Karen H Ashe

1984 …2023
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Research Output 1984 2019

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Article
Open Access
Staphylococcal Protein A
Artifacts
Brain
Western Blotting
Antibodies
1048 Citations (Scopus)

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., Mcgowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., Sanders, S., Zehr, C., O'Campo, K., Hardy, J., Prada, C. M., Eckman, C., Younkin, S., Hsiao, K. & Duff, K., Apr 4 1998, In : Nature Medicine. 4, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

Presenilin-1
Amyloid beta-Protein Precursor
Mutant Proteins
Transgenes
Amyloid
298 Citations (Scopus)

Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesné, S., Ashe, K. H., Muchowski, P. J. & Mucke, L., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 23818-23828 11 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid Plaques
299 Citations (Scopus)

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy

Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K. H., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M. & Janus, C., Apr 4 2007, In : Journal of Neuroscience. 27, 14, p. 3650-3662 13 p.

Research output: Contribution to journalArticle

Tauopathies
Memory Disorders
Neurofibrillary Tangles
tau Proteins
Alzheimer Disease
824 Citations (Scopus)

Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease

Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H. & Younkin, S. G., Jan 15 2001, In : Journal of Neuroscience. 21, 2, p. 372-381 10 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Transgenic Mice
Blood Proteins
Alzheimer Disease
formic acid
329 Citations (Scopus)

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., Hutton, M. & Ashe, K. H., Nov 16 2005, In : Journal of Neuroscience. 25, 46, p. 10637-10647 11 p.

Research output: Contribution to journalArticle

Tauopathies
Neurofibrillary Tangles
Memory Disorders
Transgenes
Neocortex
193 Citations (Scopus)

Age-related amyloid β deposition in transgenic mice overexpressing both alzheimer mutant presenilin 1 and amyloid β precursor protein swedish mutant is not associated with global neuronal loss

Takeuchi, A., Irizarry, M. C., Duff, K., Saido, T. C., Ashe, K. H., Hasegawa, M., Mann, D. M. A., Hyman, B. T. & Iwatsubo, T., Jan 1 2000, In : American Journal of Pathology. 157, 1, p. 331-339 9 p.

Research output: Contribution to journalArticle

Presenilin-1
Amyloid beta-Protein Precursor
Amyloid
Transgenic Mice
Frontal Lobe
446 Citations (Scopus)

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Ashe, K. H., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H. B. & Carlson, G., Jan 1 1995, In : Neuron. 15, 5, p. 1203-1218 16 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenes
Amyloid
Cerebrum
Age of Onset
35 Citations (Scopus)

Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

Steidl, J. V., Gomez-Isla, T., Mariash, A., Ashe, K. H. & Boland, L. M., Feb 10 2003, In : Neuroreport. 14, 2, p. 219-223 5 p.

Research output: Contribution to journalArticle

Synucleins
Neuronal Plasticity
Transgenic Mice
Perforant Pathway
Long-Term Potentiation
25 Citations (Scopus)

A minute fraction of Syrian golden hamster retinal ganglion cells project bilaterally

Hsiao, K., Sachs, G. M. & Schneider, G. E., Jan 1 1984, In : Journal of Neuroscience. 4, 2, p. 259-367 109 p.

Research output: Contribution to journalArticle

Benzimidazoles
Efferent Pathways
Axonal Transport
Visual Pathways
Retinal Ganglion Cells
46 Citations (Scopus)

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

Paulson, J. B., Ramsden, M., Forster, C., Sherman, M. A., McGowan, E. & Ashe, K. H., Sep 2008, In : American Journal of Pathology. 173, 3, p. 762-772 11 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Amyloid Plaques
Transgenes
Alzheimer Disease
Pathology
488 Citations (Scopus)

Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress

Smith, M. A., Hirai, K., Ashe, K. H., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M. & Perry, G., May 1 1998, In : Journal of Neurochemistry. 70, 5, p. 2212-2215 4 p.

Research output: Contribution to journalArticle

Oxidative stress
Amyloid
Transgenic Mice
Oxidative Stress
Alzheimer Disease
151 Citations (Scopus)

Amyloid-β deposits lead to retinal degeneration in a mouse model of Alzheimer disease

Ning, A., Cui, J., To, E., Ashe, K. H. & Matsubara, J., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5136-5143 8 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Amyloid Plaques
Amyloid
Alzheimer Disease
Chemokine CCL2
241 Citations (Scopus)

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Holtzman, D. M., Fagan, A. M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S. M., Bales, K., Ashe, K. H., Irizarry, M. C. & Hyman, B. T., Jun 30 2000, In : Annals of Neurology. 47, 6, p. 739-747 9 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Apolipoproteins E
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoprotein E4
536 Citations (Scopus)

APP(Sw) transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1

Irizarry, M. C., McNamara, M., Fedorchak, K., Ashe, K. H. & Hyman, B. T., Jan 1 1997, In : Journal of Neuropathology and Experimental Neurology. 56, 9, p. 965-973 9 p.

Research output: Contribution to journalArticle

Neuropil
Amyloid Plaques
Transgenic Mice
Transgenes
Amyloid
133 Citations (Scopus)

A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome

Hsiao, K. K., Cass, C., Schellenberg, G. D., Bird, T., Devine-Gage, E., Wisniewski, H. & Prusiner, S. B., Jan 1 1991, In : Neurology. 41, 5, p. 681-684 4 p.

Research output: Contribution to journalArticle

Telencephalon
Mutation
Genes
Valine
Spouses
1 Citation (Scopus)

A proposed strategic research program for Alzheimer's disease

Ashe, K. H., Jan 1 1994, In : Neurobiology of Aging. 15, SUPPL. 2, p. 113-115 3 p.

Research output: Contribution to journalArticle

Animal Disease Models
Amyloid beta-Protein Precursor
Alzheimer Disease
Research

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

Smith, B. R., Nelson, K. M., Kemper, L. J., Leinonen-Wright, K., Petersen, A., Keene, C. D. & Ashe, K. H., Jul 30 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Caspase 2
Lewy Body Disease
Dementia
Lewy Bodies
Parkinson Disease

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients

Liu, P., Smith, B. R., Huang, E. S., Mahesh, A., Vonsattel, J. P. G., Petersen, A. J., Gomez-Pastor, R. & Ashe, K. H., Jul 30 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Caspase 2
Huntington Disease
Brain Diseases
Neurodegenerative Diseases
Trinucleotide Repeat Expansion
2138 Citations (Scopus)

A specific amyloid-β protein assembly in the brain impairs memory

Lesne, S. E., Ming, T. K., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Mar 16 2006, In : Nature. 440, 7082, p. 352-357 6 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Alzheimer Disease
Brain
Amyloid
Amyloidogenic Proteins
16 Citations (Scopus)

A tale about tau

Ashe, K. H., Aug 30 2007, In : New England Journal of Medicine. 357, 9

Research output: Contribution to journalArticle

tau Proteins
Memory Disorders
Mutant Proteins
Amyloid
175 Citations (Scopus)

Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

Niwa, K., Younkin, L., Ebeling, C., Turner, S. K., Westaway, D., Younkin, S., Ashe, K. H., Carlson, G. A. & Iadecola, C., Aug 15 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 17, p. 9735-9740 6 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Amyloid beta-Protein Precursor
Neocortex
Hyperemia
Presenilin-1
280 Citations (Scopus)

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits

Holcomb, L. A., Gordon, M. N., Jantzen, P., Ashe, K. H., Duff, K. & Morgan, D., Nov 6 1999, In : Behavior genetics. 29, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

Presenilin-1
Amyloid beta-Protein Precursor
Amyloid Plaques
amyloid
Transgenic Mice
34 Citations (Scopus)
Ocular Physiological Phenomena
Benzimidazoles
Efferent Pathways
Axonal Transport
Visual Pathways
236 Citations (Scopus)

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Lesné, S. E., Sherman, M. A., Grant, M., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Ashe, K. H., Jan 1 2013, In : Brain. 136, 5, p. 1383-1398 16 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Brain
Microtubule Proteins
tau Proteins
44 Citations (Scopus)

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K. R., Ramsden, M., Cleary, J. & Ashe, K. H., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1268-1276 9 p.

Research output: Contribution to journalArticle

Caspase 2
Tauopathies
Dendritic Spines
Alzheimer Disease
Data storage equipment
64 Citations (Scopus)

Caveolin-3 upregulation activates β-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease

Nishiyama, K., Trapp, B. D., Ikezu, T., Ransohoff, R. M., Tomita, T., Iwatsubo, T., Kanazawa, I., Ashe, K. H., Lisanti, M. P. & Okamoto, T., Aug 1 1999, In : Journal of Neuroscience. 19, 15, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

Caveolin 3
Amyloid Precursor Protein Secretases
Amyloid beta-Protein Precursor
Alzheimer Disease
Presenilins
12 Citations (Scopus)

Characterization of a novel mouse model of Alzheimer's disease - Amyloid pathology and unique β-amyloid oligomer profile

Liu, P., Paulson, J. B., Forster, C. L., Shapiro, S. L., Ashe, K. H. & Zahs, K. R., May 6 2015, In : PloS one. 10, 5, e0126317.

Research output: Contribution to journalArticle

Pathology
amyloid
Alzheimer disease
Tetracycline
Oligomers
90 Citations (Scopus)

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Reed, M. N., Hofmeister, J. J., Jungbauer, L., Welzel, A. T., Yu, C., Sherman, M. A., Lesne, S. E., LaDu, M. J., Walsh, D. M., Ashe, K. H. & Cleary, J. P., Oct 1 2011, In : Neurobiology of Aging. 32, 10, p. 1784-1794 11 p.

Research output: Contribution to journalArticle

Brain
Amyloid
Cognition
Transgenic Mice
Uncertainty
51 Citations (Scopus)

Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults

Handoko, M., Grant, M., Kuskowski, M. A., Zahs, K. R., Wallin, A., Blennow, K. & Ashe, K. H., Jan 1 2013, In : JAMA Neurology. 70, 5, p. 594-599 6 p.

Research output: Contribution to journalArticle

Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Sampling Studies
Investigational Therapies
3333 Citations (Scopus)

Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice

Ashe, K. H., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. & Cole, G., Oct 15 1996, In : Science. 274, 5284, p. 99-102 4 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Amyloid Plaques
Memory Disorders
Transgenic Mice
Congo Red
157 Citations (Scopus)

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., Lesne, S. E., Falinska, A., Younkin, L. H., Younkin, S. G., Rowan, M., Cleary, J., Wallis, R. A., Sun, G. Y., Cole, G., Frautschy, S., Anwyl, R. & Ashe, K. H., Mar 1 2008, In : Brain. 131, 3, p. 651-664 14 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Non-Steroidal Anti-Inflammatory Agents
Cyclooxygenase 2
Amyloid
Serum Amyloid A Protein
254 Citations (Scopus)

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H. & Younkin, S. G., Apr 14 2004, In : Journal of Neuroscience. 24, 15, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Apolipoproteins E
Alzheimer Disease
Lipids
Brain
561 Citations (Scopus)

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Sep 2 2004, In : Neuron. 43, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Omega-3 Fatty Acids
Alzheimer Disease
Pathology
Actins
24 Citations (Scopus)

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Reed, M. N., Liu, P., Kotilinek, L. A. & Ashe, K. H., Sep 1 2010, In : Behavioural Brain Research. 212, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

Memory Disorders
Water
Alzheimer Disease
230 Citations (Scopus)

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

Benzing, W. C., Wujek, J. R., Ward, E. K., Shaffer, D., Ashe, K. H., Younkin, S. G. & Brunden, K. R., Nov 1 1999, In : Neurobiology of Aging. 20, 6, p. 581-589 9 p.

Research output: Contribution to journalArticle

Neuroglia
Transgenic Mice
Alzheimer Disease
Inflammation
Interleukin-1
301 Citations (Scopus)

Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

Pappolla, M. A., Chyan, Y. J., Omar, R. A., Hsiao, K., Perry, G., Smith, M. A. & Bozner, P., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 871-877 7 p.

Research output: Contribution to journalArticle

Amyloid
Transgenic Mice
Alzheimer Disease
Oxidative Stress
Antioxidants
221 Citations (Scopus)

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

Breitner, J. C., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. E., Green, R. C., Ismail, M. S., Martin, B. K., Mullan, M. J., Sabbagh, M. & Tariot, P. N., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 402-411 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Anti-Inflammatory Agents
Naproxen
Pharmaceutical Preparations
Cerebrospinal Fluid
1 Citation (Scopus)
Open Access
Tauopathies
phenotype
Trans-Activators
Tetracycline
Transgenes
82 Citations (Scopus)

Genes contributing to prion pathogenesis

Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., Groth, D. F., Yehiely, F., Korth, C., Moore, R. C., Tatzelt, J., Rubinstein, E., Boucheix, C., Yang, X., Stanley, P., Lisanti, M. P., Dwek, R. A., Rudd, P. M., Moskovitz, J., Epstein, C. J. & 13 others, Cruz, T. D., Kuziel, W. A., Maeda, N., Sap, J., Ashe, K. H., Carlson, G. A., Tesseur, I., Wyss-Coray, T., Mucke, L., Weisgraber, K. H., Mahley, R. W., Cohen, F. E. & Prusiner, S. B., Jul 1 2008, In : Journal of General Virology. 89, 7, p. 1777-1778 2 p.

Research output: Contribution to journalArticle

Prions
Prion Diseases
Genes
Protein Isoforms
Interleukin-1 Type I Receptors
133 Citations (Scopus)

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice

Carlson, G. A., Borchelt, D. R., Dake, A., Turner, S., Danielson, V., Coffin, J. D., Eckman, C., Meiners, J., Nilsen, S. P., Younkin, S. G. & Ashe, K. H., Oct 1 1997, In : Human molecular genetics. 6, 11, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenic Mice
Phenotype
Transgenes
Premature Mortality
6 Citations (Scopus)

Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau

Orr, M. E., Pitstick, R., Canine, B., Ashe, K. H. & Carlson, G. A., Jun 18 2012, In : PloS one. 7, 6, e39328.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Phosphorylation
dementia
Neurology
Stem cells
33 Citations (Scopus)

Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein

Cha, J. H. J., Farrell, L. A., Ahmed, S. F., Frey, A., Ashe, K. H., Young, A. B., Penney, J. B., Locascio, J. J., Hyman, B. T. & Irizarry, M. C., Jan 1 2001, In : Neurobiology of Disease. 8, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Glutamate Receptors
Transgenic Mice
Hippocampus
Amyloid
31 Citations (Scopus)

Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice

Liu, P., Kemper, L. J., Wang, J., Zahs, K. R., Ashe, K. H. & Pasinetti, G. M., Jan 1 2011, In : Journal of Alzheimer's Disease. 26, 4, p. 657-666 10 p.

Research output: Contribution to journalArticle

Grape Seed Extract
Alzheimer Disease
Brain
Transgenic Mice
Amyloid beta-Protein Precursor

Human cerebrospinal fluid 6E10- immunoreactive protein species contain amyloid precursor protein fragments

Grant, M. K. O., Handoko, M., Rozga, M., Brinkmalm, G., Portelius, E., Blennow, K., Ashe, K. H., Zahs, K. R. & Liu, P., Feb 1 2019, In : PloS one. 14, 2, e0212815.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
Amyloid beta-Protein Precursor
cerebrospinal fluid
amyloid
Cerebrospinal Fluid
230 Citations (Scopus)

Human prion diseases

Prusiner, S. B. & Ashe, K. H., Jan 1 1994, In : Annals of Neurology. 35, 4, p. 385-395 11 p.

Research output: Contribution to journalArticle

Prion Diseases
Scrapie
Kuru
Bovine Spongiform Encephalopathy
Protein Isoforms
211 Citations (Scopus)

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

Lim, G. P., Yang, F., Chu, T., Gahtan, E., Ubeda, O., Beech, W., Overmier, J. B., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Dec 1 2001, In : Neurobiology of Aging. 22, 6, p. 983-991 9 p.

Research output: Contribution to journalArticle

Ibuprofen
Transgenic Mice
Pathology
Entorhinal Cortex
Amyloid beta-Protein Precursor
770 Citations (Scopus)

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for alzheimer's disease

Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., Tran, T., Ubeda, O., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Aug 1 2000, In : Journal of Neuroscience. 20, 15, p. 5709-5714 6 p.

Research output: Contribution to journalArticle

Ibuprofen
Alzheimer Disease
Pathology
Inflammation
Amyloid Plaques
17 Citations (Scopus)

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression

Krezowski, J., Knudson, D., Ebeling, C., Pitstick, R., Giri, R. K., Schenk, D., Westaway, D., Younkin, L., Younkin, S. G., Ashe, K. H. & Carlson, G. A., Sep 15 2004, In : Human molecular genetics. 13, 18, p. 1989-1997 9 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transgenes
Chromosomes, Human, Pair 14
Peptides
Amyloid Plaques
748 Citations (Scopus)

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., Younkin, S. G. & Ashe, K. H., Mar 1 1999, In : Nature neuroscience. 2, 3, p. 271-276 6 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Long-Term Potentiation
Amyloid beta-Protein Precursor
Transgenic Mice
Learning