19972022
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Research Output 1997 2019

2019

Bone morphogenetic proteins: Their role in regulating osteoclast differentiation

Huntley, R., Jensen, E. D., Gopalakrishnan, R. & Mansky, K., Jun 1 2019, In : Bone Reports. 10, 100207.

Research output: Contribution to journalReview article

Open Access
Bone Morphogenetic Proteins
Osteoclasts
Osseointegration
Anabolic Agents
Bone and Bones

Inactivating Mutation in IRF8 Promotes Osteoclast Transcriptional Programs and Increases Susceptibility to Tooth Root Resorption

Thumbigere-Math, V., Foster, B. L., Bachu, M., Yoshii, H., Brooks, S. R., Coulter, A., Chavez, M. B., Togi, S., Neely, A. L., Deng, Z., Mansky, K., Ozato, K. & Somerman, M. J., Jun 1 2019, In : Journal of Bone and Mineral Research. 34, 6, p. 1155-1168 14 p.

Research output: Contribution to journalArticle

Tooth Resorption
Root Resorption
Tooth Root
Osteoclasts
Mutation
1 Citation (Scopus)

Regulation of osteoclast differentiation and skeletal maintenance by histone deacetylases

Faulkner, B., Astleford, K. & Mansky, K., Jan 1 2019, In : Molecules. 24, 7, 1355.

Research output: Contribution to journalReview article

Open Access
Histone Deacetylases
Osteoclasts
bones
gene expression
maintenance
1 Citation (Scopus)
Chronic Periodontitis
Gingival Crevicular Fluid
Health
Periodontitis
Proteins
2018
2 Citations (Scopus)

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors

Tasca, A. W., Astleford, K., Blixt, N. C., Jensen, E. D., Gopalakrishnan, R. & Mansky, K., Sep 1 2018, In : PloS one. 13, 9, e0203404.

Research output: Contribution to journalArticle

osteoclasts
Osteoclasts
bone formation
Osteogenesis
Bone
2017
3 Citations (Scopus)

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions

Aukes, K., Forsman, C., Brady, N. J., Astleford, K., Blixt, N., Sachdev, D., Jensen, E. D., Mansky, K. & Schwertfeger, K., Oct 1 2017, In : PloS one. 12, 10, e0185736.

Research output: Contribution to journalArticle

Open Access
fibroblast growth factors
osteoclasts
Fibroblast Growth Factors
Osteoclasts
lesions (animal)
7 Citations (Scopus)

Class II and IV HDACs function as inhibitors of osteoclast differentiation

Blixt, N. C., Faulkner, B. K., Astleford, K., Lelich, R., Schering, J., Spencer, E., Gopalakrishnan, R., Jensen, E. D. & Mansky, K., Sep 1 2017, In : PLoS One. 12, 9, e0185441.

Research output: Contribution to journalArticle

Open Access
osteoclasts
Histone Deacetylases
Osteoclasts
histones
Gene Expression
5 Citations (Scopus)

Regulation of osteoclast differentiation by myosin X

Tasca, A. W., Astleford, K., Lederman, A., Jensen, E. D., Lee, B. S., Gopalakrishnan, R. & Mansky, K., Dec 1 2017, In : Scientific reports. 7, 1, 7603.

Research output: Contribution to journalArticle

Osteoclasts
Myosins
Nanotubes
Cytoskeletal Proteins
Integrins
2015
9 Citations (Scopus)

Deletion of histone deacetylase 7 in osteoclasts decreases bone mass in mice by interactions with MITF

Stemig, M., Astelford, K., Emery, A., Cho, J. J., Allen, B., Huang, T. H., Gopalakrishnan, R., Mansky, K. C. & Jensen, E. D., Apr 15 2015, In : PloS one. 10, 4, e0123843.

Research output: Contribution to journalArticle

histone deacetylase
osteoclasts
Histone Deacetylases
Osteoclasts
Bone
10 Citations (Scopus)

Smad1/5 and Smad4 expression are important for osteoclast differentiation

Tasca, A. W., Stemig, M., Broege, A., Huang, B., Davydova, J., Zwijsen, A., Umans, L., Jensen, E. D., Gopalakrishnan, R. & Mansky, K., Jul 1 2015, In : Journal of Cellular Biochemistry. 116, 7, p. 1350-1360 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Recombinases
Adenoviridae
Genes
Cathepsin K
5 Citations (Scopus)

The Function of Twisted Gastrulation in Regulating Osteoclast Differentiation is Dependent on BMP Binding

Huntley, R., Davydova, J., Petryk, A., Billington, C. J., Jensen, E. D., Mansky, K. & Gopalakrishnan, R., Oct 1 2015, In : Journal of Cellular Biochemistry. 116, 10, p. 2239-2246 8 p.

Research output: Contribution to journalArticle

Gastrulation
Bone Morphogenetic Proteins
Osteoclasts
Protein Binding
Osteogenesis
2013
29 Citations (Scopus)

Bone morphogenetic proteins signal via SMAD and mitogen activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis

Broege, A., Pham, L., Jensen, E. D., Emery, A., Huang, T. H., Stemig, M., Beppu, H., Petryk, A., O'Connor, M. B., Mansky, K. & Gopalakrishnan, R., Dec 27 2013, In : Journal of Biological Chemistry. 288, 52, p. 37230-37240 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Mitogen-Activated Protein Kinases
Osteogenesis
Bone
Bone Remodeling
3 Citations (Scopus)
Osteoclasts
Fusion reactions
Macrophages
Bone
Bone Marrow
2011
24 Citations (Scopus)

Bone morphogenetic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation

Pham, L., Beyer, K., Jensen, E. D., Sotillo Rodriguez, J. E., Davydova, J., Yamamoto, M., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2011, In : Journal of Cellular Biochemistry. 112, 3, p. 793-803 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Gastrulation
Bone Morphogenetic Proteins
Osteoclasts
Viruses
6 Citations (Scopus)

Glycosylation oftwisted gastrulation is required for BMP binding and activity during craniofacial development

Billington, C. J., Fiebig, J. E., Forsman, C., Pham, L., Burbach, N., Sun, M., Jaskoll, T., Mansky, K., Gopalakrishnan, R., O'Connor, M. B., Mueller, T. D. & Petryk, A., Dec 1 2011, In : Frontiers in Physiology. 2 SEP, Article 59.

Research output: Contribution to journalArticle

Gastrulation
Bone Morphogenetic Proteins
Glycosylation
Protein Binding
Exons
43 Citations (Scopus)

HDAC3 and HDAC7 have opposite effects on osteoclast differentiation

Pham, L., Kaiser, B., Romsa, A., Schwarz, T., Gopalakrishnan, R., Jensen, E. D. & Mansky, K., Apr 8 2011, In : Journal of Biological Chemistry. 286, 14, p. 12056-12065 10 p.

Research output: Contribution to journalArticle

Osteoclasts
Histone Deacetylases
trichostatin A
Butyric Acid
Osteoblasts
2010
12 Citations (Scopus)

Aging, human immunodeficiency virus, and bone health.

Mansky, K., Dec 1 2010, In : Clinical Interventions in Aging. 5, p. 285-292 8 p.

Research output: Contribution to journalArticle

Highly Active Antiretroviral Therapy
HIV
Bone and Bones
Virus Diseases
Health
71 Citations (Scopus)

Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors

Jensen, E. D., Pham, L., Billington, C. J., Espe, K., Carlson, A. E., Westendorf, J. J., Petryk, A., Gopalakrishnan, R. & Mansky, K., Mar 1 2010, In : Journal of Cellular Biochemistry. 109, 4, p. 672-682 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Bone and Bones
Proteins
Osteoblasts
4 Citations (Scopus)

C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3

Schwarz, T., Murphy, S., Sohn, C. & Mansky, K., Apr 16 2010, In : Biochemical and Biophysical Research Communications. 394, 4, p. 890-895 6 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Osteoclasts
Macrophage Colony-Stimulating Factor
Cytoplasm
Phosphotransferases
27 Citations (Scopus)

Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts

Grigsby, I. F., Pham, L., Gopalakrishnan, R., Mansky, L. M. & Mansky, K., Jan 15 2010, In : Biochemical and Biophysical Research Communications. 391, 3, p. 1324-1329 6 p.

Research output: Contribution to journalArticle

Tenofovir
Osteoclasts
Down-Regulation
Bone Density
Bone
44 Citations (Scopus)

Tenofovir-associated bone density loss

Grigsby, I. F., Pham, L., Mansky, L. M., Gopalakrishnan, R. & Mansky, K., Apr 19 2010, In : Therapeutics and Clinical Risk Management. 6, 1, p. 41-47 7 p.

Research output: Contribution to journalReview article

Tenofovir
Bone Density
Bone
Bone Development
Bone and Bones
48 Citations (Scopus)

Tenofovir treatment of primary osteoblasts alters gene expression profiles: Implications for bone mineral density loss

Grigsby, I. F., Pham, L., Mansky, L. M., Gopalakrishnan, R., Carlson, A. E. & Mansky, K., Mar 26 2010, In : Biochemical and Biophysical Research Communications. 394, 1, p. 48-53 6 p.

Research output: Contribution to journalArticle

Tenofovir
Osteoblasts
Transcriptome
Gene expression
Bone Density
16 Citations (Scopus)

The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts

Schwarz, T., Sohn, C., Kaiser, B., Jensen, E. D. & Mansky, K., Apr 1 2010, In : Journal of Cellular Biochemistry. 109, 5, p. 967-974 8 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Osteoclasts
Transcriptional Activation
Chemical activation
Proteasome Endopeptidase Complex
2009
46 Citations (Scopus)

Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signaling

Sotillo Rodriguez, J. E., Mansky, K., Jensen, E. D., Carlson, A. E., Schwarz, T., Pham, L., MacKenzie, B., Prasad, H., Rohrer, M. D., Petryk, A. & Gopalakrishnan, R., Nov 1 2009, In : Journal of Bone and Mineral Research. 24, 11, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

Gastrulation
Bone Morphogenetic Proteins
Metabolic Bone Diseases
Osteogenesis
Osteoclasts
14 Citations (Scopus)

Sp proteins and Runx2 mediate regulation of matrix gla protein (MGP) expression by parathyroid hormone

Suttamanatwong, S., Jensen, E. D., Schilling, J., Franceschi, R. T., Carlson, A. E., Mansky, K. & Gopalakrishnan, R., May 15 2009, In : Journal of Cellular Biochemistry. 107, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

Core Binding Factor Alpha 1 Subunit
Parathyroid Hormone
Osteoblasts
Sp Transcription Factors
Genes
2007
116 Citations (Scopus)

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation

Sharma, S. M., Bronisz, A., Hu, R., Patel, K., Mansky, K., Sif, S. & Ostrowski, M. C., May 25 2007, In : Journal of Biological Chemistry. 282, 21, p. 15921-15929 9 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Osteoclasts
Macrophage Colony-Stimulating Factor
Genes
Gene Expression
2006
49 Citations (Scopus)

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors

Bronisz, A., Sharma, S. M., Hu, R., Godlewski, J., Tzivion, G., Mansky, K. & Ostrowski, M. C., Sep 1 2006, In : Molecular biology of the cell. 17, 9, p. 3897-3906 10 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Osteoclasts
Macrophage Colony-Stimulating Factor
Transcription Factor 3
Colony-Stimulating Factor Receptors
2003
24 Citations (Scopus)

Ets-2 interacts with co-repressor BS69 to repress target gene expression

Wei, G., Schaffner, A. E., Baker, K. M., Mansky, K. C. & Ostrowski, M. C., May 1 2003, In : Anticancer Research. 23, 3 A, p. 2173-2178 6 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Phosphorylation
Gene Expression
Transfection
Two-Hybrid System Techniques
2002
169 Citations (Scopus)

Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling

Mansky, K. C., Sankar, U., Han, J. & Ostrowski, M. C., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11077-11083 7 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
p38 Mitogen-Activated Protein Kinases
Ligands
Osteoclasts
Phosphorylation
27 Citations (Scopus)

The microphthalmia transcription factor (MITF) contains two N-terminal domains required for transactivation of osteoclast target promoters and rescue of mi mutant osteoclasts

Mansky, K. C., Marfatia, K., Purdom, G. H., Luchin, A., Hume, D. A. & Ostrowski, M. C., Feb 1 2002, In : Journal of Leukocyte Biology. 71, 2, p. 295-303 9 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Osteoclasts
Transcriptional Activation
Genes
Gene Expression
45 Citations (Scopus)

The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter

Mansky, K. C., Sulzbacher, S., Purdom, G., Nelsen, L., Hume, D. A., Rehli, M. & Ostrowski, M. C., Feb 1 2002, In : Journal of Leukocyte Biology. 71, 2, p. 304-310 7 p.

Research output: Contribution to journalArticle

Microphthalmia-Associated Transcription Factor
Polytetrafluoroethylene
Osteoclasts
Transfection
Protein Isoforms
1997
41 Citations (Scopus)

Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions

Mansky, K. C., Batiza, A. & Lambert, P. F., Sep 26 1997, In : Journal of Virology. 71, 10, p. 7600-7608 9 p.

Research output: Contribution to journalArticle

Bovine papillomavirus 1
Simian virus 40
Viral Tumor Antigens
DNA replication
DNA Replication