1984 …2019

Research output per year

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Research Output

1984

Chapter 27. Stable Isotopes in Drug Metabolism and Disposition

Baillie, T. A., Rettenmeier, A. W., Peterson, L. A. & Castagnoli, N., Jan 1 1984, In : Annual Reports in Medicinal Chemistry. 19, C, p. 273-282 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
1985

Metabolism of the Nigrostriatal Toxin 1-Methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine by Liver Homogenate Fractions

Weissman, J., Trevor, A., Chiba, K., Peterson, L. A., Caldera, P., Castagnoli, N. & Baillie, T., Aug 1985, In : Journal of Medicinal Chemistry. 28, 8, p. 997-1001 5 p.

Research output: Contribution to journalArticle

70 Scopus citations
60 Scopus citations

Studies on the molecular mechanism of bioactivation of the selective nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Chiba, K., Peterson, L. A., Castagnoli, K. P. & Trevor, A. J., Nov 6 1985, In : Drug Metabolism and Disposition. 13, 3, p. 342-347 6 p.

Research output: Contribution to journalArticle

114 Scopus citations
1987

Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts

Guengerich, F. P., Peterson, L. A., Cmarik, J. L., Koga, N. & Inskeep, P. B., Jan 1 1987, In : Environmental health perspectives. 76, p. 15-18 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Stereochemical Studies on the Cytochrome P-450 Catalyzed Oxidation of (s)-nicotine to the (s)-Nicotine Δ1'(5')-Iminium Species

Peterson, L. A., Trevor, A. & Castagnoli, N., Feb 1 1987, In : Journal of Medicinal Chemistry. 30, 2, p. 249-254 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
1988

Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters

Guengerich, F. P., Peterson, L. A. & Bocker, R. H., Jan 1 1988, In : Journal of Biological Chemistry. 263, 17, p. 8176-8183 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Evidence for an Episulfonium Ion Intermediate in the Formation of S-[2-(N7-Guanyl)ethyl]glutathione in DNA

Peterson, L. A., Harris, T. M. & Guengerich, F. P., May 1988, In : Journal of the American Chemical Society. 110, 10, p. 3284-3291 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Regio- and Stereochemical Studies on the α-Carbon Oxidation of (S)-Nicotine by Cytochrome P-450 Model Systems

Peterson, L. A. & Castagnoli, N., Mar 1 1988, In : Journal of Medicinal Chemistry. 31, 3, p. 637-640 4 p.

Research output: Contribution to journalArticle

26 Scopus citations
1990
33 Scopus citations
51 Scopus citations
1991
186 Scopus citations

In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Peterson, L. A., Mathew, R., Murphy, S. E., Trushin, N. & Hecht, S. S., Nov 1 1991, In : Carcinogenesis. 12, 11, p. 2069-2072 4 p.

Research output: Contribution to journalArticle

38 Scopus citations
52 Scopus citations
1992
20 Scopus citations

DNA and hemoglobin adducts as markers of metabolic activation of tobacco- specific carcinogens

Foiles, P. G., Murphy, S. E., Peterson, L. A., Carmella, S. G. & Hecht, S. S., Jun 1 1992, In : Cancer Research. 52, 9 SUPPL., p. 2698s-2701s

Research output: Contribution to journalArticle

17 Scopus citations
1993

Pyridyloxobutyl DNA Adducts Inhibit the Repair of O6-Methylguanine

Peterson, L. A., Liu, X. K. & Hecht, S. S., Jun 1993, In : Cancer Research. 53, 12, p. 2780-2785 6 p.

Research output: Contribution to journalArticle

67 Scopus citations
139 Scopus citations
62 Scopus citations
1994

Formation of NADP(H) Analogs of Tobacco-Specific Nitrosamines in Rat Liver and Pancreatic Microsomes

Peterson, L. A., Dennis, K. N., Stearns, R. A. & Hecht, S. S., Sep 1 1994, In : Chemical research in toxicology. 7, 5, p. 599-608 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tobacco-specific nitrosamines.

Hecht, S. S., Peterson, L. A. & Spratt, T. E., 1994, In : IARC scientific publications. 125, p. 91-106 16 p.

Research output: Contribution to journalReview article

11 Scopus citations
1995

Identification of cis-2-Butene-1,4-dial as a Microsomal Metabolite of Furan

Chen, L. J., Hecht, S. S. & Peterson, L. A., Oct 1995, In : Chemical research in toxicology. 8, 7, p. 903-906 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Stereoselectivity and isotope effects associated with cytochrome P450- catalyzed oxidation of (S)-nicotine: The possibility of initial hydrogen atom abstraction in the formation of the δ1',5'-nicotinium ion

Carlson, T. J., Jones, J. P., Peterson, L., Castagnoli, N., Iyer, K. R. & Trager, W. F., Jan 1 1995, In : Drug Metabolism and Disposition. 23, 7, p. 749-756 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
1996

Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities

Williams, G. M., Iatropoulos, M. J., Wang, C. X., Ali, N., Rivenson, A., Peterson, L. A., Schulz, C. & Gebhardt, R., Oct 1 1996, In : Carcinogenesis. 17, 10, p. 2253-2258 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Effects of dietary fat content on the metabolism of NNK and on DNA methylation induced by NNK

El-Bayoumy, K., Prokopczyk, B., Peterson, L. A., Desai, D., Amin, S., Reddy, B. S., Hoffmann, D. & Wynder, E., Jan 1 1996, In : Nutrition and Cancer. 26, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
17 Scopus citations
1997
97 Scopus citations

Corrigendum: Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate (Cancer Letters (1997) 112 (119-125))

Morse, M. A., Lu, J., Gopalakrishnan, R., Peterson, L. A., D'Ambrosio, S. M., Wani, G. & Stoner, G. D., Jan 1 1997, In : Cancer Letters. 116, 1, 1 p.

Research output: Contribution to journalComment/debate

Mechanism of enhancement of esophageal tumorigenesis by 6-phenylhexyl isothiocyanate

Morse, M. A., Jerry, L., Gopalakrishnan, R., Peterson, L. A., Wani, G. & Stoner, G. D., Jan 15 1997, In : Cancer Letters. 112, 1, p. 119-125 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Metabolic activation of aromatic amines by human pancreas

Anderson, K. E., Hammons, G. J., Kadlubar, F. F., Potter, J. D., Kaderlik, K. R., Ilett, K. F., Minchin, R. F., Teitel, C. H., Chou, H. C., Martin, M. V., Guengerich, F. P., Barone, G. W., Lang, N. P. & Peterson, L. A., May 1 1997, In : Carcinogenesis. 18, 5, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

81 Scopus citations

N-Nitrosobenzylmethylamine is activated to a DNA benzylating agent in rats

Peterson, L. A., Jan 1 1997, In : Chemical research in toxicology. 10, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
92 Scopus citations
1998

An improved method for construction of directionally cloned cDNA libraries from microdissected cells

Peterson, L. A., Brown, M. R., Carlisle, A. J., Kohn, E. C., Liotta, L. A., Emmert-Buck, M. R. & Krizman, D. B., Dec 1 1998, In : Cancer Research. 58, 23, p. 5326-5328 3 p.

Research output: Contribution to journalArticle

45 Scopus citations
17 Scopus citations
1999

Metabolism of N-nitrosobenzylmethylamine by human cytochrome p-450 enzymes

Morse, M. A., Lu, J., Stoner, G. D., Murphy, S. E. & Peterson, L. A., Jan 1 1999, In : Journal of Toxicology and Environmental Health - Part A. 58, 7, p. 397-411 15 p.

Research output: Contribution to journalArticle

25 Scopus citations
27 Scopus citations
2000

A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay

Peterson, L. A., Naruko, K. C. & Predecki, D. P., Jul 1 2000, In : Chemical research in toxicology. 13, 7, p. 531-534 4 p.

Research output: Contribution to journalArticle

70 Scopus citations
2001

An improved synthesis of radiolabeled 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone

Peterson, L. A., Spratt, T. E., Shan, W., Wang, L., Subotkowski, W. & Roth, R., Jul 9 2001, In : Journal of Labelled Compounds and Radiopharmaceuticals. 44, 6, p. 445-450 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: Implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

Peterson, L. A., Thomson, N. M., Crankshaw, D. L., Donaldson, E. E. & Kenney, P. J., Aug 1 2001, In : Cancer Research. 61, 15, p. 5757-5763 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
2002

Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan

Byrns, M. C., Predecki, D. P. & Peterson, L. A., Apr 3 2002, In : Chemical research in toxicology. 15, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Mutagenesis by O6-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells

Pauly, G. T., Peterson, L. A. & Moschel, R. C., Mar 4 2002, In : Chemical research in toxicology. 15, 2, p. 165-169 5 p.

Research output: Contribution to journalArticle

58 Scopus citations
2003
4 Scopus citations

Nucleophilic reactions between thiols and a tobacco specific nitrosamine metabolite, 4-hydroxy-1-(3-pyridyl)-1-butanone

Peterson, L. A., Predecki, D. P., Thomson, N. M., Villalta, P. W. & Donaldson, E. E., May 1 2003, In : Chemical research in toxicology. 16, 5, p. 661-667 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Solution Structure of an O6-[4-oxo-4-(3-Pyridyl)butyl]guanine Adduct in an 11mer DNA Duplex: Evidence for Formation of a Base Triplex

Peterson, L. A., Vu, C., Hingerty, B. E., Broyde, S. & Cosman, M., Nov 18 2003, In : Biochemistry. 42, 45, p. 13134-13144 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

Jalas, J. R., McIntee, E. J., Kenney, P. M. J., Upadhyaya, P., Peterson, L. A. & Hecht, S. S., Jun 1 2003, In : Chemical research in toxicology. 16, 6, p. 794-806 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
32 Scopus citations
2004
21 Scopus citations
52 Scopus citations

The Repair of the Tobacco Specific Nitrosamine Derived Adduct O 6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O 6-Alkylguanine-DNA Alkyltransferase Variants

Mijal, R. S., Thomson, N. M., Fleischer, N. L., Pauly, G. T., Moschel, R. C., Kanugula, S., Fang, Q., Pegg, A. E. & Peterson, L. A., Mar 1 2004, In : Chemical research in toxicology. 17, 3, p. 424-434 11 p.

Research output: Contribution to journalArticle

56 Scopus citations
2005

Glutathione trapping to measure microsomal oxidation of furan to cis-2-butene-1,4-dial

Peterson, L. A., Cummings, M. E., Vu, C. C. & Matter, B. A., Oct 1 2005, In : Drug Metabolism and Disposition. 33, 10, p. 1453-1458 6 p.

Research output: Contribution to journalArticle

54 Scopus citations