20092022
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Research Output 2009 2019

9 Citations (Scopus)

A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers

Agarwal, S. K., Kriel, R. L., Cloyd, J. C., Coles, L. D., Scherkenbach, L. A., Tobin, M. H. & Krach, L. E., Jan 1 2014, In : Journal of Child Neurology. 30, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

Baclofen
Healthy Volunteers
Pharmacokinetics
Biological Availability
Area Under Curve
3 Citations (Scopus)

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 1 2017, In : PM and R. 9, 8, p. 743-750 8 p.

Research output: Contribution to journalArticle

Baclofen
Volunteers
Pharmacokinetics
Contracts
Biological Availability
24 Citations (Scopus)

Canine status epilepticus: A translational platform for human therapeutic trials

Leppik, I. E., Patterson, N., Coles, L. D., Craft, E. M. & Cloyd, J. C., Oct 1 2011, In : Epilepsia. 52, SUPPL. 8, p. 31-34 4 p.

Research output: Contribution to journalArticle

Status Epilepticus
Canidae
etiracetam
Epilepsy
Therapeutics
9 Citations (Scopus)

Canine status epilepticus treated with fosphenytoin: A proof of principle study

Patterson, N., Leppik, I. E., Coles, L. D., Podell, M., Vite, C. H., Bush, W. & Cloyd, J. C., Jun 1 2015, In : Epilepsia. 56, 6, p. 882-887 6 p.

Research output: Contribution to journalArticle

Status Epilepticus
Canidae
Phenytoin
Seizures
Dogs
4 Citations (Scopus)

Clinical tolerance and toxicity of intravenous baclofen: A pilot study in a canine model

Krach, L. E., Kriel, R. L., Patterson, N., Scherkenbach, L. A., Coles, L. D. & Cloyd, J. C., Nov 7 2011, In : Journal of Pediatric Rehabilitation Medicine. 4, 2, p. 89-98 10 p.

Research output: Contribution to journalArticle

Baclofen
Canidae
Dogs
Ataxia
Biological Availability
20 Citations (Scopus)

Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice

Coles, L. D., Lee, I. J., Hassan, H. E. & Eddington, N. D., Jan 1 2009, In : Journal of Pharmaceutical Sciences. 98, 8, p. 2832-2846 15 p.

Research output: Contribution to journalArticle

Saquinavir
Buprenorphine
Methadone
Placenta
Fetus
2 Citations (Scopus)

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

EpiBioS4Rx Study Group Investigators, Mar 1 2019, In : Neurobiology of Disease. 123, p. 115-121 7 p.

Research output: Contribution to journalReview article

Open Access
Post-Traumatic Epilepsy
Temporal Lobe
Longitudinal Studies
Seizures
Wounds and Injuries
27 Citations (Scopus)

Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR)

Coles, L. D., Lee, I. J., Voulalas, P. J. & Eddington, N. D., Dec 7 2009, In : Molecular pharmaceutics. 6, 6, p. 1816-1825 10 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Progesterone
Estradiol
Saquinavir
Cell Line
20 Citations (Scopus)

Feasibility study of a caregiver seizure alert system in canine epilepsy

Coles, L. D., Patterson, N., Sheffield, W. D., Mavoori, J., Higgins, J., Michael, B., Leyde, K., Cloyd, J. C., Litt, B., Vite, C. & Worrell, G. A., Oct 1 2013, In : Epilepsy Research. 106, 3, p. 456-460 5 p.

Research output: Contribution to journalArticle

Feasibility Studies
Caregivers
Canidae
Epilepsy
Seizures
15 Citations (Scopus)

Interaction of n-acetylcysteine and cysteine in human plasma

Radtke, K. K., Coles, L. D., Mishra, U., Orchard, P. J., Holmay, M. & Cloyd, J. C., Jan 1 2012, In : Journal of Pharmaceutical Sciences. 101, 12, p. 4653-4659 7 p.

Research output: Contribution to journalArticle

Acetylcysteine
Cysteine
Adrenoleukodystrophy
Antioxidants

Intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats

Rautiola, D., Maglalang, P. D., Cheryala, N., Nelson, K., Georg, G., Fine, J. M., Svitak, A. L., Faltesek, K. A., Hanson, L. R., Mishra, U., Coles, L. D., Cloyd, J. C. & Siegel, R. A., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 796-805 10 p.

Research output: Contribution to journalArticle

Open Access
Prodrugs
Diazepam
Enzymes
Solubility
Pharmaceutical Preparations
15 Citations (Scopus)
Acetylcysteine
Intravenous Administration
Oxidation-Reduction
Glutathione
Brain
1 Citation (Scopus)

Intravenous topiramate: Pharmacokinetics in dogs with naturally occurring epilepsy

Vuu, I., Coles, L. D., Maglalang, P., Leppik, I. E., Worrell, G., Crepeau, D., Mishra, U., Cloyd, J. C. & Patterson, N., Dec 5 2016, In : Frontiers in Veterinary Science. 3, DEC, 107.

Research output: Contribution to journalArticle

epilepsy
pharmacokinetics
Epilepsy
Pharmacokinetics
Dogs

Lessons from the Established Status Epilepticus Treatment Trial

Cock, H. R., Coles, L. D., Elm, J., Silbergleit, R., Chamberlain, J. M., Cloyd, J. C., Fountain, N., Shinnar, S., Lowenstein, D., Conwit, R., Bleck, T. P. & Kapur, J., Jan 1 2019, (Accepted/In press) In : Epilepsy and Behavior. 106296.

Research output: Contribution to journalArticle

Status Epilepticus
etiracetam
Emergencies
Seizures
Therapeutics
77 Citations (Scopus)

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Oz, G., Cloyd, J. C. & Tuite, P. J., Jul 1 2013, In : Clinical Neuropharmacology. 36, 4, p. 103-106 4 p.

Research output: Contribution to journalArticle

Gaucher Disease
Acetylcysteine
Glutathione
Parkinson Disease
Brain
4 Citations (Scopus)

Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: A preliminary study

Scherkenbach, L. A., Coles, L. D., Patterson, N., Cloyd, J. C., Krach, L. E. & Kriel, R. L., Jan 1 2014, In : Journal of Pharmacy and Pharmacology. 66, 7, p. 935-942 8 p.

Research output: Contribution to journalArticle

Baclofen
Pharmacokinetics
Dogs
Glasgow Coma Scale
Therapeutics

Regulatory Aspects for Drug Development

Coles, L. D., Klitgaard, H., Kuker, M. & Cloyd, J. C., Jan 1 2017, Models of Seizures and Epilepsy: Second Edition. Elsevier Inc., p. 69-82 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epilepsy
Drug Repositioning
Pharmaceutical Preparations
Orphan Drug Production
Research Personnel
18 Citations (Scopus)
Open Access
Acetylcysteine
Glutathione
Parkinson Disease
Oxidative Stress
Pharmacokinetics
2 Citations (Scopus)

Rescue therapies for seizure emergencies: New modes of administration

Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 1 2018, In : Epilepsia. 59, p. 207-215 9 p.

Research output: Contribution to journalArticle

Emergency Treatment
Solubility
Seizures
Diazepam
Lipids
2 Citations (Scopus)

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

For the EpiBioS4Rx Study Group, Mar 1 2019, In : Neurobiology of Disease. 123, p. 110-114 5 p.

Research output: Contribution to journalReview article

Open Access
Computational Biology
Epilepsy
Post-Traumatic Epilepsy
Biomarkers
Contusions
18 Citations (Scopus)
Orphan Drug Production
Neglected Diseases
Rare Diseases
Industry
Research
1 Citation (Scopus)

Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial

Sathe, A. G., Tillman, H., Coles, L. D., Elm, J. J., Silbergleit, R., Chamberlain, J., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P. & Cloyd, J. C., Jan 1 2019, In : Academic Emergency Medicine. 26, 8, p. 940-943 4 p.

Research output: Contribution to journalLetter

Status Epilepticus
Benzodiazepines
Therapeutics
3 Citations (Scopus)
Status Epilepticus
Phenytoin
Canidae
Pharmacokinetics
Clinical Trials