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Research Output 2000 2019

2019

Inflammation as a Target in Cancer Therapy

Leon-Cabrera, S., Schwertfeger, K. & Terrazas, L. I., Jan 1 2019, In : Mediators of inflammation. 2019, 1 p.

Research output: Contribution to journalEditorial

Open Access
Inflammation
Neoplasms
Therapeutics

JAK/STAT inhibition in macrophages promotes therapeutic resistance by inducing expression of protumorigenic factors

Irey, E. A., Lassiter, C. M., Brady, N. J., Chuntova, P., Wang, Y., Knutson, T. P., Henzler, C., Chaffee, T. S., Vogel, R. I., Nelson, A. C., Farrar, M. A. & Schwertfeger, K., Jun 18 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12442-12451 10 p.

Research output: Contribution to journalArticle

Janus Kinases
Macrophages
STAT3 Transcription Factor
Neoplasms
Tumor Microenvironment
2018
2 Citations (Scopus)
Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Carcinoma
Secondary Prevention
Neoplasms
1 Citation (Scopus)
Neoplastic Stem Cells
Breast Neoplasms
Phenotype
human PELP1 protein
Neoplasms
1 Citation (Scopus)
Macrophages
Neoplasms
Neoplasm Metastasis
Therapeutics
Aryl Hydrocarbon Receptors
Glucocorticoid Receptors
Paclitaxel
Breast Neoplasms
Phenotype
2017
3 Citations (Scopus)
fibroblast growth factors
osteoclasts
Fibroblast Growth Factors
Osteoclasts
lesions (animal)
1 Citation (Scopus)
Open Access
Macrophages
Proline
Cell Movement
Glutamic Acid
Breast
14 Citations (Scopus)
Neoplastic Stem Cells
Progesterone Receptors
Breast Neoplasms
Ligands
Genes
2 Citations (Scopus)

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development

Brady, N. J., Farrar, M. A. & Schwertfeger, K., Aug 1 2017, In : Developmental Biology. 428, 1, p. 232-244 13 p.

Research output: Contribution to journalArticle

Open Access
Human Mammary Glands
Macrophages
Aromatase
Morphogenesis
Estrogen Receptors
2016
28 Citations (Scopus)

Macrophages: Regulators of the inflammatory microenvironment during mammary gland development and breast cancer

Brady, N. J., Chuntova, P. & Schwertfeger, K., Jan 1 2016, In : Mediators of Inflammation. 2016, 4549676.

Research output: Contribution to journalReview article

Human Mammary Glands
Macrophages
Breast Neoplasms
Immune System
Inflammation Mediators
2015
8 Citations (Scopus)

EIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells

Avdulov, S. V., Herrera, J., Smith, K., Peterson, M., Gomez-Garcia, J. R., Beadnell, T. C., Schwertfeger, K., Benyumov, A., Manivel, J. C., Li, S., Bielinsky, A. K., Yee, D., Bitterman, P. B. & Polunovsky, V. A., Feb 15 2015, In : Cancer Research. 75, 4, p. 687-697 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-4E
Breast
Stem Cells
DNA Replication
Lactation
8 Citations (Scopus)

Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival

Farooqui, M., Bohrer, L. R., Brady, N. J., Chuntova, P., Kemp, S. E., Wardwell, C. T., Nelson, A. C. & Schwertfeger, K., Jul 29 2015, In : Molecular Cancer. 14, 1, 138.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 1
Cell Survival
Carcinogenesis
Breast
Carcinoma, Intraductal, Noninfiltrating
59 Citations (Scopus)

Hyaluronan, inflammation, and breast cancer progression

Schwertfeger, K., Cowman, M. K., Telmer, P. G., Turley, E. A. & Mc Carthy, J. B., Jan 1 2015, In : Frontiers in immunology. 6, JUN, 236.

Research output: Contribution to journalReview article

Hyaluronic Acid
Breast Neoplasms
Inflammation
Neoplasms
CD44 Antigens
42 Citations (Scopus)
Hyaluronic Acid
Polymers
Cellular Microenvironment
Disaccharides
Toll-Like Receptors
9 Citations (Scopus)

Triptolide enhances the tumoricidal activity of TRAIL against renal cell carcinoma

Brincks, E. L., Kucaba, T. A., James, B. R., Murphy, K. A., Schwertfeger, K., Sangwan, V., Banerjee, S., Saluja, A. K. & Griffith, T. S., Dec 1 2015, In : FEBS Journal. 282, 24, p. 4747-4765 19 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
TNF-Related Apoptosis-Inducing Ligand Receptors
Tumors
Death Domain Receptors
Cells
2014
24 Citations (Scopus)
Fibroblast Growth Factor Receptors
Tumor Microenvironment
Hyaluronic Acid
Licensure
Breast Neoplasms
24 Citations (Scopus)
Fibroblast Growth Factor Receptors
Tumor Microenvironment
Hyaluronic Acid
Licensure
Breast Neoplasms
24 Citations (Scopus)
Fibroblast Growth Factor Receptors
Tumor Microenvironment
Hyaluronic Acid
Licensure
Breast Neoplasms
24 Citations (Scopus)

Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation

Bohrer, L. R., Chuntova, P., Bade, L. K., Beadnell, T. C., Leon, R. P., Brady, N. J., Ryu, Y., Goldberg, J. E., Schmechel, S. C., Koopmeiners, J., Mc Carthy, J. B. & Schwertfeger, K., Jan 1 2014, In : Cancer Research. 74, 1, p. 374-386 13 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Tumor Microenvironment
Hyaluronic Acid
Licensure
Breast Neoplasms
3 Citations (Scopus)
Acinar Cells
protein kinase C
Tetradecanoylphorbol Acetate
Carcinogens
Protein Kinase C
290 Citations (Scopus)
Long Noncoding RNA
Neoplasms
Genes
Proteins
myc Genes
2013
16 Citations (Scopus)

BMP-binding protein twisted gastrulation is required in mammary gland epithelium for normal ductal elongation and myoepithelial compartmentalization

Forsman, C., Ng, B. C., Heinze, R. K., Kuo, C., Sergi, C., Gopalakrishnan, R., Yee, D., Graf, D., Schwertfeger, K. & Petryk, A., Jan 1 2013, In : Developmental Biology. 373, 1, p. 95-106 12 p.

Research output: Contribution to journalArticle

Gastrulation
Bone Morphogenetic Proteins
Human Mammary Glands
Protein Binding
Carrier Proteins
18 Citations (Scopus)
Fibroblast Growth Factor Receptors
Breast Neoplasms
Gene Amplification
Therapeutics
Human Mammary Glands
2012
27 Citations (Scopus)

Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner

Reed, J. R., Stone, M. D., Beadnell, T. C., Ryu, Y., Griffin, T. J. & Schwertfeger, K., Sep 24 2012, In : PLoS One. 7, 9, e45877.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Macrophages
mammary neoplasms (animal)
Tumors
macrophages
43 Citations (Scopus)
Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
43 Citations (Scopus)
Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
43 Citations (Scopus)
Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
43 Citations (Scopus)
Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
43 Citations (Scopus)

Macrophages promote fibroblast growth factor receptor-driven tumor cell migration and invasion in a Cxcr2-dependent manner

Bohrer, L. R. & Schwertfeger, K., Oct 1 2012, In : Molecular Cancer Research. 10, 10, p. 1294-1305 12 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor Receptors
Cell Movement
Macrophages
Receptor, Fibroblast Growth Factor, Type 1
Neoplasms
2011
21 Citations (Scopus)
p38 Mitogen-Activated Protein Kinases
Human Mammary Glands
Breast Neoplasms
Breast
Epithelial Cells
18 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Epidermal Growth Factor Receptor
Carcinogenesis
Breast
Epithelial Cells
82 Citations (Scopus)
Progesterone Receptors
Tissue
Membranes
Ovarian Neoplasms
Fish
2010
40 Citations (Scopus)
Mouse mammary tumor virus
Fibroblast Growth Factor Receptors
Fibroblast Growth Factors
Oncogene Proteins
Catenins
32 Citations (Scopus)
Human Mammary Glands
Epithelial Cells
117 Citations (Scopus)
Action Potentials
Breast Neoplasms
Cytokines
Therapeutics
Interleukin-1beta
2009
46 Citations (Scopus)

Fibroblast growth factors in development and cancer: Insights from the mammary and prostate glands

Schwertfeger, K., Nov 26 2009, In : Current Drug Targets. 10, 7, p. 632-644 13 p.

Research output: Contribution to journalReview article

Fibroblast Growth Factors
Human Mammary Glands
Prostatic Neoplasms
Breast Neoplasms
Embryonic Development
52 Citations (Scopus)

Interleukin-1beta and fibroblast growth factor receptor 1 cooperate to induce cyclooxygenase-2 during early mammary tumourigenesis

Reed, J. R., Leon, R. P., Hall, M. K. & Schwertfeger, K., Apr 24 2009, In : Breast Cancer Research. 11, 2, R21.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Cyclooxygenase 2
Interleukin-1beta
Breast
Interleukin-1
2007
49 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 2
Receptor, Fibroblast Growth Factor, Type 1
Epithelial-Mesenchymal Transition
Receptor Protein-Tyrosine Kinases
Cell Survival
2006
54 Citations (Scopus)

A critical role for the inflammatory response in a mouse model of preneoplastic progression

Schwertfeger, K. L., Xian, W., Kaplan, A. M., Burnett, S. H., Cohen, D. A. & Rosen, J. M., Jun 1 2006, In : Cancer Research. 66, 11, p. 5676-5685 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Macrophages
Transgenic Mice
Breast
Epithelium
36 Citations (Scopus)
Human Mammary Glands
Breast
Macrophages
Epithelial Cells
Stromal Cells
36 Citations (Scopus)

MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells

Limesand, K. H., Schwertfeger, K. L. & Anderson, S. M., Dec 1 2006, In : Molecular and Cellular Biology. 26, 23, p. 8840-8856 17 p.

Research output: Contribution to journalArticle

Acinar Cells
Apoptosis
Salivary Glands
Etoposide
Phosphorylation
2005
113 Citations (Scopus)
Cell Movement
Cell Survival
Breast
Epithelial Cells
Cell Proliferation
2004
27 Citations (Scopus)
Human Mammary Glands
Xanthine Dehydrogenase
Milk
Lipids
Breast
2003
103 Citations (Scopus)

Expression of constitutively activated Akt in the mammary gland leads to excess lipid synthesis during pregnancy and lactation

Schwertfeger, K. L., McManaman, J. L., Palmer, C. A., Neville, M. C. & Anderson, S. M., Jun 1 2003, In : Journal of Lipid Research. 44, 6, p. 1100-1112 13 p.

Research output: Contribution to journalArticle

Human Mammary Glands
Lactation
Transgenic Mice
Milk
Lipids
2001
142 Citations (Scopus)
Human Mammary Glands
Transgenic Mice
Mouse mammary tumor virus
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase Inhibitors
2000
250 Citations (Scopus)

An atlas of mouse mammary gland development

Richert, M. M., Schwertfeger, K. L., Ryder, J. W. & Anderson, S. M., Jan 1 2000, In : Journal of mammary gland biology and neoplasia. 5, 2, p. 227-241 15 p.

Research output: Contribution to journalArticle

Atlases
Human Mammary Glands
Estrous Cycle
Growth
Lactation
29 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
Prolactin
Prolactin Receptors
Phosphotransferases
Sheep