Karen H Ashe

1984 …2023

Research output per year

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Research Output

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Article
2019
Open Access
Open Access
1 Scopus citations
Open Access
2 Scopus citations
Open Access
5 Scopus citations

Human cerebrospinal fluid 6E10- immunoreactive protein species contain amyloid precursor protein fragments

Grant, M. K. O., Handoko, M., Rozga, M., Brinkmalm, G., Portelius, E., Blennow, K., Ashe, K. H., Zahs, K. R. & Liu, P., Feb 2019, In : PloS one. 14, 2, e0212815.

Research output: Contribution to journalArticle

Open Access

Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction

Teravskis, P. J., Oxnard, B. R., Miller, E. C., Kemper, L. J., Ashe, K. H. & Liao, D., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Lo, C. H., Lim, C. K. W., Ding, Z., Wickramasinghe, S. P., Braun, A. R., Ashe, K. H., Rhoades, E., Thomas, D. D. & Sachs, J. N., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice

Liu, P., Reichl, J. H., Rao, E. R., McNellis, B. M., Huang, E. S., Hemmy, L. S., Forster, C. L., Kuskowski, M. A., Borchelt, D. R., Vassar, R., Ashe, K. H. & Zahs, K. R., Jan 1 2017, In : Journal of Alzheimer's Disease. 56, 2, p. 743-761 19 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2016

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J. & Ashe, K. H., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1268-1276 9 p.

Research output: Contribution to journalArticle

52 Scopus citations
2015

Characterization of a novel mouse model of Alzheimer's disease - Amyloid pathology and unique β-amyloid oligomer profile

Liu, P., Paulson, J. B., Forster, C. L., Shapiro, S. L., Ashe, K. H. & Zahs, K. R., May 6 2015, In : PloS one. 10, 5, e0126317.

Research output: Contribution to journalArticle

13 Scopus citations

Morris water maze test: Optimization for mouse strain and testing environment

Weitzner, D. S., Engler-Chiurazzi, E. B., Kotilinek, L. A., Ashe, K. H. & Reed, M. N., Jun 22 2015, In : Journal of Visualized Experiments. 2015, 100, e52706.

Research output: Contribution to journalArticle

19 Scopus citations

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

Liu, P., Reed, M. N., Kotilinek, L. A., Grant, M. K. O., Forster, C. L., Qiang, W., Shapiro, S. L., Reichl, J. H., Chiang, A. C. A., Jankowsky, J. L., Wilmot, C. M., Cleary, J. P., Zahs, K. R. & Ashe, K. H., Jun 23 2015, In : Cell reports. 11, 11, p. 1760-1771 12 p.

Research output: Contribution to journalArticle

74 Scopus citations
2014

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents

Qi, Y., Klyubin, I., Harney, S. C., Hu, N. W., Cullen, W. K., Grant, M. K., Steffen, J., Wilson, E. N., Do Carmo, S., Remy, S., Fuhrmann, M., Ashe, K. H., Cuello, A. C. & Rowan, M. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 175.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Lesné, S. E., Sherman, M. A., Grant, M., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Ashe, K. H., May 2013, In : Brain. 136, 5, p. 1383-1398 16 p.

Research output: Contribution to journalArticle

245 Scopus citations

Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults

Handoko, M., Grant, M., Kuskowski, M., Zahs, K. R., Wallin, A., Blennow, K. & Ashe, K. H., May 2013, In : JAMA Neurology. 70, 5, p. 594-599 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Prions, prionoids and pathogenic proteins in Alzheimer disease

Ashe, K. H. & Aguzzi, A., Jan 1 2013, In : Prion. 7, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

59 Scopus citations

β-Amyloid oligomers in aging and alzheimer's disease

Zahs, K. R. & Ashe, K. H., Sep 12 2013, In : Frontiers in Aging Neuroscience. 5, JUL, article 28.

Research output: Contribution to journalArticle

40 Scopus citations
2012

Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau

Orr, M. E., Pitstick, R., Canine, B., Ashe, K. H. & Carlson, G. A., Jun 18 2012, In : PloS one. 7, 6, e39328.

Research output: Contribution to journalArticle

7 Scopus citations

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

De Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L. & Hyman, B. T., Feb 23 2012, In : Neuron. 73, 4, p. 685-697 13 p.

Research output: Contribution to journalArticle

735 Scopus citations
2011

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Reed, M. N., Hofmeister, J. J., Jungbauer, L., Welzel, A. T., Yu, C., Sherman, M. A., Lesné, S., LaDu, M. J., Walsh, D. M., Ashe, K. H. & Cleary, J. P., Oct 1 2011, In : Neurobiology of Aging. 32, 10, p. 1784-1794 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

Breitner, J. C., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. E., Green, R. C., Ismail, M. S., Martin, B. K., Mullan, M. J., Sabbagh, M. & Tariot, P. N., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 402-411 10 p.

Research output: Contribution to journalArticle

225 Scopus citations

Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice

Liu, P., Kemper, L. J., Wang, J., Zahs, K. R., Ashe, K. H. & Pasinetti, G. M., 2011, In : Journal of Alzheimer's Disease. 26, 4, p. 657-666 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Reed, M. N., Liu, P., Kotilinek, L. A. & Ashe, K. H., Sep 1 2010, In : Behavioural Brain Research. 212, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., Pitstick, R., Carlson, G. A., Lanier, L. M., Yuan, L. L., Ashe, K. H. & Liao, D., Dec 22 2010, In : Neuron. 68, 6, p. 1067-1081 15 p.

Research output: Contribution to journalArticle

425 Scopus citations
2008

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

Paulson, J. B., Ramsden, M., Forster, C., Sherman, M. A., McGowan, E. & Ashe, K. H., Sep 2008, In : American Journal of Pathology. 173, 3, p. 762-772 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Amyloid-β deposits lead to retinal degeneration in a mouse model of Alzheimer disease

Ning, A., Cui, J., To, E., Ashe, K. H. & Matsubara, J., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5136-5143 8 p.

Research output: Contribution to journalArticle

154 Scopus citations

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., Lesne, S., Falinska, A., Younkin, L. H., Younkin, S. G., Rowan, M., Cleary, J., Wallis, R. A., Sun, G. Y., Cole, G., Frautschy, S., Anwyl, R. & Ashe, K. H., Mar 1 2008, In : Brain. 131, 3, p. 651-664 14 p.

Research output: Contribution to journalArticle

160 Scopus citations

Genes contributing to prion pathogenesis

Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., Groth, D. F., Yehiely, F., Korth, C., Moore, R. C., Tatzelt, J., Rubinstein, E., Boucheix, C., Yang, X., Stanley, P., Lisanti, M. P., Dwek, R. A., Rudd, P. M., Moskovitz, J., Epstein, C. J. & 13 others, Cruz, T. D., Kuziel, W. A., Maeda, N., Sap, J., Ashe, K. H., Carlson, G. A., Tesseur, I., Wyss-Coray, T., Mucke, L., Weisgraber, K. H., Mahley, R. W., Cohen, F. E. & Prusiner, S. B., Jul 1 2008, In : Journal of General Virology. 89, 7, p. 1777-1778 2 p.

Research output: Contribution to journalArticle

83 Scopus citations

In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons

Spires-Jones, T. L., De Calignon, A., Matsui, T., Zehr, C., Pitstick, R., Wu, H. Y., Osetek, J. D., Jones, P. B., Bacskai, B. J., Feany, M. B., Carlson, G. A., Ashe, K. H., Lewis, J. & Hyman, B. T., Jan 23 2008, In : Journal of Neuroscience. 28, 4, p. 862-867 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures

Poling, A., Morgan-Paisley, K., Panos, J. J., Kim, E. M., O'Hare, E., Cleary, J. P., Lesné, S., Ashe, K. H., Porritt, M. & Baker, L. E., Nov 21 2008, In : Behavioural Brain Research. 193, 2, p. 230-234 5 p.

Research output: Contribution to journalArticle

65 Scopus citations

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

Lesne, S. E., Kotilinek, L. & Ashe, K. H., Feb 6 2008, In : Neuroscience. 151, 3, p. 745-749 5 p.

Research output: Contribution to journalArticle

124 Scopus citations
2007

Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesné, S., Ashe, K. H., Muchowski, P. J. & Mucke, L., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 23818-23828 11 p.

Research output: Contribution to journalArticle

303 Scopus citations

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy

Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M. & Janus, C., Apr 4 2007, In : Journal of Neuroscience. 27, 14, p. 3650-3662 13 p.

Research output: Contribution to journalArticle

309 Scopus citations

A tale about tau

Ashe, K. H., Aug 30 2007, In : New England Journal of Medicine. 357, 9

Research output: Contribution to journalArticle

16 Scopus citations

Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

Huifang, M., Lesné, S., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M., Younkin, L., Younkin, S., Forster, C., Sergeant, N., Delacourte, A., Vassar, R., Citron, M., Kofuji, P., Boland, L. M. & Ashe, K. H., May 8 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 19, p. 8167-8172 6 p.

Research output: Contribution to journalArticle

87 Scopus citations
2006

A specific amyloid-β protein assembly in the brain impairs memory

Lesne, S. E., Ming, T. K., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Mar 16 2006, In : Nature. 440, 7082, p. 352-357 6 p.

Research output: Contribution to journalArticle

2172 Scopus citations

In search of the molecular basis of memory loss in Alzheimer disease

Ashe, K. H., Oct 1 2006, In : Alzheimer disease and associated disorders. 20, 4, p. 200-201 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular basis of memory loss in the TG2576 mouse model of Alzheimer's disease

Ashe, K. H., Jul 2006, In : Journal of Alzheimer's Disease. 9, SUPPL. 3, p. 123-126 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

Spires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H. & Hyman, B. T., May 2006, In : American Journal of Pathology. 168, 5, p. 1598-1607 10 p.

Research output: Contribution to journalArticle

255 Scopus citations
2005

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., Hutton, M. & Ashe, K. H., Nov 16 2005, In : Journal of Neuroscience. 25, 46, p. 10637-10647 11 p.

Research output: Contribution to journalArticle

341 Scopus citations

Mechanisms of memory loss in Aβ and tau mouse models

Ashe, K. H., Aug 1 2005, In : Biochemical Society transactions. 33, 4, p. 591-594 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

Medicine: Tau suppression in a neurodegenerative mouse model improves memory function

Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McCowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M. & Ashe, K. H., Jul 15 2005, In : Science. 309, 5733, p. 476-481 6 p.

Research output: Contribution to journalArticle

1257 Scopus citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J. & Ashe, K. H., Jan 1 2005, In : Nature neuroscience. 8, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

1342 Scopus citations

The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention

Walsh, D. M., Klyubin, I., Shankar, G. M., Townsend, M., Fadeeva, J. V., Betts, V., Podlisny, M. B., Cleary, J. P., Ashe, K. H., Rowan, M. J. & Selkoe, D. J., Nov 1 2005, In : Biochemical Society transactions. 33, 5, p. 1087-1090 4 p.

Research output: Contribution to journalArticle

178 Scopus citations
2004

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H. & Younkin, S. G., Apr 14 2004, In : Journal of Neuroscience. 24, 15, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

257 Scopus citations

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Sep 2 2004, In : Neuron. 43, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

567 Scopus citations

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression

Krezowski, J., Knudson, D., Ebeling, C., Pitstick, R., Giri, R. K., Schenk, D., Westaway, D., Younkin, L., Younkin, S. G., Ashe, K. H. & Carlson, G. A., Sep 15 2004, In : Human molecular genetics. 13, 18, p. 1989-1997 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2003

Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

Steidl, J. V., Gomez-Isla, T., Mariash, A., Ashe, K. H. & Boland, L. M., Feb 10 2003, In : Neuroreport. 14, 2, p. 219-223 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Motor dysfunction and gliosis with preserved dopaminergic markers in human α-synuclein A30P transgenic mice

Gomez-Isla, T., Irizarry, M. C., Mariash, A., Cheung, B., Soto, O., Schrump, S., Sondel, J., Kotilinek, L., Day, J., Schwarzschild, M. A., Cha, J. H. J., Newell, K., Miller, D. W., Uéda, K., Young, A. B., Hyman, B. T. & Ashe, K. H., Mar 1 2003, In : Neurobiology of Aging. 24, 2, p. 245-258 14 p.

Research output: Contribution to journalArticle

143 Scopus citations
2002

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

Urbanc, B., Cruz, L., Le, R., Sanders, J., Hsiao Ashe, K., Duff, K., Stanley, H. E., Irizarry, M. C. & Hyman, B. T., Oct 29 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 22, p. 13990-13995 6 p.

Research output: Contribution to journalArticle

164 Scopus citations