1984 …2019

Research output per year

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Research Output

Article
186 Scopus citations

Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans

Grill, A. E., Schmitt, T., Gates, L. A., Lu, D., Bandyopadhyay, D., Yuan, J. M., Murphy, S. E. & Peterson, L. A., Jul 20 2015, In : Chemical research in toxicology. 28, 7, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts

Guengerich, F. P., Peterson, L. A., Cmarik, J. L., Koga, N. & Inskeep, P. B., Jan 1 1987, In : Environmental health perspectives. 76, p. 15-18 4 p.

Research output: Contribution to journalArticle

33 Scopus citations
20 Scopus citations

An improved method for construction of directionally cloned cDNA libraries from microdissected cells

Peterson, L. A., Brown, M. R., Carlisle, A. J., Kohn, E. C., Liotta, L. A., Emmert-Buck, M. R. & Krizman, D. B., Dec 1 1998, In : Cancer Research. 58, 23, p. 5326-5328 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Peterson, L. A., Spratt, T. E., Shan, W., Wang, L., Subotkowski, W. & Roth, R., Jul 9 2001, In : Journal of Labelled Compounds and Radiopharmaceuticals. 44, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay

Peterson, L. A., Naruko, K. C. & Predecki, D. P., Jul 1 2000, In : Chemical research in toxicology. 13, 7, p. 531-534 4 p.

Research output: Contribution to journalArticle

70 Scopus citations

Chapter 27. Stable Isotopes in Drug Metabolism and Disposition

Baillie, T. A., Rettenmeier, A. W., Peterson, L. A. & Castagnoli, N., Jan 1 1984, In : Annual Reports in Medicinal Chemistry. 19, C, p. 273-282 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
97 Scopus citations

Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan

Byrns, M. C., Predecki, D. P. & Peterson, L. A., Apr 3 2002, In : Chemical research in toxicology. 15, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Comparative metabolism of furan in rodent and human cryopreserved hepatocytes

Gates, L. A., Phillips, M. B., Matter, B. A. & Peterson, L. A., Jul 2014, In : Drug Metabolism and Disposition. 42, 7, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Covalent modification of cytochrome c by reactive metabolites of Furan

Phillips, M. B., Sullivan, M. M., Villalta, P. W. & Peterson, L. A., Jan 21 2014, In : Chemical research in toxicology. 27, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters

Guengerich, F. P., Peterson, L. A. & Bocker, R. H., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 8176-8183 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Decomposition of S-nitrosocysteine via S- To N-transnitrosation

Peterson, L. A., Wagener, T., Sies, H. & Stahl, W., May 1 2007, In : Chemical research in toxicology. 20, 5, p. 721-723 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan

Lu, D., Sullivan, M. M., Phillips, M. B. & Peterson, L. A., Jun 15 2009, In : Chemical research in toxicology. 22, 6, p. 997-1007 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Depurinating acylfulvene-DNA adducts: Characterizing cellular chemical reactions of a selective antitumor agent

Gong, J., Vaidyanathan, V. G., Yu, X., Kensler, T. W., Peterson, L. A. & Sturla, S. J., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 2101-2111 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial

Byrns, M. C., Vu, C. C., Neidigh, J. W., Abad, J. L., Jones, R. A. & Peterson, L. A., Mar 1 2006, In : Chemical research in toxicology. 19, 3, p. 414-420 7 p.

Research output: Contribution to journalArticle

56 Scopus citations
21 Scopus citations

Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities

Williams, G. M., Iatropoulos, M. J., Wang, C. X., Ali, N., Rivenson, A., Peterson, L. A., Schulz, C. & Gebhardt, R., Oct 1 1996, In : Carcinogenesis. 17, 10, p. 2253-2258 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase

Coulter, R., Blandino, M., Tomlinson, J. M., Pauly, G. T., Krajewska, M., Moschel, R. C., Peterson, L. A., Pegg, A. E. & Spratt, T. E., Dec 1 2007, In : Chemical research in toxicology. 20, 12, p. 1966-1971 6 p.

Research output: Contribution to journalArticle

31 Scopus citations

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., Jan 1 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

DNA and hemoglobin adducts as markers of metabolic activation of tobacco- specific carcinogens

Foiles, P. G., Murphy, S. E., Peterson, L. A., Carmella, S. G. & Hecht, S. S., Jun 1 1992, In : Cancer Research. 52, 9 SUPPL., p. 2698s-2701s

Research output: Contribution to journalArticle

17 Scopus citations

DNA sequence context affects repair of the tobacco-specific adduct O 6-[4-oxo-4-(3-pyridyl)butyl]guanine by human O6- alkylguanine-DNA alkyltransferases

Mijal, R. S., Kanugula, S., Vu, C. C., Fang, Q., Pegg, A. E. & Peterson, L. A., May 1 2006, In : Cancer Research. 66, 9, p. 4968-4974 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Effects of dietary fat content on the metabolism of NNK and on DNA methylation induced by NNK

El-Bayoumy, K., Prokopczyk, B., Peterson, L. A., Desai, D., Amin, S., Reddy, B. S., Hoffmann, D. & Wynder, E., Jan 1 1996, In : Nutrition and Cancer. 26, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Electrophilic intermediates produced by bioactivation of furan

Peterson, L. A., Jul 1 2006, In : Drug Metabolism Reviews. 38, 4, p. 615-626 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Evidence for an Episulfonium Ion Intermediate in the Formation of S-[2-(N7-Guanyl)ethyl]glutathione in DNA

Peterson, L. A., Harris, T. M. & Guengerich, F. P., May 1988, In : Journal of the American Chemical Society. 110, 10, p. 3284-3291 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
17 Scopus citations

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P. & 2 others, Pegg, A. E. & Tainer, J. A., Jun 11 2009, In : Nature. 459, 7248, p. 808-813 6 p.

Research output: Contribution to journalArticle

83 Scopus citations

Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice

Urban, A. M., Upadhyaya, P., Cao, Q. & Peterson, L. A., Oct 15 2012, In : Chemical research in toxicology. 25, 10, p. 2167-2178 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Formation of 1,4-dioxo-2-butene-derived adducts of 2′-deoxyadenosine and 2′-deoxycytidine in oxidized DNA

Chen, B., Vu, C. C., Byrns, M. C., Dedon, P. C. & Peterson, L. A., Aug 1 2006, In : Chemical research in toxicology. 19, 8, p. 982-985 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Formation of NADP(H) Analogs of Tobacco-Specific Nitrosamines in Rat Liver and Pancreatic Microsomes

Peterson, L. A., Dennis, K. N., Stearns, R. A. & Hecht, S. S., Sep 1 1994, In : Chemical research in toxicology. 7, 5, p. 599-608 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
4 Scopus citations

Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial

Peterson, L. A., Cummings, M. E., Vu, C. C. & Matter, B. A., Oct 1 2005, In : Drug Metabolism and Disposition. 33, 10, p. 1453-1458 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated rats

Peterson, L. A., Cummings, M. E., Chan, J. Y., Vu, C. C. & Matter, B. A., Sep 1 2006, In : Chemical research in toxicology. 19, 9, p. 1138-1141 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Identification of cis-2-Butene-1,4-dial as a Microsomal Metabolite of Furan

Chen, L. J., Hecht, S. S. & Peterson, L. A., Oct 1995, In : Chemical research in toxicology. 8, 7, p. 903-906 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Identification of furan metabolites derived from cysteine - Cis-2-butene-1,4-dial - Lysine cross-links

Lu, D. & Peterson, L. A., Jan 18 2010, In : Chemical research in toxicology. 23, 1, p. 142-151 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Individual Differences in the Response of Human β-Lymphoblastoid Cells to the Cytotoxic, Mutagenic, and DNA-Damaging Effects of a DNA Methylating Agent, N-Methylnitrosourethane

Peterson, L. A., Ignatovich, I. V., Grill, A. E., Beauchamp, A., Ho, Y. Y., Dilernia, A. S. & Zhang, L., Nov 18 2019, In : Chemical research in toxicology. 32, 11, p. 2214-2226 13 p.

Research output: Contribution to journalArticle

Inhaled Furan Selectively Damages Club Cells in Lungs of A/J Mice

Tǎbǎran, A. F., O’Sullivan, M. G., Seabloom, D. E., Vevang, K. R., Smith, W. E., Wiedmann, T. S. & Peterson, L. A., Oct 1 2019, In : Toxicologic Pathology. 47, 7, p. 842-850 9 p.

Research output: Contribution to journalArticle

Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

Peterson, L. A., Thomson, N. M., Crankshaw, D. L., Donaldson, E. E. & Kenney, P. J., Aug 1 2001, In : Cancer Research. 61, 15, p. 5757-5763 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: Synthesis, reductase-mediated bioactivation, and cellular toxicity

Gong, J., Neels, J. F., Yu, X., Kensler, T. W., Peterson, L. A. & Sturla, S. J., Apr 20 2006, In : Journal of medicinal chemistry. 49, 8, p. 2593-2599 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
33 Scopus citations

In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Peterson, L. A., Mathew, R., Murphy, S. E., Trushin, N. & Hecht, S. S., Nov 1 1991, In : Carcinogenesis. 12, 11, p. 2069-2072 4 p.

Research output: Contribution to journalArticle

38 Scopus citations

Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate

Morse, M. A., Jerry, L., Gopalakrishnan, R., Peterson, L. A., Wani, G. & Stoner, G. D., Jan 15 1997, In : Cancer Letters. 112, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolic activation of aromatic amines by human pancreas

Anderson, K. E., Hammons, G. J., Kadlubar, F. F., Potter, J. D., Kaderlik, K. R., Ilett, K. F., Minchin, R. F., Teitel, C. H., Chou, H. C., Martin, M. V., Guengerich, F. P., Barone, G. W., Lang, N. P. & Peterson, L. A., May 1 1997, In : Carcinogenesis. 18, 5, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

Metabolism of N-nitrosobenzylmethylamine by human cytochrome p-450 enzymes

Morse, M. A., Lu, J., Stoner, G. D., Murphy, S. E. & Peterson, L. A., Jan 1 1999, In : Journal of Toxicology and Environmental Health - Part A. 58, 7, p. 397-411 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

Metabolism of the Nigrostriatal Toxin 1-Methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine by Liver Homogenate Fractions

Weissman, J., Trevor, A., Chiba, K., Peterson, L. A., Caldera, P., Castagnoli, N. & Baillie, T., Aug 1985, In : Journal of Medicinal Chemistry. 28, 8, p. 997-1001 5 p.

Research output: Contribution to journalArticle

70 Scopus citations

Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Sandercock, L. E., Hahn, J. N., Li, L., Luchman, H., Giesbrecht, J. L., Peterson, L. A. & Jirik, F. R., Apr 1 2008, In : Carcinogenesis. 29, 4, p. 866-874 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mutagenesis by O6-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells

Pauly, G. T., Peterson, L. A. & Moschel, R. C., Mar 4 2002, In : Chemical research in toxicology. 15, 2, p. 165-169 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

Mutagenicity of furan in female Big Blue B6C3F1 mice

Terrell, A. N., Huynh, M., Grill, A. E., Kovi, R. C., O'Sullivan, M. G., Guttenplan, J. B., Ho, Y. Y. & Peterson, L. A., Aug 2014, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 770, p. 46-54 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

N-Nitrosobenzylmethylamine is activated to a DNA benzylating agent in rats

Peterson, L. A., Jan 1 1997, In : Chemical research in toxicology. 10, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

17 Scopus citations