Laurent Bonnac

20042020

Research output per year

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Research Output

2020
2018
Open Access
6 Scopus citations
2016

5-Azacytidine enhances the mutagenesis of HIV-1 by reduction to 5-aza-2'-deoxycytidine

Rawson, J. M. O., Daly, M. B., Xie, J., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. E. & Mansky, L. M., Apr 2016, In : Antimicrobial agents and chemotherapy. 60, 4, p. 2318-2325 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Dual anti-HIV mechanism of clofarabine

Daly, M. B., Roth, M. E., Bonnac, L., Maldonado, J. O., Xie, J., Clouser, C. L., Patterson, S. E., Kim, B. & Mansky, L. M., Mar 24 2016, In : Retrovirology. 13, 1, 20.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Synergistic reduction of HIV-1 infectivity by 5-azacytidine and inhibitors of ribonucleotide reductase

Rawson, J. M. O., Roth, M. E., Xie, J., Daly, M. B., Clouser, C. L., Landman, S. R., Reilly, C. S., Bonnac, L., Kim, B., Patterson, S. E. & Mansky, L. M., Jun 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 11, p. 2410-2422 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2015

Lack of mutational hot spots during decitabine-mediated HIV-1 mutagenesis

Rawson, J. M. O., Landman, S. R., Reilly, C. S., Bonnac, L., Patterson, S. & Mansky, L. M., Nov 1 2015, In : Antimicrobial agents and chemotherapy. 59, 11, p. 6834-6843 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014
10 Scopus citations

Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1

Dapp, M. J., Bonnac, L., Patterson, S. E. & Mansky, L. M., Jan 2014, In : Journal of virology. 88, 1, p. 354-363 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
25 Scopus citations

Variability of apoptosis and response in N1-S1 rodent hepatomas to benzamide riboside and correlation to early changes in water apparent diffusion coefficient and sodium MR imaging

Faramarzalian, A., McLennan, G., Bennett, S. L., Babsky, A., Bansal, N., Lieber, M., Bonnac, L., Pankiewicz, K. & Jayaram, H. N., Jun 1 2013, In : Journal of Vascular and Interventional Radiology. 24, 6, p. 894-900 7 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

Tumor response and apoptosis of N1-S1 rodent hepatomas in response to intra-arterial and intravenous benzamide riboside

McLennan, G., Bennett, S. L., Ju, S., Babsky, A., Bansal, N., Shorten, M. L., Levitin, S., Bonnac, L., Panciewicz, K. W. & Jayaram, H. N., Jun 1 2012, In : Cardiovascular and Interventional Radiology. 35, 3, p. 645-652 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2011

The Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine

Lee, S. E., Elphick, L. M., Kramer, H. B., Jones, A. M. E., Child, E. S., Anderson, A. A., Bonnac, L., Suwaki, N., Kessler, B. M., Gouverneur, V. & Mann, D. J., Mar 7 2011, In : ChemBioChem. 12, 4, p. 633-640 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues

Bonnac, L., Lee, S. E., Giuffredi, G. T., Elphick, L. M., Anderson, A. A., Child, E. S., Mann, D. J. & Gouverneur, V., Mar 12 2010, In : Organic and Biomolecular Chemistry. 8, 6, p. 1445-1454 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2009

A quantitative comparison of wild-type and gatekeeper mutant Cdk2 for chemical genetic studies with ATP analogues

Elphick, L. M., Lee, S. E., Child, E. S., Prasad, A., Pignocchi, C., Thibaudeau, S., Anderson, A. A., Bonnac, L., Gouverneur, V. & Mann, D. J., Jun 15 2009, In : ChemBioChem. 10, 9, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Exploring the roles of protein kinases using chemical genetics

Elphick, L. M., Lee, S. E., Anderson, A. A., Child, E. S., Bonnac, L., Gouverneur, V. & Mann, D. J., Oct 1 2009, In : Future Medicinal Chemistry. 1, 7, p. 1233-1241 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis and reactivity of novel γ-phosphate modified ATP analogues

Lee, S. E., Elphick, L. M., Anderson, A. A., Bonnac, L., Child, E. S., Mann, D. J. & Gouverneur, V., Jul 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 14, p. 3804-3807 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Technical Aspects of Imaging and Transfemoral Arterial Treatment of N1-S1 Tumors in Rats: An Appropriate Model to Test the Biology and Therapeutic Response to Transarterial Treatments of Liver Cancers

Ju, S., McLennan, G., Bennett, S. L., Liang, Y., Bonnac, L., Pankiewicz, K. W. & Jayaram, H. N., Mar 1 2009, In : Journal of Vascular and Interventional Radiology. 20, 3, p. 410-414 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2008

Nicotinamide adenine dinucleotide based therapeutics

Chen, L., Petrelli, R., Felczak, K., Gao, G., Bonnac, L., Yu, J. S., Bennett, E. M. & Pankicwicz, K. W., Mar 1 2008, In : Current medicinal chemistry. 15, 7, p. 650-670 21 p.

Research output: Contribution to journalReview article

45 Scopus citations
2007

Efficient synthesis of benzamide riboside, a potential anticancer agent

Bonnac, L. F., Gao, G. Y., Chen, L., Patterson, S. E., Jayaram, H. N. & Pankiewicz, K. W., Oct 1 2007, In : Nucleosides, Nucleotides and Nucleic Acids. 26, 10-12, p. 1249-1253 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Methylenebis(sulfonamide) linked nicotinamide adenine dinucleotide analogue as an inosine monophosphate dehydrogenase inhibitor

Chen, L., Gao, G., Bonnac, L., Wilson, D. J., Bennett, E. M., Jayaram, H. N. & Pankiewicz, K. W., Jun 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 11, p. 3152-3155 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Probing binding requirements of NAD kinase with modified substrate (NAD) analogues

Bonnac, L., Chen, L., Pathak, R., Gao, G., Ming, Q., Bennett, E., Felczak, K., Kullberg, M., Patterson, S. E., Mazzola, F., Magni, G. & Pankiewicz, K. W., Mar 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 6, p. 1512-1515 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues

Chen, L., Gao, G., Felczak, K., Bonnac, L., Patterson, S. E., Wilson, D., Bennett, E. M., Jayaram, H. N., Hedstrom, L. & Pankiewicz, K. W., Nov 15 2007, In : Journal of medicinal chemistry. 50, 23, p. 5743-5751 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Rational design and synthesis of novel nucleotide anti-Giardia agents

Suk, D. H., Bonnac, L., Dykstra, C. C., Pankiewicz, K. W. & Patterson, S. E., Apr 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 7, p. 2064-2067 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis

Bonnac, L., Gao, G. Y., Chen, L., Felczak, K., Bennett, E. M., Xu, H., Kim, T. S., Liu, N., Oh, H. W., Tonge, P. J. & Pankiewicz, K. W., Aug 15 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 16, p. 4588-4591 4 p.

Research output: Contribution to journalArticle

14 Scopus citations
2006
2004

Carbonic anhydrase inhibitors: Aliphatic N-phosphorylated sulfamates - A novel zinc-anchoring group leading to nanomolar inhibitors

Bonnac, L., Innocent, A., Winum, J. Y., Casini, A., Montero, J. L., Scozzafava, A., Barragan, V. & Supuran, C. T., Jun 2004, In : Journal of Enzyme Inhibition and Medicinal Chemistry. 19, 3, p. 275-278 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
3 Scopus citations