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RNA Medicine & Life Sciences
DNA Medicine & Life Sciences
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Crystal structure Chemical Compounds
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Base Pairing Medicine & Life Sciences
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Projects 2016 2020

APOBEC3 STRUCTURAL STUDIES

Harris, R., Aihara, H., Harki, D. A., Nazarian, S. & Shi, K.

NIH NIGMS NATL INST OF GENERAL

4/15/162/29/20

Project: Research project

Research Output 1999 2019

Cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis

Shi, K., Cho, S., Aukema, K. G., Lee, T., Bera, A. K., Seffernick, J. L., Wackett, L. P. & Aihara, H., Jun 2019, In : PloS one. 14, 6, e0216979.

Research output: Contribution to journalArticle

Open Access
Hydrolases
hydrolases
Catalysis
catalytic activity
acids

Insight into subtilisin E-S7 cleavage pattern based on crystal structure and hydrolysates peptide analysis

Tang, H., Zhang, J., Shi, K., Aihara, H. & Du, G., May 7 2019, In : Biochemical and Biophysical Research Communications. 512, 3, p. 623-628 6 p.

Research output: Contribution to journalArticle

ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate
Subtilisins
Crystal structure
Peptides
Protein Engineering

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

Kirberger, S. E., Ycas, P. D., Johnson, J. A., Chen, C., Ciccone, M. F., Woo, R. W. L., Urick, A. K., Zahid, H., Shi, K., Aihara, H., McAllister, S. D., Kashani-Sabet, M., Shi, J., Dickson, A., Dos Santos, C. O. & Pomerantz, W. C. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 7, p. 2020-2027 8 p.

Research output: Contribution to journalArticle

inhibitors
selectivity
Ligands
ligands
proteins
1 Citation (Scopus)

Comment on structural basis of DUX4/IGH-driven transactivation

Aihara, H., Shi, K., Lee, J. K., Bosnakovski, D. & Kyba, M., Sep 1 2018, In : Leukemia. 32, 9, p. 2090-2092 3 p.

Research output: Contribution to journalLetter

Open Access
Transcriptional Activation
1 Citation (Scopus)

Crystal Structure of Entamoeba histolytica Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication

Kurniawan, F., Shi, K., Kurahashi, K., Bielinsky, A. K. & Aihara, H., May 25 2018, In : iScience. 3, p. 102-109 8 p.

Research output: Contribution to journalArticle

Open Access
Entamoeba histolytica
DNA replication
crystal structure
DNA Replication
biophysics