Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Bi-substrate Inhibitors of SARS-CoV-2 Nsp14 Methyltransferase
Chen, L. (PI), Geraghty, R. J. (CoI) & Xie, J. (CoI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
6/15/22 → 5/31/25
Project: Research project
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Optimizing Zika NS5 Methyltransferase Inhibitors
Chen, L. (PI), Geraghty, R. J. (CoI) & Xie, J. (CoI)
NIH NATIONAL INST OF ALLERGY & INFECT DI
2/1/20 → 1/31/23
Project: Research project
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Exploiting SIRT2 for Breast Cancer Therapy
Chen, L. (PI)
EMORY UNIVERSITY, U.S. DEPARTMENT OF DEFENSE
8/1/19 → 7/31/21
Project: Research project
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Nicotinamide-based Sirtuin 2 inhibitors as anti-HCMV agents
Begum, D., Ai, T., Wilson, D. J., Chen, L. & Geraghty, R. J., Mar 2026, In: Antiviral Research. 247, 106356.Research output: Contribution to journal › Article › peer-review
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p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity
Ding, R., Edwards, T. C., Goswami, P., Wilson, D. J., Dreis, C. D., Ye, Y., Geraghty, R. J. & Chen, L., Jan 2025, In: Pharmaceuticals. 18, 1, 131.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs
Ai, T., Wilson, D. J. & Chen, L., Nov 2023, In: Molecules. 28, 22, 7655.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation
Zhang, Q., Tang, W., Stancanelli, E., Jung, E., Syed, Z., Pagadala, V., Saidi, L., Chen, C. Z., Gao, P., Xu, M., Pavlinov, I., Li, B., Huang, W., Chen, L., Liu, J., Xie, H., Zheng, W. & Ye, Y., Dec 2023, In: Nature communications. 14, 1, 5777.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
Bisubstrate Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 Nsp14 Methyltransferase
Jung, E., Soto-Acosta, R., Xie, J., Wilson, D., Dreis, C. D., Majima, R., Edwards, T., Geraghty, R. J. & Chen, L., Sep 8 2022, In: ACS Medicinal Chemistry Letters. 13, 9, p. 1477-1484 8 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Link opens in a new tab Scopus citations