20092022

Research output per year

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Research Output

2020

Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease—A Pilot Study

Sathe, A. G., Tuite, P., Chen, C., Ma, Y., Chen, W., Cloyd, J., Low, W. C., Steer, C. J., Lee, B. Y., Zhu, X. H. & Coles, L. D., Jan 1 2020, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

2019

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

EpiBioS4Rx Study Group Investigators, Mar 2019, In : Neurobiology of Disease. 123, p. 115-121 7 p.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

Intranasal coadministration of a diazepam prodrug with a converting enzyme results in rapid absorption of diazepam in rats

Rautiola, D., Maglalang, P. D., Cheryala, N., Nelson, K. M., Georg, G. I., Fine, J. M., Svitak, A. L., Faltesek, K. A., Hanson, L. R., Mishra, U., Coles, L. D., Cloyd, J. C. & Siegel, R. A., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 796-805 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Lessons from the Established Status Epilepticus Treatment Trial

Cock, H. R., Coles, L. D., Elm, J., Silbergleit, R., Chamberlain, J. M., Cloyd, J. C., Fountain, N., Shinnar, S., Lowenstein, D., Conwit, R., Bleck, T. P. & Kapur, J., Jan 1 2019, (Accepted/In press) In : Epilepsy and Behavior. 106296.

Research output: Contribution to journalArticle

1 Scopus citations

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

For the EpiBioS4Rx Study Group, Mar 2019, In : Neurobiology of Disease. 123, p. 110-114 5 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Underdosing of Benzodiazepines in Patients With Status Epilepticus Enrolled in Established Status Epilepticus Treatment Trial

Sathe, A. G., Tillman, H., Coles, L. D., Elm, J. J., Silbergleit, R., Chamberlain, J., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., Lowenstein, D. H., Conwit, R. A., Bleck, T. P. & Cloyd, J. C., Jan 1 2019, In : Academic Emergency Medicine. 26, 8, p. 940-943 4 p.

Research output: Contribution to journalLetter

2 Scopus citations
2018
Open Access
23 Scopus citations

Rescue therapies for seizure emergencies: New modes of administration

Maglalang, P. D., Rautiola, D., Siegel, R. A., Fine, J. M., Hanson, L. R., Coles, L. D. & Cloyd, J. C., Oct 2018, In : Epilepsia. 59, p. 207-215 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

A Randomized Dose Escalation Study of Intravenous Baclofen in Healthy Volunteers: Clinical Tolerance and Pharmacokinetics

Schmitz, N. S., Krach, L. E., Coles, L. D., Mishra, U., Agarwal, S. K., Cloyd, J. C. & Kriel, R. L., Aug 2017, In : PM and R. 9, 8, p. 743-750 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulatory Aspects for Drug Development

Coles, L. D., Klitgaard, H., Kuker, M. & Cloyd, J. C., Jan 1 2017, Models of Seizures and Epilepsy: Second Edition. Elsevier Inc., p. 69-82 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Intravenous topiramate: Pharmacokinetics in dogs with naturally occurring epilepsy

Vuu, I., Coles, L. D., Maglalang, P., Leppik, I. E., Worrell, G., Crepeau, D., Mishra, U., Cloyd, J. C. & Patterson, E. E., Dec 5 2016, In : Frontiers in Veterinary Science. 3, DEC, 107.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Canine status epilepticus treated with fosphenytoin: A proof of principle study

Patterson, E. E., Leppik, I. E., Coles, L. D., Podell, M., Vite, C. H., Bush, W. & Cloyd, J. C., Jun 1 2015, In : Epilepsia. 56, 6, p. 882-887 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
18 Scopus citations
3 Scopus citations
2014

A pilot study assessing pharmacokinetics and tolerability of oral and intravenous baclofen in healthy adult volunteers

Agarwal, S. K., Kriel, R. L., Cloyd, J. C., Coles, L. D., Scherkenbach, L. A., Tobin, M. H. & Krach, L. E., Jan 1 2014, In : Journal of Child Neurology. 30, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: A preliminary study

Scherkenbach, L. A., Coles, L. D., Patterson, E. E., Cloyd, J. C., Krach, L. E. & Kriel, R. L., Jul 2014, In : Journal of Pharmacy and Pharmacology. 66, 7, p. 935-942 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Feasibility study of a caregiver seizure alert system in canine epilepsy

Coles, L. D., Patterson, E. E., Sheffield, W. D., Mavoori, J., Higgins, J., Michael, B., Leyde, K., Cloyd, J. C., Litt, B., Vite, C. & Worrell, G. A., Oct 1 2013, In : Epilepsy Research. 106, 3, p. 456-460 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C. & Tuite, P. J., Jul 1 2013, In : Clinical Neuropharmacology. 36, 4, p. 103-106 4 p.

Research output: Contribution to journalArticle

82 Scopus citations
2012

Interaction of n-acetylcysteine and cysteine in human plasma

Radtke, K. K., Coles, L. D., Mishra, U., Orchard, P. J., Holmay, M. & Cloyd, J. C., Dec 2012, In : Journal of Pharmaceutical Sciences. 101, 12, p. 4653-4659 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
18 Scopus citations
2011

Canine status epilepticus: A translational platform for human therapeutic trials

Leppik, I. E., Patterson, E. N., Coles, L. D., Craft, E. M. & Cloyd, J. C., Oct 1 2011, In : Epilepsia. 52, SUPPL. 8, p. 31-34 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Clinical tolerance and toxicity of intravenous baclofen: A pilot study in a canine model

Krach, L. E., Kriel, R. L., Patterson, N., Scherkenbach, L. A., Coles, L. D. & Cloyd, J. C., Nov 7 2011, In : Journal of Pediatric Rehabilitation Medicine. 4, 2, p. 89-98 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2009

Distribution of saquinavir, methadone, and buprenorphine in maternal brain, placenta, and fetus during two different gestational stages of pregnancy in mice

Coles, L. D., Lee, I. J., Hassan, H. E. & Eddington, N. D., Aug 2009, In : Journal of Pharmaceutical Sciences. 98, 8, p. 2832-2846 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Estradiol and progesterone-mediated regulation of P-gp in P-gp overexpressing cells (NCI-ADR-RES) and placental cells (JAR)

Coles, L. D., Lee, I. J., Voulalas, P. J. & Eddington, N. D., Dec 7 2009, In : Molecular pharmaceutics. 6, 6, p. 1816-1825 10 p.

Research output: Contribution to journalArticle

27 Scopus citations