19972020

Research output per year

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Research Output

2020

Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes

Blixt, N., Norton, A., Zhang, A., Aparicio, C., Prasad, H., Gopalakrishnan, R., Jensen, E. D. & Mansky, K. C., Sep 2020, In : Bone. 138, 115466.

Research output: Contribution to journalArticle

Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength

Robinson, J. W., Blixt, N. C., Norton, A., Mansky, K. C., Ye, Z., Aparicio, C., Wagner, B. M., Benton, A. M., Warren, G. L., Khosla, S., Gaddy, D., Suva, L. J. & Potter, L. R., Jun 2020, In : Bone. 135, 115320.

Research output: Contribution to journalArticle

Open Access
2019

Bone morphogenetic proteins: Their role in regulating osteoclast differentiation

Huntley, R., Jensen, E. D., Gopalakrishnan, R. & Mansky, K., Jun 2019, In : Bone Reports. 10, 100207.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption

Thumbigere-Math, V., Foster, B. L., Bachu, M., Yoshii, H., Brooks, S. R., Coulter, A., Chavez, M. B., Togi, S., Neely, A. L., Deng, Z., Mansky, K. C., Ozato, K. & Somerman, M. J., Jun 2019, In : Journal of Bone and Mineral Research. 34, 6, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Regulation of osteoclast differentiation and skeletal maintenance by histone deacetylases

Faulkner, B., Astleford, K. & Mansky, K., Jan 1 2019, In : Molecules. 24, 7, 1355.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
6 Scopus citations
2018

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors

Tasca, A., Astleford, K., Blixt, N. C., Jensen, E. D., Gopalakrishnan, R. & Mansky, K. C., Sep 2018, In : PloS one. 13, 9, e0203404.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions

Aukes, K., Forsman, C., Brady, N. J., Astleford, K., Blixt, N., Sachdev, D., Jensen, E. D., Mansky, K. C. & Schwertfeger, K. L., Oct 2017, In : PloS one. 12, 10, e0185736.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Class II and IV HDACs function as inhibitors of osteoclast differentiation

Blixt, N. C., Faulkner, B. K., Astleford, K., Lelich, R., Schering, J., Spencer, E., Gopalakrishnan, R., Jensen, E. D. & Mansky, K. C., Sep 2017, In : PloS one. 12, 9, e0185441.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Regulation of osteoclast differentiation by myosin X

Tasca, A., Astleford, K., Lederman, A., Jensen, E. D., Lee, B. S., Gopalakrishnan, R. & Mansky, K. C., Dec 1 2017, In : Scientific reports. 7, 1, 7603.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2015

Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF

Stemig, M., Astelford, K., Emery, A., Cho, J. J., Allen, B., Huang, T. H., Gopalakrishnan, R., Mansky, K. C. & Jensen, E. D., Apr 15 2015, In : PloS one. 10, 4, e0123843.

Research output: Contribution to journalArticle

12 Scopus citations

Smad1/5 and Smad4 expression are important for osteoclast differentiation

Tasca, A., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E. D., Gopalakrishnan, R. & Mansky, K. C., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding

Huntley, R., Davydova, J., Petryk, A., Billington, C. J., Jensen, E. D., Mansky, K. C. & Gopalakrishnan, R., Oct 1 2015, In : Journal of Cellular Biochemistry. 116, 10, p. 2239-2246 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M., Mansky, K. & Gopalakrishnan, R., Dec 27 2013, In : Journal of Biological Chemistry. 288, 52, p. 37230-37240 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
4 Scopus citations
2011

Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation

Pham, L., Beyer, K., Jensen, E. D., Sotillo Rodriguez, J. E., Davydova, J., Yamamoto, M., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2011, In : Journal of Cellular Biochemistry. 112, 3, p. 793-803 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Glycosylation oftwisted gastrulation is required for BMP binding and activity during craniofacial development

Billington, C. J., Fiebig, J. E., Forsman, C. L., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O'Connor, M. B., Mueller, T. D. & Petryk, A., 2011, In : Frontiers in Physiology. 2 SEP, Article 59.

Research output: Contribution to journalArticle

6 Scopus citations

HDAC3 and HDAC7 have opposite effects on osteoclast differentiation

Pham, L., Kaiser, B., Romsa, A., Schwarz, T., Gopalakrishnan, R., Jensen, E. D. & Mansky, K., Apr 8 2011, In : Journal of Biological Chemistry. 286, 14, p. 12056-12065 10 p.

Research output: Contribution to journalArticle

48 Scopus citations
2010

Aging, human immunodeficiency virus, and bone health.

Mansky, K. C., 2010, In : Clinical interventions in aging. 5, p. 285-292 8 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors

Jensen, E. D., Pham, L., Billington, C. J., Espe, K., Carlson, A. E., Westendorf, J. J., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2010, In : Journal of Cellular Biochemistry. 109, 4, p. 672-682 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3

Schwarz, T., Murphy, S., Sohn, C. & Mansky, K., Apr 16 2010, In : Biochemical and Biophysical Research Communications. 394, 4, p. 890-895 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts

Grigsby, I. F., Pham, L., Gopalakrishnan, R., Mansky, L. M. & Mansky, K. C., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1324-1329 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tenofovir-associated bone density loss

Grigsby, I. F., Pham, L., Mansky, L. M., Gopalakrishnan, R. & Mansky, K. C., Apr 19 2010, In : Therapeutics and Clinical Risk Management. 6, 1, p. 41-47 7 p.

Research output: Contribution to journalReview article

48 Scopus citations
49 Scopus citations

The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts

Schwarz, T., Sohn, C., Kaiser, B., Jensen, E. D. & Mansky, K., Apr 1 2010, In : Journal of Cellular Biochemistry. 109, 5, p. 967-974 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling

Sotillo Rodriguez, J. E., Mansky, K., Jensen, E. D., Carlson, A. E., Schwarz, T., Pham, L., MacKenzie, B., Prasad, H., Rohrer, M. D., Petryk, A. & Gopalakrishnan, R., Nov 1 2009, In : Journal of Bone and Mineral Research. 24, 11, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone

Suttamanatwong, S., Jensen, E. D., Schilling, J., Franceschi, R. T., Carlson, A. E., Mansky, K. & Gopalakrishnan, R., May 15 2009, In : Journal of Cellular Biochemistry. 107, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation

Sharma, S. M., Bronisz, A., Hu, R., Patel, K., Mansky, K. C., Sif, S. & Ostrowski, M. C., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15921-15929 9 p.

Research output: Contribution to journalArticle

126 Scopus citations
2006

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors

Bronisz, A., Sharma, S. M., Hu, R., Godlewski, J., Tzivion, G., Mansky, K. C. & Ostrowski, M. C., Sep 1 2006, In : Molecular biology of the cell. 17, 9, p. 3897-3906 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2003

Ets-2 interacts with co-repressor BS69 to repress target gene expression

Wei, G., Schaffner, A. E., Baker, K. M., Mansky, K. C. & Ostrowski, M. C., May 1 2003, In : Anticancer Research. 23, 3 A, p. 2173-2178 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
2002

Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling

Mansky, K. C., Sankar, U., Han, J. & Ostrowski, M. C., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11077-11083 7 p.

Research output: Contribution to journalArticle

176 Scopus citations

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. & Ostrowski, M. C., Feb 1 2002, In : Journal of Leukocyte Biology. 71, 2, p. 295-303 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter

Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. & Ostrowski, M. C., Feb 1 2002, In : Journal of Leukocyte Biology. 71, 2, p. 304-310 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
1997

Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions

Mansky, K. C., Batiza, A. & Lambert, P. F., Sep 26 1997, In : Journal of virology. 71, 10, p. 7600-7608 9 p.

Research output: Contribution to journalArticle

40 Scopus citations