1993 …2022
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Research Output 1993 2019

2019
1 Citation (Scopus)

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Brinkman, C. C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33

Research output: Contribution to journalArticle

Open Access
Lysosphingolipid Receptors
Endothelial Cells
T-Lymphocytes
Cell Movement
Vascular Cell Adhesion Molecule-1

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K. L., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 1 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
T-cells
Deoxyglucose
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
T-lymphocytes
1 Citation (Scopus)

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

Simon, T., Li, L., Wagner, C., Zhang, T., Saxena, V., Brinkman, C. C., Tostanoski, L. H., Ostrand-Rosenberg, S., Jewell, C., Shea-Donohue, T., Hippen, K. L., Blazar, B. R., Abdi, R. & Bromberg, J. S., Oct 1 2019, In : Transplantation. 103, 10, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

Laminin
Immunity
Lymph Nodes
T-Lymphocytes
Dystroglycans
1 Citation (Scopus)

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI Insight. 4, 5

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Regulatory T-Lymphocytes
T-Lymphocytes
Cell Transplantation
Transplantation
4 Citations (Scopus)

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Liu, B., Salgado, O. C., Singh, S., Hippen, K. L., Maynard, J. C., Burlingame, A. L., Ball, L. E., Blazar, B. R., Farrar, M. A., Hogquist, K. A. & Ruan, H-B., Dec 1 2019, In : Nature communications. 10, 1, 354.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
proteins
effectors
T-Cell Antigen Receptor
2018
10 Citations (Scopus)

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D. A., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T. R., Curtsinger, J. M., Davis, Z. B., Zhang, B., Cooley, S. A., Cichocki, F. M., Blazar, B. R. & Miller, J. S., Jul 1 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Natural Killer Cells
Natural Killer Cell Receptors
Tumor Microenvironment
Programmed Cell Death 1 Receptor
6 Citations (Scopus)

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 57.

Research output: Contribution to journalShort survey

Open Access
Graft vs Host Disease
Regulatory T-Lymphocytes
MicroRNAs
Knockout Mice
Long Noncoding RNA
5 Citations (Scopus)

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes

Fiore, A., Ugel, S., De Sanctis, F., Sandri, S., Fracasso, G., Trovato, R., Sartoris, S., Solito, S., Mandruzzato, S., Vascotto, F., Hippen, K. L., Mondanelli, G., Grohmann, U., Piro, G., Carbone, C., Melisi, D., Lawlor, R. T., Scarpa, A., Lamolinara, A., Iezzi, M. & 6 others, Fassan, M., Bicciato, S., Blazar, B. R., Sahin, U., Murray, P. J. & Bronte, V., Dec 1 2018, In : Nature communications. 9, 1, 5193.

Research output: Contribution to journalArticle

Open Access
monocytes
Immunosuppressive Agents
immunosuppression
Tumors
Monocytes
8 Citations (Scopus)

Minimum information about T regulatory cells: A step toward reproducibility and standardization

Fuchs, A., Gliwinski, M., Grageda, N., Spiering, R., Abbas, A. K., Appel, S., Bacchetta, R., Battaglia, M., Berglund, D., Blazar, B., Bluestone, J. A., Bornhäuser, M., Brinke, A. T., Brusko, T. M., Cools, N., Cuturi, M. C., Geissler, E., Giannoukakis, N., Golab, K., Hafler, D. A. & 41 others, van Ham, S. M., Hester, J., Hippen, K., Di Ianni, M., Ilic, N., Isaacs, J., Issa, F., Iwaszkiewicz-Grzes, D., Jaeckel, E., Joosten, I., Klatzmann, D., Koenen, H., Kooten, C. V., Korsgren, O., Kretschmer, K., Levings, M., Marek-Trzonkowska, N. M., Martinez-Llordella, M., Miljkovic, D., Mills, K. H. G., Miranda, J. P., Piccirillo, C. A., Putnam, A. L., Ritter, T., Roncarolo, M. G., Sakaguchi, S., Sánchez-Ramón, S., Sawitzki, B., Sofronic-Milosavljevic, L., Sykes, M., Tang, Q., Vives-Pi, M., Waldmann, H., Witkowski, P., Wood, K. J., Gregori, S., Hilkens, C. M. U., Lombardi, G., Lord, P., Martinez-Caceres, E. M. & Trzonkowski, P., Jan 15 2018, In : Frontiers in immunology. 8, JAN, 1844.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Antigen-Presenting Cells
Research Personnel
Autoimmune Diseases
Clinical Trials
8 Citations (Scopus)

miR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg)

Lu, Y., Gao, J., Zhang, S., Gu, J., Lu, H., Xia, Y., Zhu, Q., Qian, X., Zhang, F., Zhang, C., Shen, H., Hippen, K. L., Blazar, B. R., Lu, L. & Wang, X., Feb 19 2018, In : Cell death & disease. 9, 3, 1 p.

Research output: Contribution to journalArticle

Open Access
Autophagy
Regulatory T-Lymphocytes
Graft vs Host Disease
Autoimmune Diseases
Cell Survival
28 Citations (Scopus)

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8 + T cells

Borges Da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A. & Jameson, S. C., Jul 12 2018, In : Nature. 559, 7713, p. 264-268 5 p.

Research output: Contribution to journalArticle

Open Access
Purinergic Receptors
T-Lymphocytes
Adenosine Triphosphate
Immune System
Immunologic Memory
3 Citations (Scopus)

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C. S., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S. & 6 others, Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. & Blazar, B. R., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4604-4621 18 p.

Research output: Contribution to journalArticle

Open Access
Intermediate Filaments
Graft vs Host Disease
Vimentin
Regulatory T-Lymphocytes
Protein Kinase C
2017
6 Citations (Scopus)

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific Reports. 7, 1, 1633.

Research output: Contribution to journalArticle

Open Access
Endothelial Cells
Chemotactic Factors
T-Lymphocytes
Cell Movement
Leukocytes
30 Citations (Scopus)

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

Gu, J., Ni, X., Pan, X., Lu, H., Lu, Y., Zhao, J., Zheng, S. G., Hippen, K. L., Wang, X. & Lu, L., Jun 1 2017, In : Cellular and Molecular Immunology. 14, 6, p. 521-528 8 p.

Research output: Contribution to journalArticle

Open Access
Th17 Cells
Th1 Cells
Regulatory T-Lymphocytes
Autoimmune Diseases
Forkhead Transcription Factors
1 Citation (Scopus)

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L., Dec 1 2017, In : Scientific reports. 7, 1, 4258.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Protein Kinase C
Fetal Blood
Eragrostis
Immunological Synapses
9 Citations (Scopus)

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R., Dec 1 2017, In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Contribution to journalArticle

Open Access
Kynurenine
Regulatory T-Lymphocytes
Tryptophan
Graft vs Host Disease
Interleukin-2
18 Citations (Scopus)

Optimization of cGMP purification and expansion of umbilical cord blood–derived T-regulatory cells in support of first-in-human clinical trials

McKenna, D. H., Sumstad, D., Kadidlo, D. M., Batdorf, B., Lord, C. J., Merkel, S. C., Koellner, C. M., Curtsinger, J. M., June, C. H., Riley, J. L., Levine, B. L., Miller, J. S., Brunstein, C. G., Wagner, J. E., Blazar, B. R. & Hippen, K. L., Feb 1 2017, In : Cytotherapy. 19, 2, p. 250-262 13 p.

Research output: Contribution to journalArticle

Open Access
Umbilical Cord
Regulatory T-Lymphocytes
Fetal Blood
Clinical Trials
Graft vs Host Disease
8 Citations (Scopus)
Hematopoietic Stem Cell Transplantation
Microbiota
Pathogens
Stem cells
Immune system
2016
19 Citations (Scopus)

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Schönle, A., Hartl, F. A., Mentzel, J., Nöltner, T., Rauch, K. S., Prestipino, A., Wohlfeil, S. A., Apostolova, P., Hechinger, A. K., Melchinger, W., Fehrenbach, K., Guadamillas, M. C., Follo, M., Prinz, G., Ruess, A. K., Pfeifer, D., Del Pozo, M. A., Schmitt-Graeff, A., Duyster, J., Hippen, K. I. & 4 others, Blazar, B. R., Schachtrup, K., Minguet, S. & Zeiser, R., Apr 14 2016, In : Blood. 127, 15, p. 1930-1939 10 p.

Research output: Contribution to journalArticle

Caveolin 1
T-cells
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Cell Differentiation
58 Citations (Scopus)

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J., Webber, B. R., Knipping, F., Lonetree, C. L., Tennis, N., DeFeo, A. P., McElroy, A. N., Starker, C. G., Lee, C., Merkel, S., Lund, T. C., Kelly-Spratt, K. S., Jensen, M. C., Voytas, D. F., Von Kalle, C., Schmidt, M., Gabriel, R., Hippen, K. L., Miller, J. S., Scharenberg, A. M. & 2 others, Tolar, J. & Blazar, B. R., Mar 1 2016, In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Lymphocytes
T-Cell Antigen Receptor
Adoptive Immunotherapy
Neoplasm Antigens
17 Citations (Scopus)

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Graft vs Host Disease
MicroRNAs
T-cells
Grafts
7 Citations (Scopus)

Preclinical Testing of Antihuman CD28 Fab′ Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease

Hippen, K. L., Watkins, B., Tkachev, V., Lemire, A. M., Lehnen, C., Riddle, M. J., Singh, K., Panoskaltsis-Mortari, A., Vanhove, B., Tolar, J., Kean, L. S. & Blazar, B. R., Dec 1 2016, In : Transplantation. 100, 12, p. 2630-2639 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Primates
Rodentia
Animal Models
Antibodies
17 Citations (Scopus)

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Brinkman, C. C., Iwami, D., Hritzo, M. K., Xiong, Y., Ahmad, S., Simon, T., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Jun 21 2016, In : Nature communications. 7, 12021.

Research output: Contribution to journalArticle

Lymphotoxin beta Receptor
Transendothelial and Transepithelial Migration
Lymphotoxin-alpha
Allografts
T-cells
133 Citations (Scopus)

Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., Riley, J. L., June, C. H., Le, C., Weisdorf, D. J., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Feb 25 2016, In : Blood. 127, 8, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Regulatory T-Lymphocytes
Fetal Blood
Grafts
Toxicity
2014
173 Citations (Scopus)
Acute Myeloid Leukemia
Natural Killer Cells
Interleukin-2
Fusion reactions
Interleukin-15
67 Citations (Scopus)

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Zanin-Zhorov, A., Weiss, J. M., Nyuydzefe, M. S., Chen, W., Scher, J. U., Mo, R., Depoil, D., Rao, N., Liu, B., Wei, J., Lucas, S., Koslow, M., Roche, M., Schueller, O., Weiss, S., Poyurovsky, M. V., Tonra, J., Hippen, K. L., Dustin, M. L., Blazar, B. R. & 2 others, Liu, C. J. & Waksal, S. D., Nov 25 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 47, p. 16814-16819 6 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Interleukin-17
Down-Regulation
T-Lymphocytes
Regulatory T-Lymphocytes
2013
49 Citations (Scopus)
Adoptive Immunotherapy
Virus Activation
Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
2012
50 Citations (Scopus)

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Hippen, K. L., Bucher, C., Schirm, D. K., Bearl, A. M., Brender, T., Mink, K. A., Waggie, K. S., De Latour, R. P., Janin, A., Curtsinger, J. M., Dillon, S. R., Miller, J. S., Socie, G. & Blazar, B. R., Jan 12 2012, In : Blood. 119, 2, p. 619-628 10 p.

Research output: Contribution to journalArticle

Lymphocytes
Graft vs Host Disease
Grafts
T-cells
Gastrointestinal Tract
30 Citations (Scopus)

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

Zanin-Zhorov, A., Lin, J., Scher, J., Kumari, S., Blair, D., Hippen, K. L., Blazar, B. R., Abramson, S. B., Lafaille, J. J. & Dustin, M. L., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

Immunological Synapses
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
NFATC Transcription Factors
Proteins
2011
87 Citations (Scopus)

Clinical perspectives for regulatory T cells in transplantation tolerance

Hippen, K. L., Riley, J. L., June, C. H. & Blazar, B. R., Dec 1 2011, In : Seminars in Immunology. 23, 6, p. 462-468 7 p.

Research output: Contribution to journalReview article

Transplantation Tolerance
Hematopoietic Stem Cell Transplantation
Cell Transplantation
Regulatory T-Lymphocytes
Adoptive Transfer
142 Citations (Scopus)

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

Hippen, K. L., Merkel, S. C., Schirm, D. K., Nelson, C., Tennis, N. C., Riley, J. L., June, C. H., Miller, J. S., Wagner, J. E. & Blazar, B. R., Jun 1 2011, In : American Journal of Transplantation. 11, 6, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Regulatory T-Lymphocytes
Sirolimus
T-Lymphocytes
Adoptive Transfer
629 Citations (Scopus)

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics

Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T., Levine, B. L., June, C. H., Rubinstein, P., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Jan 20 2011, In : Blood. 117, 3, p. 1061-1070 10 p.

Research output: Contribution to journalArticle

Blood Safety
Regulatory T-Lymphocytes
Fetal Blood
Blood
Kinetics
206 Citations (Scopus)

Massive ex vivo expansion of human natural regulatory T cells (T regs) with minimal loss of in vivo functional activity

Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H., Bromberg, J. S., Levine, B. L., Riley, J. L., June, C. H., Scheinberg, P., Douek, D. C., Miller, J. S., Wagner, J. E. & Blazar, B. R., May 18 2011, In : Science Translational Medicine. 3, 83, 83ra41.

Research output: Contribution to journalArticle

Graft vs Host Disease
Regulatory T-Lymphocytes
Antigen-Presenting Cells
Autoimmunity
Fetal Blood
112 Citations (Scopus)

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L. & 15 others, Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L. & Schultze, J. L., Sep 1 2011, In : Nature immunology. 12, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Genome
Untranslated Regions
Self Tolerance
Chromatin Assembly and Disassembly
2010
194 Citations (Scopus)

Protein kinase C-θ mediates negative feedback on regulatory T cell function

Zanin-Zhorov, A., Ding, Y., Kumari, S., Attur, M., Hippen, K. L., Brown, M., Blazar, B. R., Abramson, S. B., Lafaille, J. J. & Dustin, M. L., Apr 16 2010, In : Science. 328, 5976, p. 372-376 5 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Protein Kinase C
Eragrostis
Immunological Synapses
Cytokines
2009
35 Citations (Scopus)
Regulatory T-Lymphocytes
Mesenchymal Stromal Cells
Fetal Blood
Cell Transplantation
Graft vs Host Disease
2008
31 Citations (Scopus)

B cell receptor basal signaling regulates antigen-induced ig light chain rearrangements

Schram, B. R., Tze, L. E., Ramsey, L. B., Liu, J., Najera, L., Vegoe, A. L., Hardy, R. R., Hippen, K. L., Farrar, M. A. & Behrens, T. W., Apr 1 2008, In : Journal of Immunology. 180, 7, p. 4728-4741 14 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
B-Lymphocytes
Light
Antigens
Down-Regulation
106 Citations (Scopus)

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

Hippen, K. L., Harker-Murray, P., Porter, S. B., Merkel, S. C., Londer, A., Taylor, D. K., Bina, M., Panoskaltsis-Mortari, A., Rubinstein, P., Van Rooijen, N., Golovina, T. N., Suhoski, M. M., Miller, J. S., Wagner, J. E., June, C. H., Riley, J. L. & Blazar, B. R., Oct 1 2008, In : Blood. 112, 7, p. 2847-2857 11 p.

Research output: Contribution to journalArticle

T-cells
Tumor Necrosis Factor Receptors
Antigen-Presenting Cells
Regulatory T-Lymphocytes
Fetal Blood
2007
115 Citations (Scopus)

Role for Msh5 in the regulation of Ig class switch recombination

Sekine, H., Ferreira, R. C., Pan-Hammarström, Q., Graham, R. R., Ziemba, B., De Vries, S. S., Liu, J., Hippen, K. L., Koeuth, T., Ortmann, W., Iwahori, A., Elliott, M. K., Offer, S., Hegg, C. S., Du, L., Novitzke, J., Lee, A. T., Zhao, N., Tompkins, J. D., Altshuler, D. & 8 others, Gregersen, P. K., Cunningham-Rundles, C., Harris, R., Her, C., Nelson, D. L., Hammarström, L., Gilkeson, G. S. & Behrens, T. W., Apr 24 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 17, p. 7193-7198 6 p.

Research output: Contribution to journalArticle

Genetic Recombination
IgA Deficiency
Common Variable Immunodeficiency
Joints
Alleles
2006
8 Citations (Scopus)

Attenuation of IL-7 receptor signaling is not required for allelic exclusion

Will, W. M., Aaker, J. D., Burchill, M. A., Harmon, I. R., O'Neil, J. J., Goetz, C. A., Hippen, K. L. & Farrar, M. A., Mar 15 2006, In : Journal of Immunology. 176, 6, p. 3350-3355 6 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
V(D)J Recombination
Transgenic Mice
B-Lymphocytes
Interleukin-7
46 Citations (Scopus)

Genomic view of systemic autoimmunity in MRLlpr mice

Liu, J., Karypis, G., Hippen, K. L., Vegoe, A. L., Ruiz, P., Gilkeson, G. S. & Behrens, T. W., Mar 1 2006, In : Genes and Immunity. 7, 2, p. 156-168 13 p.

Research output: Contribution to journalArticle

Autoimmunity
Genes
Kidney
Spleen
Gene Components
2005
105 Citations (Scopus)

Basal immunoglobulin signaling actively maintains developmental stage in immature B cells

Tze, L. E., Schram, B. R., Lam, K. P., Hogquist, K. A., Hippen, K. L., Liu, J., Shinton, S. A., Otipoby, K. L., Rodine, P. R., Vegoe, A. L., Kraus, M., Hardy, R. R., Schlissel, M. S., Rajewsky, K. & Behrens, T. W., Mar 2005, In : PLoS Biology. 3, 3, p. 463-475 13 p., e82.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
immunoglobulins
B-lymphocytes
Immunoglobulins
immatures
59 Citations (Scopus)

In vivo assessment of the relative contributions of deletion, anergy, and editing to B cell self-tolerance

Hippen, K. L., Schram, B. R., Tze, L. E., Pape, K. A., Jenkins, M. K. & Behrens, T. W., Jul 15 2005, In : Journal of Immunology. 175, 2, p. 909-916 8 p.

Research output: Contribution to journalArticle

Self Tolerance
B-Lymphocytes
Membranes
Bromodeoxyuridine
Transgenic Mice
13 Citations (Scopus)

Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus

Behrens, T. W., Graham, R. R., Kyogoku, C., Baechler, E. C., Ramos, P. S., Gillett, C., Bauer, J., Ortmann, W. A., Hippen, K. L., Peterson, E. J., Langefeld, C. D., Moser, K. L., Gaffney, P. M. & Gregersen, P. K., Dec 1 2005, Genetics of Autoimmunity. Vol. 267. p. 145-160 16 p. (Novartis Foundation Symposium; vol. 267).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Systemic Lupus Erythematosus
Protein Tyrosine Phosphatases
Disease Susceptibility
Medical Genetics
Haplotypes
2004
43 Citations (Scopus)

Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-XL and c-myc

Swanson, P. J., Kuslak, S. L., Fang, W., Tze, L., Gaffney, P., Selby, S., Hippen, K. L., Nunez, G., Sidman, C. L. & Behrens, T. W., Jun 1 2004, In : Journal of Immunology. 172, 11, p. 6684-6691 8 p.

Research output: Contribution to journalArticle

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transgenic Mice
B-Lymphocytes
Interleukin-7
Neoplasms
2003
19 Citations (Scopus)

Late immature B cells (IgMhighIgDneg) undergo a light chain receptor editing response to soluble self-antigen

Tze, L. E., Hippen, K. L. & Behrens, T. W., Jul 15 2003, In : Journal of Immunology. 171, 2, p. 678-682 5 p.

Research output: Contribution to journalArticle

B-Lymphoid Precursor Cells
Autoantigens
Light
Transgenes
Genetic Recombination
104 Citations (Scopus)

Visualization of the genesis and fate of isotype-switched B cells during a primary immune response

Pape, K. A., Kouskoff, V., Nemazee, D., Tang, H. L., Cyster, J. G., Tze, L. E., Hippen, K. L., Behrens, T. W. & Jenkins, M., Jun 16 2003, In : Journal of Experimental Medicine. 197, 12, p. 1677-1687 11 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Germinal Center
Immunoglobulin Class Switching
Antigens
Helper-Inducer T-Lymphocytes
2000
164 Citations (Scopus)

CD5 maintains tolerance in anergic B cells

Hippen, K. L., Tze, L. E. & Behrens, T. W., Mar 6 2000, In : Journal of Experimental Medicine. 191, 5, p. 883-889 7 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Immunoglobulin M
Clonal Anergy
T-Lymphocyte Subsets
Muramidase
42 Citations (Scopus)

Ig light chain receptor editing in anergic B cells

Tze, L. E., Baness, E. A., Hippen, K. L. & Behrens, T. W., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 6796-6802 7 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Light
Bone Marrow
Interleukin-7
Bone Marrow Cells
1997
105 Citations (Scopus)

FcγRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

Hippen, K. L., Buhl, A. M., D'Ambrosio, D., Nakamura, K., Persin, C. & Cambier, J. C., Jan 1 1997, In : Immunity. 7, 1, p. 49-58 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Hydrolysis
B-Lymphocytes
CD80 Antigens
Phosphatidylinositol 3-Kinase