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Blood-brain transport and drug delivery to the brain

1973 …2019
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Personal profile

Research interests

  • blood-brain transport
  • brain endothelium
  • neurovascular unit
  • Brain energy metabolism
  • Blood-brain barrier genomics
  • drug delivery to CNS
  • transporter inhibitors as anticancer agents
  • cerebral anoxia, ischemia
  • Re-engineering the blood-brain barrier

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Brain Medicine & Life Sciences
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Blood-Brain Barrier Medicine & Life Sciences
Microvessels Medicine & Life Sciences
Endothelial Cells Medicine & Life Sciences
Monocarboxylic Acid Transporters Medicine & Life Sciences
Glucose Medicine & Life Sciences

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Projects 2000 2019

Muscle Fatigue
Ketosis
Myocardium
Skeletal Muscle
Mutation
Triple Negative Breast Neoplasms
Pharmaceutical Preparations
Mouth Neoplasms
Felidae
Energy Metabolism

Research Output 1973 2019

A novel MCT1 and MCT4 dual inhibitor reduces mitochondrial metabolism and inhibits tumour growth of feline oral squamous cell carcinoma

Khammanivong, A., Saha, J., Spartz, A. K., Sorenson, B. S., Bush, A. G., Korpela, D. M., Gopalakrishnan, R., Jonnalagadda, S., Mereddy, V. R., O'Brien, T. D., Drewes, L. R. & Dickerson, E. B., Jan 1 2019, (Accepted/In press) In : Veterinary and Comparative Oncology.

Research output: Contribution to journalArticle

Felidae
squamous cell carcinoma
Squamous Cell Carcinoma
mouth
cats
2 Citations (Scopus)

Development and radiosynthesis of the first 18F-labeled inhibitor of monocarboxylate transporters (MCTs)

Sadeghzadeh, M., Moldovan, R. P., Fischer, S., Wenzel, B., Ludwig, F. A., Teodoro, R., Deuther-Conrad, W., Jonnalagadda, S., Jonnalagadda, S. K., Gudelis, E., Šačkus, A., Higuchi, K., Ganapathy, V., Mereddy, V. R., Drewes, L. R. & Brust, P., Jun 30 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, 8, p. 411-424 14 p.

Research output: Contribution to journalArticle

Imaging techniques
Neoplasms
Chemotherapy
Carbonates
4-coumaric acid

Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment

Nelson, G. L., Ronayne, C. T., Solano, L. N., Jonnalagadda, S. K., Jonnalagadda, S., Rumbley, J., Holy, J., Rose-Hellekant, T., Drewes, L. R. & Mereddy, V. R., Dec 1 2019, In : Scientific reports. 9, 1, 18266.

Research output: Contribution to journalArticle

Open Access
Antineoplastic Agents
Coumaric Acids
Acids
Glycolysis
Metabolic Networks and Pathways
3 Citations (Scopus)

Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors

Jonnalagadda, S., Jonnalagadda, S. K., Ronayne, C. T., Nelson, G. L., Solano, L. N., Rumbley, J. N., Holy, J. M., Mereddy, V. R. & Drewes, L. R., Mar 22 2019, In : Oncotarget. 10, 24, p. 2355-2368 14 p.

Research output: Contribution to journalArticle

Open Access
Glycolysis
Acids
Triple Negative Breast Neoplasms
Neoplasms
Exercise Test
1 Citation (Scopus)

The year in review: Progress in brain barriers and brain fluid research in 2018

Keep, R. F., Jones, H. C. & Drewes, L. R., Feb 5 2019, In : Fluids and Barriers of the CNS. 16, 1, 4.

Research output: Contribution to journalReview article

Open Access
Brain
Research
Brain Diseases
Endothelium
Pharmaceutical Preparations