Karen H Ashe

1984 …2020

Research output per year

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Research Output

2005

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., Hutton, M. & Ashe, K. H., Nov 16 2005, In : Journal of Neuroscience. 25, 46, p. 10637-10647 11 p.

Research output: Contribution to journalArticle

364 Scopus citations

Mechanisms of memory loss in Aβ and tau mouse models

Ashe, K. H., Aug 1 2005, In : Biochemical Society transactions. 33, 4, p. 591-594 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

Medicine: Tau suppression in a neurodegenerative mouse model improves memory function

Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McCowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M. & Ashe, K. H., Jul 15 2005, In : Science. 309, 5733, p. 476-481 6 p.

Research output: Contribution to journalArticle

1315 Scopus citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J. & Ashe, K. H., Jan 1 2005, In : Nature neuroscience. 8, 1, p. 79-84 6 p.

Research output: Contribution to journalArticle

1366 Scopus citations

The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention

Walsh, D. M., Klyubin, I., Shankar, G. M., Townsend, M., Fadeeva, J. V., Betts, V., Podlisny, M. B., Cleary, J. P., Ashe, K. H., Rowan, M. J. & Selkoe, D. J., Nov 2005, In : Biochemical Society transactions. 33, 5, p. 1087-1090 4 p.

Research output: Contribution to journalArticle

181 Scopus citations
2004

Creating APP transgenic lines in mice

Iyadurai, S. J. P. & Ashe, K. H., Jan 1 2004, Amyloid Precursor Protein: A Practical Approach. CRC Press, p. 185-200 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H. & Younkin, S. G., Apr 14 2004, In : Journal of Neuroscience. 24, 15, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

263 Scopus citations

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Sep 2 2004, In : Neuron. 43, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

580 Scopus citations

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression

Krezowski, J., Knudson, D., Ebeling, C., Pitstick, R., Giri, R. K., Schenk, D., Westaway, D., Younkin, L., Younkin, S. G., Ashe, K. H. & Carlson, G. A., Sep 15 2004, In : Human molecular genetics. 13, 18, p. 1989-1997 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2003

Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

Steidl, J. V., Gomez-Isla, T., Mariash, A., Ashe, K. H. & Boland, L. M., Feb 10 2003, In : Neuroreport. 14, 2, p. 219-223 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Motor dysfunction and gliosis with preserved dopaminergic markers in human α-synuclein A30P transgenic mice

Gomez-Isla, T., Irizarry, M. C., Mariash, A., Cheung, B., Soto, O., Schrump, S., Sondel, J., Kotilinek, L., Day, J., Schwarzschild, M. A., Cha, J. H. J., Newell, K., Miller, D. W., Uéda, K., Young, A. B., Hyman, B. T. & Ashe, K. H., Mar 1 2003, In : Neurobiology of Aging. 24, 2, p. 245-258 14 p.

Research output: Contribution to journalArticle

146 Scopus citations
2002

Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease

Urbanc, B., Cruz, L., Le, R., Sanders, J., Hsiao Ashe, K., Duff, K., Stanley, H. E., Irizarry, M. C. & Hyman, B. T., Oct 29 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 22, p. 13990-13995 6 p.

Research output: Contribution to journalArticle

164 Scopus citations

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

Kotilinek, L. A., Bacskai, B., Westerman, M., Kawarabayashi, T., Younkin, L., Hyman, B. T., Younkin, S. & Ashe, K. H., Aug 1 2002, In : Journal of Neuroscience. 22, 15, p. 6331-6335 5 p.

Research output: Contribution to journalArticle

Open Access
374 Scopus citations

The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease

Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G. & Ashe, K. H., Mar 1 2002, In : Journal of Neuroscience. 22, 5, p. 1858-1867 10 p.

Research output: Contribution to journalArticle

Open Access
589 Scopus citations
2001

Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease

Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H. & Younkin, S. G., Jan 15 2001, In : Journal of Neuroscience. 21, 2, p. 372-381 10 p.

Research output: Contribution to journalArticle

Open Access
839 Scopus citations

Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein

Cha, J. H. J., Farrell, L. A., Ahmed, S. F., Frey, A., Hsiao-Ashe, K. K., Young, A. B., Penney, J. B., Locascio, J. J., Hyman, B. T. & Irizarry, M. C., Jan 1 2001, In : Neurobiology of Disease. 8, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

Lim, G. P., Yang, F., Chu, T., Gahtan, E., Ubeda, O., Beech, W., Overmier, J. B., Hsiao-Ashec, K., Frautschy, S. A. & Cole, G. M., Dec 1 2001, In : Neurobiology of Aging. 22, 6, p. 983-991 9 p.

Research output: Contribution to journalArticle

214 Scopus citations

Induction of NADPH cytochrome P450 reductase by the Alzheimer β-protein. Amyloid as a 'foreign body'

Pappolla, M. A., Omar, R. A., Chyan, Y. J., Ghiso, J., Hsiao, K., Bozner, P., Perry, G., Smith, M. A. & Cruz-Sanchez, F., Jul 19 2001, In : Journal of Neurochemistry. 78, 1, p. 121-128 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Learning and memory in transgenic mice modeling Alzheimer's disease

Ashe, K. H., Dec 1 2001, In : Learning and Memory. 8, 6, p. 301-308 8 p.

Research output: Contribution to journalReview article

206 Scopus citations

Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: Implications for neural system disruption

Le, R., Cruz, L., Urbanc, B., Knowles, R. B., Hsiao-Ashe, K., Duff, K., Irizarry, M. C., Stanley, H. E. & Hyman, B. T., Jan 1 2001, In : Journal of neuropathology and experimental neurology. 60, 8, p. 753-758 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

β-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: In Vitro and in Vivo mechanisms related to Alzheimer's disease

Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H. & Sweatt, J. D., Jun 15 2001, In : Journal of Neuroscience. 21, 12, p. 4125-4133 9 p.

Research output: Contribution to journalArticle

448 Scopus citations
2000

Age-related amyloid β deposition in transgenic mice overexpressing both alzheimer mutant presenilin 1 and amyloid β precursor protein swedish mutant is not associated with global neuronal loss

Takeuchi, A., Irizarry, M. C., Duff, K., Saido, T. C., Ashe, K. H., Hasegawa, M., Mann, D. M. A., Hyman, B. T. & Iwatsubo, T., Jan 1 2000, In : American Journal of Pathology. 157, 1, p. 331-339 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Holtzman, D. M., Fagan, A. M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S. M., Bales, K., Ashe, K. H., Irizarry, M. C. & Hyman, B. T., Jun 30 2000, In : Annals of Neurology. 47, 6, p. 739-747 9 p.

Research output: Contribution to journalArticle

246 Scopus citations

Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

Niwa, K., Younkin, L., Ebeling, C., Turner, S. K., Westaway, D., Younkin, S., Ashe, K. H., Carlson, G. A. & Iadecola, C., Aug 15 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 17, p. 9735-9740 6 p.

Research output: Contribution to journalArticle

186 Scopus citations

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for alzheimer's disease

Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., Tran, T., Ubeda, O., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Aug 1 2000, In : Journal of Neuroscience. 20, 15, p. 5709-5714 6 p.

Research output: Contribution to journalArticle

Open Access
786 Scopus citations

Plaque-associated α-synuclein (NACP) pathology in aged transgenic mice expressing amyloid precursor protein

Yang, F., Uéda, K., Chen, P. P., Ashe, K. H. & Cole, G. M., Jan 24 2000, In : Brain Research. 853, 2, p. 381-383 3 p.

Research output: Contribution to journalArticle

51 Scopus citations

Synaptic structure and function in transgenic APP mice

Ashe, K. H., Jan 1 2000, In : Annals of the New York Academy of Sciences. 924, p. 39-41 3 p.

Research output: Contribution to journalArticle

11 Scopus citations
1999

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits

Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K. & Morgan, D., Nov 6 1999, In : Behavior genetics. 29, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

286 Scopus citations

Caveolin-3 upregulation activates β-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease

Nishiyama, K., Trapp, B. D., Ikezu, T., Ransohoff, R. M., Tomita, T., Iwatsubo, T., Kanazawa, I., Hsiao, K. K., Lisanti, M. P. & Okamoto, T., Aug 1 1999, In : Journal of Neuroscience. 19, 15, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

Benzing, W. C., Wujek, J. R., Ward, E. K., Shaffer, D., Ashe, K. H., Younkin, S. G. & Brunden, K. R., Nov 1 1999, In : Neurobiology of Aging. 20, 6, p. 581-589 9 p.

Research output: Contribution to journalArticle

235 Scopus citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

Chapman, P. F., White, G. L., Jones, M. W., Cooper-Blacketer, D., Marshall, V. J., Irizarry, M., Younkin, L., Good, M. A., Bliss, T. V. P., Hyman, B. T., Younkin, S. G. & Ashe, K. H., Mar 1 1999, In : Nature neuroscience. 2, 3, p. 271-276 6 p.

Research output: Contribution to journalArticle

770 Scopus citations

Serum amyloid P is not present in amyloid β deposits of a transgenic animal model

Shi, J., Perry, G., Aliev, G., Smith, M. A., Ashe, K. H. & Friedland, R. P., Jan 1 1999, In : Neuroreport. 10, 15, p. 3229-3232 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S. K., Fischer, E., Younkin, S., Borchelt, D. R., Hsiao, K. K. & Carlson, G. A., Feb 1 1999, In : Nature neuroscience. 2, 2, p. 157-161 5 p.

Research output: Contribution to journalArticle

317 Scopus citations
1998

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., Mcgowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., Sanders, S., Zehr, C., O'Campo, K., Hardy, J., Prada, C. M., Eckman, C., Younkin, S., Hsiao, K. & Duff, K., Apr 4 1998, In : Nature Medicine. 4, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

1069 Scopus citations

Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress

Smith, M. A., Hirai, K., Ashe, K. H., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M. & Perry, G., May 1 1998, In : Journal of Neurochemistry. 70, 5, p. 2212-2215 4 p.

Research output: Contribution to journalArticle

496 Scopus citations

Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

Pappolla, M. A., Chyan, Y. J., Omar, R. A., Hsiao, K., Perry, G., Smith, M. A. & Bozner, P., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 871-877 7 p.

Research output: Contribution to journalArticle

306 Scopus citations

Microglial response to amyloid plaques in APPsw transgenic mice

Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B., Saido, T. C., Hsiao, K. & Cole, G. M., Jan 1 1998, In : American Journal of Pathology. 152, 1, p. 307-317 11 p.

Research output: Contribution to journalArticle

457 Scopus citations

Response to Letter to the Editor regarding JNEN 1997;56:965-73

Irizarry, M. C., Hsiao, K. & Hyman, B. T., Jan 1998, In : Journal of neuropathology and experimental neurology. 57, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Transgenic mice expressing Alzheimer amyloid precursor proteins

Ashe, K. H., Nov 1 1998, In : Experimental Gerontology. 33, 7-8, p. 883-889 7 p.

Research output: Contribution to journalArticle

99 Scopus citations
1997

APP(Sw) transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1

Irizarry, M. C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B. T., Sep 1997, In : Journal of neuropathology and experimental neurology. 56, 9, p. 965-973 9 p.

Research output: Contribution to journalArticle

546 Scopus citations

From prion diseases to Alzheimer's disease

Hsiao, K. K., Jan 1 1997, In : Journal of Neural Transmission, Supplement. 49, p. 135-144 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice

Carlson, G. A., Borchelt, D. R., Dake, A., Turner, S., Danielson, V., Coffin, J. D., Eckman, C., Meiners, J., Nilsen, S. P., Younkin, S. G. & Hsiao, K. K., Oct 1997, In : Human molecular genetics. 6, 11, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein

Zhang, F., Eckman, C., Younkin, S., Hsiao, K. K. & Iadecola, C., 1997, In : Journal of Neuroscience. 17, 20, p. 7655-7661 7 p.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations
1996

Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. & Cole, G., Oct 15 1996, In : Science. 274, 5284, p. 99-102 4 p.

Research output: Contribution to journalArticle

3412 Scopus citations
1995

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Ashe, K. H., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H. B. & Carlson, G., Nov 1995, In : Neuron. 15, 5, p. 1203-1218 16 p.

Research output: Contribution to journalArticle

453 Scopus citations

Understanding the biology of β-amyloid precursor proteins in transgenic mice

Hsiao, K. K., Jan 1 1995, In : Neurobiology of Aging. 16, 4, p. 705-706 2 p.

Research output: Contribution to journalArticle

6 Scopus citations
1994

A proposed strategic research program for Alzheimer's disease

Hsiao, K., 1994, In : Neurobiology of Aging. 15, SUPPL. 2, p. 113-115 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human prion diseases

Prusiner, S. B. & Hsiao, K. K., Apr 1994, In : Annals of Neurology. 35, 4, p. 385-395 11 p.

Research output: Contribution to journalArticle

230 Scopus citations

Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein

Hsiao, K. K., Groth, D., Scott, M., Yang, S. L., Serban, H., Rapp, D., Foster, D., Torchia, M., DeArmond, S. J. & Prusiner, S. B., Sep 13 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 19, p. 9126-9130 5 p.

Research output: Contribution to journalArticle

263 Scopus citations