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Lester R Drewes

 https://orcid.org/0000-0002-7440-0387

Accepting PhD Students

PhD projects

Blood-brain transport and drug delivery to the brain

1973 …2019
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Personal profile

Research interests

  • blood-brain transport
  • brain endothelium
  • neurovascular unit
  • Brain energy metabolism
  • Blood-brain barrier genomics
  • drug delivery to CNS
  • transporter inhibitors as anticancer agents
  • cerebral anoxia, ischemia
  • Re-engineering the blood-brain barrier

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 2 Similar Profiles
Brain Medicine & Life Sciences
Facilitative Glucose Transport Proteins Medicine & Life Sciences
Canidae Medicine & Life Sciences
Blood-Brain Barrier Medicine & Life Sciences
Microvessels Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Monocarboxylic Acid Transporters Medicine & Life Sciences
Glucose Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2019

Monocarboxylate Transporter 1 (MTC-1) mutations in patie

Drewes, L. R.

Whiteside Inst. for Clinical Research

1/1/17 → 8/31/19

Project: Research project

Muscle Fatigue
Ketosis
Myocardium
Skeletal Muscle
Mutation

Pericytic laminin regulates pericyte differentiation and

Yao, Y. & Drewes, L. R.

AMERICAN HEART ASSOCIATION, INC.

7/1/16 → 6/30/17

Project: Research project

Pericytes

Development of Novel Drugs for High Risk Triple Negative

Drewes, L. R. & Rose-Hellekant, T.

US ARMY MED RESEARCH & MATERIEL COMMAND

3/15/15 → 8/31/19

Project: Research project

Triple Negative Breast Neoplasms
Pharmaceutical Preparations

Evaluating the Feasibility of Intranasal FLT Delivery fo

Drewes, L. R.

Essentia Institute of Rural Health

2/1/15 → 12/31/16

Project: Research project

Brain Neoplasms

Targeting energy metabolism as a novel approach for the

Dickerson, E. B., Drewes, L. R. & O'Brien, T. D.

Morris Animal Foundation

10/1/14 → 12/31/19

Project: Research project

Mouth Neoplasms
Felidae
Energy Metabolism

Research Output 1973 2019

A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma

Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Jan 1 2019, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journal › Article

Felidae
squamous cell carcinoma
Squamous Cell Carcinoma
mouth
cats
2 Citations (Scopus)

Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)

Sadeghzadeh, M., Moldovan, R. P., Fischer, S., Wenzel, B., Ludwig, F. A., Teodoro, R., Deuther-Conrad, W., Jonnalagadda, S., Jonnalagadda, S. K., Gudelis, E., Šačkus, A., Higuchi, K., Ganapathy, V., Mereddy, V. R., Drewes, L. R. & Brust, P., Jun 30 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, 8, p. 411-424 14 p.

Research output: Contribution to journal › Article

Imaging techniques
Neoplasms
Chemotherapy
Carbonates
4-coumaric acid

Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment

Nelson, G. L., Ronayne, C. T., Solano, L. N., Jonnalagadda, S. K., Jonnalagadda, S., Rumbley, J., Holy, J., Rose-Hellekant, T., Drewes, L. R. & Mereddy, V. R., Dec 1 2019, In : Scientific reports. 9, 1, 18266.

Research output: Contribution to journal › Article

Open Access
Antineoplastic Agents
Coumaric Acids
Acids
Glycolysis
Metabolic Networks and Pathways
3 Citations (Scopus)

Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors

Jonnalagadda, S., Jonnalagadda, S. K., Ronayne, C. T., Nelson, G. L., Solano, L. N., Rumbley, J. N., Holy, J. M., Mereddy, V. R. & Drewes, L. R., Mar 22 2019, In : Oncotarget. 10, 24, p. 2355-2368 14 p.

Research output: Contribution to journal › Article

Open Access
Glycolysis
Acids
Triple Negative Breast Neoplasms
Neoplasms
Exercise Test
1 Citation (Scopus)

The year in review: Progress in brain barriers and brain fluid research in 2018

Keep, R. F., Jones, H. C. & Drewes, L. R., Feb 5 2019, In : Fluids and Barriers of the CNS. 16, 1, 4.

Research output: Contribution to journal › Review article

Open Access
Brain
Research
Brain Diseases
Endothelium
Pharmaceutical Preparations