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Research Output 2000 2018

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Article
2018
8 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Mesenchymal Stromal Cells
Interleukin-8
Macrophages
Interleukin-8A Receptors

Relationship between the efficacy of cardiac cell therapy and the inhibition of differentiation of human iPSC-Derived nonmyocyte cardiac cells into Myofibroblast-like cells

Gao, L., Yang, L., Wang, L., Geng, Z., Wei, Y., Gourley, G. & Zhang, J., Jan 1 2018, In : Circulation research. 123, 12, p. 1313-1325 13 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Myofibroblasts
Cell- and Tissue-Based Therapy
Transforming Growth Factors
Pericytes
2017
16 Citations (Scopus)
Open Access
Idiopathic Pulmonary Fibrosis
Calcium-Binding Proteins
Mesenchymal Stromal Cells
Fibrosis
Myofibroblasts
11 Citations (Scopus)

Lactate promotes synthetic phenotype in vascular smooth muscle cells

Yang, L., Gao, L., Nickel, T., Yang, J., Zhou, J., Gilbertsen, A. J., Geng, Z., Johnson, C., Young, B., Henke, C. A., Gourley, G. R. & Zhang, J., Jan 1 2017, In : Circulation research. 121, 11, p. 1251-1262 12 p.

Research output: Contribution to journalArticle

Open Access
Vascular Smooth Muscle
Smooth Muscle Myocytes
Lactic Acid
Phenotype
Monocarboxylic Acid Transporters
85 Citations (Scopus)

Myocardial Tissue Engineering with Cells Derived from Human-Induced Pluripotent Stem Cells and a Native-Like, High-Resolution, 3-Dimensionally Printed Scaffold

Gao, L., Kupfer, M. E., Jung, J. P., Yang, L., Zhang, P., Da Sie, Y., Tran, Q., Ajeti, V., Freeman, B. T., Fast, V. G., Campagnola, P. J., Ogle, B. M. & Zhang, J., Apr 14 2017, In : Circulation research. 120, 8, p. 1318-1325 8 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Tissue Engineering
Cardiac Myocytes
Smooth Muscle Myocytes
Extracellular Matrix
7 Citations (Scopus)

Quantitative Proteomics and Immunohistochemistry Reveal Insights into Cellular and Molecular Processes in the Infarct Border Zone One Month after Myocardial Infarction

Yang, L., Gregorich, Z. R., Cai, W., Zhang, P., Young, B., Gu, Y., Zhang, J. J. & Ge, Y., May 5 2017, In : Journal of Proteome Research. 16, 5, p. 2101-2112 12 p.

Research output: Contribution to journalArticle

Open Access
Proteomics
Immunohistochemistry
Myocardial Infarction
Up-Regulation
Down-Regulation
2016
23 Citations (Scopus)

Differentiation of human induced-pluripotent stem cells into smooth-muscle cells: Two novel protocols

Yang, L., Geng, Z., Nickel, T., Johnson, C., Gao, L., Dutton, J. R., Hou, C. & Zhang, J. J., Jan 1 2016, In : PloS one. 11, 1, 0147155.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
smooth muscle
myocytes
Smooth Muscle Myocytes
2014
23 Citations (Scopus)

Deficiency of GDNF receptor GFRα1 in Alzheimer's neurons results in neuronal death

Konishi, Y., Yang, L., He, P., Lindholm, K., Lu, B., Li, R. & Shen, Y., Sep 24 2014, In : Journal of Neuroscience. 34, 39, p. 13127-13138 12 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor Receptors
Glial Cell Line-Derived Neurotrophic Factor
Alzheimer Disease
Neurons
Glutamate Receptors
2013
28 Citations (Scopus)

What does complement do in Alzheimer's disease? Old molecules with new insights

Shen, Y., Yang, L. & Li, R., Oct 12 2013, In : Translational Neurodegeneration. 2, 1, 21.

Research output: Contribution to journalArticle

Alzheimer Disease
Complement Activation
Poisons
Brain
Cell Surface Receptors
2011
29 Citations (Scopus)

Novel biomarker candidates to predict hepatic fibrosis in hepatitis C identified by serum proteomics

Yang, L., Rudser, K. D., Higgins, L., Rosen, H. R., Zaman, A., Corless, C. L., David, L. & Gourley, G. R., Nov 1 2011, In : Digestive Diseases and Sciences. 56, 11, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

Hepatitis C
Proteomics
Fibrosis
Biomarkers
Liver
2010
59 Citations (Scopus)

Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients

Cheng, X., Yang, L., He, P., Li, R. & Shen, Y., 2010, In : Journal of Alzheimer's Disease. 19, 2, p. 621-630 10 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Brain Diseases
Alzheimer Disease
Brain
Amyloidogenic Proteins
6 Citations (Scopus)

Proteomic analysis of biopsied human colonic mucosa

Gourley, G. R., Yang, L., Higgins, L., Riviere, M. A. & David, L. L., Jul 1 2010, In : Journal of pediatric gastroenterology and nutrition. 51, 1, p. 46-54 9 p.

Research output: Contribution to journalArticle

Proteomics
Mucous Membrane
Liquid Chromatography
Proteins
Electrophoresis
2007
47 Citations (Scopus)

Induction of tumorigenesis and metastasis by the murine orthologue of tumor protein D52

Lewis, J. D., Payton, L. A., Whitford, J. G., Byrne, J. A., Smith, D. I., Yang, L. B. & Bright, R. K., Feb 1 2007, In : Molecular Cancer Research. 5, 2, p. 133-144 12 p.

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasm Metastasis
Neoplasms
Proteins
Transforming Growth Factors
2004
386 Citations (Scopus)

Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

Li, R., Lindholm, K., Yang, L. B., Yue, X., Citron, M., Yan, R., Beach, T., Sue, L., Sebbagh, M., Cai, H., Wong, P., Price, D. & Shen, Y., Mar 9 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 10, p. 3632-3637 6 p.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Amyloid
Alzheimer Disease
Peptides
Brain
145 Citations (Scopus)

Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-β Protein-Induced Neuron Death

Li, R., Yang, L., Lindholm, K., Konishi, Y., Yue, X., Hampel, H., Zhang, D. & Shen, Y., Feb 18 2004, In : Journal of Neuroscience. 24, 7, p. 1760-1771 12 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Type I
Amyloidogenic Proteins
Death Domain Receptors
Tumor Necrosis Factor Receptors
Neurons
2002
27 Citations (Scopus)

Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system

Konishi, Y., Lindholm, K., Yang, L. B., Li, R. & Shen, Y., Jan 1 2002, In : American Journal of Pathology. 161, 5, p. 1567-1576 10 p.

Research output: Contribution to journalArticle

Neurons
DNA
Brain
Aminobutyrates
Parietal Lobe
194 Citations (Scopus)

Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways

Yang, L., Lindholm, K., Konishi, Y., Li, R. & Shen, Y., Apr 15 2002, In : Journal of Neuroscience. 22, 8, p. 3025-3032 8 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Signal Transduction
Neurons
p38 Mitogen-Activated Protein Kinases
Brain
2001
114 Citations (Scopus)

Complement activation by neurofibrillary tangles in Alzheimer's disease

Shen, Y., Lue, L. F., Yang, L., Roher, A., Kuo, Y. M., Strohmeyer, R., Goux, W. J., Lee, V., Johnson, G. V. W., Webster, S. D., Cooper, N. R., Bradt, B. & Rogers, J., Jun 15 2001, In : Neuroscience Letters. 305, 3, p. 165-168 4 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Complement Activation
Alzheimer Disease
Classical Complement Pathway
tau Proteins
275 Citations (Scopus)

Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro

Lue, L. F., Rydel, R., Brigham, E. F., Yang, L. B., Hampel, H., Murphy, G. M., Brachova, L., Yan, S. D., Walker, D. G., Shen, Y. & Rogers, J., Jul 30 2001, In : Glia. 35, 1, p. 72-79 8 p.

Research output: Contribution to journalArticle

Microglia
Alzheimer Disease
Macrophage Colony-Stimulating Factor
Nitrogen
Complement C1q
2000
93 Citations (Scopus)

Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease

Yang, L. B., Li, R., Meri, S., Rogers, J. & Shen, Y., Oct 15 2000, In : Journal of Neuroscience. 20, 20, p. 7505-7509 5 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Complement System Proteins
Complement Membrane Attack Complex
Type C Phospholipases
Complement C9
124 Citations (Scopus)

Estrogen enhances uptake of amyloid β-protein by microglia derived from the human cortex

Li, R., Shen, Y., Yang, L. B., Lue, L. F., Finch, C. & Rogers, J., Sep 26 2000, In : Journal of Neurochemistry. 75, 4, p. 1447-1454 8 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Microglia
Estrogens
Estrogen Receptors
Alzheimer Disease