Karen H Ashe

1984 …2020

Research output per year

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Research Output

Article
Open Access

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Holcomb, L., Gordon, M. N., Mcgowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., Sanders, S., Zehr, C., O'Campo, K., Hardy, J., Prada, C. M., Eckman, C., Younkin, S., Hsiao, K. & Duff, K., Apr 4 1998, In : Nature Medicine. 4, 1, p. 97-100 4 p.

Research output: Contribution to journalArticle

1069 Scopus citations

Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesné, S., Ashe, K. H., Muchowski, P. J. & Mucke, L., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 23818-23828 11 p.

Research output: Contribution to journalArticle

309 Scopus citations

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy

Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M. & Janus, C., Apr 4 2007, In : Journal of Neuroscience. 27, 14, p. 3650-3662 13 p.

Research output: Contribution to journalArticle

322 Scopus citations

Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease

Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H. & Younkin, S. G., Jan 15 2001, In : Journal of Neuroscience. 21, 2, p. 372-381 10 p.

Research output: Contribution to journalArticle

Open Access
839 Scopus citations

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., Hutton, M. & Ashe, K. H., Nov 16 2005, In : Journal of Neuroscience. 25, 46, p. 10637-10647 11 p.

Research output: Contribution to journalArticle

364 Scopus citations

Age-related amyloid β deposition in transgenic mice overexpressing both alzheimer mutant presenilin 1 and amyloid β precursor protein swedish mutant is not associated with global neuronal loss

Takeuchi, A., Irizarry, M. C., Duff, K., Saido, T. C., Ashe, K. H., Hasegawa, M., Mann, D. M. A., Hyman, B. T. & Iwatsubo, T., Jan 1 2000, In : American Journal of Pathology. 157, 1, p. 331-339 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

Ashe, K. H., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecola, C., Clark, H. B. & Carlson, G., Nov 1995, In : Neuron. 15, 5, p. 1203-1218 16 p.

Research output: Contribution to journalArticle

453 Scopus citations

Altered short-term hippocampal synaptic plasticity in mutant α-synuclein transgenic mice

Steidl, J. V., Gomez-Isla, T., Mariash, A., Ashe, K. H. & Boland, L. M., Feb 10 2003, In : Neuroreport. 14, 2, p. 219-223 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

A minute fraction of Syrian golden hamster retinal ganglion cells project bilaterally

Hsiao, K., Sachs, G. M. & Schneider, G. E., 1984, In : Journal of Neuroscience. 4, 2, p. 259-367 109 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

Paulson, J. B., Ramsden, M., Forster, C., Sherman, M. A., McGowan, E. & Ashe, K. H., Sep 2008, In : American Journal of Pathology. 173, 3, p. 762-772 11 p.

Research output: Contribution to journalArticle

47 Scopus citations

Amyloid-β deposition in Alzheimer transgenic mice is associated with oxidative stress

Smith, M. A., Hirai, K., Ashe, K. H., Pappolla, M. A., Harris, P. L. R., Siedlak, S. L., Tabaton, M. & Perry, G., May 1 1998, In : Journal of Neurochemistry. 70, 5, p. 2212-2215 4 p.

Research output: Contribution to journalArticle

496 Scopus citations

Amyloid-β deposits lead to retinal degeneration in a mouse model of Alzheimer disease

Ning, A., Cui, J., To, E., Ashe, K. H. & Matsubara, J., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5136-5143 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model

Holtzman, D. M., Fagan, A. M., Mackey, B., Tenkova, T., Sartorius, L., Paul, S. M., Bales, K., Ashe, K. H., Irizarry, M. C. & Hyman, B. T., Jun 30 2000, In : Annals of Neurology. 47, 6, p. 739-747 9 p.

Research output: Contribution to journalArticle

246 Scopus citations

APP(Sw) transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1

Irizarry, M. C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B. T., Sep 1997, In : Journal of neuropathology and experimental neurology. 56, 9, p. 965-973 9 p.

Research output: Contribution to journalArticle

546 Scopus citations

A prion protein variant in a family with the telencephalic form of Gerstmann-Sträussler-Scheinker syndrome

Hsiao, K. K., Cass, C., Schellenberg, G. D., Bird, T., Devine-Gage, E., Wisniewski, H. & Prusiner, S. B., May 1991, In : Neurology. 41, 5, p. 681-684 4 p.

Research output: Contribution to journalArticle

134 Scopus citations

A proposed strategic research program for Alzheimer's disease

Hsiao, K., 1994, In : Neurobiology of Aging. 15, SUPPL. 2, p. 113-115 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
4 Scopus citations
Open Access
6 Scopus citations

A specific amyloid-β protein assembly in the brain impairs memory

Lesne, S. E., Ming, T. K., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Mar 16 2006, In : Nature. 440, 7082, p. 352-357 6 p.

Research output: Contribution to journalArticle

2219 Scopus citations

A tale about tau

Ashe, K. H., Aug 30 2007, In : New England Journal of Medicine. 357, 9

Research output: Contribution to journalArticle

16 Scopus citations

Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

Niwa, K., Younkin, L., Ebeling, C., Turner, S. K., Westaway, D., Younkin, S., Ashe, K. H., Carlson, G. A. & Iadecola, C., Aug 15 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 17, p. 9735-9740 6 p.

Research output: Contribution to journalArticle

186 Scopus citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits

Holcomb, L. A., Gordon, M. N., Jantzen, P., Hsiao, K., Duff, K. & Morgan, D., Nov 6 1999, In : Behavior genetics. 29, 3, p. 177-185 9 p.

Research output: Contribution to journalArticle

286 Scopus citations
Open Access
35 Scopus citations

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Lesné, S. E., Sherman, M. A., Grant, M., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Ashe, K. H., May 2013, In : Brain. 136, 5, p. 1383-1398 16 p.

Research output: Contribution to journalArticle

263 Scopus citations

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J. & Ashe, K. H., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1268-1276 9 p.

Research output: Contribution to journalArticle

62 Scopus citations

Caveolin-3 upregulation activates β-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease

Nishiyama, K., Trapp, B. D., Ikezu, T., Ransohoff, R. M., Tomita, T., Iwatsubo, T., Kanazawa, I., Hsiao, K. K., Lisanti, M. P. & Okamoto, T., Aug 1 1999, In : Journal of Neuroscience. 19, 15, p. 6538-6548 11 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Characterization of a novel mouse model of Alzheimer's disease - Amyloid pathology and unique β-amyloid oligomer profile

Liu, P., Paulson, J. B., Forster, C. L., Shapiro, S. L., Ashe, K. H. & Zahs, K. R., May 6 2015, In : PloS one. 10, 5, e0126317.

Research output: Contribution to journalArticle

14 Scopus citations

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Reed, M. N., Hofmeister, J. J., Jungbauer, L., Welzel, A. T., Yu, C., Sherman, M. A., Lesné, S., LaDu, M. J., Walsh, D. M., Ashe, K. H. & Cleary, J. P., Oct 2011, In : Neurobiology of Aging. 32, 10, p. 1784-1794 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults

Handoko, M., Grant, M., Kuskowski, M., Zahs, K. R., Wallin, A., Blennow, K. & Ashe, K. H., May 2013, In : JAMA Neurology. 70, 5, p. 594-599 6 p.

Research output: Contribution to journalArticle

52 Scopus citations

Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F. & Cole, G., Oct 15 1996, In : Science. 274, 5284, p. 99-102 4 p.

Research output: Contribution to journalArticle

3412 Scopus citations

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., Lesne, S., Falinska, A., Younkin, L. H., Younkin, S. G., Rowan, M., Cleary, J., Wallis, R. A., Sun, G. Y., Cole, G., Frautschy, S., Anwyl, R. & Ashe, K. H., Mar 2008, In : Brain. 131, 3, p. 651-664 14 p.

Research output: Contribution to journalArticle

165 Scopus citations
1 Scopus citations

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

Kawarabayashi, T., Shoji, M., Younkin, L. H., Wen-Lang, L., Dickson, D. W., Murakami, T., Matsubara, E., Abe, K., Ashe, K. H. & Younkin, S. G., Apr 14 2004, In : Journal of Neuroscience. 24, 15, p. 3801-3809 9 p.

Research output: Contribution to journalArticle

263 Scopus citations

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

Calon, F., Lim, G. P., Yang, F., Morihara, T., Teter, B., Ubeda, O., Rostaing, P., Triller, A., Salem, N., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Sep 2 2004, In : Neuron. 43, 5, p. 633-645 13 p.

Research output: Contribution to journalArticle

580 Scopus citations

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Reed, M. N., Liu, P., Kotilinek, L. A. & Ashe, K. H., Sep 1 2010, In : Behavioural Brain Research. 212, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

Benzing, W. C., Wujek, J. R., Ward, E. K., Shaffer, D., Ashe, K. H., Younkin, S. G. & Brunden, K. R., Nov 1 1999, In : Neurobiology of Aging. 20, 6, p. 581-589 9 p.

Research output: Contribution to journalArticle

235 Scopus citations

Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo

Pappolla, M. A., Chyan, Y. J., Omar, R. A., Hsiao, K., Perry, G., Smith, M. A. & Bozner, P., Apr 1 1998, In : American Journal of Pathology. 152, 4, p. 871-877 7 p.

Research output: Contribution to journalArticle

306 Scopus citations

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

Breitner, J. C., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. E., Green, R. C., Ismail, M. S., Martin, B. K., Mullan, M. J., Sabbagh, M. & Tariot, P. N., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 402-411 10 p.

Research output: Contribution to journalArticle

233 Scopus citations
Open Access
17 Scopus citations

Genes contributing to prion pathogenesis

Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., Groth, D. F., Yehiely, F., Korth, C., Moore, R. C., Tatzelt, J., Rubinstein, E., Boucheix, C., Yang, X., Stanley, P., Lisanti, M. P., Dwek, R. A., Rudd, P. M., Moskovitz, J., Epstein, C. J. & 13 others, Cruz, T. D., Kuziel, W. A., Maeda, N., Sap, J., Ashe, K. H., Carlson, G. A., Tesseur, I., Wyss-Coray, T., Mucke, L., Weisgraber, K. H., Mahley, R. W., Cohen, F. E. & Prusiner, S. B., Jul 2008, In : Journal of General Virology. 89, 7, p. 1777-1778 2 p.

Research output: Contribution to journalArticle

87 Scopus citations

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice

Carlson, G. A., Borchelt, D. R., Dake, A., Turner, S., Danielson, V., Coffin, J. D., Eckman, C., Meiners, J., Nilsen, S. P., Younkin, S. G. & Hsiao, K. K., Oct 1997, In : Human molecular genetics. 6, 11, p. 1951-1959 9 p.

Research output: Contribution to journalArticle

137 Scopus citations

Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau

Orr, M. E., Pitstick, R., Canine, B., Ashe, K. H. & Carlson, G. A., Jun 18 2012, In : PloS one. 7, 6, e39328.

Research output: Contribution to journalArticle

7 Scopus citations

Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein

Cha, J. H. J., Farrell, L. A., Ahmed, S. F., Frey, A., Hsiao-Ashe, K. K., Young, A. B., Penney, J. B., Locascio, J. J., Hyman, B. T. & Irizarry, M. C., Jan 1 2001, In : Neurobiology of Disease. 8, 1, p. 90-102 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice

Liu, P., Kemper, L. J., Wang, J., Zahs, K. R., Ashe, K. H. & Pasinetti, G. M., 2011, In : Journal of Alzheimer's Disease. 26, 4, p. 657-666 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Human cerebrospinal fluid 6E10- immunoreactive protein species contain amyloid precursor protein fragments

Grant, M. K. O., Handoko, M., Rozga, M., Brinkmalm, G., Portelius, E., Blennow, K., Ashe, K. H., Zahs, K. R. & Liu, P., Feb 2019, In : PloS one. 14, 2, e0212815.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Human prion diseases

Prusiner, S. B. & Hsiao, K. K., Apr 1994, In : Annals of Neurology. 35, 4, p. 385-395 11 p.

Research output: Contribution to journalArticle

230 Scopus citations

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

Lim, G. P., Yang, F., Chu, T., Gahtan, E., Ubeda, O., Beech, W., Overmier, J. B., Hsiao-Ashec, K., Frautschy, S. A. & Cole, G. M., Dec 1 2001, In : Neurobiology of Aging. 22, 6, p. 983-991 9 p.

Research output: Contribution to journalArticle

214 Scopus citations

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for alzheimer's disease

Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., Tran, T., Ubeda, O., Ashe, K. H., Frautschy, S. A. & Cole, G. M., Aug 1 2000, In : Journal of Neuroscience. 20, 15, p. 5709-5714 6 p.

Research output: Contribution to journalArticle

Open Access
786 Scopus citations

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression

Krezowski, J., Knudson, D., Ebeling, C., Pitstick, R., Giri, R. K., Schenk, D., Westaway, D., Younkin, L., Younkin, S. G., Ashe, K. H. & Carlson, G. A., Sep 15 2004, In : Human molecular genetics. 13, 18, p. 1989-1997 9 p.

Research output: Contribution to journalArticle

18 Scopus citations