Projects per year
Personal profile
Research interests
D. Boris-Lawrie has extensive expertise in the fields of retrovirology and gene expression and training graduate students that are successful in the biomedical workforce. She has had the opportunity to lead (PI) or collaborate (co-I) on NIH funded grants (R01, P50, P01) and establish a track record in team building, which has resulted in several publications in peer-reviewed journals. Her research is focused on unraveling genetic, biochemical and biophysical interactions of ribonucleoprotein complexes using viral models to understand progression to cancer and productive infections. In ground-breaking work, Dr. Boris-Lawrie and her lab group discovered and characterized of the necessary role of RNA helicase A/DHX9 in the translation of selected viral and host mRNAs, which has led to the realization nuclear RNA-binding proteins regulate protein synthesis in the cytoplasm. These studies also led to the discovery of the functional and structural conservation of the DHX9-responsive element across the Retroviridae and in RNAs expressed by animals and humans. Dr. Boris-Lawrie's mechanistic studies are exposing non-coding RNA-based therapeutic target to control disorders caused by viruses and transformed cells.
Research interests
Retroviruses, Oncogenic viruses, Viral vectors, RNA structural biology, RNA-protein interactions
Professional Information
Fellow, American Academy of Microbiology
Fellow, AAAS
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External Positions
NIH Recombinant DNA Advisory Committee, NIH
Aug 1 2016 → Jul 31 2020
Research Interest Keywords
- Virology
- Molecular Biology
- Cancer
- RNA Structural Biology
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Collaborations and top research areas from the last five years
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Epigenetic modification of HIV-1 Cap
Boris-Lawrie, K. (PI)
NATIONAL INSTITUTES OF HEALTH (NIH)
8/14/24 → 6/30/25
Project: Research project
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Characterization of RHA:RT interactions in HIV-1 reverse transcription
Boris-Lawrie, K. (PI)
UNIVERSITY OF MISSOURI, NATIONAL INSTITUTES OF HEALTH (NIH)
5/1/22 → 4/30/25
Project: Research project
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HIV-1 cap epigenetic modification
Boris-Lawrie, K. (PI)
NIH Nat'l Inst of Allergy & Infect Dis
8/10/23 → 8/10/24
Project: Research project
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Structural studies of essential RNA elements involved in HIV-1 reverse transcription initiation
Boris-Lawrie, K. (PI)
UNIVERSITY OF MISSOURI, NIH Nat'l Inst of Allergy & Infect Dis
7/1/19 → 6/30/23
Project: Research project
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Structural studies of essential RNA elements involved in
Boris-Lawrie, K. (PI)
UNIVERSITY OF MISSOURI, NATIONAL INSTITUTES OF HEALTH (NIH)
9/30/17 → 6/30/19
Project: Research project
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The basal translation rate of authentic HIV-1 RNA is regulated by 5'UTR nt-pairings at junction of R and U5
Boeras, I., Seufzer, B., Brady, S., Rendahl, A., Heng, X. & Boris-Lawrie, K., Dec 1 2017, In: Scientific reports. 7, 1, 6902.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Identification of conserved, primary sequence motifs that direct retrovirus RNA fate
Singh, G., Rife, B., Seufzer, B., Salemi, M., Rendahl, A. & Boris-Lawrie, K., Aug 21 2018, In: Nucleic Acids Research. 46, 14, p. 7366-7378 13 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
HIV-1 and two avian retroviral 5' untranslated regions bind orthologous human and chicken RNA binding proteins
Stake, M., Singh, D., Singh, G., Marcela Hernandez, J., Kaddis Maldonado, R., Parent, L. J. & Boris-Lawrie, K., Dec 1 2015, In: Virology. 486, p. 307-320 14 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Thriving under stress: Selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eiF4E translation activity
Sharma, A., Yilmaz, A., Marsh, K., Cochrane, A. & Boris-Lawrie, K., Mar 2012, In: PLoS pathogens. 8, 3, e1002612.Research output: Contribution to journal › Article › peer-review
Open Access74 Scopus citations -
Human and animal retroviruses: HIV-1 infection is a risk factor for malignancy
Hayes, A. M. & Boris-Lawrie, K., Jan 1 2012, Cancer Associated Viruses. Springer US, p. 585-611 27 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter