Karunya K Kandimalla

19982023
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Research Output 1998 2019

2019
1 Citation (Scopus)

Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

Gali, C. C., Fanaee-Danesh, E., Zandl-Lang, M., Albrecher, N. M., Tam-Amersdorfer, C., Stracke, A., Sachdev, V., Reichmann, F., Sun, Y., Avdili, A., Reiter, M., Kratky, D., Holzer, P., Lass, A., Kandimalla, K. K. & Panzenboeck, U., Sep 1 2019, In : Molecular and Cellular Neuroscience. 99, 103390.

Research output: Contribution to journalArticle

Open Access
Lipoprotein Receptors
Insulin Receptor
Autophagy
Blood-Brain Barrier
Amyloid
2 Citations (Scopus)

Apolipoprotein A-I crosses the blood-brain barrier through clathrin-independent and cholesterol-mediated endocytosis

Zhou, A. L., Swaminathan, S. K., Curran, G. L., Poduslo, J. F., Lowe, V. J., Li, L. & Kandimalla, K. K., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 369, 3, p. 481-488 8 p.

Research output: Contribution to journalArticle

Clathrin
Apolipoprotein A-I
Endocytosis
Blood-Brain Barrier
Cholesterol
2 Citations (Scopus)

Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain

Ahlschwede, K. M., Curran, G. L., Rosenberg, J. T., Grant, S. C., Sarkar, G., Jenkins, R. B., Ramakrishnan, S., Poduslo, J. F. & Kandimalla, K. K., Feb 1 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 16, p. 258-266 9 p.

Research output: Contribution to journalArticle

Amyloid
Nanoparticles
Peptides
Brain
Alzheimer Disease
1 Citation (Scopus)

Design, Development, and Characterization of Imiquimod-Loaded Chitosan Films for Topical Delivery

Layek, B., Rahman Nirzhor, S. S., Rathi, S., Kandimalla, K. K., Wiedmann, T. S. & Prabha, S., Feb 1 2019, In : AAPS PharmSciTech. 20, 2, 58.

Research output: Contribution to journalArticle

imiquimod
Chitosan
cream
chitosan
patient compliance
1 Citation (Scopus)

Development and validation of a sensitive LC-MS/MS method for the estimation of scopolamine in human serum

Swaminathan, S. K., Fisher, J., Brogden, N. K. & Kandimalla, K. K., Feb 5 2019, In : Journal of Pharmaceutical and Biomedical Analysis. 164, p. 41-46 6 p.

Research output: Contribution to journalArticle

Scopolamine Hydrobromide
Assays
Serum
formic acid
Motion Sickness
2018
1 Citation (Scopus)

Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking

Omtri, R. S., Thompson, K. J., Tang, X., Gali, C. C., Panzenboeck, U., Davidson, M. W., Kalari, K. R. & Kandimalla, K. K., Mar 1 2018, In : Neuroscience. 373, p. 159-168 10 p.

Research output: Contribution to journalArticle

Endocytosis
Alzheimer Disease
Brain
Peptides
Poisons
18 Citations (Scopus)

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

Open Access
Receptors, Serotonin, 5-HT4
G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions
Tryptophan
3 Citations (Scopus)

High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia

Chernick, D., Ortiz-Valle, S., Jeong, A., Swaminathan, S. K., Kandimalla, K. K., Rebeck, G. W. & Li, L., Dec 1 2018, In : Journal of Neurochemistry. 147, 5, p. 647-662 16 p.

Research output: Contribution to journalArticle

Open Access
Microglia
Apolipoproteins E
HDL Lipoproteins
Amyloid
Astrocytes
9 Citations (Scopus)

Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain

Swaminathan, S. K., Ahlschwede, K. M., Sarma, V. V., Curran, G. L., Omtri, R., Decklever, T., Lowe, V. J., Poduslo, J. F. & Kandimalla, K. K., May 1 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 5, p. 904-918 15 p.

Research output: Contribution to journalArticle

Amyloid
Insulin
Brain
Permeability
Alzheimer Disease

Sensitive Determination of Fentanyl in Low-Volume Serum Samples by LC-MS/MS

Swaminathan, S. K., Fisher, J. & Kandimalla, K. K., Oct 1 2018, In : AAPS PharmSciTech. 19, 7, p. 2812-2817 6 p.

Research output: Contribution to journalArticle

fentanyl
Fentanyl
Serum
formic acid
sampling

Your brain scan may be a reflection of your genes

Lowe, V. J., Kalari, K. R. & Kandimalla, K. K., Sep 1 2018, In : Brain. 141, 9, p. 2539-2541 3 p.

Research output: Contribution to journalComment/debate

Open Access
Brain
Genes
2017
8 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N., Jeraldo, P. R., Walther-Antonio, M. R., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L., Weinshilboum, R. L., Boughey, J. C., Kocher, J. P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PloS one. 12, 11, e0188873.

Research output: Contribution to journalArticle

Open Access
Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
2016
5 Citations (Scopus)

BBBomics-human blood brain barrier transcriptomics hub

Kalari, K. R., Thompson, K. J., Nair, A. A., Tang, X., Bockol, M. A., Jhawar, N., Swaminathan, S. K., Lowe, V. J. & Kandimalla, K. K., Mar 1 2016, In : Frontiers in Neuroscience. 10, MAR, 71.

Research output: Contribution to journalArticle

Blood-Brain Barrier
2014
33 Citations (Scopus)

Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits

Agyare, E. K., Jaruszewski, K. M., Curran, G. L., Rosenberg, J. T., Grant, S. C., Lowe, V. J., Ramakrishnan, S., Paravastu, A. K., Poduslo, J. F. & Kandimalla, K. K., Jul 10 2014, In : Journal of Controlled Release. 185, 1, p. 121-129 9 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Cerebral Amyloid Angiopathy
Amyloid
Cyclophosphamide
Gadolinium DTPA
25 Citations (Scopus)

Multimodal Nanoprobes to target cerebrovascular amyloid in Alzheimer's disease brain

Jaruszewski, K. M., Curran, G. L., Swaminathan, S. K., Rosenberg, J. T., Grant, S. C., Ramakrishnan, S., Lowe, V. J., Poduslo, J. F. & Kandimalla, K. K., Feb 1 2014, In : Biomaterials. 35, 6, p. 1967-1976 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Nanoprobes
Amyloid
Brain
Alzheimer Disease
2013
20 Citations (Scopus)

Ability of chitosan gels to disrupt bacterial biofilms and their applications in the treatment of bacterial vaginosis

Kandimalla, K. K., Borden, E., Omtri, R., Boyapati, S. P., Smith, M., Lebby, K., Mulpuru, M. & Gadde, M., Jan 1 2013, In : Journal of Pharmaceutical Sciences. 102, 7, p. 2096-2101 6 p.

Research output: Contribution to journalArticle

Bacterial Vaginosis
Chitosan
Biofilms
Gels
Coloring Agents
10 Citations (Scopus)

Traffic jam at the blood-brain barrier promotes greater accumulation of Alzheimer's disease amyloid-β proteins in the cerebral vasculature

Agyare, E. K., Leonard, S. R., Curran, G. L., Yu, C. C., Lowe, V. J., Paravastu, A. K., Poduslo, J. F. & Kandimalla, K. K., May 6 2013, In : Molecular Pharmaceutics. 10, 5, p. 1557-1565 9 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloidogenic Proteins
Blood-Brain Barrier
Alzheimer Disease
Brain
2012
16 Citations (Scopus)

Alzheimer's disease amyloid β-protein mutations and deletions that define neuronal binding/internalization as early stage nonfibrillar/fibrillar aggregates and late stage fibrils

Poduslo, J. F., Howell, K. G., Olson, N. C., Ramirez-Alvarado, M. & Kandimalla, K. K., May 15 2012, In : Biochemistry. 51, 19, p. 3993-4003 11 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Sequence Deletion
Alzheimer Disease
Rigidity
Neurons
33 Citations (Scopus)

Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein

Jaruszewski, K. M., Ramakrishnan, S., Poduslo, J. F. & Kandimalla, K. K., Feb 1 2012, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 8, 2, p. 250-260 11 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloidogenic Proteins
Chitosan
Amyloid
Nanoparticles
26 Citations (Scopus)

Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: Ramifications for the Alzheimer's drug discovery

Omtri, R., Davidson, M. W., Arumugam, B., Poduslo, J. F. & Kandimalla, K. K., Jul 2 2012, In : Molecular pharmaceutics. 9, 7, p. 1887-1897 11 p.

Research output: Contribution to journalArticle

Drug Discovery
Fluorescein
Alzheimer Disease
Neurons
Endosomes

Role of nanotechnology in the diagnosis and treatment of alzheimer's disease

Jaruszewski, K. M., Omtri, R. & Kandimalla, K. K., Dec 1 2012, Current Advances in the Medical Application of Nanotechnology. Bentham Science Publishers Ltd., p. 107-124 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanotechnology
Alzheimer Disease
Amyloid Plaques
Amyloid
Neurodegenerative diseases
2010
5 Citations (Scopus)

Biphasic flux profiles of melatonin: The Yin-Yang of transdermal permeation enhancement mediated by fatty alcohol enhancers

Kandimalla, K. K., Babu, R. J. & Singh, M., Jan 1 2010, In : Journal of Pharmaceutical Sciences. 99, 1, p. 209-218 10 p.

Research output: Contribution to journalArticle

Yin-Yang
Fatty Alcohols
Melatonin
Chemical Phenomena
Skin
19 Citations (Scopus)

HH domain of Alzheimer's disease Aβ provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neurons

Poduslo, J. F., Gilles, E. J., Ramakrishnan, M., Howell, K. G., Wengenack, T. M., Curran, G. L. & Kandimalla, K. K., Jan 21 2010, In : PloS one. 5, 1, e8813.

Research output: Contribution to journalArticle

Amyloid Plaques
amyloid
Alzheimer disease
Histidine
Amyloid
2009
53 Citations (Scopus)

Mechanism of Neuronal versus endothelial cell uptake of Alzheimer's disease amyloid β protein

Kandimalla, K. K., Scott, O. G., Fulzele, S., Davidson, M. W. & Poduslo, J. F., Jan 1 2009, In : PloS one. 4, 2, e4627.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Endothelial cells
amyloid
Alzheimer disease
endothelial cells
50 Citations (Scopus)

Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid β peptide-capturing and plaque-binding monoclonal antibodies

Ramakrishnan, M., Kandimalla, K. K., Wengenack, T. M., Howell, K. G. & Poduslo, J. F., Nov 3 2009, In : Biochemistry. 48, 43, p. 10405-10415 11 p.

Research output: Contribution to journalArticle

Surface Plasmon Resonance
Surface plasmon resonance
Amyloid
Alzheimer Disease
Monoclonal Antibodies
2008
65 Citations (Scopus)

Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy

Agyare, E. K., Curran, G. L., Ramakrishnan, M., Yu, C. C., Poduslo, J. F. & Kandimalla, K. K., Nov 1 2008, In : Pharmaceutical research. 25, 11, p. 2674-2684 11 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloid Plaques
Amyloid
Brain
Endothelial cells
37 Citations (Scopus)

Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Aβ42 for magnetic resonance molecular imaging

Ramakrishnan, M., Wengenack, T. M., Kandimalla, K. K., Curran, G. L., Gilles, E. J., Ramirez-Alvarado, M., Lin, J., Garwood, M., Jack, C. R. & Poduslo, J. F., Aug 1 2008, In : Pharmaceutical research. 25, 8, p. 1861-1872 12 p.

Research output: Contribution to journalArticle

Molecular imaging
Immunoglobulin Fragments
Molecular Imaging
Amyloid Plaques
Polyamines
2007
64 Citations (Scopus)

In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques

Poduslo, J. F., Ramakrishnan, M., Holasek, S. S., Ramirez-Alvarado, M., Kandimalla, K. K., Gilles, E. J., Curran, G. L. & Wengenack, T. M., Jul 1 2007, In : Journal of Neurochemistry. 102, 2, p. 420-433 14 p.

Research output: Contribution to journalArticle

Molecular imaging
Immunoglobulin Fragments
Molecular Imaging
Amyloid Plaques
Neurology
13 Citations (Scopus)

Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice

Kandimalla, K. K., Wengenack, T. M., Curran, G. L., Gilles, E. J. & Poduslo, J. F., Aug 1 2007, In : Journal of Pharmacology and Experimental Therapeutics. 322, 2, p. 541-549 9 p.

Research output: Contribution to journalArticle

Aptitude
Amyloid Plaques
Contrast Media
Transgenic Mice
Alzheimer Disease
2006
9 Citations (Scopus)

Physiological and biophysical factors that influence Alzheimer's disease amyloid plaque targeting of native and putrescine modified human amyloid β40

Kandimalla, K. K., Curran, G. L., Holasek, S. S., Gilles, E. J., Wengenack, T. M., Ramirez-Alvarado, M. & Poduslo, J. F., Jun 27 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Putrescine
Amyloid Plaques
Amyloid
Alzheimer Disease
Brain
2005
51 Citations (Scopus)

Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice

Holasek, S. S., Wengenack, T. M., Kandimalla, K. K., Montano, C., Gregor, D. M., Curran, G. L. & Poduslo, J. F., May 31 2005, In : Brain Research. 1045, 1-2, p. 185-198 14 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
p38 Mitogen-Activated Protein Kinases
Transgenic Mice
Phosphotransferases
27 Citations (Scopus)
Chlorpheniramine
Olfactory Mucosa
Nose
P-Glycoprotein
Brain
40 Citations (Scopus)

Localization and differential activity of P-glycoprotein in the bovine olfactory and nasal respiratory mucosae

Kandimalla, K. K. & Donovan, M. D., Jul 1 2005, In : Pharmaceutical Research. 22, 7, p. 1121-1128 8 p.

Research output: Contribution to journalArticle

Respiratory Mucosa
Nasal Mucosa
P-Glycoprotein
Etoposide
Olfactory Mucosa
47 Citations (Scopus)
Amyloidogenic Proteins
Amyloid Plaques
Blood-Brain Barrier
Transgenic Mice
Alzheimer Disease
19 Citations (Scopus)
Triprolidine
Hydroxyzine
Olfactory Mucosa
Nose
Brain
2000
189 Citations (Scopus)

Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery

Kanikkannan, N., Kandimalla, K., Lamba, S. S. & Singh, M., Jan 1 2000, In : Current Medicinal Chemistry. 7, 6, p. 593-608 16 p.

Research output: Contribution to journalReview article

Structure-Activity Relationship
Drug delivery
Skin
Pharmaceutical Preparations
Permeation
1999
48 Citations (Scopus)

Effect of fatty acids on the permeation of melatonin across rat and pig skin in-vitro and on the transepidermal water loss in rats in-vivo

Kandimalla, K., Kanikkannan, N., Andega, S. & Singh, M., Jan 1 1999, In : Journal of Pharmacy and Pharmacology. 51, 7, p. 783-790 8 p.

Research output: Contribution to journalArticle

Melatonin
Swine
Fatty Acids
Skin
Water
51 Citations (Scopus)

Optimization of a vehicle mixture for the transdermal delivery of melatonin using artificial neural networks and response surface method

Kandimalla, K. K., Kanikkannan, N. & Singh, M., Aug 27 1999, In : Journal of Controlled Release. 61, 1-2, p. 71-82 12 p.

Research output: Contribution to journalArticle

Melatonin
Aptitude
Propylene Glycol
Pineal Gland
Solubility
1998

Penetration of melatonin through rat skin using fatty acids as enhancers

Kandimalla, K. & Singh, M., Jan 1 1998, In : Proceedings of the Controlled Release Society. 25, p. 603-604 2 p.

Research output: Contribution to journalArticle

Melatonin
Fatty Acids
Skin