Kevin D Wickman

1992 …2025

Research output per year

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Research Output

2020

Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice

DeBaker, M. C., Robinson, J. M., Moen, J. K., Wickman, K. & Lee, A. M., Jun 2020, In : Alcohol. 85, p. 57-64 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
Open Access

Unequal interactions between alcohol and nicotine co-consumption: suppression and enhancement of concurrent drug intake

DeBaker, M. C., Moen, J. K., Robinson, J. M., Wickman, K. & Lee, A. M., Apr 1 2020, In : Psychopharmacology. 237, 4, p. 967-978 12 p.

Research output: Contribution to journalArticle

2019

Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Linsdley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., Mar 20 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1294-1299 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Correction to: Analgesic effects of the GIRK activator, VU0466551, Alone and in combination with morphine in acute and persistent pain models (ACS Chemical Neuroscience (2019) 10:3 (1294-1299) DOI: 10.1021/acschemneuro.8b00370)

Abney, K. K., Bubser, M., Du, Y., Kozek, K. A., Bridges, T. M., Lindsley, C. W., Daniels, J. S., Morrison, R. D., Wickman, K., Hopkins, C. R., Jones, C. K. & Weaver, C. D., May 15 2019, In : ACS Chemical Neuroscience. 10, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Open Access

VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir3 channels and reduces stress-induced hyperthermia in mice

Vo, B., Abney, K. K., Anderson, A., Marron Fernandez de Velasco, E., Benneyworth, M. A., Daniels, J. S., Morrison, R. D., Hopkins, C. R., Weaver, C. D. & Wickman, K. D., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2238-2249 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Atrial GIRK channels mediate the effects of vagus nerve stimulation on heart rate dynamics and arrhythmogenesis

Lee, S. W., Anderson, A., Guzman, P. A., Nakano, A., Tolkacheva, E. G. & Wickman, K., Jul 19 2018, In : Frontiers in Physiology. 9, JUL, 943.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
Open Access

Differential association of GABA B receptors with their effector ion channels in Purkinje cells

Luján, R., Aguado, C., Ciruela, F., Cózar, J., Kleindienst, D., de la Ossa, L., Bettler, B., Wickman, K., Watanabe, M., Shigemoto, R. & Fukazawa, Y., Apr 1 2018, In : Brain Structure and Function. 223, 3, p. 1565-1587 23 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Expression and relevance of the G protein-gated K+ channel in the mouse ventricle

Anderson, A., Kulkarni, K., Marron Fernandez De Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G. & Wickman, K., Dec 1 2018, In : Scientific reports. 8, 1, 1192.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Inhibition of pyramidal neurons in the basal amygdala promotes fear learning

Tipps, M., de Velasco, E. M. F., Schaeffer, A. & Wickman, K., Sep 1 2018, In : eNeuro. 5, 5, e0272-18.2018.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart

Kulkarni, K., Xie, X., De Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K. & Tolkacheva, E. G., Apr 2018, In : PloS one. 13, 4, e0193798.

Research output: Contribution to journalArticle

Open Access
2017

Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators

Wieting, J. M., Vadukoot, A. K., Sharma, S., Abney, K. K., Bridges, T. M., Daniels, J. S., Morrison, R. D., Wickman, K., Weaver, C. D. & Hopkins, C. R., Sep 20 2017, In : ACS Chemical Neuroscience. 8, 9, p. 1873-1879 7 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

GIRK2 splice variants and neuronal G protein-gated K+ channels: Implications for channel function and behavior

Marron Fernandez De Velasco, E., Zhang, L., Vo, B. N., Tipps, M., Farris, S., Xia, Z., Anderson, A., Carlblom, N., Weaver, C. D., Dudek, S. M. & Wickman, K., Dec 1 2017, In : Scientific reports. 7, 1, 1639.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice

McCall, N. M., Kotecki, L., Dominguez-Lopez, S., Marron Fernandez De Velasco, E., Carlblom, N., Sharpe, A. L., Beckstead, M. J. & Wickman, K., Feb 1 2017, In : Neuropsychopharmacology. 42, 3, p. 707-715 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
Open Access
3 Scopus citations
2016

A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAb receptor-activated GIRK currents in vta dopamine neurons

Munoz, M. B., Rifkin, R., Padgett, C. L., Wickman, K., Contet, C., Moss, S. J. & Slesinger, P. A., Mar 16 2016, In : Journal of Neuroscience. 36, 11, p. 3106-3114 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Mesirca, P., Bidaud, I., Briec, F., Evain, S., Torrente, A. G., Le Quang, K., Leoni, A. L., Baudot, M., Marger, L., Chong, A. C. Y., Nargeot, J., Striessnig, J., Wickman, K., Charpentier, F. & Mangoni, M. E., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. E932-E941

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

G-protein-gated inwardly rectifying potassium channels modulate respiratory depression by Opioids

Montandon, G., Ren, J., Victoria, N. C., Liu, H., Wickman, K., Greer, J. J. & Horner, R. L., Mar 1 2016, In : Anesthesiology. 124, 3, p. 641-650 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning

Victoria, N. C., Marron Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M. A., Zink, A. N., Martemyanov, K. A. & Wickman, K., Nov 15 2016, In : Biological Psychiatry. 80, 10, p. 796-806 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol

Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A. & Contet, C., Jun 2 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 22, p. 7091-7096 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

GIRK Channel Plasticity and Implications for Drug Addiction

Marron Fernandez de Velasco, E., McCall, N. & Wickman, K. D., Jan 1 2015, International Review of Neurobiology - Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels, 2015. Harris, R. A. & Jenner, P. (eds.). Academic Press Inc., p. 201-238 38 p. (International Review of Neurobiology; vol. 123).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

GIRK channels modulate opioid-induced motor activity in a cell type- and subunit-dependent manner

Kotecki, L., Hearing, M., McCall, N. M., de Velasco, E. M. F., Pravetoni, M., Arora, D., Victoria, N. C., Munoz, M. B., Xia, Z., Slesinger, P. A., Weaver, C. D. & Wickman, K., May 6 2015, In : Journal of Neuroscience. 35, 18, p. 7131-7142 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

Preface

Slesinger, P. A. & Wickman, K., Jan 1 2015, In : International Review of Neurobiology. 123, p. xi-xii

Research output: Contribution to journalEditorial

1 Scopus citations

Sex differences in GABABR-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortex

Marron Fernandez De Velasco, E., Hearing, M., Xia, Z., Victoria, N. C., Luján, R. & Wickman, K., Aug 1 2015, In : Neuropharmacology. 95, p. 353-360 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation

Mesirca, P., Alig, J., Torrente, A. G., Müller, J. C., Marger, L., Rollin, A., Marquilly, C., Vincent, A., Dubel, S., Bidaud, I., Fernandez, A., Seniuk, A., Engeland, B., Singh, J., Miquerol, L., Ehmke, H., Eschenhagen, T., Nargeot, J., Wickman, K., Isbrandt, D. & 1 others, Mangoni, M. E., Aug 21 2014, In : Nature communications. 5, 4664.

Research output: Contribution to journalArticle

30 Scopus citations

G-protein-coupled inward rectifier potassium current contributes to ventricular repolarization

Liang, B., Nissen, J. D., Laursen, M., Wang, X., Skibsbye, L., Hearing, M. C., Andersen, M. N., Rasmussen, H. B., Wickman, K., Grunnet, M., Olesen, S. P. & Jespersen, T., Jan 1 2014, In : Cardiovascular Research. 101, 1, p. 175-184 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
35 Scopus citations

Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by the novel anxiolytic drug, ML297

Wydeven, N., Marron Fernandez De Velasco, E., Du, Y., Benneyworth, M. A., Hearing, M. C., Fischer, R. A., Thomas, M. J., Weaver, C. D. & Wickman, K., Jul 22 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 29, p. 10755-10760 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

New insights into the therapeutic potential of Girk channels

Luján, R., Marron Fernandez de Velasco, E., Aguado, C. & Wickman, K., Jan 2014, In : Trends in Neurosciences. 37, 1, p. 20-29 10 p.

Research output: Contribution to journalReview article

67 Scopus citations

RGS6, but Not RGS4, Is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate

Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K. A. & Wickman, K., Jan 24 2014, In : Journal of Biological Chemistry. 289, 4, p. 2440-2449 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K. & Martemyanov, K. A., Jan 1 2014, In : eLife. 3, p. e02053

Research output: Contribution to journalArticle

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K. & Martemyanov, K. A., Jan 1 2014, In : eLife. 3, p. e02053

Research output: Contribution to journalArticle

33 Scopus citations

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating Hippocampal GABABR-GIRK signaling

Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K. & Martemyanov, K. A., Apr 22 2014, In : eLife. 2014, 3, e02053.

Research output: Contribution to journalLetter

5 Scopus citations
2013

Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons

Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K. A., Wickman, K. & Luján, R., Dec 1 2013, In : Hippocampus. 23, 12, p. 1231-1245 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons

Booker, S. A., Gross, A., Althof, D., Shigemoto, R., Bettler, B., Frotscher, M., Hearing, M., Wickman, K., Watanabe, M., Kulik, Á. & Vida, I., May 10 2013, In : Journal of Neuroscience. 33, 18, p. 7961-7974 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.

Posokhova, E., Ng, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L. G., Wickman, K. & Martemyanov, K. A., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

25 Scopus citations

Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex

Hearing, M., Kotecki, L., MarronFernandezdeVelasco, E., Fajardo-Serrano, A., Chung, H. J., Luján, R. & Wickman, K., Oct 2 2013, In : Neuron. 80, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

56 Scopus citations

The G-protein-gated K+ channel, iKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation

Mesirca, P., Marger, L., Toyoda, F., Rizzetto, R., Audoubert, M., Dubel, S., Torrente, A. G., DiFrancesco, M. L., Muller, J. C., Leoni, A. L., Couette, B., Nargeot, J., Clapham, D. E., Wickman, K. & Mangoni, M. E., Sep 5 2013, In : Journal of General Physiology. 142, 2, p. 113-126 14 p.

Research output: Contribution to journalArticle

33 Scopus citations
2012

Behavioral characterization of mice lacking Trek channels

Mirkovic, K., Palmersheim, J., Lesage, F. & Wickman, K., Aug 23 2012, In : Frontiers in Behavioral Neuroscience. AUGUST

Research output: Contribution to journalArticle

1 Scopus citations

Behavioral characterization of mice lacking Trek channels

Mirkovic, K., Palmersheim, J., Lesage, F. & Wickman, K., Sep 7 2012, In : Frontiers in Behavioral Neuroscience. SEPTEMBER

Research output: Contribution to journalArticle

18 Scopus citations

Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system

Hearing, M. C., Zink, A. N. & Wickman, K. D., Aug 1 2012, In : Reviews in the Neurosciences. 23, 4, p. 325-351 27 p.

Research output: Contribution to journalReview article

26 Scopus citations

Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity

Wydeven, N., Young, D., Mirkovic, K. & Wickman, K. D., Dec 26 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. 21492-21497 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2011

Acute cocaine exposure weakens GABAB receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area

Arora, D., Hearing, M., Haluk, D. M., Mirkovic, K., Fajardo-Serrano, A., Wessendorf, M. W., Watanabe, M., Luján, R. & Wickman, K., Aug 24 2011, In : Journal of Neuroscience. 31, 34, p. 12251-12257 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Developmental regulation of G protein-gated inwardly-rectifying K + (GIRK/Kir3) channel subunits in the brain

Fernández-Alacid, L., Watanabe, M., Molnár, E., Wickman, K. & Luján, R., Dec 1 2011, In : European Journal of Neuroscience. 34, 11, p. 1724-1736 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene

Mirkovic, K. & Wickman, K., Oct 27 2011, In : Neuroscience. 194, p. 11-18 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels

Sohn, J. W., Xu, Y., Jones, J. E., Wickman, K., Williams, K. W. & Elmquist, J. K., Aug 11 2011, In : Neuron. 71, 3, p. 488-497 10 p.

Research output: Contribution to journalArticle

107 Scopus citations
2010

Altered neurotransmission in the mesolimbic reward system of Girk -/- mice

Arora, D., Haluk, D. M., Kourrich, S., Pravetoni, M., Fernández-Alacid, L., Nicolau, J. C., Luján, R. & Wickman, K., Sep 1 2010, In : Journal of Neurochemistry. 114, 5, p. 1487-1497 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Evaluation of study design variables and their impact on food-maintained operant responding in mice

Haluk, D. M. & Wickman, K., Mar 5 2010, In : Behavioural Brain Research. 207, 2, p. 394-401 8 p.

Research output: Contribution to journalArticle

8 Scopus citations