20092020

Research output per year

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Article
2020

Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

Neurological Emergencies Treatment Trials, Apr 11 2020, In : The Lancet. 395, 10231, p. 1217-1224 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access

The association of patient weight and dose of fosphenytoin, levetiracetam, and valproic acid with treatment success in status epilepticus

Sathe, A. G., Elm, J. J., Cloyd, J. C., Chamberlain, J. M., Silbergleit, R., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P. & Coles, L. D., Jun 1 2020, In : Epilepsia. 61, 6, p. e66-e70

Research output: Contribution to journalArticle

2019

Intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats

Rautiola, D., Maglalang, P. D., Cheryala, N., Nelson, K. M., Georg, G. I., Fine, J. M., Svitak, A. L., Faltesek, K. A., Hanson, L. R., Mishra, U., Coles, L. D., Cloyd, J. C. & Siegel, R. A., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 796-805 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Lessons from the Established Status Epilepticus Treatment Trial

Cock, H. R., Coles, L. D., Elm, J., Silbergleit, R., Chamberlain, J. M., Cloyd, J. C., Fountain, N., Shinnar, S., Lowenstein, D., Conwit, R., Bleck, T. P. & Kapur, J., Dec 2019, In : Epilepsy and Behavior. 101, 106296.

Research output: Contribution to journalArticle

2 Scopus citations
2018
Open Access
33 Scopus citations

Rescue therapies for seizure emergencies: New modes of administration

Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 2018, In : Epilepsia. 59, p. 207-215 9 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2017

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 2017, In : PM and R. 9, 8, p. 743-750 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Intravenous topiramate: Pharmacokinetics in dogs with naturally occurring epilepsy

Vuu, I., Coles, L. D., Maglalang, P., Leppik, I. E., Worrell, G., Crepeau, D., Mishra, U., Cloyd, J. C. & Patterson, E. E., Dec 5 2016, In : Frontiers in Veterinary Science. 3, DEC, 107.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2015

Canine status epilepticus treated with fosphenytoin: A proof of principle study

Patterson, E. E., Leppik, I. E., Coles, L. D., Podell, M., Vite, C. H., Bush, W. & Cloyd, J. C., Jun 1 2015, In : Epilepsia. 56, 6, p. 882-887 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
19 Scopus citations
3 Scopus citations
2014

A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers

Agarwal, S. K., Kriel, R. L., Cloyd, J. C., Coles, L. D., Scherkenbach, L. A., Tobin, M. H. & Krach, L. E., Jan 1 2014, In : Journal of Child Neurology. 30, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: A preliminary study

Scherkenbach, L. A., Coles, L. D., Patterson, E. E., Cloyd, J. C., Krach, L. E. & Kriel, R. L., Jul 2014, In : Journal of Pharmacy and Pharmacology. 66, 7, p. 935-942 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Feasibility study of a caregiver seizure alert system in canine epilepsy

Coles, L. D., Patterson, E. E., Sheffield, W. D., Mavoori, J., Higgins, J., Michael, B., Leyde, K., Cloyd, J. C., Litt, B., Vite, C. & Worrell, G. A., Oct 1 2013, In : Epilepsy Research. 106, 3, p. 456-460 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C. & Tuite, P. J., Jul 1 2013, In : Clinical Neuropharmacology. 36, 4, p. 103-106 4 p.

Research output: Contribution to journalArticle

88 Scopus citations
2012

Interaction of n-acetylcysteine and cysteine in human plasma

Radtke, K. K., Coles, L. D., Mishra, U., Orchard, P. J., Holmay, M. & Cloyd, J. C., Dec 2012, In : Journal of Pharmaceutical Sciences. 101, 12, p. 4653-4659 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
18 Scopus citations
2011

Canine status epilepticus: A translational platform for human therapeutic trials

Leppik, I. E., Patterson, E. N., Coles, L. D., Craft, E. M. & Cloyd, J. C., Oct 1 2011, In : Epilepsia. 52, SUPPL. 8, p. 31-34 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Clinical tolerance and toxicity of intravenous baclofen: A pilot study in a canine model

Krach, L. E., Kriel, R. L., Patterson, N., Scherkenbach, L. A., Coles, L. D. & Cloyd, J. C., Nov 7 2011, In : Journal of Pediatric Rehabilitation Medicine. 4, 2, p. 89-98 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice

Coles, L. D., Lee, I. J., Hassan, H. E. & Eddington, N. D., Aug 2009, In : Journal of Pharmaceutical Sciences. 98, 8, p. 2832-2846 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR)

Coles, L. D., Lee, I. J., Voulalas, P. J. & Eddington, N. D., Dec 7 2009, In : Molecular pharmaceutics. 6, 6, p. 1816-1825 10 p.

Research output: Contribution to journalArticle

29 Scopus citations