1984 …2019

Research output per year

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Research Output

2019

Individual Differences in the Response of Human β-Lymphoblastoid Cells to the Cytotoxic, Mutagenic, and DNA-Damaging Effects of a DNA Methylating Agent, N-Methylnitrosourethane

Peterson, L. A., Ignatovich, I. V., Grill, A. E., Beauchamp, A., Ho, Y. Y., Dilernia, A. S. & Zhang, L., Nov 18 2019, In : Chemical research in toxicology. 32, 11, p. 2214-2226 13 p.

Research output: Contribution to journalArticle

Inhaled Furan Selectively Damages Club Cells in Lungs of A/J Mice

Tǎbǎran, A. F., O’Sullivan, M. G., Seabloom, D. E., Vevang, K. R., Smith, W. E., Wiedmann, T. S. & Peterson, L. A., Oct 1 2019, In : Toxicologic Pathology. 47, 7, p. 842-850 9 p.

Research output: Contribution to journalArticle

2018

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Jan 1 2018, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2017
Open Access
17 Scopus citations

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Open Access
15 Scopus citations
2015

Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans

Grill, A. E., Schmitt, T., Gates, L. A., Lu, D., Bandyopadhyay, D., Yuan, J. M., Murphy, S. E. & Peterson, L. A., Jul 20 2015, In : Chemical research in toxicology. 28, 7, p. 1508-1516 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Comparative metabolism of furan in rodent and human cryopreserved hepatocytes

Gates, L. A., Phillips, M. B., Matter, B. A. & Peterson, L. A., Jul 2014, In : Drug Metabolism and Disposition. 42, 7, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Covalent modification of cytochrome c by reactive metabolites of Furan

Phillips, M. B., Sullivan, M. M., Villalta, P. W. & Peterson, L. A., Jan 21 2014, In : Chemical research in toxicology. 27, 1, p. 129-135 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice

Narayanapillai, S. C., Balbo, S., Leitzman, P., Grill, A. E., Upadhyaya, P., Shaik, A. A., Zhou, B., Gerard O'Sullivan, M., Peterson, L. A., Lu, J., Hecht, S. S. & Xing, C., 2014, In : Carcinogenesis. 35, 10, p. 2365-2372 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mutagenicity of furan in female Big Blue B6C3F1 mice

Terrell, A. N., Huynh, M., Grill, A. E., Kovi, R. C., O'Sullivan, M. G., Guttenplan, J. B., Ho, Y. Y. & Peterson, L. A., Aug 2014, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 770, p. 46-54 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Reactive metabolites in the biotransformation of molecules containing a furan ring

Peterson, L. A., Jan 18 2013, In : Chemical research in toxicology. 26, 1, p. 6-25 20 p.

Research output: Contribution to journalReview article

86 Scopus citations

Role of aldehydes in the toxic and mutagenic effects of nitrosamines

Peterson, L. A., Urban, A. M., Vu, C. C., Cummings, M. E., Brown, L. C., Warmka, J. K., Li, L., Wattenberg, E. V., Patel, Y., Stram, D. O. & Pegg, A. E., Nov 4 2013, In : Chemical research in toxicology. 26, 10, p. 1464-1473 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice

Urban, A. M., Upadhyaya, P., Cao, Q. & Peterson, L. A., Oct 15 2012, In : Chemical research in toxicology. 25, 10, p. 2167-2178 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes

Gates, L. A., Lu, D. & Peterson, L. A., Mar 2012, In : Drug Metabolism and Disposition. 40, 3, p. 596-601 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Polyamines are traps for reactive intermediates in furan metabolism

Peterson, L. A., Phillips, M. B., Lu, D. & Sullivan, M. M., Nov 21 2011, In : Chemical research in toxicology. 24, 11, p. 1924-1936 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Aug 12 2010, Respiratory Toxicology. Elsevier Inc., Vol. 8. p. 351-377 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
20 Scopus citations

Identification of furan metabolites derived from cysteine - Cis-2-butene-1,4-dial - Lysine cross-links

Lu, D. & Peterson, L. A., Jan 18 2010, In : Chemical research in toxicology. 23, 1, p. 142-151 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

Degraded protein adducts of cis-2-butene-1,4-dial are urinary and hepatocyte metabolites of furan

Lu, D., Sullivan, M. M., Phillips, M. B. & Peterson, L. A., Jun 15 2009, In : Chemical research in toxicology. 22, 6, p. 997-1007 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Flipping of alkylated DNA damage bridges base and nucleotide excision repair

Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., Santibanez-Koref, M. F., Millington, C., Arvai, A. S., Kroeger, M. D., Peterson, L. A., Williams, D. M., Fried, M. G., Margison, G. P. & 2 others, Pegg, A. E. & Tainer, J. A., Jun 11 2009, In : Nature. 459, 7248, p. 808-813 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines

Li, L., Perdigao, J., Pegg, A. E., Lao, Y., Hecht, S. S., Lindgren, B. R., Reardon, J. T., Sancar, A., Wattenberg, E. V. & Peterson, L. A., Aug 17 2009, In : Chemical research in toxicology. 22, 8, p. 1464-1472 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Sandercock, L. E., Hahn, J. N., Li, L., Luchman, H., Giesbrecht, J. L., Peterson, L. A. & Jirik, F. R., Apr 1 2008, In : Carcinogenesis. 29, 4, p. 866-874 9 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

Decomposition of S-nitrosocysteine via S- To N-transnitrosation

Peterson, L. A., Wagener, T., Sies, H. & Stahl, W., May 1 2007, In : Chemical research in toxicology. 20, 5, p. 721-723 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Depurinating acylfulvene-DNA adducts: Characterizing cellular chemical reactions of a selective antitumor agent

Gong, J., Vaidyanathan, V. G., Yu, X., Kensler, T. W., Peterson, L. A. & Sturla, S. J., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 2101-2111 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase

Coulter, R., Blandino, M., Tomlinson, J. M., Pauly, G. T., Krajewska, M., Moschel, R. C., Peterson, L. A., Pegg, A. E. & Spratt, T. E., Dec 1 2007, In : Chemical research in toxicology. 20, 12, p. 1966-1971 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
2006

Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial

Byrns, M. C., Vu, C. C., Neidigh, J. W., Abad, J. L., Jones, R. A. & Peterson, L. A., Mar 1 2006, In : Chemical research in toxicology. 19, 3, p. 414-420 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

DNA sequence context affects repair of the tobacco-specific adduct O 6-[4-oxo-4-(3-pyridyl)butyl]guanine by human O6- alkylguanine-DNA alkyltransferases

Mijal, R. S., Kanugula, S., Vu, C. C., Fang, Q., Pegg, A. E. & Peterson, L. A., May 1 2006, In : Cancer Research. 66, 9, p. 4968-4974 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Electrophilic intermediates produced by bioactivation of furan

Peterson, L. A., Jul 1 2006, In : Drug Metabolism Reviews. 38, 4, p. 615-626 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Formation of 1,4-dioxo-2-butene-derived adducts of 2′-deoxyadenosine and 2′-deoxycytidine in oxidized DNA

Chen, B., Vu, C. C., Byrns, M. C., Dedon, P. C. & Peterson, L. A., Aug 1 2006, In : Chemical research in toxicology. 19, 8, p. 982-985 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of a cis-2-butene-1,4-dial-derived glutathione conjugate in the urine of furan-treated rats

Peterson, L. A., Cummings, M. E., Chan, J. Y., Vu, C. C. & Matter, B. A., Sep 1 2006, In : Chemical research in toxicology. 19, 9, p. 1138-1141 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: Synthesis, reductase-mediated bioactivation, and cellular toxicity

Gong, J., Neels, J. F., Yu, X., Kensler, T. W., Peterson, L. A. & Sturla, S. J., Apr 20 2006, In : Journal of medicinal chemistry. 49, 8, p. 2593-2599 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases

Choi, J. Y., Chowdhury, G., Zang, H., Angel, K. C., Vu, C. C., Peterson, L. A. & Guengerich, F. P., Dec 15 2006, In : Journal of Biological Chemistry. 281, 50, p. 38244-38256 13 p.

Research output: Contribution to journalArticle

100 Scopus citations
2005

Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial

Peterson, L. A., Cummings, M. E., Vu, C. C. & Matter, B. A., Oct 2005, In : Drug Metabolism and Disposition. 33, 10, p. 1453-1458 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents

Mijal, R. S., Loktionova, N. A., Vu, C. C., Pegg, A. E. & Peterson, L. A., Oct 1 2005, In : Chemical research in toxicology. 18, 10, p. 1619-1625 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Synthesis of [13C4]furan

Vu, C. C. & Peterson, L. A., Feb 1 2005, In : Journal of Labelled Compounds and Radiopharmaceuticals. 48, 2, p. 117-121 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis of a 2′-deoxyguanosine adduct of cis-2-butene-1,4-dial, a reactive metabolite of furan

Vu, C. C. & Peterson, L. A., Jun 1 2005, In : Chemical research in toxicology. 18, 6, p. 1012-1017 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2004
21 Scopus citations
52 Scopus citations

The Repair of the Tobacco Specific Nitrosamine Derived Adduct O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O 6-Alkylguanine-DNA Alkyltransferase Variants

Mijal, R. S., Thomson, N. M., Fleischer, N. L., Pauly, G. T., Moschel, R. C., Kanugula, S., Fang, Q., Pegg, A. E. & Peterson, L. A., Mar 1 2004, In : Chemical research in toxicology. 17, 3, p. 424-434 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2003
4 Scopus citations

Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanone

Peterson, L. A., Predecki, D. P., Thomson, N. M., Villalta, P. W. & Donaldson, E. E., May 1 2003, In : Chemical research in toxicology. 16, 5, p. 661-667 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Solution Structure of an O6-[4-oxo-4-(3-Pyridyl)butyl]guanine Adduct in an 11mer DNA Duplex: Evidence for Formation of a Base Triplex

Peterson, L. A., Vu, C., Hingerty, B. E., Broyde, S. & Cosman, M., Nov 18 2003, In : Biochemistry. 42, 45, p. 13134-13144 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Jalas, J. R., McIntee, E. J., Kenney, P. M. J., Upadhyaya, P., Peterson, L. A. & Hecht, S. S., Jun 1 2003, In : Chemical research in toxicology. 16, 6, p. 794-806 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
32 Scopus citations
2002

Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan

Byrns, M. C., Predecki, D. P. & Peterson, L. A., Apr 3 2002, In : Chemical research in toxicology. 15, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mutagenesis by O6-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells

Pauly, G. T., Peterson, L. A. & Moschel, R. C., Mar 4 2002, In : Chemical research in toxicology. 15, 2, p. 165-169 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
2001

An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Peterson, L. A., Spratt, T. E., Shan, W., Wang, L., Subotkowski, W. & Roth, R., Jul 9 2001, In : Journal of Labelled Compounds and Radiopharmaceuticals. 44, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

Peterson, L. A., Thomson, N. M., Crankshaw, D. L., Donaldson, E. E. & Kenney, P. J., Aug 1 2001, In : Cancer Research. 61, 15, p. 5757-5763 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
2000

A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay

Peterson, L. A., Naruko, K. C. & Predecki, D. P., Jul 1 2000, In : Chemical research in toxicology. 13, 7, p. 531-534 4 p.

Research output: Contribution to journalArticle

71 Scopus citations