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Research Output 1981 2019

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Article
2019
Blepharospasm
Type A Botulinum Toxins
Neuromuscular Junction
Eyelids
Muscles
2018

Changing muscle function with sustained glial derived neurotrophic factor treatment of rabbit extraocular muscle

Fitzpatrick, K. R., Cucak, A. & McLoon, L. K., Aug 1 2018, In : PLoS One. 13, 8, e0202861.

Research output: Contribution to journalArticle

Open Access
Oculomotor Muscles
neurotrophins
Nerve Growth Factors
neuroglia
Neuroglia
2 Citations (Scopus)

Composition, architecture, and functional implications of the connective tissue network of the extraocular muscles

McLoon, L. K., Vicente, A., Fitzpatrick, K. R., Lindström, M. & Pedrosa Domellöf, F., Jan 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 1, p. 322-329 8 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Connective Tissue
Collagen
Muscles
Elastin
13 Citations (Scopus)

Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling

Verma, M., Asakura, Y., Murakonda, B. S. R., Pengo, T., Latroche, C., Chazaud, B., McLoon, L. K. & Asakura, A., Oct 4 2018, In : Cell Stem Cell. 23, 4, p. 530-543.e9

Research output: Contribution to journalArticle

Muscle Cells
Vascular Endothelial Growth Factor A
Blood Vessels
Endothelial Cells
Muscles

Visualizing neuronal adaptation over time after treatment of strabismus

Fleuriet, J. & McLoon, L. K., Oct 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 12, p. 5022-5024 3 p.

Research output: Contribution to journalArticle

Open Access
Strabismus
2017
1 Citation (Scopus)

Effects of retinoic acid signaling on extraocular muscle myogenic precursor cells in vitro

Hebert, S. L., Fitzpatrick, K. R., McConnell, S. A., Cucak, A., Yuan, C. & McLoon, L. K., Dec 1 2017, In : Experimental Cell Research. 361, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Tretinoin
Retinoid X Receptors
Retinoic Acid Receptors
Desmin
2016
5 Citations (Scopus)

Abnormally small neuromuscular junctions in the extraocular muscles from subjects with idiopathic nystagmus and nystagmus associated with albinism

McLoon, L. K., Willoughby, C. L., Anderson, J. S., Bothun, E. D., Stager, D., Felius, J., Lee, H. & Gottlob, I., Apr 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 4, p. 1912-1920 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Albinism
Neuromuscular Junction
Muscles
Brain-Derived Neurotrophic Factor
2 Citations (Scopus)

A novel explanation of corneal clouding in a bone marrow transplant-treated patient with Hurler syndrome

Yuan, C., Bothun, E. D., Hardten, D. R., Tolar, J. & McLoon, L. K., Jul 1 2016, In : Experimental Eye Research. 148, p. 83-89 7 p.

Research output: Contribution to journalArticle

Mucopolysaccharidosis I
Cornea
Bone Marrow
Transplants
Collagen
6 Citations (Scopus)

Improvement of Eye Alignment in Adult Strabismic Monkeys by Sustained IGF-1 Treatment

McLoon, L. K., Christiansen, S. P., Ghose, G. M., Das, V. E. & Mustari, M. J., Nov 1 2016, In : Investigative ophthalmology & visual science. 57, 14, p. 6070-6078 9 p.

Research output: Contribution to journalArticle

Somatomedins
Haplorhini
Exotropia
Muscles
Primates
3 Citations (Scopus)

Prolongation of relaxation time in extraocular muscles with brain derived neurotrophic factor in adult rabbit

Nelson, K. R., Stevens, S. M. & McLoon, L. K., Oct 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 13, p. 5834-5842 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Brain-Derived Neurotrophic Factor
Rabbits
Neuromuscular Junction
Muscles
2015
11 Citations (Scopus)

Abnormal activity of neurons in abducens nucleus of strabismic monkeys

Walton, M. M. G., Mustari, M. J., Willoughby, C. L. & McLoon, L. K., Nov 20 2015, In : Investigative Ophthalmology and Visual Science. 56, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

Haplorhini
Neurons
Saccades
Strabismus
Abducens Nucleus
8 Citations (Scopus)

Adaptability of the immature ocular motor control system: Unilateral IGF-1 medial rectus treatment

Willoughby, C. L., Fleuriet, J., Walton, M. M., Mustari, M. J. & McLoon, L. K., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 6, p. 3484-3495 12 p.

Research output: Contribution to journalArticle

Strabismus
Oculomotor Muscles
Insulin-Like Growth Factor I
Haplorhini
Muscles
11 Citations (Scopus)

Adaptation of slow myofibers: The effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates

Willoughby, C. L., Fleuriet, J., Walton, M. M., Mustari, M. J. & McLoon, L. K., Jan 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 6, p. 3467-3483 17 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Brain-Derived Neurotrophic Factor
Primates
Myosins
Muscles
18 Citations (Scopus)

C57BL/6 life span study: Age-related declines in muscle power production and contractile velocity

Graber, T. G., Kim, J. H., Grange, R. W., McLoon, L. K. & Thompson, L. V., Apr 17 2015, In : AGE. 37, 3, 36.

Research output: Contribution to journalArticle

Skeletal Muscle
Muscles
Myosin Light Chains
Myosin Heavy Chains
Inbred C57BL Mouse
14 Citations (Scopus)

Disease course in mdx:Utrophin+/− mice: comparison of three mouse models of duchenne muscular dystrophy

McDonald, A. A., Hebert, S. L., Kunz, M. D., Ralles, S. J. & McLoon, L. K., Jan 1 2015, In : Physiological Reports. 3, 4, e12391.

Research output: Contribution to journalArticle

Utrophin
Inbred mdx Mouse
Duchenne Muscular Dystrophy
Muscles
Phenotype
1 Citation (Scopus)

Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis

McDonald, A. A., Hebert, S. L. & McLoon, L. K., Nov 1 2015, In : Neuromuscular Disorders. 25, 11, p. 873-887 15 p., 3088.

Research output: Contribution to journalArticle

Oculomotor Muscles
Utrophin
Inbred mdx Mouse
Muscular Dystrophies
Muscles
2014
8 Citations (Scopus)

Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin+/- mice

McDonald, A. A., Kunz, M. D. & McLoon, L. K., Jan 21 2014, In : PloS one. 9, 1, e86424.

Research output: Contribution to journalArticle

Oculomotor Muscles
Utrophin
Inbred mdx Mouse
gamma radiation
Muscle
4 Citations (Scopus)

Wnt and extraocular muscle sparing in amyotrophic lateral sclerosis

McLoon, L. K., Harandi, V. M., Brännström, T., Andersen, P. M. & Liu, J. X., Jan 1 2014, In : Investigative Ophthalmology and Visual Science. 55, 9, p. 5482-5496 15 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Amyotrophic Lateral Sclerosis
Neuromuscular Junction
Extremities
Muscles
2013
13 Citations (Scopus)

Postulating a role for connective tissue elements in inferior oblique muscle overaction

Stager, D., McLoon, L. K. & Felius, J., Oct 23 2013, In : Transactions of the American Ophthalmological Society. 111, p. 119-132 14 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Connective Tissue
Elastin
Craniofacial Dysostosis
Collagen
22 Citations (Scopus)

The Role of Pitx2 in Maintaining the Phenotype of Myogenic Precursor Cells in the Extraocular Muscles

Hebert, S. L., Daniel, M. L. & McLoon, L. K., Mar 7 2013, In : PloS one. 8, 3, e58405.

Research output: Contribution to journalArticle

Open Access
Oculomotor Muscles
myocytes
Muscle
Phenotype
phenotype
2012
1 Citation (Scopus)

Effects of sequential injections of hepatocyte growth factor and insulin-like growth factor-I on adult rabbit extraocular muscle

Willoughby, C. L., Ralles, S., Christiansen, S. P. & McLoon, L. K., Aug 1 2012, In : Journal of AAPOS. 16, 4, p. 354-360 7 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Hepatocyte Growth Factor
Insulin-Like Growth Factor I
Rabbits
Injections
7 Citations (Scopus)

Effects of the sustained release of IGF-1 on extraocular muscle of the infant non-human primate: Adaptations at the effector organ level

Willoughby, C. L., Christiansen, S. P., Mustari, M. J. & McLoon, L. K., Jan 1 2012, In : Investigative Ophthalmology and Visual Science. 53, 1, p. 68-75 8 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Somatomedins
Primates
Muscles
Blinking
7 Citations (Scopus)

Extraocular muscles in patients with infantile nystagmus: Adaptations at the effector level

Berg, K. T., Hunter, D. G., Bothun, E. D., Antunes-Foschini, R. & McLoon, L. K., Mar 1 2012, In : Archives of Ophthalmology. 130, 3, p. 343-349 7 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Neuromuscular Junction
Nerve Fibers
Regeneration
Phenotype
2011
23 Citations (Scopus)

A continuum of myofibers in adult rabbit extraocular muscle: Force, shortening velocity, and patterns of myosin heavy chain colocalization

McLoon, L. K., Park, H. N., Kim, J. H., Pedrosa-Domellöf, F. & Thompson, L. V., Oct 1 2011, In : Journal of Applied Physiology. 111, 4, p. 1178-1189 12 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Myosin Heavy Chains
Protein Isoforms
Rabbits
Eye Movements
11 Citations (Scopus)

Modulating neuromuscular junction density changes in botulinum toxin-treated orbicularis oculi muscle

Harrison, A. R., Berbos, Z., Zaldivar, R. A., Anderson, B. C., Semmer, M., Lee, M. S. & McLoon, L. K., Feb 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 2, p. 982-986 5 p.

Research output: Contribution to journalArticle

Botulinum Toxins
Neuromuscular Junction
Insulin Antibodies
Growth Factor Receptors
Corticotropin-Releasing Hormone
35 Citations (Scopus)

Sparing of extraocular muscle in aging and muscular dystrophies: A myogenic precursor cell hypothesis

Kallestad, K. M., Hebert, S. L., McDonald, A. A., Daniel, M. L., Cu, S. R. & McLoon, L. K., Jan 1 2011, In : Experimental Cell Research. 317, 6, p. 873-885 13 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Muscular Dystrophies
Extremities
Muscles
Oxidative Stress
3 Citations (Scopus)

Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: Potential for strabismus treatment

Anderson, B. C., Daniel, M. L., Kendall, J. D., Christiansen, S. P. & McLoon, L. K., Jun 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 7, p. 4021-4029 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Bone Morphogenetic Protein 4
Strabismus
Rabbits
Muscles
2010
25 Citations (Scopus)

Defining the heterogeneity of skeletal muscle-derived side and main population cells isolated immediately ex vivo

Kallestad, K. M. & McLoon, L. K., Mar 1 2010, In : Journal of Cellular Physiology. 222, 3, p. 676-684 9 p.

Research output: Contribution to journalArticle

Side-Population Cells
Muscle
Skeletal Muscle
Flow cytometry
Coloring Agents
8 Citations (Scopus)
Oculomotor Muscles
Thyroid Hormones
Rabbits
Myosin Heavy Chains
Protein Isoforms
20 Citations (Scopus)

Effects of recession versus tenotomy surgery without recession in adult rabbit extraocular muscle

Christiansen, S. P., Antunes-Foschini, R. S. & McLoon, L. K., Nov 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 11, p. 5646-5656 11 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Tenotomy
Myosin Heavy Chains
Rabbits
Muscles
85 Citations (Scopus)

Intranasal delivery of neurotrophic factors BDNF, CNTF, EPO, and NT-4 to the CNS

Alcalá-Barraza, S. R., Lee, M. S., Hanson, L. R., McDonald, A. A., Frey, W. H. & McLoon, L. K., Apr 1 2010, In : Journal of Drug Targeting. 18, 3, p. 179-190 12 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Erythropoietin
Central Nervous System
19 Citations (Scopus)

Pegylated interferon alpha-associated optic neuropathy

Berg, K. T., Nelson, B., Harrison, A. R., McLoon, L. K. & Lee, M. S., Jun 1 2010, In : Journal of Neuro-Ophthalmology. 30, 2, p. 117-122 6 p.

Research output: Contribution to journalArticle

Ischemic Optic Neuropathy
Optic Nerve Diseases
Interferon-alpha
Peripheral Nervous System Diseases
Chronic Hepatitis C
2009
84 Citations (Scopus)
Neuroprotective Agents
Optic Nerve
Optic Nerve Injuries
Ischemic Optic Neuropathy
Ocular Hypertension
2008
9 Citations (Scopus)

Activated satellite cells in medial rectus muscles of patients with strabismus

Antunes-Foschini, R. S., Miyashita, D., Bicas, H. E. A. & McLoon, L. K., Jan 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 1, p. 215-220 6 p.

Research output: Contribution to journalArticle

Strabismus
Muscles
Up-Regulation
Paraffin Embedding
Neuromuscular Diseases
3 Citations (Scopus)

Botulinum toxin pretreatment augments the weakening effect of injection with ricin-mAb35 in rabbit extraocular muscle

Christiansen, S. P., Anderson, B. C. & McLoon, L. K., Apr 1 2008, In : Journal of AAPOS. 12, 2, p. 122-127 6 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Ricin
Botulinum Toxins
Rabbits
Muscles
12 Citations (Scopus)

Myogenic growth factors can decrease extraocular muscle force generation: A potential biological approach to the treatment of strabismus

Anderson, B. C., Christiansen, S. P. & McLoon, L. K., Jan 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 1, p. 221-229 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Strabismus
Intercellular Signaling Peptides and Proteins
Muscles
Myosin Heavy Chains
2007
24 Citations (Scopus)

Myofiber length and three-dimensional localization of NMJs in normal and botulinum toxin-treated adult extraocular muscles

Harrison, A. R., Anderson, B. C., Thompson, L. V. & McLoon, L. K., Aug 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 8, p. 3594-3601 8 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Botulinum Toxins
Neuromuscular Junction
Rabbits
Muscles
27 Citations (Scopus)

Neuroprotective effects of brimonidine treatment in a rodent model of ischemic optic neuropathy

Danylkova, N. O., Alcala, S. R., Pomeranz, H. D. & McLoon, L. K., Feb 1 2007, In : Experimental Eye Research. 84, 2, p. 293-301 9 p.

Research output: Contribution to journalArticle

Ischemic Optic Neuropathy
Neuroprotective Agents
Rodentia
Axons
Ophthalmic Solutions
2006
20 Citations (Scopus)

Effect of recurrent laryngeal nerve section on the laryngeal muscles of adult rabbits

Shinners, M. J., Goding, G. & McLoon, L. K., Mar 1 2006, In : Otolaryngology - Head and Neck Surgery. 134, 3, p. 413-418 6 p.

Research output: Contribution to journalArticle

Laryngeal Muscles
Recurrent Laryngeal Nerve
Myosin Heavy Chains
Rabbits
Bromodeoxyuridine
22 Citations (Scopus)

Histological and morphometric evaluation of transient retinal and optic nerve ischemia in rat

Danylkova, N. O., Pomeranz, H. D., Alcala, S. R. & McLoon, L. K., Jun 22 2006, In : Brain Research. 1096, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

Ischemic Optic Neuropathy
Optic Nerve Injuries
Wounds and Injuries
Hypoxia-Inducible Factor 1
Ischemia
40 Citations (Scopus)

Increased extraocular muscle strength with direct injection of insulin-like growth factor-I

Anderson, B. C., Christiansen, S. P., Grandt, S., Grange, R. W. & McLoon, L. K., Jun 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 6, p. 2461-2467 7 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Muscle Strength
Insulin-Like Growth Factor I
Muscles
Injections
21 Citations (Scopus)

Increasing Muscle Strength as a Treatment for Strabismus: Sustained Release of Insulin-like Growth Factor-1 in Rabbit Extraocular Muscle

McLoon, L. K., Anderson, B. C. & Christiansen, S. P., Oct 1 2006, In : Journal of AAPOS. 10, 5, p. 424-429 6 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Strabismus
Muscle Strength
Somatomedins
Insulin-Like Growth Factor I
1 Citation (Scopus)
Irritants
Corticotropin-Releasing Hormone
Touch
Eyelids
Rabbits
38 Citations (Scopus)

The effect of resection on satellite cell activity in rabbit extraocular muscle

Christiansen, S. P. & McLoon, L. K., Feb 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 2, p. 605-613 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Rabbits
Muscles
Bromodeoxyuridine
Myosin Heavy Chains
2005
38 Citations (Scopus)
Myosin Heavy Chains
myosin heavy chains
Rattus norvegicus
Protein Isoforms
Skeletal Muscle
43 Citations (Scopus)

Botulinum toxin treatment of extraocular muscles in rabbits results in increased myofiber remodeling

Ugalde, I., Christiansen, S. P. & McLoon, L. K., Nov 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 11, p. 4114-4120 7 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Type A Botulinum Toxins
Botulinum Toxins
Rabbits
Bromodeoxyuridine
13 Citations (Scopus)

Effect of endurance exercise on myosin heavy chain isoform expression in diabetic rats with peripheral neuropathy

Snow, L. M., Sanchez, O. A., McLoon, L. K., Serfass, R. C. & Thompson, L. V., Oct 1 2005, In : American Journal of Physical Medicine and Rehabilitation. 84, 10, p. 770-779 10 p.

Research output: Contribution to journalArticle

Myosin Heavy Chains
Peripheral Nervous System Diseases
Protein Isoforms
Running
Skeletal Muscle
26 Citations (Scopus)

Myonuclear addition to uninjured laryngeal myofibers in adult rabbits

Goding, G., Al-Sharif, K. I. & McLoon, L. K., Jan 1 2005, In : Annals of Otology, Rhinology and Laryngology. 114, 7, p. 552-557 6 p.

Research output: Contribution to journalArticle

Laryngeal Muscles
Bromodeoxyuridine
Rabbits
Skeletal Muscle Satellite Cells
Extremities
10 Citations (Scopus)

Myosin heavy chain isoform immunolabelling in diabetic rats with peripheral neuropathy

Snow, L. M., Sanchez, O. A., McLoon, L. K., Serfass, R. C. & Thompson, L. V., Oct 3 2005, In : Acta Histochemica. 107, 3, p. 221-229 9 p.

Research output: Contribution to journalArticle

Myosin Heavy Chains
Peripheral Nervous System Diseases
Protein Isoforms
Insulin
Muscles
2004
80 Citations (Scopus)

Continuous myofiber remodeling in uninjured extraocular myofibers: Myonuclear turnover and evidence for apoptosis

McLoon, L. K., Rowe, J., Wirtschafter, J. & McCormick, K. M., May 1 2004, In : Muscle and Nerve. 29, 5, p. 707-715 9 p.

Research output: Contribution to journalArticle

Oculomotor Muscles
Bromodeoxyuridine
Apoptosis
Dystrophin
Skeletal Muscle