19972019
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Research Output 1997 2019

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2019

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

Bellamri, M., Yao, L., Bonala, R., Johnson, F., von Weymarn, L. B. & Turesky, R., Jul 1 2019, In : Archives of Toxicology. 93, 7, p. 1893-1902 10 p.

Research output: Contribution to journalArticle

Tobacco
Carcinogens
DNA Adducts
Urinary Bladder
Amines
2018

Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N- glucuronide by African American Smokers

Murphy, S. E., von Weymarn, L. B., Parenteau, M., Stepanov, I., Tiirikainen, M., Lemarchand, L. & Park, S. L., Mar 19 2018, In : Chemical Research in Toxicology. 31, 3, p. 168-175 8 p.

Research output: Contribution to journalArticle

Glucuronides
African Americans
Genotype
Glucuronosyltransferase
Tobacco
2 Citations (Scopus)

In Vivo Stable Isotope Labeling and Mass Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats

Dator, R., von Weymarn, L. B., Villalta, P. W., Hooyman, C. J., Maertens, L. A., Upadhyaya, P., Murphy, S. E. & Balbo, S., Oct 16 2018, In : Analytical Chemistry. 90, 20, p. 11863-11872 10 p.

Research output: Contribution to journalArticle

Tobacco
Metabolites
Isotopes
Carcinogens
Labeling
5 Citations (Scopus)

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain

Teitelbaum, A. M., Murphy, S. E., Akk, G., Baker, T. B., Germann, A., von Weymarn, L. B., Bierut, L. J., Goate, A., Kharasch, E. D. & Bloom, A. J., Jan 1 2018, In : Pharmacogenomics Journal. 18, 1, p. 136-143 8 p.

Research output: Contribution to journalArticle

dimethylaniline monooxygenase (N-oxide forming)
Tobacco Use Disorder
Nicotine
Brain
Enzymes
2016
3 Citations (Scopus)

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Chanickal Narayanapillai, S., von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
4 Citations (Scopus)
nornicotine
Anabasine
Tobacco
Liquid chromatography
Alkaloids
2013
16 Citations (Scopus)

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

Bloom, A. J., Murphy, S. E., Martinez, M., Von Weymarn, L. B., Bierut, L. J. & Goate, A., Feb 1 2013, In : Pharmacogenetics and Genomics. 23, 2, p. 62-68 7 p.

Research output: Contribution to journalArticle

dimethylaniline monooxygenase (N-oxide forming)
Nicotine
Tobacco Products
Haplotypes
Cotinine
6 Citations (Scopus)

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among european americans

Bloom, A. J., Von Weymarn, L. B., Martinez, M., Bierut, L. J., Goate, A. & Murphy, S. E., Dec 1 2013, In : Pharmacogenetics and Genomics. 23, 12, p. 706-716 11 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Nicotine
Alleles
Cotinine
Gene Frequency
2012
14 Citations (Scopus)

CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine Δ5′(1′)iminium ion

von Weymarn, L. B., Retzlaff, C. & Murphy, S. E., Nov 1 2012, In : Journal of Pharmacology and Experimental Therapeutics. 343, 2, p. 307-315 9 p.

Research output: Contribution to journalArticle

Nicotine
Ions
Cotinine
Enzymes
Carbon Monoxide
23 Citations (Scopus)
Menthol
Cytochrome P-450 Enzyme System
Nicotine
Tobacco
Metabolism
2011
20 Citations (Scopus)
Nicotine
Carcinogenesis
Lung
Neoplasms
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
55 Citations (Scopus)

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans

Bloom, J., Hinrichs, A. L., Wang, J. C., von Weymarn, L. B., Kharasch, E. D., Bierut, L. J., Goate, A. & Murphy, S. E., Jul 1 2011, In : Pharmacogenetics and Genomics. 21, 7, p. 403-416 14 p.

Research output: Contribution to journalArticle

Nicotine
Cytochrome P-450 Enzyme System
Alleles
Cotinine
Haplotypes
2010
21 Citations (Scopus)

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption

Berg, J. Z., von Weymarn, L. B., Thompson, E. A., Wickham, K. M., Weisensel, N. A., Hatsukami, D. K. & Murphy, S. E., Jan 1 2010, In : Cancer Epidemiology Biomarkers and Prevention. 19, 6, p. 1423-1431 9 p.

Research output: Contribution to journalArticle

Nicotine
Genotype
Cotinine
Alleles
Glucuronides
2009
29 Citations (Scopus)

Eukaryotic initiation factor 4E binding protein family of proteins: Sentinels at a translational control checkpoint in lung tumor defense

Kim, Y. Y., von Weymarn, L. B., Larsson, O., Fan, D., Underwood, J. M., Peterson, M. S., Hecht, S. S., Polunovsky, V. A. & Bitterman, P. B., Nov 1 2009, In : Cancer Research. 69, 21, p. 8455-8462 8 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Peptide Initiation Factors
Cytochrome P-450 Enzyme System
Carrier Proteins
Butanones
2007
36 Citations (Scopus)
Cotinine
Liquid chromatography
Tandem Mass Spectrometry
Nicotine
Liquid Chromatography
58 Citations (Scopus)
Carcinogens
Tobacco
Lung
Microsomes
Cytochrome P-450 Enzyme System
16 Citations (Scopus)

Effects of eleven isothiocyanates on P450 2A6- and 2A13-catalyzed coumarin 7-hydroxylation

von Weymarn, L. B., Chun, J. A., Knudsen, G. A. & Hollenberg, P. F., Sep 1 2007, In : Chemical Research in Toxicology. 20, 9, p. 1252-1259 8 p.

Research output: Contribution to journalArticle

Isothiocyanates
Hydroxylation
coumarin 7
isothiocyanic acid
Carcinogenesis
2006
63 Citations (Scopus)

Effects of benzyl and phenethyl isothiocyanate on P450s 2A6 and 2A13: Potential for chemoprevention in smokers

von Weymarn, L. B., Chun, J. A. & Hollenberg, P. F., Apr 1 2006, In : Carcinogenesis. 27, 4, p. 782-790 9 p.

Research output: Contribution to journalArticle

Chemoprevention
Isothiocyanates
Hydroxylation
Nicotine
Nitrosamines
44 Citations (Scopus)

Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism

von Weymarn, L. B., Brown, K. M. & Murphy, S. E., Jan 1 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 1, p. 295-303 9 p.

Research output: Contribution to journalArticle

Nicotine
Cotinine
Enzymes
Tobacco
Aldehyde Oxidase
2005
48 Citations (Scopus)

Effects of 8-methoxypsoralen on cytochrome P450 2A13

von Weymarn, L. B., Zhang, Q. Y., Ding, X. & Hollenberg, P. F., Sep 6 2005, In : Carcinogenesis. 26, 3, p. 621-629 9 p.

Research output: Contribution to journalArticle

Methoxsalen
Cytochrome P-450 Enzyme System
Apoproteins
Heme
Lung Neoplasms
13 Citations (Scopus)
Cotinine
Metabolism
Cytochrome P-450 Enzyme System
Metabolites
Nicotine
2004
12 Citations (Scopus)
Cytochrome P-450 CYP2B1
Alkynes
Ether
Amino Acids
Cytochromes
18 Citations (Scopus)
Heme
Carbon Monoxide
Pyrroles
tert-butyl 1-methyl-2-propynyl ether
NADP
2003
31 Citations (Scopus)

CYP2A13-catalysed coumarin metabolism: Comparison with CYP2A5 and CYP2A6

von Weymarn, L. B. & Murphy, S. E., Jan 1 2003, In : Xenobiotica. 33, 1, p. 73-81 9 p.

Research output: Contribution to journalArticle

Epoxidation
Metabolism
Baculoviridae
Hydroxylation
7-hydroxycoumarin
2001
19 Citations (Scopus)

Coumarin metabolism by rat esophageal microsomes and cytochrome P450 2A3

von Weymarn, L. B. & Murphy, S. E., Oct 31 2001, In : Chemical Research in Toxicology. 14, 10, p. 1386-1392 7 p.

Research output: Contribution to journalArticle

Microsomes
Metabolism
Cytochrome P-450 Enzyme System
Rats
Hydroxylation
1999
32 Citations (Scopus)
nitrosobenzylmethylamine
Hydroxylation
Microsomes
Catalysis
Cytochrome P-450 Enzyme System
12 Citations (Scopus)
Phosphofructokinase-2
Liver
Rats
Nuclear magnetic resonance
Histidine
1997
18 Citations (Scopus)

Novel phosphoinositides in barley aleurone cells: Additional evidence for the presence of phosphatidyl-scyllo-inositol

Narasimhan, B., Pliska-Matyshak, G., Kinnard, R., Carstensen, S., Ritter, M. A., Von Weymarn, L. & Murthy, P. P. N., Jan 1 1997, In : Plant physiology. 113, 4, p. 1385-1393 9 p.

Research output: Contribution to journalArticle

aleurone cells
Inositol
Hordeum
Phosphatidylinositols
barley