Accepting PhD Students

PhD projects

RNA viruses that cause cancer and AIDS

Willing to speak to media

1987 …2020

Research output per year

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Personal profile

Research interests

D. Boris-Lawrie has extensive expertise in the fields of retrovirology and gene expression and training graduate students that are successful in the biomedical workforce. She has had the opportunity to lead (PI) or collaborate (co-I) on NIH funded grants (R01, P50, P01) and establish a track record in team building, which has resulted in several publications in peer-reviewed journals. Her research is focused on unraveling genetic, biochemical and biophysical interactions of ribonucleoprotein complexes using viral models to understand progression to cancer and productive infections. In ground-breaking work, Dr. Boris-Lawrie and her lab group discovered and characterized of the necessary role of RNA helicase A/DHX9 in the translation of selected viral and host mRNAs, which has led to the realization nuclear RNA-binding proteins regulate protein synthesis in the cytoplasm. These studies also led to the discovery of the functional and structural conservation of the DHX9-responsive element across the Retroviridae and in RNAs expressed by animals and humans. Dr. Boris-Lawrie's mechanistic studies are exposing non-coding RNA-based therapeutic target to control disorders caused by viruses and transformed cells. 

 

Research interests

Retroviruses, Oncogenic viruses, Viral vectors, RNA structural biology, RNA-protein interactions

Professional Information

Fellow, American Academy of Microbiology

Fellow, AAAS

 

External Positions

NIH Recombinant DNA Advisory Committee, NIH

Aug 1 2016Jul 31 2020

Research interests

  • Virology
  • Molecular Biology
  • Cancer
  • RNA Structural Biology

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Projects

  • Research Output

    The basal translation rate of authentic HIV-1 RNA is regulated by 5'UTR nt-pairings at junction of R and U5

    Boeras, I., Seufzer, B., Brady, S., Rendahl, A., Heng, X. & Boris-Lawrie, K., Dec 1 2017, In : Scientific reports. 7, 1, 6883.

    Research output: Contribution to journalArticle

    Open Access
  • 5 Scopus citations

    Identification of conserved, primary sequence motifs that direct retrovirus RNA fate

    Singh, G., Rife, BD., Seufzer, B., Salemi, M., Rendahl, A. & Boris-Lawrie, K., Aug 21 2018, In : Nucleic Acids Research. 46, 14, p. 7366-7378 13 p.

    Research output: Contribution to journalArticle

    Open Access
  • HIV-1 and two avian retroviral 5' untranslated regions bind orthologous human and chicken RNA binding proteins

    Stake, M., Singh, D., Singh, G., Marcela Hernandez, J., Kaddis Maldonado, R., Parent, L. J. & Boris-Lawrie, K., Dec 1 2015, In : Virology. 486, p. 307-320 14 p.

    Research output: Contribution to journalArticle

  • 11 Scopus citations

    Thriving under stress: Selective translation of HIV-1 structural protein mRNA during Vpr-mediated impairment of eiF4E translation activity

    Sharma, A., Yilmaz, A., Marsh, K., Cochrane, A. & Boris-Lawrie, K., Mar 1 2012, In : PLoS pathogens. 8, 3, e1002612.

    Research output: Contribution to journalArticle

  • 47 Scopus citations

    Human and animal retroviruses: HIV-1 infection is a risk factor for malignancy

    Hayes, A. M. & Boris-Lawrie, K., Jan 1 2012, Cancer Associated Viruses. Springer US, p. 585-611 27 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter