Kaylee Schwertfeger

20002023
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Research Output 2000 2019

2019

Inflammation as a Target in Cancer Therapy

Leon-Cabrera, S., Schwertfeger, K. & Terrazas, L. I., Jan 1 2019, In : Mediators of inflammation. 2019, 1 p.

Research output: Contribution to journalEditorial

Open Access
Inflammation
Neoplasms
Therapeutics
1 Citation (Scopus)

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

Irey, E. A., Lassiter, C. M., Brady, N. J., Chuntova, P., Wang, Y., Knutson, T. P., Henzler, C., Chaffee, T. S., Vogel, R. I., Nelson, A. C., Farrar, M. A. & Schwertfeger, K., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12442-12451 10 p.

Research output: Contribution to journalArticle

Janus Kinases
Macrophages
STAT3 Transcription Factor
Neoplasms
Tumor Microenvironment

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Brian, B. F., Jolicoeur, A. S., Guerrero, C. R., Nunez, M. G., Sychev, Z. E., Hegre, S. A., Sætrom, P., Habib, N., Drake, J. M., Schwertfeger, K. L. & Freedman, T. S., Jul 2019, In : eLife. 8, e46043.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
src-Family Kinases
Macrophages
Myeloid Cells
Tuning
2018
5 Citations (Scopus)

Breaking through to the Other Side: Microenvironment Contributions to DCIS Initiation and Progression

Nelson, A. C., Machado, H. L. & Schwertfeger, K., Dec 1 2018, In : Journal of mammary gland biology and neoplasia. 23, 4, p. 207-221 15 p.

Research output: Contribution to journalReview article

Open Access
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Carcinoma
Secondary Prevention
Neoplasms
2 Citations (Scopus)

Cancer stem cell phenotypes in ER+ breast cancer models are promoted by PELP1/AIB1 complexes

Truong, T. H., Hu, H., Temiz, N. A., Hagen, K. M., Girard, B. J., Brady, N. J., Schwertfeger, K., Lange, C. A. & Ostrander, J. H., Apr 1 2018, In : Molecular Cancer Research. 16, 4, p. 707-719 13 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Breast Neoplasms
Phenotype
human PELP1 protein
Neoplasms
4 Citations (Scopus)

Distant Relations: Macrophage Functions in the Metastatic Niche

Doak, G. R., Schwertfeger, K. & Wood, D. K., Jun 1 2018, In : Trends in Cancer. 4, 6, p. 445-459 15 p.

Research output: Contribution to journalReview article

Open Access
Macrophages
Neoplasms
Neoplasm Metastasis
Therapeutics

Taxol induces brk-dependent prosurvival phenotypes in TNBC cells through an AhR/GR/HIF-driven signaling axis

Regan Anderson, T. M., Ma, S., Perez Kerkvliet, C. J., Peng, Y., Helle, T. M., Krutilina, R. I., Raj, G. V., Cidlowski, J. A., Ostrander, J. H., Schwertfeger, K., Seagroves, T. N. & Lange, C. A., Nov 1 2018, In : Molecular Cancer Research. 16, 11, p. 1761-1772 12 p.

Research output: Contribution to journalArticle

Open Access
Aryl Hydrocarbon Receptors
Glucocorticoid Receptors
Paclitaxel
Breast Neoplasms
Phenotype
2017
3 Citations (Scopus)

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions

Aukes, K., Forsman, C., Brady, N. J., Astleford, K., Blixt, N., Sachdev, D., Jensen, E. D., Mansky, K. & Schwertfeger, K., Oct 1 2017, In : PloS one. 12, 10, e0185736.

Research output: Contribution to journalArticle

Open Access
fibroblast growth factors
osteoclasts
Fibroblast Growth Factors
Osteoclasts
lesions (animal)
1 Citation (Scopus)
Open Access
Macrophages
Proline
Cell Movement
Glutamic Acid
Breast
16 Citations (Scopus)

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Knutson, T. P., Truong, T. H., Ma, S., Brady, N. J., Sullivan, M. E., Raj, G., Schwertfeger, K. & Lange, C. A., Apr 17 2017, In : Journal of Hematology and Oncology. 10, 1, 89.

Research output: Contribution to journalArticle

Open Access
Neoplastic Stem Cells
Progesterone Receptors
Breast Neoplasms
Ligands
Genes
2 Citations (Scopus)

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development

Brady, N. J., Farrar, M. A. & Schwertfeger, K., Aug 1 2017, In : Developmental Biology. 428, 1, p. 232-244 13 p.

Research output: Contribution to journalArticle

Open Access
Human Mammary Glands
Macrophages
Aromatase
Morphogenesis
Estrogen Receptors
2016
31 Citations (Scopus)

Macrophages: Regulators of the inflammatory microenvironment during mammary gland development and breast cancer

Brady, N. J., Chuntova, P. & Schwertfeger, K., Jan 1 2016, In : Mediators of Inflammation. 2016, 4549676.

Research output: Contribution to journalReview article

Human Mammary Glands
Macrophages
Breast Neoplasms
Immune System
Inflammation Mediators
2015
9 Citations (Scopus)

EIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells

Avdulov, S. V., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J., Beadnell, T. C., Schwertfeger, K., Benyumov, A., Manivel, J. C., Li, S., Bielinsky, A. K., Yee, D., Bitterman, P. B. & Polunovsky, V. A., Feb 15 2015, In : Cancer Research. 75, 4, p. 687-697 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Breast
Stem Cells
DNA Replication
Lactation
8 Citations (Scopus)

Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival

Farooqui, M., Bohrer, L. R., Brady, N. J., Chuntova, P., Kemp, S. E., Wardwell, C. T., Nelson, A. C. & Schwertfeger, K., Jul 29 2015, In : Molecular Cancer. 14, 1, 138.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 1
Cell Survival
Carcinogenesis
Breast
Carcinoma, Intraductal, Noninfiltrating
65 Citations (Scopus)

Hyaluronan, inflammation, and breast cancer progression

Schwertfeger, K., Cowman, M. K., Telmer, P. G., Turley, E. A. & Mc Carthy, J. B., Jan 1 2015, In : Frontiers in immunology. 6, JUN, 236.

Research output: Contribution to journalReview article

Hyaluronic Acid
Breast Neoplasms
Inflammation
Neoplasms
CD44 Antigens
49 Citations (Scopus)

The content and size of hyaluronan in biological fluids and tissues

Cowman, M. K., Lee, H. G., Schwertfeger, K. L., McCarthy, J. B. & Turley, E. A., Jan 1 2015, In : Frontiers in immunology. 6, JUN, 261.

Research output: Contribution to journalReview article

Hyaluronic Acid
Polymers
Cellular Microenvironment
Disaccharides
Toll-Like Receptors
10 Citations (Scopus)

Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma

Brincks, E. L., Kucaba, T. A., James, B. R., Murphy, K. A., Schwertfeger, K., Sangwan, V., Banerjee, S., Saluja, A. K. & Griffith, T. S., Dec 1 2015, In : FEBS Journal. 282, 24, p. 4747-4765 19 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
TNF-Related Apoptosis-Inducing Ligand Receptors
Tumors
Death Domain Receptors
Cells
2014
25 Citations (Scopus)

Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation

Bohrer, L. R., Chuntova, P., Bade, L. K., Beadnell, T. C., Leon, R. P., Brady, N. J., Ryu, Y., Goldberg, J. E., Schmechel, S. C., Koopmeiners, J., Mc Carthy, J. B. & Schwertfeger, K., Jan 1 2014, In : Cancer Research. 74, 1, p. 374-386 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Tumor Microenvironment
Hyaluronic Acid
Licensure
Breast Neoplasms
3 Citations (Scopus)

Building bridges toward invasion: Tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini

Klos, K. S., Warmka, J. K., Drachenberg, D. M., Chang, L., Luxton, G. W. G., Leung, C. T., Schwertfeger, K. & Wattenberg, E. V., Mar 5 2014, In : PloS one. 9, 3, e90722.

Research output: Contribution to journalArticle

Acinar Cells
protein kinase C
Tetradecanoylphorbol Acetate
Carcinogens
Protein Kinase C
312 Citations (Scopus)

PVT1 dependence in cancer with MYC copy-number increase

Tseng, Y. Y., Moriarity, B. S., Gong, W., Akiyama, R., Tiwari, A., Kawakami, H., Ronning, P., Reuland, B., Guenther, K., Beadnell, T. C., Essig, J., Otto, G. M., O'Sullivan, M. G., Largaespada, D. A., Schwertfeger, K. L., Marahrens, Y., Kawakami, Y. & Bagchi, A., Jan 1 2014, In : Nature. 512, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasms
Genes
Proteins
myc Genes
2013
18 Citations (Scopus)

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization

Forsman, C., Ng, B. C., Heinze, R. K., Kuo, C., Sergi, C., Gopalakrishnan, R., Yee, D., Graf, D., Schwertfeger, K. & Petryk, A., Jan 1 2013, In : Developmental Biology. 373, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Gastrulation
Bone Morphogenetic Proteins
Human Mammary Glands
Protein Binding
Carrier Proteins
19 Citations (Scopus)

The FGF/FGF receptor axis as a therapeutic target in breast cancer

Brady, N. J., Chuntova, P., Bade, L. K. & Schwertfeger, K. L., Jul 1 2013, In : Expert Review of Endocrinology and Metabolism. 8, 4, p. 391-402 12 p.

Research output: Contribution to journalReview article

Fibroblast Growth Factor Receptors
Breast Neoplasms
Gene Amplification
Therapeutics
Human Mammary Glands
2012
28 Citations (Scopus)

Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner

Reed, J. R., Stone, M. D., Beadnell, T. C., Ryu, Y., Griffin, T. J. & Schwertfeger, K., Sep 24 2012, In : PloS one. 7, 9, e45877.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Macrophages
mammary neoplasms (animal)
Tumors
macrophages
44 Citations (Scopus)

Macrophages promote fibroblast growth factor receptor-driven tumor cell migration and invasion in a Cxcr2-dependent manner

Bohrer, L. R. & Schwertfeger, K., Oct 1 2012, In : Molecular Cancer Research. 10, 10, p. 1294-1305 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
2011
21 Citations (Scopus)

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK

Lofgren, K. A., Ostrander, J. H., Housa, D., Hubbard, G. K., Locatelli, A., Bliss, R. L., Schwertfeger, K. & Lange, C. A., Sep 17 2011, In : Breast Cancer Research. 13, 5, R89.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Human Mammary Glands
Breast Neoplasms
Breast
Epithelial Cells
18 Citations (Scopus)

Mammary tumorigenesis induced by fibroblast growth factor receptor 1 requires activation of the epidermal growth factor receptor

Bade, L. K., Goldberg, J. E., DeHut, H. A., Hall, M. K. & Schwertfeger, K. L., Sep 15 2011, In : Journal of cell science. 124, 18, p. 3106-3117 12 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Epidermal Growth Factor Receptor
Carcinogenesis
Breast
Epithelial Cells
85 Citations (Scopus)

Membrane progesterone receptor expression in mammalian tissues: A review of regulation and physiological implications

Dressing, G. E., Goldberg, J. E., Charles, N. J., Schwertfeger, K. & Lange, C. A., Jan 1 2011, In : Steroids. 76, 1-2, p. 11-17 7 p.

Research output: Contribution to journalReview article

Progesterone Receptors
Tissue
Membranes
Ovarian Neoplasms
Fish
2010
41 Citations (Scopus)

Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer

Pond, A. C., Herschkowitz, J. I., Schwertfeger, K., Welm, B., Zhang, Y., York, B., Cardiff, R. D., Hilsenbeck, S., Perou, C. M., Creighton, C. J., Lloyd, R. E. & Rosen, J. M., Jun 15 2010, In : Cancer Research. 70, 12, p. 4868-4879 12 p.

Research output: Contribution to journalArticle

Mouse mammary tumor virus
Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Oncogene Proteins
Catenins
34 Citations (Scopus)

Immune cell location and function during post-natal mammary gland development

Reed, J. R. & Schwertfeger, K., Sep 1 2010, In : Journal of mammary gland biology and neoplasia. 15, 3, p. 329-339 11 p.

Research output: Contribution to journalReview article

Human Mammary Glands
Epithelial Cells
119 Citations (Scopus)

Proinflammatory cytokines in breast cancer: Mechanisms of action and potential targets for therapeutics

Goldberg, J. E. & Schwertfeger, K. L., Dec 1 2010, In : Current Drug Targets. 11, 9, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Action Potentials
Breast Neoplasms
Cytokines
Therapeutics
Interleukin-1beta
2009
48 Citations (Scopus)

Fibroblast growth factors in development and cancer: Insights from the mammary and prostate glands

Schwertfeger, K., Nov 26 2009, In : Current Drug Targets. 10, 7, p. 632-644 13 p.

Research output: Contribution to journalReview article

Fibroblast Growth Factors
Human Mammary Glands
Prostatic Neoplasms
Breast Neoplasms
Embryonic Development
52 Citations (Scopus)

Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis

Reed, J. R., Leon, R. P., Hall, M. K. & Schwertfeger, K., Apr 24 2009, In : Breast Cancer Research. 11, 2, R21.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Cyclooxygenase 2
Interleukin-1beta
Breast
Interleukin-1
2007
49 Citations (Scopus)

Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition

Xian, W., Schwertfeger, K. & Rosen, J. M., Apr 1 2007, In : Molecular Endocrinology. 21, 4, p. 987-1000 14 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Receptor, Fibroblast Growth Factor, Type 1
Epithelial-Mesenchymal Transition
Receptor Protein-Tyrosine Kinases
Cell Survival
2006
55 Citations (Scopus)

A critical role for the inflammatory response in a mouse model of preneoplastic progression

Schwertfeger, K. L., Xian, W., Kaplan, A. M., Burnett, S. H., Cohen, D. A. & Rosen, J. M., Jun 1 2006, In : Cancer Research. 66, 11, p. 5676-5685 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Macrophages
Transgenic Mice
Breast
Epithelium
36 Citations (Scopus)

Mammary gland macrophages: Pleiotropic functions in mammary development

Schwertfeger, K., Rosen, J. M. & Cohen, D. A., Oct 1 2006, In : Journal of mammary gland biology and neoplasia. 11, 3-4, p. 229-238 10 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Breast
Macrophages
Epithelial Cells
Stromal Cells
38 Citations (Scopus)

MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells

Limesand, K. H., Schwertfeger, K. L. & Anderson, S. M., Dec 1 2006, In : Molecular and cellular biology. 26, 23, p. 8840-8856 17 p.

Research output: Contribution to journalArticle

Acinar Cells
Apoptosis
Salivary Glands
Etoposide
Phosphorylation
2005
114 Citations (Scopus)

Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model

Xian, W., Schwertfeger, K. L., Vargo-Gogola, T. & Rosen, J. M., Nov 21 2005, In : Journal of Cell Biology. 171, 4, p. 663-673 11 p.

Research output: Contribution to journalArticle

Cell Movement
Cell Survival
Breast
Epithelial Cells
Cell Proliferation
2004
27 Citations (Scopus)

Regulation of milk lipid formation and secretion in the mouse mammary gland

McManaman, J. L., Palmer, C. A., Anderson, S., Schwertfeger, K. & Neville, M. C., Oct 12 2004, In : Advances in Experimental Medicine and Biology. 554, p. 263-279 17 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Xanthine Dehydrogenase
Milk
Lipids
Breast
2003
104 Citations (Scopus)

Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation

Schwertfeger, K. L., McManaman, J. L., Palmer, C. A., Neville, M. C. & Anderson, S. M., Jun 1 2003, In : Journal of Lipid Research. 44, 6, p. 1100-1112 13 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Lactation
Transgenic Mice
Milk
Lipids
2001
143 Citations (Scopus)

Mammary gland involution is delayed by activated Akt in transgenic mice

Schwertfeger, K. L., Richert, M. M. & Anderson, S. M., Jan 1 2001, In : Molecular Endocrinology. 15, 6, p. 867-881 15 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Transgenic Mice
Mouse mammary tumor virus
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase Inhibitors
2000
253 Citations (Scopus)

An atlas of mouse mammary gland development

Richert, M. M., Schwertfeger, K. L., Ryder, J. W. & Anderson, S. M., Jan 1 2000, In : Journal of mammary gland biology and neoplasia. 5, 2, p. 227-241 15 p.

Research output: Contribution to journalArticle

Atlases
Human Mammary Glands
Estrous Cycle
Growth
Lactation
29 Citations (Scopus)

Prolactin stimulates activation of c-jun N-terminal kinase (JNK)

Schwertfeger, K. L., Hunter, S., Heasley, L. E., Levresse, V., Leon, R. P., DeGregori, J. & Anderson, S. M., Jan 1 2000, In : Molecular Endocrinology. 14, 10, p. 1592-1602 11 p.

Research output: Contribution to journalArticle

JNK Mitogen-Activated Protein Kinases
Prolactin
Prolactin Receptors
Phosphotransferases
Sheep