : Journal of virology. 88, 2, p. 1271-1280 10 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

5,6-Dihydro-5-aza-2′-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

Rawson, J. M., Heineman, R. H., Beach, L. B., Martin, J. L., Schnettler, E. K., Dapp, M. J., Patterson, S. E. & Mansky, L. M., Nov 15 2013, In : Bioorganic and Medicinal Chemistry. 21, 22, p. 7222-7228 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure

Holtz, C. M., Sadler, H. A. & Mansky, L. M., Jul 1 2013, In : Nucleic acids research. 41, 12, p. 6139-6148 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Interrelationship between HIV-1 fitness and mutation rate

Dapp, M. J., Heineman, R. H. & Mansky, L. M., Jan 9 2013, In : Journal of Molecular Biology. 425, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Variation of HIV-1 mutation spectra among cell types

Holtz, C. M. & Mansky, L. M., May 1 2013, In : Journal of virology. 87, 9, p. 5296-5299 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Activity of a novel combined antiretroviral therapy of gemcitabine and decitabine in a mouse model for HIV-1

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., O'Sullivan, M. G., Patterson, S. E. & Mansky, L. M., Apr 1 2012, In : Antimicrobial agents and chemotherapy. 56, 4, p. 1942-1948 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Anti-HIV-1 activity of resveratrol derivatives and synergistic inhibition of HIV-1 by the combination of resveratrol and decitabine

Clouser, C. L., Chauhan, J., Bess, M. A., Oploo, J. L. V., Zhou, D., Dimick-Gray, S., Mansky, L. M. & Patterson, S. E., Nov 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 21, p. 6642-6646 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Concomitant lethal mutagenesis of human immunodeficiency virus type 1

Dapp, M. J., Holtz, C. M. & Mansky, L. M., Jun 8 2012, In : Journal of Molecular Biology. 419, 3-4, p. 158-170 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Discovery of drugs that possess activity against feline leukemia virus

Greggs, W. M., Clouser, C. L., Patterson, S. & Mansky, L. M., Apr 1 2012, In : Journal of General Virology. 93, 4, p. 900-905 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1

Guenzel, C. A., Hérate, C., Le Rouzic, E., Maidou-Peindara, P., Sadler, H. A., Rouyez, M. C., Mansky, L. M. & Benichou, S., Mar 1 2012, In : Journal of virology. 86, 5, p. 2533-2544 12 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Analysis of the ex vivo and in vivo antiretroviral activity of gemcitabine

Clouser, C. L., Holtz, C. M., Mullett, M., Crankshaw, D. L., Briggs, J. E., Chauhan, J., Vanhoutan, I. M., Patterson, S. E. & Mansky, L. M., Feb 1 2011, In : PloS one. 6, 1, e15840.

Research output: Contribution to journalArticle

17 Scopus citations

A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses

Wu, K., Chen, L., Peng, G., Zhou, W., Pennell, C. A., Mansky, L. M., Geraghty, R. J. & Li, F., Jun 2011, In : Journal of virology. 85, 11, p. 5331-5337 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of cytoplasmic gag-gag interactions by dual-color z-scan fluorescence fluctuation spectroscopy

Fogarty, K. H., Chen, Y., Grigsby, I. F., MacDonald, P. J., Smith, E. M., Johnson, J. L., Rawson, J. M., Mansky, L. M. & Mueller, J. D., Mar 16 2011, In : Biophysical journal. 100, 6, p. 1587-1595 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms

Ni, Z., Knorr, D. A., Clouser, C. L., Hexum, M. K., Southern, P., Mansky, L. M., Park, I. H. & Kaufman, D. S., Jan 1 2011, In : Journal of virology. 85, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Triterpene derivatives that inhibit human immunodeficiency virus type 1 replication

Dorr, C. R., Yemets, S. V., Kolomitsyna, O. N., Krasutsky, P. & Mansky, L. M., Jan 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 1, p. 542-545 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

APOBEC3G contributes to HIV-1 variation through sublethal mutagenesis

Sadler, H. A., Stenglein, M. D., Harris, R. S. & Mansky, L. M., Jul 1 2010, In : Journal of virology. 84, 14, p. 7396-7404 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Biophysical analysis of HTLV-1 particles reveals novel insights into particle morphology and Gag stochiometry

Grigsby, I. F., Zhang, W., Johnson, J. L., Fogarty, K. H., Chen, Y., Rawson, J. M., Crosby, A. J., Mueller, J. D. & Mansky, L. M., Sep 20 2010, In : Retrovirology. 7, 75.

Research output: Contribution to journalArticle

24 Scopus citations

Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts

Grigsby, I. F., Pham, L., Gopalakrishnan, R., Mansky, L. M. & Mansky, K. C., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1324-1329 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Exploiting drug repositioning for discovery of a novel HIV combination therapy

Clouser, C. L., Patterson, S. E. & Mansky, L. M., Sep 2010, In : Journal of virology. 84, 18, p. 9301-9309 9 p.

Research output: Contribution to journalArticle

63 Scopus citations
49 Scopus citations

Viral mutation rates

Sanjuán, R., Nebot, M. R., Chirico, N., Mansky, L. M. & Belshaw, R., Oct 2010, In : Journal of virology. 84, 19, p. 9733-9748 16 p.

Research output: Contribution to journalArticle

487 Scopus citations
2009

5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1

Dapp, M. J., Clouser, C. L., Patterson, S. & Mansky, L. M., Nov 2009, In : Journal of virology. 83, 22, p. 11950-11958 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Fluorescence fluctuation spectroscopy on viral-like particles reveals variable Gag stoichiometry

Chen, Y., Wu, B., Musier-Forsyth, K., Mansky, L. M. & Mueller, J. D., Jan 1 2009, In : Biophysical journal. 96, 5, p. 1961-1969 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2008

Deciphering evolutionary mechanisms between mutualistic and pathogenic symbioses

Nishiguchi, M. K., Hirsch, A. M., Devinney, R., Vedantam, G., Riley, M. A. & Mansky, L. M., Jun 1 2008, In : Vie et Milieu. 58, 2, p. 87-106 20 p.

Research output: Contribution to journalArticle

9 Scopus citations